ZA913503B - Hirudins and a method for their recombinant production - Google Patents

Hirudins and a method for their recombinant production

Info

Publication number
ZA913503B
ZA913503B ZA913503A ZA913503A ZA913503B ZA 913503 B ZA913503 B ZA 913503B ZA 913503 A ZA913503 A ZA 913503A ZA 913503 A ZA913503 A ZA 913503A ZA 913503 B ZA913503 B ZA 913503B
Authority
ZA
South Africa
Prior art keywords
hirudins
recombinant production
recombinant
production
Prior art date
Application number
ZA913503A
Other languages
English (en)
Inventor
Luca Benatti
Benatti Luca
Paolo Carminati
Carminati Paolo
Jacqueline Lansen
Lansen Jacqueline
Guy Mazue
Mazue Guy
Romeo Roncucci
Roncucci Romeo
Paolo Sarmientos
Sarmientos Paolo
Emanuela Scacheri
Scacheri Emanuela
Philippe De Taxis Du Poet
De Taxis Du Poet Philippe
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ZA913503B publication Critical patent/ZA913503B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA913503A 1990-05-10 1991-05-08 Hirudins and a method for their recombinant production ZA913503B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909010552A GB9010552D0 (en) 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins

Publications (1)

Publication Number Publication Date
ZA913503B true ZA913503B (en) 1992-02-26

Family

ID=10675801

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913503A ZA913503B (en) 1990-05-10 1991-05-08 Hirudins and a method for their recombinant production

Country Status (16)

Country Link
EP (1) EP0482144A1 (no)
JP (1) JPH05500615A (no)
KR (1) KR920703817A (no)
CN (1) CN1057294A (no)
AU (1) AU7652591A (no)
CA (1) CA2063575A1 (no)
CS (1) CS133191A3 (no)
FI (1) FI920058A0 (no)
GB (1) GB9010552D0 (no)
HU (1) HUT59961A (no)
IE (1) IE911578A1 (no)
IL (1) IL98074A0 (no)
NO (1) NO920116L (no)
PT (1) PT97604A (no)
WO (1) WO1991017250A1 (no)
ZA (1) ZA913503B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU648124B2 (en) * 1990-11-08 1994-04-14 Japan Energy Corporation Hirudine mutant, production thereof, anticoagulant, secretory vector, microorganism transformed by said vector, and production of product from said microorganism
HU214698B (hu) * 1992-04-09 1998-06-29 Gyógyszerkutató Intézet Kft. Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
DE102005002978B4 (de) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
WO2013110354A1 (en) 2012-01-25 2013-08-01 Université Catholique de Louvain Compositions and methods for cell transplantation
WO2012101181A1 (en) 2011-01-25 2012-08-02 Université Catholique de Louvain Compositions and methods for cell transplantation
CN108220369B (zh) * 2017-12-04 2021-03-12 广东双骏生物科技有限公司 一种生产重组水蛭素的方法
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN114736289B (zh) * 2022-03-17 2023-07-18 华南理工大学 一种带有酪氨酸硫酸化修饰的水蛭素的化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins

Also Published As

Publication number Publication date
CN1057294A (zh) 1991-12-25
KR920703817A (ko) 1992-12-18
FI920058A0 (fi) 1992-01-07
IE911578A1 (en) 1991-11-20
IL98074A0 (en) 1992-06-21
NO920116L (no) 1992-03-10
JPH05500615A (ja) 1993-02-12
NO920116D0 (no) 1992-01-09
PT97604A (pt) 1992-02-28
CA2063575A1 (en) 1991-11-11
WO1991017250A1 (en) 1991-11-14
AU7652591A (en) 1991-11-27
HUT59961A (en) 1992-07-28
EP0482144A1 (en) 1992-04-29
HU9200088D0 (en) 1992-06-29
CS133191A3 (en) 1992-01-15
GB9010552D0 (en) 1990-07-04

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