NO904668L - Fremgangsmaate for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-pgi2-derivater. - Google Patents
Fremgangsmaate for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-pgi2-derivater.Info
- Publication number
- NO904668L NO904668L NO90904668A NO904668A NO904668L NO 904668 L NO904668 L NO 904668L NO 90904668 A NO90904668 A NO 90904668A NO 904668 A NO904668 A NO 904668A NO 904668 L NO904668 L NO 904668L
- Authority
- NO
- Norway
- Prior art keywords
- trinor
- phenylene
- inter
- procedure
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/247—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Luminescent Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4687389 | 1989-02-27 | ||
JP4687489 | 1989-02-27 | ||
PCT/JP1990/000237 WO1990010003A1 (fr) | 1989-02-27 | 1990-02-27 | PREPARATION DE DERIVES DE 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI¿2? |
Publications (4)
Publication Number | Publication Date |
---|---|
NO904668D0 NO904668D0 (no) | 1990-10-26 |
NO904668L true NO904668L (no) | 1990-12-27 |
NO176962B NO176962B (no) | 1995-03-20 |
NO176962C NO176962C (no) | 1995-06-28 |
Family
ID=26387021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO904668A NO176962C (no) | 1989-02-27 | 1990-10-26 | Fremgangsmåte for fremstilling av 5,6,7-trinor-4,8-inter-m-fenylen-PGI2-derivater |
Country Status (12)
Country | Link |
---|---|
US (2) | US5202447A (no) |
EP (1) | EP0463162B1 (no) |
JP (2) | JP2527277B2 (no) |
AT (1) | ATE105555T1 (no) |
AU (1) | AU634213B2 (no) |
CA (1) | CA2028626C (no) |
DE (1) | DE69008851T2 (no) |
DK (1) | DK0463162T3 (no) |
ES (1) | ES2053180T3 (no) |
FI (1) | FI106715B (no) |
NO (1) | NO176962C (no) |
WO (1) | WO1990010003A1 (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2012081C (en) * | 1989-03-14 | 2000-08-29 | Shigeki Itou | 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi 2 derivatives |
US5169959A (en) * | 1991-09-23 | 1992-12-08 | Iowa State University Research Foundation, Inc. | Free radical-catalyzed synthesis of benzoprostacyclins |
US6103914A (en) * | 1997-02-21 | 2000-08-15 | Toray Industries, Inc. | Method of producing optically active material of tricyclic compound |
ATE402182T1 (de) * | 1998-04-06 | 2008-08-15 | Basf Se | Verfahren zur herstellung von grignardverbindungen |
JP3340732B1 (ja) * | 2001-10-05 | 2002-11-05 | 日本医薬品工業株式会社 | シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物 |
GB0215757D0 (en) * | 2002-07-08 | 2002-08-14 | Cascade Biochem Ltd | Benzoprostacyclin intermediates methods for their preparation and products derived therefrom |
KR100903311B1 (ko) * | 2002-09-18 | 2009-06-17 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 및 그를 위한 출발물질 |
JP6174575B2 (ja) * | 2011-06-16 | 2017-08-02 | ラング バイオテクノロジー インコーポレーテッド | ベラプロストの製造方法 |
CN103509044A (zh) * | 2012-06-21 | 2014-01-15 | 上海天伟生物制药有限公司 | 贝前列素钠中间体及其制备方法 |
JP6263604B2 (ja) | 2013-03-25 | 2018-01-17 | ユナイテッド セラピューティクス コーポレイション | チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法 |
EP3145919A4 (en) | 2014-05-20 | 2018-03-14 | Lung Biotechnology PBC | Methods for producing beraprost and its derivatives |
KR101986966B1 (ko) * | 2015-08-12 | 2019-06-07 | 유나이티드 쎄러퓨틱스 코포레이션 | 베라프로스트의 제조 방법 |
US20200171026A1 (en) | 2017-07-27 | 2020-06-04 | Allergan, Inc. | Prostacyclin receptor agonists for reduction of body fat |
US11560363B2 (en) | 2018-10-22 | 2023-01-24 | United Therapeutics Corporation | Synthesis of esuberaprost prodrugs |
CN118496185A (zh) * | 2020-03-19 | 2024-08-16 | 江西科睿药业有限公司 | 一种贝前列素及其盐的中间体及其制备方法 |
US11884640B2 (en) | 2021-06-02 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom |
WO2023276983A1 (ja) * | 2021-06-28 | 2023-01-05 | 大内新興化学工業株式会社 | ベラプロストまたは光学活性体の合成中間体およびその製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57144277A (en) * | 1981-03-02 | 1982-09-06 | Toray Ind Inc | Cyclopentabenzofuran derivative |
JPS57144233A (en) * | 1981-03-02 | 1982-09-06 | Toray Ind Inc | Cyclopentene derivative |
JPS57144276A (en) * | 1981-03-03 | 1982-09-06 | Toray Ind Inc | 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative |
JPS58124778A (ja) * | 1982-01-20 | 1983-07-25 | Toray Ind Inc | 5,6,7−トリノル−4,8−インタ−m−フエニレンPGI↓2誘導体 |
US4880939A (en) * | 1986-12-11 | 1989-11-14 | Toray Industries | 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives |
CA2012081C (en) * | 1989-03-14 | 2000-08-29 | Shigeki Itou | 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi 2 derivatives |
-
1990
- 1990-02-27 ES ES90903426T patent/ES2053180T3/es not_active Expired - Lifetime
- 1990-02-27 AU AU51077/90A patent/AU634213B2/en not_active Expired
- 1990-02-27 EP EP90903426A patent/EP0463162B1/en not_active Expired - Lifetime
- 1990-02-27 US US07/601,783 patent/US5202447A/en not_active Expired - Lifetime
- 1990-02-27 CA CA002028626A patent/CA2028626C/en not_active Expired - Lifetime
- 1990-02-27 DE DE69008851T patent/DE69008851T2/de not_active Expired - Lifetime
- 1990-02-27 WO PCT/JP1990/000237 patent/WO1990010003A1/ja active IP Right Grant
- 1990-02-27 JP JP2503652A patent/JP2527277B2/ja not_active Expired - Lifetime
- 1990-02-27 AT AT9090903426T patent/ATE105555T1/de not_active IP Right Cessation
- 1990-02-27 DK DK90903426.6T patent/DK0463162T3/da active
- 1990-10-26 FI FI905315A patent/FI106715B/fi active IP Right Grant
- 1990-10-26 NO NO904668A patent/NO176962C/no not_active IP Right Cessation
-
1992
- 1992-11-20 US US07/957,357 patent/US5420310A/en not_active Expired - Lifetime
-
1995
- 1995-11-27 JP JP7331130A patent/JP2836556B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2028626C (en) | 1997-12-09 |
EP0463162A1 (en) | 1992-01-02 |
NO176962C (no) | 1995-06-28 |
AU5107790A (en) | 1990-09-26 |
WO1990010003A1 (fr) | 1990-09-07 |
EP0463162B1 (en) | 1994-05-11 |
DE69008851T2 (de) | 1994-08-18 |
JP2836556B2 (ja) | 1998-12-14 |
ATE105555T1 (de) | 1994-05-15 |
US5202447A (en) | 1993-04-13 |
NO176962B (no) | 1995-03-20 |
AU634213B2 (en) | 1993-02-18 |
DK0463162T3 (da) | 1994-06-20 |
US5420310A (en) | 1995-05-30 |
NO904668D0 (no) | 1990-10-26 |
JP2527277B2 (ja) | 1996-08-21 |
DE69008851D1 (de) | 1994-06-16 |
JPH08225561A (ja) | 1996-09-03 |
FI905315A0 (fi) | 1990-10-26 |
FI106715B (fi) | 2001-03-30 |
CA2028626A1 (en) | 1990-08-28 |
ES2053180T3 (es) | 1994-07-16 |
EP0463162A4 (en) | 1992-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |