NO329933B1 - Heterocykliske forbindelser, farmasoytiske sammensetninger samt anvendelser derav - Google Patents
Heterocykliske forbindelser, farmasoytiske sammensetninger samt anvendelser derav Download PDFInfo
- Publication number
- NO329933B1 NO329933B1 NO20043900A NO20043900A NO329933B1 NO 329933 B1 NO329933 B1 NO 329933B1 NO 20043900 A NO20043900 A NO 20043900A NO 20043900 A NO20043900 A NO 20043900A NO 329933 B1 NO329933 B1 NO 329933B1
- Authority
- NO
- Norway
- Prior art keywords
- ylcarbonyloxy
- phenylalanine
- diethylamino
- pyrimidin
- pyrrolidin
- Prior art date
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38302002P | 2002-05-24 | 2002-05-24 | |
| PCT/US2003/016804 WO2003099809A1 (fr) | 2002-05-24 | 2003-05-27 | Composes heterocycliques inhibiteurs de l'adhesion leucocytaire provoquee par des integrines $g(a)4 |
Publications (2)
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|---|---|
| NO20043900L NO20043900L (no) | 2004-11-10 |
| NO329933B1 true NO329933B1 (no) | 2011-01-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| NO20043900A NO329933B1 (no) | 2002-05-24 | 2004-09-17 | Heterocykliske forbindelser, farmasoytiske sammensetninger samt anvendelser derav |
Country Status (23)
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| US (3) | US7026328B2 (fr) |
| EP (1) | EP1507775B1 (fr) |
| JP (1) | JP4469715B2 (fr) |
| KR (1) | KR100978832B1 (fr) |
| CN (1) | CN1314682C (fr) |
| AT (1) | ATE419243T1 (fr) |
| AU (1) | AU2003240823C1 (fr) |
| BR (1) | BR0308881A (fr) |
| CA (1) | CA2481926C (fr) |
| DE (1) | DE60325583D1 (fr) |
| DK (1) | DK1507775T3 (fr) |
| EA (1) | EA008256B1 (fr) |
| EC (1) | ECSP045425A (fr) |
| ES (1) | ES2320436T3 (fr) |
| HK (1) | HK1072608A1 (fr) |
| IL (2) | IL164225A0 (fr) |
| MX (1) | MXPA04010995A (fr) |
| NO (1) | NO329933B1 (fr) |
| NZ (1) | NZ535504A (fr) |
| TW (1) | TWI281470B (fr) |
| UA (1) | UA76339C2 (fr) |
| WO (1) | WO2003099809A1 (fr) |
| ZA (1) | ZA200407590B (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE60036918D1 (de) * | 1999-01-22 | 2007-12-13 | Elan Pharm Inc | Verbindungen die die vla-4 vermittelte adhäsion von leukozyten inhibieren |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| AR044927A1 (es) * | 2003-06-25 | 2005-10-12 | Elan Pharm Inc | Metodos y composiciones para tratar la artritis reumatoidea |
| WO2005111020A2 (fr) * | 2004-04-30 | 2005-11-24 | Elan Pharmaceuticals, Inc. | Analogues d’hydantoïne de pyrimidine qui empêchent l’adhésion des leucocytes par l’intermédiaire de vla-4 |
| AR050425A1 (es) * | 2004-07-08 | 2006-10-25 | Elan Pharm Inc | Antagonistas multivalentes de vla-4 que comprende fracciones polimericas. composiciones farmaceuticas |
| CA2608073C (fr) | 2005-05-20 | 2013-08-06 | Elan Pharmaceuticals, Inc. | Derives d'imidazolone phenylalanine |
| CN101273035A (zh) | 2005-09-29 | 2008-09-24 | 伊兰制药公司 | 抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物 |
| EP1940826B1 (fr) * | 2005-09-29 | 2010-12-29 | Elan Pharmaceuticals Inc. | Composes de pyrimidinyl amide qui inhibent l'adherence leucocytaire a mediation par vla-4 |
| MX2008010988A (es) * | 2006-02-27 | 2008-10-20 | Elan Pharm Inc | Compuestos de pirimidinil sulfonamida que inhiben la adhesion de los leucocitos mediada por vla-4. |
| CA2641160A1 (fr) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methodes pour traiter des maladies inflammatoires et auto-immunes avec des composes inhibiteurs alpha-4 |
| HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
| US20070231319A1 (en) | 2006-03-03 | 2007-10-04 | Yednock Theodore A | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| JP2011506322A (ja) * | 2007-12-07 | 2011-03-03 | エラン ファーマシューティカルズ，インコーポレイテッド | 液性腫瘍を治療するための方法および組成物 |
| EP2085407A1 (fr) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Traitement de purpura thrombopénique idiopathique |
| MX2010011724A (es) * | 2008-04-29 | 2010-11-30 | Nsab Af Neurosearch Sweden Ab | Moduladores de neurotransmision de dopamina. |
| MX2011011326A (es) * | 2009-04-27 | 2012-02-13 | Elan Pharm Inc | Antagonistas de piridinona de las integrinas alfa-4. |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| AU2011203815B2 (en) | 2010-01-11 | 2015-11-26 | Biogen Ma Inc. | Assay for JC virus antibodies |
| JP6080521B2 (ja) * | 2012-11-30 | 2017-02-15 | インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | 広域分散医療情報ネットワークのデータ管理機構 |
| US10119976B2 (en) | 2013-05-28 | 2018-11-06 | Biogen Ma Inc. | Method of assessing risk of PML |
| ES2806276T3 (es) * | 2015-12-30 | 2021-02-17 | Univ Saint Louis | Derivados de ácido aminobenzoico meta-azaciclicos como antagonistas pan-integrina |
| CA3114240C (fr) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Derives d'imidazopyridine utilises en tant qu'inhibiteurs de l'integrine alpha4beta7 |
| AU2019373240B2 (en) | 2018-10-30 | 2023-04-20 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| CA3115830C (fr) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Composes pour inhibition de l'integrine .alpha.4.beta.7 |
| US11224600B2 (en) | 2018-10-30 | 2022-01-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| CN109541237A (zh) * | 2018-12-28 | 2019-03-29 | 吴江近岸蛋白质科技有限公司 | 纤维连接蛋白的生物学活性测定方法 |
| WO2021030438A1 (fr) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Composés pour l'inhibition de l'intégrine alpha 4 bêta 7 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2525656A1 (de) | 1974-06-19 | 1976-01-15 | Sandoz Ag | Verfahren zur herstellung neuer heterocyclischer verbindungen |
| US4073914A (en) | 1974-11-08 | 1978-02-14 | Mitsubishi Chemical Industries Limited | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
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- 2003-05-27 WO PCT/US2003/016804 patent/WO2003099809A1/fr active IP Right Grant
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- 2003-05-27 KR KR1020047018173A patent/KR100978832B1/ko not_active IP Right Cessation
- 2003-05-27 BR BR0308881-2A patent/BR0308881A/pt active Search and Examination
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