NO166283C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater.Info
- Publication number
- NO166283C NO166283C NO860725A NO860725A NO166283C NO 166283 C NO166283 C NO 166283C NO 860725 A NO860725 A NO 860725A NO 860725 A NO860725 A NO 860725A NO 166283 C NO166283 C NO 166283C
- Authority
- NO
- Norway
- Prior art keywords
- toxyiminoacetamido
- cylmethyl
- 7beta
- heterocyclylmethyl
- thiadiazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO860725A NO166283C (no) | 1985-03-01 | 1986-02-27 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater. |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1985/000102 WO1986005184A1 (en) | 1985-03-01 | 1985-03-01 | Antibacterial compound |
| NO851538A NO165842C (no) | 1984-04-23 | 1985-04-17 | Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser. |
| JP20932085 | 1985-09-20 | ||
| NO860725A NO166283C (no) | 1985-03-01 | 1986-02-27 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO860725L NO860725L (no) | 1986-09-02 |
| NO166283B NO166283B (no) | 1991-03-18 |
| NO166283C true NO166283C (no) | 1991-06-26 |
Family
ID=27304712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO860725A NO166283C (no) | 1985-03-01 | 1986-02-27 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0203271B1 (es) |
| JP (1) | JPS62149682A (es) |
| CN (1) | CN1030657C (es) |
| AR (1) | AR247398A1 (es) |
| AU (1) | AU598728B2 (es) |
| CA (1) | CA1295995C (es) |
| DE (1) | DE3688477T2 (es) |
| ES (3) | ES8705892A1 (es) |
| NO (1) | NO166283C (es) |
| NZ (1) | NZ215333A (es) |
| WO (1) | WO1986005183A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921851A (en) * | 1986-06-09 | 1990-05-01 | Takeda Chemical Industries, Ltd. | Cephem compounds, their production and use |
| JP2519054B2 (ja) * | 1986-06-09 | 1996-07-31 | 武田薬品工業株式会社 | 新規セフェム化合物 |
| DE3707019A1 (de) * | 1987-03-05 | 1988-09-15 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
| EP0304858A3 (en) * | 1987-08-25 | 1989-12-20 | Takeda Chemical Industries, Ltd. | Cephem compounds, their production and use |
| AU615966B2 (en) * | 1987-12-04 | 1991-10-17 | Takeda Chemical Industries Ltd. | Crystals of cephem hydrochloride |
| US4933334A (en) * | 1987-12-04 | 1990-06-12 | Takeda Chemical Industries, Ltd. | Antibiotic composition |
| PH27291A (en) * | 1989-01-31 | 1993-05-04 | Takeda Chemical Industries Ltd | Imidazolpyrimidazines their production and use |
| EP0440119A1 (en) * | 1990-01-31 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Imidazopyridazine compounds, their production and use |
| EP0444549B1 (en) * | 1990-03-01 | 1995-01-25 | Takeda Chemical Industries, Ltd. | Imidazopyridazines their production and use |
| JPH09110877A (ja) * | 1995-10-17 | 1997-04-28 | Katayama Seiyakushiyo:Kk | セフェム化合物、その製造法及びそれを含有する抗菌剤 |
| TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
| MX2011004636A (es) | 2008-10-31 | 2011-06-20 | Shionogi & Co | Cefarosporinas que tienen un grupo catecol. |
| CN101735245A (zh) * | 2008-11-05 | 2010-06-16 | 杨石 | 盐酸头孢唑兰及其中间体的制备方法 |
| CN102070655B (zh) * | 2009-11-23 | 2012-09-26 | 山东轩竹医药科技有限公司 | 含有咪唑环的头孢菌素衍生物 |
| JP5909441B2 (ja) | 2010-04-05 | 2016-04-26 | 塩野義製薬株式会社 | カテコール基を有するセフェム化合物 |
| US8883773B2 (en) | 2010-04-05 | 2014-11-11 | Shionogi & Co., Ltd. | Cephem compound having pseudo-catechol group |
| TWI547496B (zh) | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | 抗菌化合物 |
| CN103570749A (zh) * | 2013-11-15 | 2014-02-12 | 安徽悦康凯悦制药有限公司 | 一种头孢唑兰制备工艺 |
| CN105153201B (zh) * | 2015-08-29 | 2017-08-22 | 济南康和医药科技有限公司 | 一种盐酸头孢唑兰的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4165430A (en) * | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
| ES8306160A1 (es) * | 1981-04-03 | 1983-05-01 | Fujisawa Pharmaceutical Co | "procedimiento para preparar un nuevo compuesto de cefem". |
| DE3247614A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| DE3336757A1 (de) * | 1983-10-08 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| NO165842C (no) * | 1984-04-23 | 1991-04-17 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser. |
| PH22107A (en) * | 1984-06-07 | 1988-06-01 | Takeda Chemical Industries Ltd | 3-pyrazolo(1,5-a)pyrdinium cephem compounds |
-
1986
- 1986-02-27 EP EP86102584A patent/EP0203271B1/en not_active Expired - Lifetime
- 1986-02-27 DE DE8686102584T patent/DE3688477T2/de not_active Expired - Fee Related
- 1986-02-27 NO NO860725A patent/NO166283C/no unknown
- 1986-02-28 CA CA000502935A patent/CA1295995C/en not_active Expired - Lifetime
- 1986-02-28 AU AU54168/86A patent/AU598728B2/en not_active Ceased
- 1986-02-28 NZ NZ215333A patent/NZ215333A/xx unknown
- 1986-02-28 ES ES552525A patent/ES8705892A1/es not_active Expired
- 1986-02-28 JP JP61044991A patent/JPS62149682A/ja active Granted
- 1986-02-28 CN CN86102034A patent/CN1030657C/zh not_active Expired - Fee Related
- 1986-02-28 WO PCT/JP1986/000099 patent/WO1986005183A1/en unknown
- 1986-11-03 ES ES557182A patent/ES8801289A1/es not_active Expired
- 1986-11-03 ES ES557183A patent/ES8801290A1/es not_active Expired
-
1990
- 1990-02-07 AR AR90316105A patent/AR247398A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| ES552525A0 (es) | 1987-05-16 |
| NO860725L (no) | 1986-09-02 |
| JPH0257074B2 (es) | 1990-12-03 |
| AR247398A1 (es) | 1994-12-29 |
| DE3688477T2 (de) | 1993-09-16 |
| CA1295995C (en) | 1992-02-18 |
| EP0203271A2 (en) | 1986-12-03 |
| EP0203271A3 (en) | 1988-06-01 |
| WO1986005183A1 (en) | 1986-09-12 |
| ES8801289A1 (es) | 1988-01-01 |
| CN86102034A (zh) | 1987-01-07 |
| DE3688477D1 (de) | 1993-07-01 |
| AU5416886A (en) | 1986-09-04 |
| ES557183A0 (es) | 1988-01-01 |
| AU598728B2 (en) | 1990-07-05 |
| NO166283B (no) | 1991-03-18 |
| NZ215333A (en) | 1988-09-29 |
| ES8801290A1 (es) | 1988-01-01 |
| ES8705892A1 (es) | 1987-05-16 |
| ES557182A0 (es) | 1988-01-01 |
| CN1030657C (zh) | 1996-01-10 |
| EP0203271B1 (en) | 1993-05-26 |
| JPS62149682A (ja) | 1987-07-03 |
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