NO330983B1 - Fremgangsmate for fremstilling av pyrimidinderivater - Google Patents

Fremgangsmate for fremstilling av pyrimidinderivater

Info

Publication number
NO330983B1
NO330983B1 NO20052781A NO20052781A NO330983B1 NO 330983 B1 NO330983 B1 NO 330983B1 NO 20052781 A NO20052781 A NO 20052781A NO 20052781 A NO20052781 A NO 20052781A NO 330983 B1 NO330983 B1 NO 330983B1
Authority
NO
Norway
Prior art keywords
compound
formula
alkyl
group
preparation
Prior art date
Application number
NO20052781A
Other languages
English (en)
Norwegian (no)
Other versions
NO20052781L (no
Inventor
Mark Bailey
Lee Newton
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0229243A external-priority patent/GB0229243D0/en
Priority claimed from GB0303589A external-priority patent/GB0303589D0/en
Priority claimed from GB0318515A external-priority patent/GB0318515D0/en
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of NO20052781L publication Critical patent/NO20052781L/no
Publication of NO330983B1 publication Critical patent/NO330983B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
NO20052781A 2002-12-16 2005-06-08 Fremgangsmate for fremstilling av pyrimidinderivater NO330983B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0229243A GB0229243D0 (en) 2002-12-16 2002-12-16 Compounds and process
GB0303589A GB0303589D0 (en) 2003-02-17 2003-02-17 Compounds and process
GB0318515A GB0318515D0 (en) 2003-08-07 2003-08-07 Compounds and process
PCT/GB2003/005359 WO2004054986A2 (en) 2002-12-16 2003-12-09 Process for the preparation of pyrimidine compounds

Publications (2)

Publication Number Publication Date
NO20052781L NO20052781L (no) 2005-07-07
NO330983B1 true NO330983B1 (no) 2011-08-29

Family

ID=32600665

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20052781A NO330983B1 (no) 2002-12-16 2005-06-08 Fremgangsmate for fremstilling av pyrimidinderivater
NO20110366A NO20110366L (no) 2002-12-16 2011-03-10 Forbindelser og prosesser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20110366A NO20110366L (no) 2002-12-16 2011-03-10 Forbindelser og prosesser

Country Status (23)

Country Link
US (2) US7524955B2 (de)
EP (2) EP2088142A3 (de)
JP (2) JP4579821B2 (de)
KR (1) KR101060215B1 (de)
AR (1) AR042355A1 (de)
AT (1) ATE448209T1 (de)
AU (1) AU2003288443B2 (de)
BR (1) BR0317313A (de)
CA (1) CA2509344C (de)
CY (1) CY1110605T1 (de)
DE (1) DE60330050D1 (de)
DK (1) DK1578731T3 (de)
ES (1) ES2335279T3 (de)
HK (1) HK1080477A1 (de)
IL (1) IL168884A (de)
MX (1) MXPA05006425A (de)
MY (1) MY138051A (de)
NO (2) NO330983B1 (de)
NZ (1) NZ540722A (de)
PT (1) PT1578731E (de)
SI (1) SI1578731T1 (de)
TW (1) TWI322145B (de)
WO (1) WO2004054986A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
ATE349431T1 (de) 2001-07-13 2007-01-15 Astrazeneca Uk Ltd Herstellung von aminopyrimidinverbindungen
EP1323717A1 (de) 2001-12-27 2003-07-02 Dsm N.V. Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten
KR20030092446A (ko) * 2002-05-29 2003-12-06 주식회사 한국토종약초연구소 씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물
EP1375493A1 (de) 2002-06-17 2004-01-02 Dsm N.V. Verfahren zur Herstellung von Dioxanessigsäureester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
WO2004054986A2 (en) 2002-12-16 2004-07-01 Astrazeneca Uk Limited Process for the preparation of pyrimidine compounds
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US8153791B2 (en) 2005-12-21 2012-04-10 Janssen Pharmaceutica N.V. Substituted pyrimidinyl oxime kinase inhibitors
US8013153B2 (en) * 2006-03-23 2011-09-06 Janssen Pharmaceutica, N.V. Substituted pyrimidine kinase inhibitors
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
MX2012013475A (es) 2010-05-21 2012-12-10 Cooper Technologies Co Adapatador para retenedor de buje.

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US3278001A (en) * 1965-02-02 1966-10-11 Charles C Andrews Bearing assembly for auger conveyors
US4698340A (en) * 1984-07-19 1987-10-06 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine derivatives, processes for preparation thereof and composition containing the same
US4689414A (en) * 1986-02-24 1987-08-25 E. R. Squibb & Sons, Inc. 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs
EP0367895A1 (de) 1988-10-06 1990-05-16 Sandoz Ag Pyrimidinyl substituierte Hydroxysäuren, Laktone und Ester und diese enthaltende pharmazeutische Zusammenstellungen
FR2665159B1 (fr) 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
JP3197971B2 (ja) * 1993-03-01 2001-08-13 塩野義製薬株式会社 ５−カルボアルコキシピリミジン誘導体の合成方法
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
SK60097A3 (en) 1994-11-16 1998-01-14 Synaptic Pharma Corp Dihydropyrimidines, pharmaceutical composition containing same and use thereof
DE19517186A1 (de) * 1995-05-11 1996-11-14 Bayer Ag Verfahren zur Herstellung substituierter 2-Fluor-pyrimidine
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
US6278001B1 (en) 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
CZ184098A3 (cs) 1995-12-14 1998-11-11 Merck And Co., Inc. Způsob výroby dihydropyrimidinonů
US5958934A (en) * 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
SE9702563D0 (sv) * 1997-07-02 1997-07-02 Astra Ab Compounds
JP2001512724A (ja) 1997-08-05 2001-08-28 メルク エンド カムパニー インコーポレーテッド α１ａアドレナリン受容体拮抗薬
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
EP1193259A4 (de) * 1999-06-23 2003-01-29 Ajinomoto Kk Dihydropyrimidinderivate
WO2001004100A1 (en) * 1999-07-13 2001-01-18 Lonza Ag Process for preparing 2-amino-4-(4-fluorphenyl)-6-alkylpyrimidine-5-carboxylate
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
AU2000254249A1 (en) 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
GB0011163D0 (en) 2000-05-10 2000-06-28 Astrazeneca Ab Chemical compound
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
ATE349431T1 (de) 2001-07-13 2007-01-15 Astrazeneca Uk Ltd Herstellung von aminopyrimidinverbindungen
EP1323717A1 (de) 2001-12-27 2003-07-02 Dsm N.V. Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EP1375493A1 (de) 2002-06-17 2004-01-02 Dsm N.V. Verfahren zur Herstellung von Dioxanessigsäureester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
WO2004054986A2 (en) 2002-12-16 2004-07-01 Astrazeneca Uk Limited Process for the preparation of pyrimidine compounds
WO2004103977A2 (en) 2003-05-21 2004-12-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of pyrimidine derivatives
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
EP1697338A2 (de) 2003-12-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von statinen mit hohem syn-zu-anti-verhältnis
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
PT1578731E (pt) 2010-01-12
AU2003288443B2 (en) 2007-10-25
AU2003288443A1 (en) 2004-07-09
KR101060215B1 (ko) 2011-08-29
MY138051A (en) 2009-04-30
IL168884A (en) 2011-01-31
CY1110605T1 (el) 2015-04-29
MXPA05006425A (es) 2005-08-19
US20090264654A1 (en) 2009-10-22
CA2509344C (en) 2011-10-04
NO20052781L (no) 2005-07-07
EP2088142A3 (de) 2010-04-21
DK1578731T3 (da) 2010-02-15
HK1080477A1 (en) 2006-04-28
NO20110366L (no) 2005-07-07
CA2509344A1 (en) 2004-07-01
KR20050085674A (ko) 2005-08-29
US20060052604A1 (en) 2006-03-09
WO2004054986A3 (en) 2004-12-02
TWI322145B (en) 2010-03-21
BR0317313A (pt) 2005-11-08
EP1578731A2 (de) 2005-09-28
US7524955B2 (en) 2009-04-28
ES2335279T3 (es) 2010-03-24
JP2006515600A (ja) 2006-06-01
US8273878B2 (en) 2012-09-25
SI1578731T1 (sl) 2010-02-26
DE60330050D1 (de) 2009-12-24
EP2088142A2 (de) 2009-08-12
ATE448209T1 (de) 2009-11-15
JP5318037B2 (ja) 2013-10-16
TW200418809A (en) 2004-10-01
AR042355A1 (es) 2005-06-15
WO2004054986A8 (en) 2005-07-21
JP4579821B2 (ja) 2010-11-10
NZ540722A (en) 2008-03-28
EP1578731B1 (de) 2009-11-11
WO2004054986A2 (en) 2004-07-01
JP2010248222A (ja) 2010-11-04

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Legal Events

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