NO332976B1 - Kinazolinderivater samt farmasoytisk preparat - Google Patents
Kinazolinderivater samt farmasoytisk preparatInfo
- Publication number
- NO332976B1 NO332976B1 NO20083980A NO20083980A NO332976B1 NO 332976 B1 NO332976 B1 NO 332976B1 NO 20083980 A NO20083980 A NO 20083980A NO 20083980 A NO20083980 A NO 20083980A NO 332976 B1 NO332976 B1 NO 332976B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- salt
- hydrate
- dimethoxy
- methylaminoquinazolin
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 205
- 150000003839 salts Chemical class 0.000 claims abstract description 78
- 208000003251 Pruritus Diseases 0.000 claims abstract description 27
- 230000007803 itching Effects 0.000 claims abstract description 24
- 208000012657 Atopic disease Diseases 0.000 claims abstract description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 14
- -1 methoxy, ethoxy, 1-propoxy, 2-propoxy, methoxyethoxy, amino, methylamino, dimethylamino, ethylamino Chemical group 0.000 claims description 71
- UKFCRQFQEAFNRG-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-methylbenzoic acid Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(O)=O)C(C)=C1 UKFCRQFQEAFNRG-UHFFFAOYSA-N 0.000 claims description 27
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 15
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 150000003431 steroids Chemical class 0.000 claims description 10
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 9
- 230000001387 anti-histamine Effects 0.000 claims description 9
- 239000000739 antihistaminic agent Substances 0.000 claims description 9
- CAWVDRBRXMORSF-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-ethylbenzoic acid Chemical compound C1=C(C(O)=O)C(CC)=CC(C(=O)NC=2C=C(C=CC=2)C=2C3=CC(OC)=C(OC)C=C3N=C(NC)N=2)=C1 CAWVDRBRXMORSF-UHFFFAOYSA-N 0.000 claims description 7
- ZZQXDZSMUGHTJA-UHFFFAOYSA-N 4-n-[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]-1-n-methylbenzene-1,4-dicarboxamide Chemical compound C1=CC(C(=O)NC)=CC=C1C(=O)NC1=CC=CC(C=2C3=CC(OC)=C(OC)C=C3N=C(NC)N=2)=C1 ZZQXDZSMUGHTJA-UHFFFAOYSA-N 0.000 claims description 7
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 7
- 201000008937 atopic dermatitis Diseases 0.000 claims description 7
- DKNYHLGWEWIHOZ-UHFFFAOYSA-N 2-methoxyethyl 3-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=CC(C(=O)OCCOC)=C1 DKNYHLGWEWIHOZ-UHFFFAOYSA-N 0.000 claims description 4
- DUJAVOVVXUJZES-UHFFFAOYSA-N 2-methoxyethyl 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(=O)OCCOC)C=C1 DUJAVOVVXUJZES-UHFFFAOYSA-N 0.000 claims description 4
- XSVFNAFRARDFGN-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-propan-2-ylbenzoic acid Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(O)=O)C(C(C)C)=C1 XSVFNAFRARDFGN-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract description 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract description 4
- 125000003277 amino group Chemical group 0.000 abstract 1
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- 239000000203 mixture Substances 0.000 description 44
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- 239000013078 crystal Substances 0.000 description 38
- 238000000034 method Methods 0.000 description 37
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- 239000002904 solvent Substances 0.000 description 31
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- 238000006243 chemical reaction Methods 0.000 description 29
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- 238000011017 operating method Methods 0.000 description 1
- 239000002997 ophthalmic solution Substances 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- VUYVXCJTTQJVKJ-UHFFFAOYSA-L palladium(2+);tricyclohexylphosphane;dichloride Chemical compound Cl[Pd]Cl.C1CCCCC1P(C1CCCCC1)C1CCCCC1.C1CCCCC1P(C1CCCCC1)C1CCCCC1 VUYVXCJTTQJVKJ-UHFFFAOYSA-L 0.000 description 1
- OTYPIDNRISCWQY-UHFFFAOYSA-L palladium(2+);tris(2-methylphenyl)phosphane;dichloride Chemical compound Cl[Pd]Cl.CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C.CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C OTYPIDNRISCWQY-UHFFFAOYSA-L 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
- MXQOYLRVSVOCQT-UHFFFAOYSA-N palladium;tritert-butylphosphane Chemical compound [Pd].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C MXQOYLRVSVOCQT-UHFFFAOYSA-N 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
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- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 229950001574 riboflavin phosphate Drugs 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- WXAZIUYTQHYBFW-UHFFFAOYSA-N tris(4-methylphenyl)phosphane Chemical compound C1=CC(C)=CC=C1P(C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 WXAZIUYTQHYBFW-UHFFFAOYSA-N 0.000 description 1
- DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77462006P | 2006-02-21 | 2006-02-21 | |
| JP2006043273 | 2006-02-21 | ||
| PCT/JP2007/053066 WO2007097317A1 (ja) | 2006-02-21 | 2007-02-20 | ４－（３－ベンゾイルアミノフェニル）－６，７－ジメトキシ－２－メチルアミノキナゾリン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20083980L NO20083980L (no) | 2008-11-20 |
| NO332976B1 true NO332976B1 (no) | 2013-02-11 |
Family
ID=41429386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083980A NO332976B1 (no) | 2006-02-21 | 2008-09-18 | Kinazolinderivater samt farmasoytisk preparat |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7939540B2 (ar) |
| EP (1) | EP1992622B1 (ar) |
| CN (1) | CN101389612B (ar) |
| AU (1) | AU2007218725B2 (ar) |
| CA (1) | CA2637573C (ar) |
| MX (1) | MX2008010774A (ar) |
| NO (1) | NO332976B1 (ar) |
| PL (1) | PL1992622T3 (ar) |
| SA (1) | SA07280059B1 (ar) |
| WO (1) | WO2007097317A1 (ar) |
| ZA (1) | ZA200805756B (ar) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008010774A (es) | 2006-02-21 | 2008-09-01 | Eisai R&D Man Co Ltd | Derivados de 4-(3-benzoilaminofenil)-6, 7-dimetoxi-2-metilaminoqui nazolina. |
| EP2123641A4 (en) * | 2007-02-16 | 2011-06-22 | Eisai R&D Man Co Ltd | CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT |
| CN101687818B (zh) * | 2007-02-19 | 2012-08-22 | 卫材R&D管理有限公司 | 甲基n-[3-(6,7-二甲氧基-2-甲氨基喹唑啉-4-基)苯基]对氨羰基苯甲酸的结晶、无定形物或盐 |
| JP5060561B2 (ja) | 2007-08-17 | 2012-10-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規外用剤 |
| US8492543B2 (en) | 2007-08-17 | 2013-07-23 | Eisai R&D Management Co., Ltd. | Method for producing quinazoline derivative |
| JP6225161B2 (ja) * | 2013-02-28 | 2017-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
| EP3463366A4 (en) * | 2016-06-07 | 2020-01-08 | Dermavant Sciences GmbH | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND METHODS OF USE THEREOF |
| JP2021505621A (ja) | 2017-12-07 | 2021-02-18 | ダーマヴァント サイエンシーズ ゲーエムベーハー | Ｐｄｅ−４阻害剤の局所軟膏製剤および皮膚状態の治療におけるそれらの使用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2099112T3 (es) | 1990-09-04 | 1997-05-16 | Fujisawa Pharmaceutical Co | Pomadas que contienen un compuesto triciclico. |
| US6115962A (en) * | 1994-03-31 | 2000-09-12 | Southpac Trust International, Inc. | Sleeve for covering a flower pot |
| JP3466305B2 (ja) | 1994-12-12 | 2003-11-10 | 久光製薬株式会社 | 溶解剤および該溶解剤を含有する外用製剤 |
| CA2265630A1 (en) | 1996-09-13 | 1998-03-19 | Gerald Mcmahon | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| AR015966A1 (es) * | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
| JPH11209350A (ja) * | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
| AR029185A1 (es) | 1999-10-25 | 2003-06-18 | Yamanouchi Pharma Co Ltd | Derivado de naftiridina |
| JP3373838B2 (ja) | 1999-10-25 | 2003-02-04 | 山之内製薬株式会社 | ナフチリジン誘導体 |
| SI1511516T1 (sl) | 2002-05-28 | 2009-06-30 | Nycomed Gmbh | Topično uporaben farmacevtski pripravek |
| US20040038958A1 (en) | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| JP4387717B2 (ja) | 2003-07-11 | 2009-12-24 | 株式会社資生堂 | 油中水型皮膚外用医薬品製剤 |
| JP2005047909A (ja) | 2003-07-17 | 2005-02-24 | Santen Pharmaceut Co Ltd | ピペリジン誘導体を有効成分とする掻痒治療剤 |
| TW200503709A (en) | 2003-07-17 | 2005-02-01 | Santen Pharmaceutical Co Ltd | Itching treating agent containing piperidine derivative as active ingredient |
| WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
| JP2008137892A (ja) | 2005-03-04 | 2008-06-19 | Eisai Co Ltd | 止痒剤 |
| MX2008010774A (es) | 2006-02-21 | 2008-09-01 | Eisai R&D Man Co Ltd | Derivados de 4-(3-benzoilaminofenil)-6, 7-dimetoxi-2-metilaminoqui nazolina. |
| EP2123641A4 (en) | 2007-02-16 | 2011-06-22 | Eisai R&D Man Co Ltd | CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT |
-
2007
- 2007-02-20 MX MX2008010774A patent/MX2008010774A/es active IP Right Grant
- 2007-02-20 CN CN2007800061130A patent/CN101389612B/zh not_active Expired - Fee Related
- 2007-02-20 WO PCT/JP2007/053066 patent/WO2007097317A1/ja active Application Filing
- 2007-02-20 PL PL07714569T patent/PL1992622T3/pl unknown
- 2007-02-20 CA CA2637573A patent/CA2637573C/en active Active
- 2007-02-20 US US11/707,904 patent/US7939540B2/en active Active
- 2007-02-20 EP EP07714569A patent/EP1992622B1/en active Active
- 2007-02-20 AU AU2007218725A patent/AU2007218725B2/en not_active Ceased
- 2007-02-21 SA SA7280059A patent/SA07280059B1/ar unknown
-
2008
- 2008-07-01 ZA ZA200805756A patent/ZA200805756B/xx unknown
- 2008-09-18 NO NO20083980A patent/NO332976B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1992622A4 (en) | 2009-05-06 |
| CA2637573C (en) | 2013-07-02 |
| US7939540B2 (en) | 2011-05-10 |
| EP1992622B1 (en) | 2011-07-27 |
| WO2007097317A1 (ja) | 2007-08-30 |
| CN101389612B (zh) | 2011-09-21 |
| CN101389612A (zh) | 2009-03-18 |
| AU2007218725B2 (en) | 2011-12-01 |
| PL1992622T3 (pl) | 2012-01-31 |
| CA2637573A1 (en) | 2007-08-30 |
| MX2008010774A (es) | 2008-09-01 |
| US20070299094A1 (en) | 2007-12-27 |
| AU2007218725A1 (en) | 2007-08-30 |
| ZA200805756B (en) | 2009-04-29 |
| SA07280059B1 (ar) | 2010-11-02 |
| NO20083980L (no) | 2008-11-20 |
| EP1992622A1 (en) | 2008-11-19 |
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