NO851538L - Fremgangsmaate for fremstilling av antibakterielt virksomme cefemforbindelser - Google Patents
Fremgangsmaate for fremstilling av antibakterielt virksomme cefemforbindelserInfo
- Publication number
- NO851538L NO851538L NO851538A NO851538A NO851538L NO 851538 L NO851538 L NO 851538L NO 851538 A NO851538 A NO 851538A NO 851538 A NO851538 A NO 851538A NO 851538 L NO851538 L NO 851538L
- Authority
- NO
- Norway
- Prior art keywords
- procedure
- manufacturing anti
- cefem compounds
- bacterial effective
- bacterial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/726,438 US4788185A (en) | 1984-04-23 | 1985-04-23 | Cephalosporin compounds |
NO85854730A NO167293C (no) | 1984-04-23 | 1985-11-26 | Mellomprodukter. |
EP86102584A EP0203271B1 (en) | 1985-03-01 | 1986-02-27 | Antibacterial compounds, their production and use |
AT86102584T ATE89826T1 (de) | 1985-03-01 | 1986-02-27 | Antibakterielle verbindungen, ihre herstellung und verwendung. |
DE8686102584T DE3688477T2 (de) | 1985-03-01 | 1986-02-27 | Antibakterielle verbindungen, ihre herstellung und verwendung. |
NO860725A NO166283C (no) | 1985-03-01 | 1986-02-27 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater. |
NZ215333A NZ215333A (en) | 1985-03-01 | 1986-02-28 | Cephem compounds and pharmaceutical compositions |
JP61044991A JPS62149682A (ja) | 1985-03-01 | 1986-02-28 | 抗菌性化合物 |
PCT/JP1986/000099 WO1986005183A1 (en) | 1985-03-01 | 1986-02-28 | Antibacterial compounds, their production and use |
AR86303255A AR241534A1 (es) | 1985-03-01 | 1986-02-28 | Compuestos de 7-(2-(5-amino-1,2,4-tiazol-3-il)-2-alcoxiimino-acetamido)-3-metil-imidazo piridinio o imidazo-pirimidinio-3-cefem-4-carboxilato y sus sales. |
PT82123A PT82123B (pt) | 1985-03-01 | 1986-02-28 | Processo para a preparacao de compostos cefem com propriedades bactericidas e de composicoes farmaceuticas que os contem |
KR1019860001441A KR930007265B1 (ko) | 1985-03-01 | 1986-02-28 | 항균 화합물의 제조방법 |
HU86853A HU198726B (en) | 1985-04-17 | 1986-02-28 | Process for producing new cefemcarboxylic acid derivatives and antibacterial pharmaceutical compositions comprising same |
GR860575A GR860575B (en) | 1985-03-01 | 1986-02-28 | Antibacterial compounds their production and use |
US06/834,969 US4864022A (en) | 1985-04-17 | 1986-02-28 | 3-Condensed imidazolium-cephem compounds |
IE54886A IE60163B1 (en) | 1985-03-01 | 1986-02-28 | Antibacterial compounds, their production and use |
CN86102034A CN1030657C (zh) | 1985-03-01 | 1986-02-28 | 抗菌化合物的生产方法 |
FI860870A FI85858C (fi) | 1985-03-01 | 1986-02-28 | Foerfarande foer framstaellning av farmaceutiska 3-kondenserade imidazoliumcefemfoereningar. |
CA000502935A CA1295995C (en) | 1985-03-01 | 1986-02-28 | Antibacterial compounds, their production and use |
AU54168/86A AU598728B2 (en) | 1985-03-01 | 1986-02-28 | Antibacterial compounds, their production and use |
DK93586A DK93586A (da) | 1985-03-01 | 1986-02-28 | Cephemforbindelser samt deres fremstilling og anvendelse |
ES552525A ES8705892A1 (es) | 1985-03-01 | 1986-02-28 | Un metodo para preparar derivados de cefem |
ES557182A ES8801289A1 (es) | 1985-03-01 | 1986-11-03 | Un metodo para preparar derivados de cefem |
ES557183A ES8801290A1 (es) | 1985-03-01 | 1986-11-03 | Un metodo para preparar derivados de cefem |
US07/331,192 US4962100A (en) | 1985-04-17 | 1989-03-28 | 3-Condensed imidazolium-cephem compounds |
AR90316105A AR247398A1 (es) | 1985-03-01 | 1990-02-07 | Procedimiento para preparar compuestos de de 7-(2-(5-amino-1,2,4-tiadiazol-3- il)-2-alcoxiimino-acetamido)-3-metil-imidazopir idio o imidazopiridazinio-3 cefem-4-carboxilato |
JP16978090A JPH0730089B2 (ja) | 1985-03-01 | 1990-06-29 | 抗菌性化合物 |
SU925052288A RU2059641C1 (ru) | 1985-03-01 | 1992-06-30 | Производные цефалоспорина и их фармацевтически приемлемые соли, антибиотическая фармацевтическая композиция, производное цефалоспорина и его аддитивная соль с галоидводородной кислотой |
US08/041,849 US5409919A (en) | 1985-04-17 | 1993-04-02 | Pharmaceutically acceptable salt of 7B-[2-(5-amino-1,2,4-thio-diazol-3-yl)-2(Z)-metho-xyiminoacetamido]-3-[(imidazo[1,2-b]pyridazinium-1-yl)methyl]-3-cephem-4-carboxylate and composition comprising same |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1984/000212 WO1985004879A1 (fr) | 1984-04-23 | 1984-04-23 | Nouveaux composes de cephem |
PCT/JP1984/000270 WO1985005620A1 (en) | 1984-05-25 | 1984-05-25 | Cephem compounds |
PCT/JP1985/000102 WO1986005184A1 (en) | 1985-03-01 | 1985-03-01 | Antibacterial compound |
Publications (3)
Publication Number | Publication Date |
---|---|
NO851538L true NO851538L (no) | 1985-10-24 |
NO165842B NO165842B (no) | 1991-01-07 |
NO165842C NO165842C (no) | 1991-04-17 |
Family
ID=27304399
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO851538A NO165842C (no) | 1984-04-23 | 1985-04-17 | Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser. |
NO85854730A NO167293C (no) | 1984-04-23 | 1985-11-26 | Mellomprodukter. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO85854730A NO167293C (no) | 1984-04-23 | 1985-11-26 | Mellomprodukter. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0160252B1 (no) |
JP (1) | JPH07103130B2 (no) |
KR (2) | KR920008945B1 (no) |
AU (1) | AU580995B2 (no) |
CA (1) | CA1283096C (no) |
DE (2) | DE3586547D1 (no) |
ES (4) | ES8606362A1 (no) |
FI (1) | FI851592L (no) |
GR (1) | GR850965B (no) |
NO (2) | NO165842C (no) |
NZ (1) | NZ211858A (no) |
PH (1) | PH23134A (no) |
PT (1) | PT80328B (no) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH22107A (en) * | 1984-06-07 | 1988-06-01 | Takeda Chemical Industries Ltd | 3-pyrazolo(1,5-a)pyrdinium cephem compounds |
ATE89826T1 (de) * | 1985-03-01 | 1993-06-15 | Takeda Chemical Industries Ltd | Antibakterielle verbindungen, ihre herstellung und verwendung. |
EP0203271B1 (en) * | 1985-03-01 | 1993-05-26 | Takeda Chemical Industries, Ltd. | Antibacterial compounds, their production and use |
JP2519054B2 (ja) * | 1986-06-09 | 1996-07-31 | 武田薬品工業株式会社 | 新規セフェム化合物 |
US4921851A (en) * | 1986-06-09 | 1990-05-01 | Takeda Chemical Industries, Ltd. | Cephem compounds, their production and use |
DE3707019A1 (de) * | 1987-03-05 | 1988-09-15 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4933334A (en) * | 1987-12-04 | 1990-06-12 | Takeda Chemical Industries, Ltd. | Antibiotic composition |
AU615966B2 (en) * | 1987-12-04 | 1991-10-17 | Takeda Chemical Industries Ltd. | Crystals of cephem hydrochloride |
ATE117690T1 (de) * | 1990-03-01 | 1995-02-15 | Takeda Chemical Industries Ltd | Imidazopyridazine, ihre herstellung und verwendung. |
TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
EP1618106B1 (en) * | 2003-04-30 | 2009-11-25 | Trine Pharmaceuticals, Inc. | Carbacephem beta-lactam antibiotics |
ME02666B (me) | 2008-10-31 | 2017-06-20 | Shionogi & Co | Cefalosporin sa kateholskom grupom |
AU2011236933A1 (en) | 2010-04-05 | 2013-05-02 | Shionogi & Co., Ltd. | Cephem compound having catechol group |
TWI547496B (zh) | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | 抗菌化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4165430A (en) * | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
DE3279470D1 (en) * | 1981-04-03 | 1989-04-06 | Fujisawa Pharmaceutical Co | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
DE3336757A1 (de) * | 1983-10-08 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
-
1985
- 1985-04-17 NO NO851538A patent/NO165842C/no unknown
- 1985-04-18 PH PH32153A patent/PH23134A/en unknown
- 1985-04-18 DE DE8585104687A patent/DE3586547D1/de not_active Expired - Fee Related
- 1985-04-18 EP EP85104687A patent/EP0160252B1/en not_active Expired - Lifetime
- 1985-04-18 DE DE8585104687T patent/DE3586547T2/de not_active Expired - Lifetime
- 1985-04-22 ES ES542447A patent/ES8606362A1/es not_active Expired
- 1985-04-22 GR GR850965A patent/GR850965B/el unknown
- 1985-04-22 JP JP60086746A patent/JPH07103130B2/ja not_active Expired - Fee Related
- 1985-04-22 NZ NZ211858A patent/NZ211858A/xx unknown
- 1985-04-22 FI FI851592A patent/FI851592L/fi not_active Application Discontinuation
- 1985-04-22 PT PT80328A patent/PT80328B/pt not_active IP Right Cessation
- 1985-04-23 AU AU41700/85A patent/AU580995B2/en not_active Ceased
- 1985-04-23 KR KR1019850002737A patent/KR920008945B1/ko not_active IP Right Cessation
- 1985-04-23 CA CA000479769A patent/CA1283096C/en not_active Expired - Lifetime
- 1985-11-22 ES ES549180A patent/ES8707245A1/es not_active Expired
- 1985-11-26 NO NO85854730A patent/NO167293C/no unknown
-
1986
- 1986-04-03 ES ES553666A patent/ES8706692A1/es not_active Expired
- 1986-10-03 ES ES557129A patent/ES8800950A1/es not_active Expired
-
1991
- 1991-11-16 KR KR1019910020376A patent/KR920008953B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI851592L (fi) | 1985-10-24 |
PT80328B (en) | 1987-02-16 |
DE3586547D1 (de) | 1993-02-04 |
KR850007427A (ko) | 1985-12-04 |
NO167293C (no) | 1991-10-23 |
NO165842C (no) | 1991-04-17 |
JPS60231684A (ja) | 1985-11-18 |
EP0160252B1 (en) | 1992-08-26 |
JPH07103130B2 (ja) | 1995-11-08 |
DE3586547T2 (de) | 1993-04-15 |
NZ211858A (en) | 1988-08-30 |
FI851592A0 (fi) | 1985-04-22 |
PH23134A (en) | 1989-05-11 |
NO854730L (no) | 1985-10-24 |
AU4170085A (en) | 1985-10-31 |
KR920008945B1 (ko) | 1992-10-12 |
ES8800950A1 (es) | 1987-12-01 |
ES8606362A1 (es) | 1986-04-01 |
PT80328A (en) | 1985-05-01 |
CA1283096C (en) | 1991-04-16 |
EP0160252A2 (en) | 1985-11-06 |
DE3586547A1 (no) | 1993-02-04 |
GR850965B (no) | 1985-11-25 |
NO165842B (no) | 1991-01-07 |
KR920008953B1 (ko) | 1992-10-12 |
ES8707245A1 (es) | 1987-07-16 |
EP0160252A3 (en) | 1987-01-14 |
ES549180A0 (es) | 1987-07-16 |
NO167293B (no) | 1991-07-15 |
ES542447A0 (es) | 1986-04-01 |
ES553666A0 (es) | 1987-06-16 |
AU580995B2 (en) | 1989-02-09 |
ES557129A0 (es) | 1987-12-01 |
ES8706692A1 (es) | 1987-06-16 |
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