NO333367B1 - Blandinger inneholdende et oftalmisk preparat omfattende 5- brom-6-(2-imidazolin-2-ylamino)kinoksalintartrat - Google Patents
Blandinger inneholdende et oftalmisk preparat omfattende 5- brom-6-(2-imidazolin-2-ylamino)kinoksalintartrat Download PDFInfo
- Publication number
- NO333367B1 NO333367B1 NO20024221A NO20024221A NO333367B1 NO 333367 B1 NO333367 B1 NO 333367B1 NO 20024221 A NO20024221 A NO 20024221A NO 20024221 A NO20024221 A NO 20024221A NO 333367 B1 NO333367 B1 NO 333367B1
- Authority
- NO
- Norway
- Prior art keywords
- component
- preparation
- tartrate
- solubility
- imidazolin
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 62
- QZHBYNSSDLTCRG-UHFFFAOYSA-N 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine;2,3-dihydroxybutanedioate;hydron Chemical compound OC(=O)C(O)C(O)C(O)=O.C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 QZHBYNSSDLTCRG-UHFFFAOYSA-N 0.000 title claims description 22
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 27
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- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 17
- 229910001919 chlorite Inorganic materials 0.000 claims description 10
- 229910052619 chlorite group Inorganic materials 0.000 claims description 10
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- 230000002335 preservative effect Effects 0.000 claims description 9
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims description 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- 229940095064 tartrate Drugs 0.000 claims description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
- -1 chlorite compound Chemical class 0.000 claims description 4
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
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- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 2
- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
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- 239000000048 adrenergic agonist Substances 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 description 25
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- DUHARNKZLBMPBS-UHFFFAOYSA-N 2-[(2,4,6-trimethylphenyl)methyl]-4,5-dihydro-1h-imidazole Chemical class CC1=CC(C)=CC(C)=C1CC1=NCCN1 DUHARNKZLBMPBS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21820000P | 2000-07-14 | 2000-07-14 | |
| PCT/US2001/021552 WO2002005853A2 (en) | 2000-07-14 | 2001-07-09 | Compositions containing alpha-2-adrenergic agonist components |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20024221D0 NO20024221D0 (no) | 2002-09-04 |
| NO20024221L NO20024221L (no) | 2002-10-28 |
| NO333367B1 true NO333367B1 (no) | 2013-05-13 |
Family
ID=22814143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| NO20024221A NO333367B1 (no) | 2000-07-14 | 2002-09-04 | Blandinger inneholdende et oftalmisk preparat omfattende 5- brom-6-(2-imidazolin-2-ylamino)kinoksalintartrat |
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| EP (1) | EP1365811A2 (hu) |
| JP (3) | JP4927298B2 (hu) |
| KR (1) | KR100757656B1 (hu) |
| CN (2) | CN100569291C (hu) |
| AR (1) | AR033539A1 (hu) |
| AU (2) | AU2001273269B2 (hu) |
| BR (1) | BR0109317A (hu) |
| CA (1) | CA2402405C (hu) |
| HK (1) | HK1060519A1 (hu) |
| HU (1) | HUP0303197A3 (hu) |
| IL (2) | IL151530A0 (hu) |
| MX (1) | MXPA02008930A (hu) |
| NO (1) | NO333367B1 (hu) |
| NZ (1) | NZ521185A (hu) |
| PL (1) | PL360707A1 (hu) |
| RU (1) | RU2311928C2 (hu) |
| TW (1) | TWI287998B (hu) |
| WO (1) | WO2002005853A2 (hu) |
| ZA (1) | ZA200207413B (hu) |
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