DE69123345T2 - Sequenzielle c-termin degradierung von peptiden und proteinen - Google Patents

Sequenzielle c-termin degradierung von peptiden und proteinen

Info

Publication number
DE69123345T2
DE69123345T2 DE69123345T DE69123345T DE69123345T2 DE 69123345 T2 DE69123345 T2 DE 69123345T2 DE 69123345 T DE69123345 T DE 69123345T DE 69123345 T DE69123345 T DE 69123345T DE 69123345 T2 DE69123345 T2 DE 69123345T2
Authority
DE
Germany
Prior art keywords
degrading
peptides
proteins
sequential
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69123345T
Other languages
English (en)
Other versions
DE69123345D1 (de
Inventor
Jerome Bailey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
City of Hope
Original Assignee
City of Hope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by City of Hope filed Critical City of Hope
Application granted granted Critical
Publication of DE69123345D1 publication Critical patent/DE69123345D1/de
Publication of DE69123345T2 publication Critical patent/DE69123345T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G01N33/6821—Sequencing of polypeptides involving C-terminal degradation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69123345T 1990-08-13 1991-06-21 Sequenzielle c-termin degradierung von peptiden und proteinen Expired - Fee Related DE69123345T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/576,943 US5059540A (en) 1990-08-13 1990-08-13 Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide
PCT/US1991/004434 WO1992003737A1 (en) 1990-08-13 1991-06-21 Sequential c-terminal degradation of peptides and proteins

Publications (2)

Publication Number Publication Date
DE69123345D1 DE69123345D1 (de) 1997-01-09
DE69123345T2 true DE69123345T2 (de) 1997-06-12

Family

ID=24306641

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123345T Expired - Fee Related DE69123345T2 (de) 1990-08-13 1991-06-21 Sequenzielle c-termin degradierung von peptiden und proteinen

Country Status (8)

Country Link
US (1) US5059540A (de)
EP (2) EP0726288A1 (de)
JP (2) JP3040163B2 (de)
KR (1) KR927002498A (de)
AU (1) AU654494B2 (de)
CA (1) CA2067150A1 (de)
DE (1) DE69123345T2 (de)
WO (1) WO1992003737A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185266A (en) * 1991-10-15 1993-02-09 Applied Biosystems, Inc. Cleavage method for acyl thiohydantoins and use of the method in c-terminal peptide sequencing
US5470703A (en) * 1992-10-21 1995-11-28 Shimadzu Corporation Method for peptide C-terminal fragment sequence analysis and apparatus for collecting peptide fragment
AU4106396A (en) * 1994-11-15 1996-06-06 Eli Lilly And Company Process for performing retro-aldol reaction
US5629289A (en) * 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
JP3124507B2 (ja) * 1996-05-24 2001-01-15 セイコーインスツルメンツ株式会社 タンパク質あるいはペプチドのカルボキシ末端からのアミノ酸配列を決定する方法
US5986071A (en) * 1997-06-16 1999-11-16 City Of Hope Method for C-terminal degradation of peptides and proteins
US6277644B1 (en) 1999-03-22 2001-08-21 Beckman Coulter, Inc. Method for compositional tag sequencing
JP4257492B2 (ja) 2002-11-29 2009-04-22 日本電気株式会社 ペプチドのｃ末端アミノ酸配列解析方法
JP4086642B2 (ja) * 2002-12-10 2008-05-14 日本電気株式会社 ペプチドのｃ末端アミノ酸配列解析方法
HRP20030965A2 (en) * 2003-11-24 2005-08-31 Belupo - Lijekovi I Kozmetika D.D. Process for production of (s)-n-pentanoyl-n-[[2'-(
EP2336783A1 (de) 2009-12-18 2011-06-22 Basf Se C-terminale Sequenzierung von Aminosäuren

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4339473A (en) * 1980-08-28 1982-07-13 Rai Research Corporation Gamma radiation grafting process for preparing separator membranes for electrochemical cells
US4582875A (en) * 1984-12-07 1986-04-15 Bioprobe International, Inc. Method of activating hydroxyl groups of a polymeric carrier using 2-fluoro-1-methylpyridinium toluene-4-sulfonate
EP0217634B1 (de) * 1985-09-26 1992-06-10 Beckman Research Institute of the City of Hope Sequenzierung von Peptiden
US4861726A (en) * 1988-03-10 1989-08-29 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with acylation of thiazoloinones
US4935494A (en) * 1988-11-15 1990-06-19 City Of Hope C-terminal peptide and protein sequencing
AU639928B2 (en) * 1990-05-18 1993-08-12 City Of Hope Sequential degradation of peptides
DE69030316T2 (de) * 1990-05-18 1997-10-23 Hope City Schrittweiser c-terminaler abbau von peptiden und proteinen

Also Published As

Publication number Publication date
JPH05501762A (ja) 1993-04-02
CA2067150A1 (en) 1992-02-14
KR927002498A (ko) 1992-09-04
JP3124273B2 (ja) 2001-01-15
EP0726288A1 (de) 1996-08-14
US5059540A (en) 1991-10-22
EP0495939A4 (en) 1992-11-25
JP3040163B2 (ja) 2000-05-08
EP0495939A1 (de) 1992-07-29
EP0495939B1 (de) 1996-11-27
JP2000146983A (ja) 2000-05-26
DE69123345D1 (de) 1997-01-09
AU654494B2 (en) 1994-11-10
AU8213291A (en) 1992-03-17
WO1992003737A1 (en) 1992-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee