ES8801290A1 - Un metodo para preparar derivados de cefem - Google Patents

Un metodo para preparar derivados de cefem

Info

Publication number
ES8801290A1
ES8801290A1 ES557183A ES557183A ES8801290A1 ES 8801290 A1 ES8801290 A1 ES 8801290A1 ES 557183 A ES557183 A ES 557183A ES 557183 A ES557183 A ES 557183A ES 8801290 A1 ES8801290 A1 ES 8801290A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
optionally substituted
production
antibacterial compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557183A
Other languages
English (en)
Other versions
ES557183A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1985/000102 external-priority patent/WO1986005184A1/ja
Priority claimed from NO851538A external-priority patent/NO165842C/no
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8801290A1 publication Critical patent/ES8801290A1/es
Publication of ES557183A0 publication Critical patent/ES557183A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

METODO PARA LA PREPARACION DE DERIVADOS DE CEFEM, DE FORMULA GENERAL (I), Y SUS SALES Y ESTERES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 ES UN GRUPO AMINO QUE PUEDE ESTAR PROTEGIDO; R3'''' ES UN RESIDUO HIDROCARBONADO OPCIONALMENTE SUSTITUIDO; Z ES AZUFRE, OXIGENO O CH2; R4 ES UN ATOMO DE HIDROGENO O UN GRUPO METOXI; R13 ES UN ATOMO DE HIDROGENO O UN GRUPO METILO; Y AB ES UN GRUPO IMIDAZOLIO-1-ILO, O UNA SAL O UN ESTER DEL MISMO, CON UN COMPUESTO DE FORMULA R3''''OH, LLEVANDOSE A EFECTO LA REACCION EN UN DISOLVENTE EN PRESENCIA DE UN AGENTE DESHIDRATANTE. DE APLICACION COMO ANTIBIOTICOS EN LA TERAPIA DE ENFERMEDADES OCASIONADAS POR BACTERIAS RESISTENTES A ANTIBIOTICOS DE PENICILINA.
ES557183A 1985-03-01 1986-11-03 Un metodo para preparar derivados de cefem Expired ES8801290A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP1985/000102 WO1986005184A1 (en) 1985-03-01 1985-03-01 Antibacterial compound
NO851538A NO165842C (no) 1984-04-23 1985-04-17 Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.
JP20932085 1985-09-20

Publications (2)

Publication Number Publication Date
ES8801290A1 true ES8801290A1 (es) 1988-01-01
ES557183A0 ES557183A0 (es) 1988-01-01

Family

ID=27304712

Family Applications (3)

Application Number Title Priority Date Filing Date
ES552525A Expired ES8705892A1 (es) 1985-03-01 1986-02-28 Un metodo para preparar derivados de cefem
ES557183A Expired ES8801290A1 (es) 1985-03-01 1986-11-03 Un metodo para preparar derivados de cefem
ES557182A Expired ES8801289A1 (es) 1985-03-01 1986-11-03 Un metodo para preparar derivados de cefem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552525A Expired ES8705892A1 (es) 1985-03-01 1986-02-28 Un metodo para preparar derivados de cefem

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557182A Expired ES8801289A1 (es) 1985-03-01 1986-11-03 Un metodo para preparar derivados de cefem

Country Status (11)

Country Link
EP (1) EP0203271B1 (es)
JP (1) JPS62149682A (es)
CN (1) CN1030657C (es)
AR (1) AR247398A1 (es)
AU (1) AU598728B2 (es)
CA (1) CA1295995C (es)
DE (1) DE3688477T2 (es)
ES (3) ES8705892A1 (es)
NO (1) NO166283C (es)
NZ (1) NZ215333A (es)
WO (1) WO1986005183A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921851A (en) * 1986-06-09 1990-05-01 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JP2519054B2 (ja) * 1986-06-09 1996-07-31 武田薬品工業株式会社 新規セフェム化合物
DE3707019A1 (de) * 1987-03-05 1988-09-15 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
EP0304858A3 (en) * 1987-08-25 1989-12-20 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
US4933334A (en) * 1987-12-04 1990-06-12 Takeda Chemical Industries, Ltd. Antibiotic composition
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (en) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazine compounds, their production and use
DE69106902T2 (de) * 1990-03-01 1995-07-06 Takeda Chemical Industries Ltd Imidazopyridazine, ihre Herstellung und Verwendung.
JPH09110877A (ja) * 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
RS55365B1 (sr) 2008-10-31 2017-03-31 Shionogi & Co Cefalosporin sa kateholskom grupom
CN101735245A (zh) * 2008-11-05 2010-06-16 杨石 盐酸头孢唑兰及其中间体的制备方法
CN102070655B (zh) * 2009-11-23 2012-09-26 山东轩竹医药科技有限公司 含有咪唑环的头孢菌素衍生物
JP5852559B2 (ja) 2010-04-05 2016-02-03 塩野義製薬株式会社 擬似カテコール基を有するセフェム化合物
IN2012CN09242A (es) 2010-04-05 2015-08-21 Shionogi & Co
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
CN103570749A (zh) * 2013-11-15 2014-02-12 安徽悦康凯悦制药有限公司 一种头孢唑兰制备工艺
CN105153201B (zh) * 2015-08-29 2017-08-22 济南康和医药科技有限公司 一种盐酸头孢唑兰的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
DE3279470D1 (en) * 1981-04-03 1989-04-06 Fujisawa Pharmaceutical Co New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
DE3247614A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3336757A1 (de) * 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
NO165842C (no) * 1984-04-23 1991-04-17 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds

Also Published As

Publication number Publication date
EP0203271A3 (en) 1988-06-01
DE3688477D1 (de) 1993-07-01
ES557182A0 (es) 1988-01-01
CN86102034A (zh) 1987-01-07
ES8705892A1 (es) 1987-05-16
ES8801289A1 (es) 1988-01-01
NO860725L (no) 1986-09-02
AR247398A1 (es) 1994-12-29
CA1295995C (en) 1992-02-18
EP0203271A2 (en) 1986-12-03
CN1030657C (zh) 1996-01-10
JPH0257074B2 (es) 1990-12-03
AU5416886A (en) 1986-09-04
WO1986005183A1 (en) 1986-09-12
ES557183A0 (es) 1988-01-01
NO166283B (no) 1991-03-18
NZ215333A (en) 1988-09-29
AU598728B2 (en) 1990-07-05
DE3688477T2 (de) 1993-09-16
JPS62149682A (ja) 1987-07-03
NO166283C (no) 1991-06-26
ES552525A0 (es) 1987-05-16
EP0203271B1 (en) 1993-05-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301