NO332223B1 - Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene. - Google Patents

Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene. Download PDF

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Publication number
NO332223B1
NO332223B1 NO20053086A NO20053086A NO332223B1 NO 332223 B1 NO332223 B1 NO 332223B1 NO 20053086 A NO20053086 A NO 20053086A NO 20053086 A NO20053086 A NO 20053086A NO 332223 B1 NO332223 B1 NO 332223B1
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NO
Norway
Prior art keywords
phenyl
methyl
isobutylphenyl
oxo
oxopentanoate
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NO20053086A
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English (en)
Norwegian (no)
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NO20053086L (no
Inventor
Riccardo Bertini
Cinzia Bizzarri
Marcello Allegretti
Maria Candida Cesta
Francesco Colotta
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Dompe Pha R Ma Spa
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Application filed by Dompe Pha R Ma Spa filed Critical Dompe Pha R Ma Spa
Publication of NO20053086L publication Critical patent/NO20053086L/no
Publication of NO332223B1 publication Critical patent/NO332223B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/215—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • C—CHEMISTRY; METALLURGY
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
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NO20053086A 2002-12-10 2005-06-23 Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene. NO332223B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02027453 2002-12-10
PCT/EP2003/013946 WO2004052830A1 (en) 2002-12-10 2003-12-09 Chiral arylketones in the treatement of neutrophil-dependent inflammatory deseases

Publications (2)

Publication Number Publication Date
NO20053086L NO20053086L (no) 2005-06-23
NO332223B1 true NO332223B1 (no) 2012-07-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053086A NO332223B1 (no) 2002-12-10 2005-06-23 Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene.

Country Status (16)

Country Link
US (2) US20060247297A1 (enExample)
EP (1) EP1581474B1 (enExample)
JP (1) JP5021169B2 (enExample)
CN (1) CN100383110C (enExample)
AT (1) ATE406343T1 (enExample)
AU (1) AU2003289993B8 (enExample)
CA (1) CA2507765C (enExample)
CY (1) CY1108596T1 (enExample)
DE (1) DE60323264D1 (enExample)
DK (1) DK1581474T3 (enExample)
ES (1) ES2312834T3 (enExample)
NO (1) NO332223B1 (enExample)
PT (1) PT1581474E (enExample)
RU (1) RU2345759C2 (enExample)
SI (1) SI1581474T1 (enExample)
WO (1) WO2004052830A1 (enExample)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
RU2421213C1 (ru) * 2010-02-24 2011-06-20 Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Применение 2-гидрокси-3-метил-6-(1-метилэтенил)циклогекс-3-енона в качестве анальгезирующего средства
CN109928868A (zh) * 2019-03-22 2019-06-25 河北科技大学 1,3-双(2,5-二甲基苯基)丙-2-酮的合成方法及其应用
CN115894198B (zh) * 2022-11-04 2024-05-17 浙江永太科技股份有限公司 Qulipta的关键中间体1-(2,3,6-三氟苯基)丙烷-2-酮的制备方法
KR102597093B1 (ko) * 2023-06-07 2023-11-03 옙바이오 주식회사 줄기세포 노화 억제 신규 화합물 및 이의 약학적 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125956C (enExample) * 1960-07-26
US3591350A (en) * 1968-06-17 1971-07-06 M & T Chemicals Inc Novel plating process
SE385883B (sv) * 1972-04-10 1976-07-26 Ciba Geigy Ag Forfarande for framstellning av nya pyridinkarbonsyraestrar
JPS5842851B2 (ja) 1976-03-05 1983-09-22 三井東圧化学株式会社 ２−（４′−アルキルフエニル）プロピオン酸の製造方法
US4151172A (en) 1977-08-11 1979-04-24 E. R. Squibb & Sons, Inc. Phosphonoacyl prolines and related compounds
JPS5697249A (en) 1979-12-30 1981-08-05 Ota Seiyaku Kk Preparation of 2-arylalkane acid
JP2782359B2 (ja) 1989-06-22 1998-07-30 日本石油化学株式会社 ２―（４―イソブチルフエニル）―２―ブテン
AU644281B2 (en) 1991-04-24 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Novel thiazole derivatives
JPH05286902A (ja) * 1992-04-10 1993-11-02 Sumitomo Pharmaceut Co Ltd α−クロロ−β−ケトエステル誘導体の製造方法
IT1303249B1 (it) * 1998-10-23 2000-11-06 Dompe Spa Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
IT1317826B1 (it) * 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.

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Publication number Publication date
US9328057B2 (en) 2016-05-03
ATE406343T1 (de) 2008-09-15
WO2004052830A1 (en) 2004-06-24
AU2003289993B8 (en) 2008-05-08
RU2005121554A (ru) 2006-01-20
JP2006509022A (ja) 2006-03-16
US20090203652A1 (en) 2009-08-13
AU2003289993A1 (en) 2004-06-30
NO20053086L (no) 2005-06-23
PT1581474E (pt) 2008-12-09
HK1085721A1 (zh) 2006-09-01
JP5021169B2 (ja) 2012-09-05
CN1732145A (zh) 2006-02-08
SI1581474T1 (sl) 2009-02-28
CA2507765A1 (en) 2004-06-24
ES2312834T3 (es) 2009-03-01
CA2507765C (en) 2012-03-20
US20060247297A1 (en) 2006-11-02
DE60323264D1 (de) 2008-10-09
RU2345759C2 (ru) 2009-02-10
CN100383110C (zh) 2008-04-23
AU2003289993B2 (en) 2008-04-24
EP1581474B1 (en) 2008-08-27
DK1581474T3 (da) 2008-12-08
EP1581474A1 (en) 2005-10-05
CY1108596T1 (el) 2014-04-09

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Owner name: DOMPE FARMACEUTICI S.P.A., IT

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