NO904668L - Fremgangsmaate for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-pgi2-derivater. - Google Patents

Fremgangsmaate for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-pgi2-derivater.

Info

Publication number
NO904668L
NO904668L NO90904668A NO904668A NO904668L NO 904668 L NO904668 L NO 904668L NO 90904668 A NO90904668 A NO 90904668A NO 904668 A NO904668 A NO 904668A NO 904668 L NO904668 L NO 904668L
Authority
NO
Norway
Prior art keywords
trinor
phenylene
inter
procedure
preparation
Prior art date
Application number
NO90904668A
Other languages
English (en)
Other versions
NO904668D0 (no
NO176962C (no
NO176962B (no
Inventor
Kiyotaka Ohno
Hiroshi Nagase
Yutaka Hosono
Hisanori Wakita
Koji Kawai
Hideo Yoshiwara
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO904668D0 publication Critical patent/NO904668D0/no
Publication of NO904668L publication Critical patent/NO904668L/no
Publication of NO176962B publication Critical patent/NO176962B/no
Publication of NO176962C publication Critical patent/NO176962C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/247—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO904668A 1989-02-27 1990-10-26 Fremgangsmåte for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-PGI2-derivater NO176962C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4687389 1989-02-27
JP4687489 1989-02-27
PCT/JP1990/000237 WO1990010003A1 (fr) 1989-02-27 1990-02-27 PREPARATION DE DERIVES DE 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI¿2?

Publications (4)

Publication Number Publication Date
NO904668D0 NO904668D0 (no) 1990-10-26
NO904668L true NO904668L (no) 1990-12-27
NO176962B NO176962B (no) 1995-03-20
NO176962C NO176962C (no) 1995-06-28

Family

ID=26387021

Family Applications (1)

Application Number Title Priority Date Filing Date
NO904668A NO176962C (no) 1989-02-27 1990-10-26 Fremgangsmåte for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-PGI2-derivater

Country Status (12)

Country Link
US (2) US5202447A (no)
EP (1) EP0463162B1 (no)
JP (2) JP2527277B2 (no)
AT (1) ATE105555T1 (no)
AU (1) AU634213B2 (no)
CA (1) CA2028626C (no)
DE (1) DE69008851T2 (no)
DK (1) DK0463162T3 (no)
ES (1) ES2053180T3 (no)
FI (1) FI106715B (no)
NO (1) NO176962C (no)
WO (1) WO1990010003A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960016542B1 (ko) * 1989-03-14 1996-12-14 토레이 가부시기가이샤 2,5,6,7-테트라놀-4,8-인터-m-페닐렌 PGI₂유도체, 이것의 제조 방법 및 이를 함유하는 약제
US5169959A (en) * 1991-09-23 1992-12-08 Iowa State University Research Foundation, Inc. Free radical-catalyzed synthesis of benzoprostacyclins
WO1998037042A1 (fr) * 1997-02-21 1998-08-27 Toray Industries, Inc. Procede de production d'isomeres de composes tricycliques a activite optique
CA2326751C (en) * 1998-04-06 2009-10-06 Basf Aktiengesellschaft Method for producing grignard compounds
JP3340732B1 (ja) * 2001-10-05 2002-11-05 日本医薬品工業株式会社 シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
KR100903311B1 (ko) * 2002-09-18 2009-06-17 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법 및 그를 위한 출발물질
EP3461817B1 (en) 2011-06-16 2020-11-04 Lung Biotechnology Inc. Potassium salt of beraprost
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
JP6263604B2 (ja) 2013-03-25 2018-01-17 ユナイテッド セラピューティクス コーポレイション チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法
WO2015179427A1 (en) * 2014-05-20 2015-11-26 Lung Biotechnology Pbc Methods for producing beraprost and its derivatives
WO2017027706A1 (en) 2015-08-12 2017-02-16 United Therapeutics Corporation Process for making beraprost
EP3658187A1 (en) 2017-07-27 2020-06-03 Allergan, Inc. Prostacyclin receptor agonists for reduction of body fat
US11560363B2 (en) 2018-10-22 2023-01-24 United Therapeutics Corporation Synthesis of esuberaprost prodrugs
CN113493430B (zh) * 2020-03-19 2024-09-10 江西科睿药业有限公司 一种贝前列素及其盐的中间体及其制备方法
US11884640B2 (en) 2021-06-02 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom
TW202317527A (zh) * 2021-06-28 2023-05-01 日商大內新興化學工業股份有限公司 貝前列素或光學活性物之合成中間物及其製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144277A (en) * 1981-03-02 1982-09-06 Toray Ind Inc Cyclopentabenzofuran derivative
JPS57144233A (en) * 1981-03-02 1982-09-06 Toray Ind Inc Cyclopentene derivative
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
KR960016542B1 (ko) * 1989-03-14 1996-12-14 토레이 가부시기가이샤 2,5,6,7-테트라놀-4,8-인터-m-페닐렌 PGI₂유도체, 이것의 제조 방법 및 이를 함유하는 약제

Also Published As

Publication number Publication date
WO1990010003A1 (fr) 1990-09-07
US5420310A (en) 1995-05-30
FI905315A0 (fi) 1990-10-26
EP0463162A1 (en) 1992-01-02
NO904668D0 (no) 1990-10-26
EP0463162B1 (en) 1994-05-11
JP2527277B2 (ja) 1996-08-21
EP0463162A4 (en) 1992-05-20
FI106715B (fi) 2001-03-30
DE69008851D1 (de) 1994-06-16
ATE105555T1 (de) 1994-05-15
JP2836556B2 (ja) 1998-12-14
AU634213B2 (en) 1993-02-18
AU5107790A (en) 1990-09-26
CA2028626A1 (en) 1990-08-28
DK0463162T3 (da) 1994-06-20
US5202447A (en) 1993-04-13
CA2028626C (en) 1997-12-09
DE69008851T2 (de) 1994-08-18
ES2053180T3 (es) 1994-07-16
NO176962C (no) 1995-06-28
NO176962B (no) 1995-03-20
JPH08225561A (ja) 1996-09-03

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