JPS5697249A - Preparation of 2-arylalkane acid - Google Patents

Preparation of 2-arylalkane acid

Info

Publication number
JPS5697249A
JPS5697249A JP17320079A JP17320079A JPS5697249A JP S5697249 A JPS5697249 A JP S5697249A JP 17320079 A JP17320079 A JP 17320079A JP 17320079 A JP17320079 A JP 17320079A JP S5697249 A JPS5697249 A JP S5697249A
Authority
JP
Japan
Prior art keywords
novel
formula
compound
benzophenone
halobenzophenone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17320079A
Other languages
Japanese (ja)
Inventor
Hiroshi Ikawa
Saburo Sugai
Takashi Kodama
Mitsuya Akaboshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OTA PHARMA
OTA SEIYAKU KK
Original Assignee
OTA PHARMA
OTA SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OTA PHARMA, OTA SEIYAKU KK filed Critical OTA PHARMA
Priority to JP17320079A priority Critical patent/JPS5697249A/en
Publication of JPS5697249A publication Critical patent/JPS5697249A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an anti-inglammatory and pain- killing drug advantageously, by using an inexpensive and readily obtainable 3- halobenzophenone as a raw material, and deriving it through a novel benzophenon derivative and a novel 3-(2-oxo-3-butyl)benzophenone compound.
CONSTITUTION: A 3-halobenzophenone shown by the formula I (X is halogen) is reacted with a sodium or potassium salt of acetylacetone in the presence of a metal catalyst to give a novel benzophenone derivative shown by the formula II, which is methylated with a methylating agent in the presence of an organic solvent, an alkali aqueous solution, and phase transferring catalyst, to form a novel 3-(2-oxo-3-butyl) benzophenone compound shown by the formula III. This compound is oxidized with an oxidizing agent, to give a 2-(3-benzoylphenyl)alkanoic acid shown by the formula IV.
EFFECT: The number of processes is relatively few, and the operation of every process is simple, and the reaction conditions are mild.
COPYRIGHT: (C)1981,JPO&Japio
JP17320079A 1979-12-30 1979-12-30 Preparation of 2-arylalkane acid Pending JPS5697249A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17320079A JPS5697249A (en) 1979-12-30 1979-12-30 Preparation of 2-arylalkane acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17320079A JPS5697249A (en) 1979-12-30 1979-12-30 Preparation of 2-arylalkane acid

Publications (1)

Publication Number Publication Date
JPS5697249A true JPS5697249A (en) 1981-08-05

Family

ID=15955954

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17320079A Pending JPS5697249A (en) 1979-12-30 1979-12-30 Preparation of 2-arylalkane acid

Country Status (1)

Country Link
JP (1) JPS5697249A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885404A (en) * 1985-07-12 1989-12-05 The Upjohn Company Flurbiprofen intermediate
US9328057B2 (en) 2002-12-10 2016-05-03 Dompe' Farmaceutici S.P.A. Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885404A (en) * 1985-07-12 1989-12-05 The Upjohn Company Flurbiprofen intermediate
US9328057B2 (en) 2002-12-10 2016-05-03 Dompe' Farmaceutici S.P.A. Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases

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