DE69008851T2 - VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen. - Google Patents

VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen.

Info

Publication number
DE69008851T2
DE69008851T2 DE69008851T DE69008851T DE69008851T2 DE 69008851 T2 DE69008851 T2 DE 69008851T2 DE 69008851 T DE69008851 T DE 69008851T DE 69008851 T DE69008851 T DE 69008851T DE 69008851 T2 DE69008851 T2 DE 69008851T2
Authority
DE
Germany
Prior art keywords
trinor
inter
derivatives
producing
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69008851T
Other languages
English (en)
Other versions
DE69008851D1 (de
Inventor
Kiyotaka Ohno
Hiroshi Nagase
Yutaka Hosono
Hisanori Wakita
Koji Kawai
Hideo Yoshiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of DE69008851D1 publication Critical patent/DE69008851D1/de
Application granted granted Critical
Publication of DE69008851T2 publication Critical patent/DE69008851T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/247—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
DE69008851T 1989-02-27 1990-02-27 VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen. Expired - Lifetime DE69008851T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4687489 1989-02-27
JP4687389 1989-02-27
PCT/JP1990/000237 WO1990010003A1 (fr) 1989-02-27 1990-02-27 PREPARATION DE DERIVES DE 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI¿2?

Publications (2)

Publication Number Publication Date
DE69008851D1 DE69008851D1 (de) 1994-06-16
DE69008851T2 true DE69008851T2 (de) 1994-08-18

Family

ID=26387021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69008851T Expired - Lifetime DE69008851T2 (de) 1989-02-27 1990-02-27 VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen.

Country Status (12)

Country Link
US (2) US5202447A (de)
EP (1) EP0463162B1 (de)
JP (2) JP2527277B2 (de)
AT (1) ATE105555T1 (de)
AU (1) AU634213B2 (de)
CA (1) CA2028626C (de)
DE (1) DE69008851T2 (de)
DK (1) DK0463162T3 (de)
ES (1) ES2053180T3 (de)
FI (1) FI106715B (de)
NO (1) NO176962C (de)
WO (1) WO1990010003A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0389162B1 (de) * 1989-03-14 1993-12-08 Toray Industries, Inc. 2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate
US5169959A (en) * 1991-09-23 1992-12-08 Iowa State University Research Foundation, Inc. Free radical-catalyzed synthesis of benzoprostacyclins
US6103914A (en) * 1997-02-21 2000-08-15 Toray Industries, Inc. Method of producing optically active material of tricyclic compound
JP2003517433A (ja) * 1998-04-06 2003-05-27 ビーエーエスエフ アクチェンゲゼルシャフト グリニャール化合物の製造方法
JP3340732B1 (ja) * 2001-10-05 2002-11-05 日本医薬品工業株式会社 シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
KR100903311B1 (ko) * 2002-09-18 2009-06-17 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법 및 그를 위한 출발물질
CN105315247B (zh) * 2011-06-16 2019-07-26 琅歌生物技术股份有限公司 贝前列素的生产方法
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
JP6263604B2 (ja) 2013-03-25 2018-01-17 ユナイテッド セラピューティクス コーポレイション チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法
CA2949528A1 (en) 2014-05-20 2015-11-26 Lung Biotechnology Pbc Methods for producing beraprost and its derivatives
KR101986966B1 (ko) * 2015-08-12 2019-06-07 유나이티드 쎄러퓨틱스 코포레이션 베라프로스트의 제조 방법
JP2020528900A (ja) 2017-07-27 2020-10-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 体脂肪低減のためのプロスタサイクリン受容体アゴニスト
WO2020086367A1 (en) 2018-10-22 2020-04-30 United Therapeutics Corporation Synthesis of esuberaprost prodrugs
CN113493430A (zh) * 2020-03-19 2021-10-12 上海时莱生物技术有限公司 一种贝前列素及其盐的中间体及其制备方法
US11884640B2 (en) 2021-06-02 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom
WO2023276983A1 (ja) * 2021-06-28 2023-01-05 大内新興化学工業株式会社 ベラプロストまたは光学活性体の合成中間体およびその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144277A (en) * 1981-03-02 1982-09-06 Toray Ind Inc Cyclopentabenzofuran derivative
JPS57144233A (en) * 1981-03-02 1982-09-06 Toray Ind Inc Cyclopentene derivative
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
EP0389162B1 (de) * 1989-03-14 1993-12-08 Toray Industries, Inc. 2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate

Also Published As

Publication number Publication date
JP2527277B2 (ja) 1996-08-21
JP2836556B2 (ja) 1998-12-14
EP0463162B1 (de) 1994-05-11
US5202447A (en) 1993-04-13
JPH08225561A (ja) 1996-09-03
AU634213B2 (en) 1993-02-18
DE69008851D1 (de) 1994-06-16
NO176962B (no) 1995-03-20
US5420310A (en) 1995-05-30
NO904668D0 (no) 1990-10-26
ES2053180T3 (es) 1994-07-16
NO904668L (no) 1990-12-27
EP0463162A4 (en) 1992-05-20
DK0463162T3 (da) 1994-06-20
FI106715B (fi) 2001-03-30
ATE105555T1 (de) 1994-05-15
CA2028626C (en) 1997-12-09
WO1990010003A1 (fr) 1990-09-07
AU5107790A (en) 1990-09-26
FI905315A0 (fi) 1990-10-26
EP0463162A1 (de) 1992-01-02
CA2028626A1 (en) 1990-08-28
NO176962C (no) 1995-06-28

Similar Documents

Publication Publication Date Title
DE69008851D1 (de) VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen.
DE69332577T2 (de) Verfahren zur Herstellung von 13-Ether-Derivaten von Milbemycinen und Zwischenprodukte
ATE109456T1 (de) Verfahren zur stereoselektiven herstellung von phenylisoserinderivaten.
DE69521065D1 (de) Vitamin D3 Derivate und ein Verfahren zu ihrer Herstellung
DE69203859T2 (de) Verfahren zur herstellung von polytetramethylenätherglykol mittels eines sauren zirkoniumkatalysator.
ATE86978T1 (de) Verfahren zur herstellung von 3,5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer.
KR830007550A (ko) 시클릭아민의 제조방법
ATE210136T1 (de) Verfahren zur herstellung von alkylhydrogenchlorsilanen
ES2106936T3 (es) Derivados de carbazolona y procedimientos para su preparacion.
ATE9469T1 (de) Reaktive derivate des 3-oxa-bicyclo(4.3.0)-non-1- en-9-ons, verfahren zu ihrer herstellung und deren verwendung.
DE3767993D1 (de) Verfahren zur herstellung von thienylaethylaminen, und mittels des verfahrens hergestellte dithienylaethylamine.
DE69911430D1 (de) Verfahren zur herstellung von 1-(1h)-benzoquinolizin-3-on derivaten
ATE31928T1 (de) Acylamino-4-aza-1-adamantane, verfahren zu ihrer herstellung und ihre anwendung in der therapeutik.
ATE201874T1 (de) Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten
FR2479213B1 (de)
ATE5077T1 (de) 22-arylsulfonyl-24,25-dihydroxy-cholestane und verfahren zu ihrer herstellung.
DE69326767T2 (de) Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
ATE33024T1 (de) Verfahren zur herstellung von benzofuranderivaten.
ATE6648T1 (de) 4h-benzo(4,5)cyclohepta(1,2-b)furanderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3862910D1 (de) Verfahren zur herstellung von dien-1-olen, 9-hydroxydodec-10-enyl-1-tert.-butylether und seine verwendung als zwischenprodukt zur synthese von 8,10-dodecadienol.
Walkup et al. Preparation of 4-alkylthio-δ-1, 3-oxathianes, novel endocyclic ketene dithioacetals, via an acetalization of β-hydroxydithioesters
NO921178L (no) Cykliske peroksyacetallakton-, laktol- og eterforbindelser
JPS5758655A (en) Preoduction of novel antibiotic derivative
JPS51136674A (en) Process for preparing piperidylbenzimidazoles.
ATE244217T1 (de) Herstellung von beta-mehtylcarbapenem- zwischenprodukten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition