NO333635B1 - Gram-negativ bakterie, vaksinepreparat, anvendelse av bakterien for fremstilling av en vaksine, samt fremgangsmate for detektering av en bakterie - Google Patents
Gram-negativ bakterie, vaksinepreparat, anvendelse av bakterien for fremstilling av en vaksine, samt fremgangsmate for detektering av en bakterie Download PDFInfo
- Publication number
- NO333635B1 NO333635B1 NO20041675A NO20041675A NO333635B1 NO 333635 B1 NO333635 B1 NO 333635B1 NO 20041675 A NO20041675 A NO 20041675A NO 20041675 A NO20041675 A NO 20041675A NO 333635 B1 NO333635 B1 NO 333635B1
- Authority
- NO
- Norway
- Prior art keywords
- bacterium
- vaccine
- mannheimia haemolytica
- bacteria
- pasteurella trehalosi
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims abstract description 44
- 241000894006 Bacteria Species 0.000 title claims description 77
- 238000002360 preparation method Methods 0.000 title description 16
- 241000218561 Bibersteinia trehalosi Species 0.000 claims abstract description 85
- 241001293418 Mannheimia haemolytica Species 0.000 claims abstract description 80
- 201000010099 disease Diseases 0.000 claims abstract description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 28
- 230000001580 bacterial effect Effects 0.000 claims abstract description 26
- 241000287828 Gallus gallus Species 0.000 claims abstract description 22
- 235000013330 chicken meat Nutrition 0.000 claims abstract description 16
- 239000012634 fragment Substances 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 208000015181 infectious disease Diseases 0.000 claims description 14
- 239000002671 adjuvant Substances 0.000 claims description 12
- 241000700605 Viruses Species 0.000 claims description 9
- 210000002345 respiratory system Anatomy 0.000 claims description 9
- 238000011321 prophylaxis Methods 0.000 claims description 8
- 230000002238 attenuated effect Effects 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 6
- 210000005000 reproductive tract Anatomy 0.000 claims description 6
- 241000606767 Avibacterium paragallinarum Species 0.000 claims description 5
- 241000606856 Pasteurella multocida Species 0.000 claims description 5
- 229940051027 pasteurella multocida Drugs 0.000 claims description 5
- 230000001717 pathogenic effect Effects 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 241001519465 Avian metapneumovirus Species 0.000 claims description 3
- 230000000241 respiratory effect Effects 0.000 claims description 3
- 241000711404 Avian avulavirus 1 Species 0.000 claims description 2
- 241001516406 Avian orthoreovirus Species 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000702626 Infectious bursal disease virus Species 0.000 claims description 2
- 241000204022 Mycoplasma gallisepticum Species 0.000 claims description 2
- 241001223089 Tremovirus A Species 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 201000006082 Chickenpox Diseases 0.000 claims 1
- 206010046980 Varicella Diseases 0.000 claims 1
- 231100000676 disease causative agent Toxicity 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 5
- 241000606860 Pasteurella Species 0.000 abstract description 4
- 208000027954 Poultry disease Diseases 0.000 abstract description 4
- 230000003053 immunization Effects 0.000 abstract description 2
- 238000002649 immunization Methods 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 20
- 238000012360 testing method Methods 0.000 description 19
- 241000271566 Aves Species 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 208000032843 Hemorrhage Diseases 0.000 description 12
- 230000000740 bleeding effect Effects 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 239000002609 medium Substances 0.000 description 10
- 244000144977 poultry Species 0.000 description 9
- 235000013594 poultry meat Nutrition 0.000 description 9
- 229920001184 polypeptide Polymers 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 241001494479 Pecora Species 0.000 description 7
- 239000006161 blood agar Substances 0.000 description 7
- 210000002149 gonad Anatomy 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 108010077805 Bacterial Proteins Proteins 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 4
- 241001293415 Mannheimia Species 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 239000002158 endotoxin Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 239000002054 inoculum Substances 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 235000010446 mineral oil Nutrition 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 206010039083 rhinitis Diseases 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 239000007762 w/o emulsion Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000001262 western blot Methods 0.000 description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 3
- 102000016938 Catalase Human genes 0.000 description 3
- 108010053835 Catalase Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 229910002651 NO3 Inorganic materials 0.000 description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 102000004316 Oxidoreductases Human genes 0.000 description 3
- 108090000854 Oxidoreductases Proteins 0.000 description 3
- 238000010240 RT-PCR analysis Methods 0.000 description 3
- 206010039101 Rhinorrhoea Diseases 0.000 description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 3
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000000521 hyperimmunizing effect Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000000415 inactivating effect Effects 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 208000010753 nasal discharge Diseases 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000003127 radioimmunoassay Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 206010008631 Cholera Diseases 0.000 description 2
- 206010009269 Cleft palate Diseases 0.000 description 2
- 206010011703 Cyanosis Diseases 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 238000003794 Gram staining Methods 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 241000606752 Pasteurellaceae Species 0.000 description 2
- 108010046334 Urease Proteins 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 208000012331 ruffled feather Diseases 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 241000588851 Bordetella avium Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000027312 Bursal disease Diseases 0.000 description 1
- 241000497233 Chlorella coloniales Species 0.000 description 1
- 206010009696 Clumsiness Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 238000007900 DNA-DNA hybridization Methods 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- 208000000666 Fowlpox Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241000711450 Infectious bronchitis virus Species 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000010359 Newcastle Disease Diseases 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241001135620 Ornithobacterium rhinotracheale Species 0.000 description 1
- 101710116435 Outer membrane protein Proteins 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 208000020207 Reproductive tract disease Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 210000004317 gizzard Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000002394 ovarian follicle Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000009374 poultry farming Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 210000000253 proventriculus Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000009589 serological test Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10152307A DE10152307A1 (de) | 2001-10-26 | 2001-10-26 | Neue bakterielle Geflügelkrankheit |
| PCT/EP2002/011899 WO2003037367A2 (en) | 2001-10-26 | 2002-10-24 | New bacterium causing poultry disease and vaccine derived thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20041675L NO20041675L (no) | 2004-04-23 |
| NO333635B1 true NO333635B1 (no) | 2013-07-29 |
Family
ID=7703460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041675A NO333635B1 (no) | 2001-10-26 | 2004-04-23 | Gram-negativ bakterie, vaksinepreparat, anvendelse av bakterien for fremstilling av en vaksine, samt fremgangsmate for detektering av en bakterie |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US7794735B2 (ru) |
| EP (2) | EP1942181A1 (ru) |
| JP (2) | JP4447319B2 (ru) |
| KR (2) | KR100954175B1 (ru) |
| CN (1) | CN100471945C (ru) |
| AR (3) | AR037020A1 (ru) |
| AT (1) | ATE391767T1 (ru) |
| AU (1) | AU2002363173B2 (ru) |
| BR (1) | BR0213538A (ru) |
| CA (1) | CA2462652A1 (ru) |
| CO (1) | CO5580796A2 (ru) |
| CY (1) | CY1108178T1 (ru) |
| DE (2) | DE10152307A1 (ru) |
| DK (1) | DK1442114T3 (ru) |
| EC (1) | ECSP045083A (ru) |
| ES (1) | ES2304466T3 (ru) |
| HK (1) | HK1073862A1 (ru) |
| HR (1) | HRP20040366B1 (ru) |
| HU (1) | HU228692B1 (ru) |
| IL (1) | IL161223A0 (ru) |
| MA (1) | MA26293A1 (ru) |
| MX (1) | MXPA04003941A (ru) |
| MY (1) | MY138203A (ru) |
| NO (1) | NO333635B1 (ru) |
| NZ (1) | NZ532805A (ru) |
| PL (1) | PL206589B1 (ru) |
| PT (1) | PT1442114E (ru) |
| RU (4) | RU2456343C2 (ru) |
| SI (1) | SI1442114T1 (ru) |
| UA (2) | UA89607C2 (ru) |
| WO (1) | WO2003037367A2 (ru) |
| ZA (1) | ZA200402499B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10152307A1 (de) * | 2001-10-26 | 2003-05-08 | Boehringer Ingelheim Vetmed | Neue bakterielle Geflügelkrankheit |
| KR20130027448A (ko) * | 2009-10-09 | 2013-03-15 | 코벤하븐스 유니버시테트 | 갈리박테리움 아나티스로부터의 세포용해 ｒｔｘ-독소 |
| CN102380092A (zh) * | 2011-11-22 | 2012-03-21 | 青岛易邦生物工程有限公司 | 一种鸡传染性鼻炎灭活疫苗 |
| CN102406936A (zh) * | 2011-11-22 | 2012-04-11 | 青岛易邦生物工程有限公司 | 一种鸡传染性鼻炎灭活疫苗佐剂 |
| MX357432B (es) | 2013-03-18 | 2018-07-09 | Intervet Int Bv | Vacuna para proteger a un rumiante contra la neumonia causada por mannheimia haemolytica. |
| RU2563885C1 (ru) * | 2014-06-03 | 2015-09-27 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Способ определения антител к бактериальным антигенам |
| CN104491856A (zh) * | 2014-12-07 | 2015-04-08 | 青岛易邦生物工程有限公司 | 一种禽肺病毒病灭活疫苗的生产方法 |
| CN108728558A (zh) * | 2018-05-31 | 2018-11-02 | 广西壮族自治区兽医研究所 | 一种快速检测溶血性曼氏杆菌的pcr扩增引物及其应用 |
| CN111621450B (zh) * | 2020-07-10 | 2022-07-05 | 青岛易邦生物工程有限公司 | 一种鸭源鸡杆菌及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5855894A (en) | 1992-03-30 | 1999-01-05 | Pfizer Inc. | Pasteurella haemolytica type A-1 bacterin-toxoid vaccine |
| EP0625190B1 (en) | 1992-10-14 | 1996-12-27 | Akzo Nobel N.V. | New bacterium causing poultry disease and vaccine derived thereof |
| US5587305A (en) * | 1993-12-06 | 1996-12-24 | The United States Of America As Represented By The Department Of Agriculture | Pasteurella haemolytica transformants |
| RU94023126A (ru) * | 1994-06-16 | 1997-04-10 | Всероссийский научно-исследовательский институт экспериментальной ветеринарии им.Я.Р.Коваленко | Вакцина против пастереллеза свиней |
| RU2103355C1 (ru) * | 1995-11-23 | 1998-01-27 | Государственное Федеральное предприятие Государственный научный центр прикладной микробиологии | Способ получения аттенуированных иммуногенных штаммов pasteurella multocida |
| FR2760640B1 (fr) * | 1997-03-17 | 1999-05-28 | Vetoquinol Sa | Utilisation d'une souche de pasteurella haemolytica serotype a6 pour la preparation d'un vaccin contre la pasteurellose bovine due a pasteurella haemolytica |
| WO2001044289A2 (en) * | 1999-12-17 | 2001-06-21 | University Of Guelph Office Of The Vice President Of Research | Modified leukotoxin gene and protein |
| DE10152307A1 (de) * | 2001-10-26 | 2003-05-08 | Boehringer Ingelheim Vetmed | Neue bakterielle Geflügelkrankheit |
| US7521060B2 (en) * | 2001-10-26 | 2009-04-21 | Boehringer Ingelheim Vetmedica S.A. De C.V. | Pathogen for bacterial poultry disease |
-
2001
- 2001-10-26 DE DE10152307A patent/DE10152307A1/de not_active Withdrawn
-
2002
- 2002-10-24 HU HU0402098A patent/HU228692B1/hu not_active IP Right Cessation
- 2002-10-24 RU RU2007129099/15A patent/RU2456343C2/ru not_active IP Right Cessation
- 2002-10-24 CN CNB028212517A patent/CN100471945C/zh not_active Expired - Fee Related
- 2002-10-24 RU RU2004116134/13A patent/RU2334792C2/ru not_active IP Right Cessation
- 2002-10-24 ES ES02802303T patent/ES2304466T3/es not_active Expired - Lifetime
- 2002-10-24 MY MYPI20023986A patent/MY138203A/en unknown
- 2002-10-24 WO PCT/EP2002/011899 patent/WO2003037367A2/en active Application Filing
- 2002-10-24 JP JP2003539709A patent/JP4447319B2/ja not_active Expired - Fee Related
- 2002-10-24 CA CA002462652A patent/CA2462652A1/en not_active Abandoned
- 2002-10-24 NZ NZ532805A patent/NZ532805A/en not_active IP Right Cessation
- 2002-10-24 MX MXPA04003941A patent/MXPA04003941A/es active IP Right Grant
- 2002-10-24 AT AT02802303T patent/ATE391767T1/de active
- 2002-10-24 UA UA20040503962A patent/UA89607C2/ru unknown
- 2002-10-24 AU AU2002363173A patent/AU2002363173B2/en not_active Ceased
- 2002-10-24 EP EP08150505A patent/EP1942181A1/en not_active Withdrawn
- 2002-10-24 PT PT02802303T patent/PT1442114E/pt unknown
- 2002-10-24 PL PL369963A patent/PL206589B1/pl not_active IP Right Cessation
- 2002-10-24 KR KR1020047005166A patent/KR100954175B1/ko not_active IP Right Cessation
- 2002-10-24 EP EP02802303A patent/EP1442114B1/en not_active Expired - Lifetime
- 2002-10-24 RU RU2007148219/15A patent/RU2430967C2/ru not_active IP Right Cessation
- 2002-10-24 SI SI200230699T patent/SI1442114T1/sl unknown
- 2002-10-24 UA UAA200900431A patent/UA96948C2/ru unknown
- 2002-10-24 KR KR1020097012926A patent/KR101024887B1/ko not_active IP Right Cessation
- 2002-10-24 DE DE60226057T patent/DE60226057T2/de not_active Expired - Lifetime
- 2002-10-24 IL IL16122302A patent/IL161223A0/xx unknown
- 2002-10-24 BR BR0213538-8A patent/BR0213538A/pt active Pending
- 2002-10-24 DK DK02802303T patent/DK1442114T3/da active
- 2002-10-25 AR ARP020104046A patent/AR037020A1/es active IP Right Grant
-
2004
- 2004-03-30 ZA ZA200402499A patent/ZA200402499B/en unknown
- 2004-04-22 CO CO04037170A patent/CO5580796A2/es active IP Right Grant
- 2004-04-23 NO NO20041675A patent/NO333635B1/no not_active IP Right Cessation
- 2004-04-23 EC EC2004005083A patent/ECSP045083A/es unknown
- 2004-04-23 HR HRP20040366AA patent/HRP20040366B1/xx not_active IP Right Cessation
- 2004-05-25 MA MA27700A patent/MA26293A1/fr unknown
-
2005
- 2005-07-26 HK HK05106369.5A patent/HK1073862A1/xx not_active IP Right Cessation
-
2008
- 2008-07-07 CY CY20081100706T patent/CY1108178T1/el unknown
- 2008-07-30 AR ARP080103284A patent/AR067732A2/es unknown
- 2008-09-10 RU RU2008136404/15A patent/RU2481393C2/ru not_active IP Right Cessation
-
2009
- 2009-02-25 US US12/392,594 patent/US7794735B2/en not_active Expired - Lifetime
- 2009-08-26 US US12/548,210 patent/US7964197B2/en not_active Expired - Fee Related
- 2009-09-02 AR ARP090103365A patent/AR073482A2/es not_active Application Discontinuation
- 2009-12-03 JP JP2009275445A patent/JP5087604B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-09 US US13/103,987 patent/US20110212132A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5087604B2 (ja) | 家禽類の疾病の原因である新規バクテリアおよびそれに由来するワクチン | |
| EP2271663B1 (en) | Novel avian astrovirus | |
| Heleili et al. | Incidence of avian mycoplasmosis in the region of Batna, Eastern Algeria | |
| AU2002363173A1 (en) | New bacterium causing poultry disease and vaccine derived thereof | |
| JP3992727B2 (ja) | 家禽病を発症させる新規バクテリアとそれから誘導されたワクチン | |
| JP2005511032A5 (ru) | ||
| US7521060B2 (en) | Pathogen for bacterial poultry disease | |
| Khan et al. | Detection of Mycoplasma gallisepticum infection in field samples using a species-specific DNA probe | |
| US20030149255A1 (en) | Bird diagnostics and treatments | |
| Jusuf | Proteins of Leptospira interrogans serovar pomona type kennewicki reactive with serum antibodies of aborting mares and their fetuses | |
| WO2014037103A1 (en) | Live attenuated metabolic drift vaccine against fowl typhoid | |
| Sankar | Development and evaluation of whole cell and membrane protein vaccines against mycoplasma gallisepticum | |
| Ranjini et al. | Development and evaluation of outer membrane protein vaccine against duck pasteurellosis | |
| WO2002030321A2 (en) | Bird diagnostics and treatments | |
| Raviv | The role of Mycoplasma synoviae in commercial layer E. coli peritonitis syndrome and Mycoplasma gallisepticum intraspecific differentiation methods | |
| Shilpa et al. | Different vaccines against a local fowl cholera isolate-A comparison |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |