GB9010552D0 - Method for the recombinant production of hirudins and novel hirudins - Google Patents

Method for the recombinant production of hirudins and novel hirudins

Info

Publication number
GB9010552D0
GB9010552D0 GB909010552A GB9010552A GB9010552D0 GB 9010552 D0 GB9010552 D0 GB 9010552D0 GB 909010552 A GB909010552 A GB 909010552A GB 9010552 A GB9010552 A GB 9010552A GB 9010552 D0 GB9010552 D0 GB 9010552D0
Authority
GB
United Kingdom
Prior art keywords
hirudins
novel
recombinant production
recombinant
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB909010552A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Priority to GB909010552A priority Critical patent/GB9010552D0/en
Publication of GB9010552D0 publication Critical patent/GB9010552D0/en
Priority to CA002063575A priority patent/CA2063575A1/en
Priority to JP3506842A priority patent/JPH05500615A/en
Priority to KR1019920700048A priority patent/KR920703817A/en
Priority to PCT/EP1991/000643 priority patent/WO1991017250A1/en
Priority to HU9288A priority patent/HUT59961A/en
Priority to EP19910907785 priority patent/EP0482144A1/en
Priority to AU76525/91A priority patent/AU7652591A/en
Priority to IL98074A priority patent/IL98074A0/en
Priority to CS911331A priority patent/CS133191A3/en
Priority to CN91103025A priority patent/CN1057294A/en
Priority to PT97604A priority patent/PT97604A/en
Priority to ZA913503A priority patent/ZA913503B/en
Priority to IE157891A priority patent/IE911578A1/en
Priority to FI920058A priority patent/FI920058A0/en
Priority to NO92920116A priority patent/NO920116L/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GB909010552A 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins Pending GB9010552D0 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB909010552A GB9010552D0 (en) 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins
AU76525/91A AU7652591A (en) 1990-05-10 1991-04-05 Method for the recombinant production of hiridius and hirudin-like polypeptides
EP19910907785 EP0482144A1 (en) 1990-05-10 1991-04-05 Method for the recombinant production of hiridins and hirudin-like polypeptides
JP3506842A JPH05500615A (en) 1990-05-10 1991-04-05 Hirudin and new recombinant production method of hirudin
KR1019920700048A KR920703817A (en) 1990-05-10 1991-04-05 Recombinant preparation of hirudin and hirudin-type polypeptides
PCT/EP1991/000643 WO1991017250A1 (en) 1990-05-10 1991-04-05 Method for the recombinant production of hiridius and hirudin-like polypeptides
HU9288A HUT59961A (en) 1990-05-10 1991-04-05 Recombinant process for producing hirudine and hirudine-like new polypeptides
CA002063575A CA2063575A1 (en) 1990-05-10 1991-04-05 Method for the recombinant production of hirudins and hirudin-like polypeptides
CS911331A CS133191A3 (en) 1990-05-10 1991-05-07 Process for preparing hirudin and hirudin polypeptide
IL98074A IL98074A0 (en) 1990-05-10 1991-05-07 Recombinant production of hirudins and novel hirudins
CN91103025A CN1057294A (en) 1990-05-10 1991-05-08 The recombinant chou preparation method of r-hirudin
PT97604A PT97604A (en) 1990-05-10 1991-05-08 PROCESS FOR THE RECOMBINANT PREPARATION OF HYDRUDINES
ZA913503A ZA913503B (en) 1990-05-10 1991-05-08 Hirudins and a method for their recombinant production
IE157891A IE911578A1 (en) 1990-05-10 1991-05-09 Method for the recombinant production of hirudins and novel¹hirudins
FI920058A FI920058A0 (en) 1990-05-10 1992-01-07 FOERFARANDE FOER PRODUKTION AV HIRUDINER OCH HIRUDIN-LIKNANDE POLYPEPTIDER MED REKOMBINANTTEKNOLOGI.
NO92920116A NO920116L (en) 1990-05-10 1992-01-09 PROCEDURE FOR RECOMBINANT PREPARATION OF HIRUDINES AND HIRUD-SIMILAR POLYPEPTIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909010552A GB9010552D0 (en) 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins

Publications (1)

Publication Number Publication Date
GB9010552D0 true GB9010552D0 (en) 1990-07-04

Family

ID=10675801

Family Applications (1)

Application Number Title Priority Date Filing Date
GB909010552A Pending GB9010552D0 (en) 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins

Country Status (16)

Country Link
EP (1) EP0482144A1 (en)
JP (1) JPH05500615A (en)
KR (1) KR920703817A (en)
CN (1) CN1057294A (en)
AU (1) AU7652591A (en)
CA (1) CA2063575A1 (en)
CS (1) CS133191A3 (en)
FI (1) FI920058A0 (en)
GB (1) GB9010552D0 (en)
HU (1) HUT59961A (en)
IE (1) IE911578A1 (en)
IL (1) IL98074A0 (en)
NO (1) NO920116L (en)
PT (1) PT97604A (en)
WO (1) WO1991017250A1 (en)
ZA (1) ZA913503B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE176500T1 (en) * 1990-11-08 1999-02-15 Japan Energy Corp SECRETION VECTOR, TRANSFORMED MICROORGANISMS CONTAINED AND PRODUCTION OF PRODUCTS BY THE ABOVE MICROORGANISM
HU214698B (en) * 1992-04-09 1998-06-29 Gyógyszerkutató Intézet Kft. Process for producing recombinant desulphatohirudin hv-1 peptides
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
DE102005002978B4 (en) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Recombinant expression of proteins in a disulfide-bonded, two-chain form
DK2667878T3 (en) 2011-01-25 2016-06-27 Univ Catholique Louvain Configurations and methods for cell transplantation
WO2013110354A1 (en) 2012-01-25 2013-08-01 Université Catholique de Louvain Compositions and methods for cell transplantation
CN108220369B (en) * 2017-12-04 2021-03-12 广东双骏生物科技有限公司 Method for producing recombinant hirudin
CN115572329B (en) * 2021-06-21 2024-02-06 王大勇 Poecilobdella manillensis gene recombinant hirudin with slower activity enhancement metabolism and preparation method thereof
CN115677850B (en) * 2021-07-24 2024-03-08 王大勇 Hirudo gene mutant hirudin with strong anticoagulation activity and preparation method thereof
CN114736289B (en) * 2022-03-17 2023-07-18 华南理工大学 Chemical synthesis method of hirudin with tyrosine sulfation modification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429430A1 (en) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt GENE TECHNOLOGICAL METHOD FOR PRODUCING HIRUDINE AND MEANS FOR IMPLEMENTING THIS METHOD
DE3445517C2 (en) * 1984-12-13 1993-11-18 Ciba Geigy DNA sequence coding for a hirudin-like protein and method for producing a hirudin-like protein
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins

Also Published As

Publication number Publication date
HUT59961A (en) 1992-07-28
EP0482144A1 (en) 1992-04-29
IL98074A0 (en) 1992-06-21
AU7652591A (en) 1991-11-27
NO920116D0 (en) 1992-01-09
CS133191A3 (en) 1992-01-15
KR920703817A (en) 1992-12-18
IE911578A1 (en) 1991-11-20
PT97604A (en) 1992-02-28
ZA913503B (en) 1992-02-26
HU9200088D0 (en) 1992-06-29
FI920058A0 (en) 1992-01-07
JPH05500615A (en) 1993-02-12
NO920116L (en) 1992-03-10
CN1057294A (en) 1991-12-25
CA2063575A1 (en) 1991-11-11
WO1991017250A1 (en) 1991-11-14

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