NO920116D0 - Fremgangsmaate ved rekombinant fremstilling av hirudiner og hirudinlignende polypeptider - Google Patents

Fremgangsmaate ved rekombinant fremstilling av hirudiner og hirudinlignende polypeptider

Info

Publication number
NO920116D0
NO920116D0 NO920116A NO920116A NO920116D0 NO 920116 D0 NO920116 D0 NO 920116D0 NO 920116 A NO920116 A NO 920116A NO 920116 A NO920116 A NO 920116A NO 920116 D0 NO920116 D0 NO 920116D0
Authority
NO
Norway
Prior art keywords
hirudines
hirud
procedure
similar polypeptides
recombinant preparation
Prior art date
Application number
NO920116A
Other languages
English (en)
Other versions
NO920116L (no
Inventor
Luca Benatti
Paolo Carminati
Jaqueline Lansen
Guy Mazue
Romeo Roncucci
Paolo Sarmientos
Emanuela Scacheri
Philippe De Taxis Du Poet
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NO920116D0 publication Critical patent/NO920116D0/no
Publication of NO920116L publication Critical patent/NO920116L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO92920116A 1990-05-10 1992-01-09 Fremgangsmaate ved rekombinant fremstilling av hirudiner og hirudinlignende polypeptider NO920116L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909010552A GB9010552D0 (en) 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins
PCT/EP1991/000643 WO1991017250A1 (en) 1990-05-10 1991-04-05 Method for the recombinant production of hiridius and hirudin-like polypeptides

Publications (2)

Publication Number Publication Date
NO920116D0 true NO920116D0 (no) 1992-01-09
NO920116L NO920116L (no) 1992-03-10

Family

ID=10675801

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92920116A NO920116L (no) 1990-05-10 1992-01-09 Fremgangsmaate ved rekombinant fremstilling av hirudiner og hirudinlignende polypeptider

Country Status (16)

Country Link
EP (1) EP0482144A1 (no)
JP (1) JPH05500615A (no)
KR (1) KR920703817A (no)
CN (1) CN1057294A (no)
AU (1) AU7652591A (no)
CA (1) CA2063575A1 (no)
CS (1) CS133191A3 (no)
FI (1) FI920058A0 (no)
GB (1) GB9010552D0 (no)
HU (1) HUT59961A (no)
IE (1) IE911578A1 (no)
IL (1) IL98074A0 (no)
NO (1) NO920116L (no)
PT (1) PT97604A (no)
WO (1) WO1991017250A1 (no)
ZA (1) ZA913503B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255396A1 (en) * 1990-11-08 1992-05-09 Nippon Mining Company Limited Hirudin analog, method of manufacturing thereof and anti-coagulant composition, and secretion vector, transformed microorganisms containing said vector and manufacturing method ofproducts which is produced from said microorganism
HU214698B (hu) * 1992-04-09 1998-06-29 Gyógyszerkutató Intézet Kft. Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
DE102005002978B4 (de) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
CA2825252C (en) 2011-01-25 2018-10-16 Universite Catholique De Louvain Compositions of an antithrombin activator and a thrombin inhibitor for use in cell transplantation
US9775890B2 (en) 2012-01-25 2017-10-03 Université Catholique de Louvain Factor Xa inhibitor used with liver-derived progenitor cells
CN108220369B (zh) * 2017-12-04 2021-03-12 广东双骏生物科技有限公司 一种生产重组水蛭素的方法
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN114736289B (zh) * 2022-03-17 2023-07-18 华南理工大学 一种带有酪氨酸硫酸化修饰的水蛭素的化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins

Also Published As

Publication number Publication date
KR920703817A (ko) 1992-12-18
ZA913503B (en) 1992-02-26
FI920058A0 (fi) 1992-01-07
NO920116L (no) 1992-03-10
EP0482144A1 (en) 1992-04-29
HUT59961A (en) 1992-07-28
JPH05500615A (ja) 1993-02-12
WO1991017250A1 (en) 1991-11-14
CN1057294A (zh) 1991-12-25
CA2063575A1 (en) 1991-11-11
HU9200088D0 (en) 1992-06-29
CS133191A3 (en) 1992-01-15
PT97604A (pt) 1992-02-28
GB9010552D0 (en) 1990-07-04
IE911578A1 (en) 1991-11-20
AU7652591A (en) 1991-11-27
IL98074A0 (en) 1992-06-21

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