DK470489D0 - Fremgangsmaade til oprensning og foldning af rekombinante proteiner - Google Patents

Fremgangsmaade til oprensning og foldning af rekombinante proteiner

Info

Publication number
DK470489D0
DK470489D0 DK470489A DK470489A DK470489D0 DK 470489 D0 DK470489 D0 DK 470489D0 DK 470489 A DK470489 A DK 470489A DK 470489 A DK470489 A DK 470489A DK 470489 D0 DK470489 D0 DK 470489D0
Authority
DK
Denmark
Prior art keywords
folding
purification
procedure
recombinant proteins
recombinant
Prior art date
Application number
DK470489A
Other languages
English (en)
Other versions
DK470489A (da
Inventor
Jesse Leroy Bobbitt
Joseph Vincent Manetta
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK470489D0 publication Critical patent/DK470489D0/da
Publication of DK470489A publication Critical patent/DK470489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK470489A 1988-09-26 1989-09-25 Fremgangsmaade til oprensning og foldning af rekombinante proteiner DK470489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/248,757 US4923967A (en) 1988-09-26 1988-09-26 Purification and refolding of recombinant proteins

Publications (2)

Publication Number Publication Date
DK470489D0 true DK470489D0 (da) 1989-09-25
DK470489A DK470489A (da) 1990-03-27

Family

ID=22940546

Family Applications (1)

Application Number Title Priority Date Filing Date
DK470489A DK470489A (da) 1988-09-26 1989-09-25 Fremgangsmaade til oprensning og foldning af rekombinante proteiner

Country Status (4)

Country Link
US (1) US4923967A (da)
EP (1) EP0361830A3 (da)
JP (1) JPH02142490A (da)
DK (1) DK470489A (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047504A (en) * 1987-04-28 1991-09-10 Amgen, Inc. Method for purifying granulocyte-macrophage colony stimulating factor
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US5552302A (en) * 1989-04-24 1996-09-03 Promega Corporation Methods and compositions for production of human recombinant placental ribonuclease inhibitor
US5191063A (en) * 1989-05-02 1993-03-02 University Of Medicine And Dentistry Of New Jersey Production of biologically active polypeptides by treatment with an exogenous peptide sequence
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5151501A (en) * 1991-12-20 1992-09-29 American Cyanamid Company Method for solubilization and naturation of somatotropins utilizing sulfolane
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
CN1051092C (zh) * 1993-05-21 2000-04-05 沈阳军区后勤部军事医学研究所 一种重组大肠杆菌培养液中分离和纯化重组人白细胞介素2的方法
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5563057A (en) * 1994-10-31 1996-10-08 Wisconsin Alumni Research Foundation Method for refolding misfolded enzymes with detergent and cyclodextrin
JP2000506145A (ja) * 1996-03-08 2000-05-23 ノボ ノルディスク アクティーゼルスカブ 硫化塩によるタンパク質の結晶化
BRPI9909678B8 (pt) 1998-04-17 2021-05-25 Fujirebio Europe N V aperfeiçoados ensaios de imunodiagnóstico usando agentes redutores
DK1095056T3 (da) * 1998-07-09 2007-04-23 Barofold Inc Höjtryksrefoldning af proteinaggregater og inklusionslegemer
US20020049303A1 (en) * 1999-06-28 2002-04-25 Tang Jordan J. N. Catalytically active recombinant memapsin and methods of use thereof
JP5138851B2 (ja) * 1999-06-28 2013-02-06 オクラホマ メディカル リサーチ ファウンデーション 触媒的に活性な組換えメマプシンおよびその使用方法
US20020064835A1 (en) * 2000-07-10 2002-05-30 Diosynth Rtp, Inc. Purification of human troponin I
US6995246B1 (en) * 2000-10-19 2006-02-07 Akzo Nobel N.V. Methods for removing suspended particles from soluble protein solutions
EP1434789B1 (en) * 2000-10-31 2008-03-26 BaroFold, Inc. Improved protein disaggregation and refolding using high pressure
US20040121947A1 (en) * 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
WO2003039454A2 (en) * 2001-10-23 2003-05-15 Oklahoma Medical Research Foundation Beta-secretase inhibitors and methods of use
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
US20030134352A1 (en) * 2002-01-04 2003-07-17 Freimuth Paul I. Facilitating protein folding and solubility by use of peptide extensions
WO2004067556A1 (en) * 2003-01-31 2004-08-12 Akzo Nobel N.V. Method for protein isolation in anoxic conditions
AU2006279896A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating Alzheimer's disease
US20080161242A1 (en) * 2006-09-15 2008-07-03 Randolph Theodore W High pressure treatment of proteins for reduced immunogenicity
US20220195002A1 (en) * 2019-04-24 2022-06-23 Tanvex Biopharma Usa, Inc. Process for preparing granulocyte-colony stimulating factor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656249A (en) * 1982-06-10 1987-04-07 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
EP0111814A3 (en) * 1982-12-16 1985-08-14 Mgi Pharma, Inc. The cloning and expression of nucleotide sequences encoding bovine growth hormone
IE56372B1 (en) * 1982-12-22 1991-07-03 Genentech Inc Microbially produced rennet methods for its production and plasmids used for its production
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
EP0208539A3 (en) * 1985-07-11 1988-08-03 Repligen Corporation Folding disulfide-cross-linkable proteins

Also Published As

Publication number Publication date
JPH02142490A (ja) 1990-05-31
US4923967A (en) 1990-05-08
EP0361830A3 (en) 1991-09-18
EP0361830A2 (en) 1990-04-04
DK470489A (da) 1990-03-27

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Legal Events

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