ES8707245A1 - Un metodo para preparar nuevos derivados de cefem - Google Patents

Un metodo para preparar nuevos derivados de cefem

Info

Publication number
ES8707245A1
ES8707245A1 ES549180A ES549180A ES8707245A1 ES 8707245 A1 ES8707245 A1 ES 8707245A1 ES 549180 A ES549180 A ES 549180A ES 549180 A ES549180 A ES 549180A ES 8707245 A1 ES8707245 A1 ES 8707245A1
Authority
ES
Spain
Prior art keywords
group
stands
hydrogen atom
compound
antibacterial compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549180A
Other languages
English (en)
Other versions
ES549180A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000212 external-priority patent/WO1985004879A1/ja
Priority claimed from PCT/JP1984/000270 external-priority patent/WO1985005620A1/ja
Priority claimed from PCT/JP1985/000102 external-priority patent/WO1986005184A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8707245A1 publication Critical patent/ES8707245A1/es
Publication of ES549180A0 publication Critical patent/ES549180A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

METODO DE PREPARAR NUEVOS DERIVADOS DE CEFEM. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), O UNA SAL O UN ESTER DEL MISMO, CON UN ACIDO CARBOXILICO DE FORMULA RBOH, DONDE RB ES UN GRUPO ACILO, PARA OBTENER NUEVOS DERIVADOS DE CEFEM DE FORMULA (I) DONDE RO REPRESENTA UN GRUPO ACILO; R4 REPRESENTA UN ATOMO DE HIDROGENO, GRUPO METOXI O GRUPO FORMAMIDO; R13 REPRESENTA UN ATOMO DE HIDROGENO, GRUPO METILO, GRUPO HIDROXILO O ATOMO DE HALOGENO; Y A REPRESENTA UN GRUPO IMIDAZOL-1-ILO OPCIONALMENTE SUSTITUIDO QUE FORMA UN ANILLO CONDENSADO EN LA POSICION 2, 3 O 3, 4. TIENEN APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES549180A 1984-04-23 1985-11-22 Un metodo para preparar nuevos derivados de cefem Expired ES8707245A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP1984/000212 WO1985004879A1 (fr) 1984-04-23 1984-04-23 Nouveaux composes de cephem
PCT/JP1984/000270 WO1985005620A1 (en) 1984-05-25 1984-05-25 Cephem compounds
PCT/JP1985/000102 WO1986005184A1 (en) 1985-03-01 1985-03-01 Antibacterial compound

Publications (2)

Publication Number Publication Date
ES8707245A1 true ES8707245A1 (es) 1987-07-16
ES549180A0 ES549180A0 (es) 1987-07-16

Family

ID=27304399

Family Applications (4)

Application Number Title Priority Date Filing Date
ES542447A Expired ES8606362A1 (es) 1984-04-23 1985-04-22 "un procedimiento para preparar un derivado de cefem".
ES549180A Expired ES8707245A1 (es) 1984-04-23 1985-11-22 Un metodo para preparar nuevos derivados de cefem
ES553666A Expired ES8706692A1 (es) 1984-04-23 1986-04-03 Un metodo para preparar nuevos derivados de cefem
ES557129A Expired ES8800950A1 (es) 1984-04-23 1986-10-03 Un metodo para preparar nuevos derivados de cefem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542447A Expired ES8606362A1 (es) 1984-04-23 1985-04-22 "un procedimiento para preparar un derivado de cefem".

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES553666A Expired ES8706692A1 (es) 1984-04-23 1986-04-03 Un metodo para preparar nuevos derivados de cefem
ES557129A Expired ES8800950A1 (es) 1984-04-23 1986-10-03 Un metodo para preparar nuevos derivados de cefem

Country Status (13)

Country Link
EP (1) EP0160252B1 (es)
JP (1) JPH07103130B2 (es)
KR (2) KR920008945B1 (es)
AU (1) AU580995B2 (es)
CA (1) CA1283096C (es)
DE (2) DE3586547D1 (es)
ES (4) ES8606362A1 (es)
FI (1) FI851592L (es)
GR (1) GR850965B (es)
NO (2) NO165842C (es)
NZ (1) NZ211858A (es)
PH (1) PH23134A (es)
PT (1) PT80328B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
NO166283C (no) * 1985-03-01 1991-06-26 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater.
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4921851A (en) * 1986-06-09 1990-05-01 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JP2519054B2 (ja) * 1986-06-09 1996-07-31 武田薬品工業株式会社 新規セフェム化合物
DE3707019A1 (de) * 1987-03-05 1988-09-15 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
US4933334A (en) * 1987-12-04 1990-06-12 Takeda Chemical Industries, Ltd. Antibiotic composition
EP0444549B1 (en) * 1990-03-01 1995-01-25 Takeda Chemical Industries, Ltd. Imidazopyridazines their production and use
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
WO2004098500A2 (en) * 2003-04-30 2004-11-18 Trine Pharmaceuticals, Inc. CARBACEPHEM ss-LACTAM ANTIBIOTICS
ME02666B (me) 2008-10-31 2017-06-20 Shionogi & Co Cefalosporin sa kateholskom grupom
WO2011125967A1 (ja) 2010-04-05 2011-10-13 塩野義製薬株式会社 カテコール基を有するセフェム化合物
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
DE3279470D1 (en) * 1981-04-03 1989-04-06 Fujisawa Pharmaceutical Co New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
DE3336757A1 (de) * 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
GR850965B (es) 1985-11-25
PT80328A (en) 1985-05-01
AU580995B2 (en) 1989-02-09
ES542447A0 (es) 1986-04-01
ES557129A0 (es) 1987-12-01
JPH07103130B2 (ja) 1995-11-08
NO854730L (no) 1985-10-24
KR850007427A (ko) 1985-12-04
AU4170085A (en) 1985-10-31
NO167293C (no) 1991-10-23
EP0160252A3 (en) 1987-01-14
CA1283096C (en) 1991-04-16
PT80328B (en) 1987-02-16
EP0160252A2 (en) 1985-11-06
DE3586547T2 (de) 1993-04-15
PH23134A (en) 1989-05-11
NO165842C (no) 1991-04-17
ES8800950A1 (es) 1987-12-01
DE3586547D1 (de) 1993-02-04
ES553666A0 (es) 1987-06-16
KR920008945B1 (ko) 1992-10-12
ES549180A0 (es) 1987-07-16
KR920008953B1 (ko) 1992-10-12
NZ211858A (en) 1988-08-30
DE3586547A1 (es) 1993-02-04
NO165842B (no) 1991-01-07
EP0160252B1 (en) 1992-08-26
FI851592L (fi) 1985-10-24
JPS60231684A (ja) 1985-11-18
FI851592A0 (fi) 1985-04-22
ES8706692A1 (es) 1987-06-16
NO167293B (no) 1991-07-15
NO851538L (no) 1985-10-24
ES8606362A1 (es) 1986-04-01

Similar Documents

Publication Publication Date Title
IE892340L (en) 4-oxoquinoline-3-carboxylic acid derivatives, their¹preparation and their use
ES8800682A1 (es) Un procedimiento para la preparacion de nuevas (4-piperidinilmetil y heteropurinas)
ES8707245A1 (es) Un metodo para preparar nuevos derivados de cefem
ES8705892A1 (es) Un metodo para preparar derivados de cefem
ES8802148A1 (es) Procedimiento para preparar derivados de acido quinoloncarboxilico
ES8707541A1 (es) Un procedimiento para la preparacion de derivados de cefalosporina
ES8801230A1 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
ES8606330A1 (es) Procedimiento para preparar derivados de acidos quinolincar-boxilicos
ES8800240A1 (es) Un metodo para preparar derivados de cefem
ES8704932A1 (es) Procedimiento para preparar un derivado de acido quinoloncarboxilico
ES8606283A1 (es) Procedimiento para preparar derivados de acidos quinolon- carboxilicos
EP0342665A3 (en) Physiologically active substance tan-931, its derivatives, their production and use
GR3030506T3 (en) 1-azaadamantane derivatives as 5-ht agonists or antagonists.
AU541530B2 (en) Derivatives of indolobenzoxazine
MY108303A (en) Neuroleptic 2-substituted perhydro-1-h-pyrido [1,2-a]pyrazines.
US5563157B1 (en) Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
MY102089A (en) Antibacterial compounds.
AU559732B2 (en) Di-and-tetrahydroguinolylacetic acid esters
AU551901B2 (en) Substituted thienobenzodiazepinones
AP9400608A0 (en) "New nicotinic acid derivative".
HUP0001545A2 (hu) Karbonsavészterszármazékok, előállításuk és alkalmazásuk herbicid hatású piridazin-3-on-származékok előállítására
AU2013888A (en) Uricosuric composition
ES8704163A1 (es) Un procedimiento para preparar derivados de cefem.
ES8402303A1 (es) Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo (3.2.0) hepteno.
ES8307812A1 (es) Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.

Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506