JPS5697249A - Preparation of 2-arylalkane acid - Google Patents
Preparation of 2-arylalkane acidInfo
- Publication number
- JPS5697249A JPS5697249A JP17320079A JP17320079A JPS5697249A JP S5697249 A JPS5697249 A JP S5697249A JP 17320079 A JP17320079 A JP 17320079A JP 17320079 A JP17320079 A JP 17320079A JP S5697249 A JPS5697249 A JP S5697249A
- Authority
- JP
- Japan
- Prior art keywords
- novel
- formula
- compound
- benzophenone
- halobenzophenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as an anti-inglammatory and pain- killing drug advantageously, by using an inexpensive and readily obtainable 3- halobenzophenone as a raw material, and deriving it through a novel benzophenon derivative and a novel 3-(2-oxo-3-butyl)benzophenone compound.
CONSTITUTION: A 3-halobenzophenone shown by the formula I (X is halogen) is reacted with a sodium or potassium salt of acetylacetone in the presence of a metal catalyst to give a novel benzophenone derivative shown by the formula II, which is methylated with a methylating agent in the presence of an organic solvent, an alkali aqueous solution, and phase transferring catalyst, to form a novel 3-(2-oxo-3-butyl) benzophenone compound shown by the formula III. This compound is oxidized with an oxidizing agent, to give a 2-(3-benzoylphenyl)alkanoic acid shown by the formula IV.
EFFECT: The number of processes is relatively few, and the operation of every process is simple, and the reaction conditions are mild.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17320079A JPS5697249A (en) | 1979-12-30 | 1979-12-30 | Preparation of 2-arylalkane acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17320079A JPS5697249A (en) | 1979-12-30 | 1979-12-30 | Preparation of 2-arylalkane acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5697249A true JPS5697249A (en) | 1981-08-05 |
Family
ID=15955954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17320079A Pending JPS5697249A (en) | 1979-12-30 | 1979-12-30 | Preparation of 2-arylalkane acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5697249A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4885404A (en) * | 1985-07-12 | 1989-12-05 | The Upjohn Company | Flurbiprofen intermediate |
US9328057B2 (en) | 2002-12-10 | 2016-05-03 | Dompe' Farmaceutici S.P.A. | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases |
-
1979
- 1979-12-30 JP JP17320079A patent/JPS5697249A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4885404A (en) * | 1985-07-12 | 1989-12-05 | The Upjohn Company | Flurbiprofen intermediate |
US9328057B2 (en) | 2002-12-10 | 2016-05-03 | Dompe' Farmaceutici S.P.A. | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases |
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