NO329700B1 - Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav - Google Patents

Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav Download PDF

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Publication number
NO329700B1
NO329700B1 NO20045301A NO20045301A NO329700B1 NO 329700 B1 NO329700 B1 NO 329700B1 NO 20045301 A NO20045301 A NO 20045301A NO 20045301 A NO20045301 A NO 20045301A NO 329700 B1 NO329700 B1 NO 329700B1
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Norway
Prior art keywords
dimethyl
prop
compound
group
formula
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NO20045301A
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English (en)
Norwegian (no)
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NO20045301L (no
Inventor
Karine Caumont-Bertrand
Jamila Najib
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Genfit
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Publication date
Application filed by Genfit filed Critical Genfit
Publication of NO20045301L publication Critical patent/NO20045301L/no
Publication of NO329700B1 publication Critical patent/NO329700B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • C07C69/712Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
NO20045301A 2002-07-08 2004-12-03 Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav NO329700B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208571A FR2841900B1 (fr) 2002-07-08 2002-07-08 Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
PCT/FR2003/002127 WO2004005233A1 (fr) 2002-07-08 2003-07-08 Derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations

Publications (2)

Publication Number Publication Date
NO20045301L NO20045301L (no) 2005-02-04
NO329700B1 true NO329700B1 (no) 2010-12-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045301A NO329700B1 (no) 2002-07-08 2004-12-03 Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav

Country Status (24)

Country Link
US (3) US7943661B2 (pt)
EP (1) EP1525177B1 (pt)
JP (1) JP4575771B2 (pt)
KR (1) KR100974577B1 (pt)
CN (1) CN100548960C (pt)
AT (1) ATE365703T1 (pt)
AU (1) AU2003264698B2 (pt)
BR (1) BRPI0312398B8 (pt)
CA (1) CA2490986C (pt)
CY (1) CY1108085T1 (pt)
DE (1) DE60314633T2 (pt)
DK (1) DK1525177T3 (pt)
EA (1) EA011090B1 (pt)
ES (1) ES2287528T3 (pt)
FR (1) FR2841900B1 (pt)
IL (2) IL165696A0 (pt)
MX (1) MXPA05000427A (pt)
NO (1) NO329700B1 (pt)
NZ (1) NZ538051A (pt)
PL (1) PL207362B1 (pt)
PT (1) PT1525177E (pt)
SI (1) SI1525177T1 (pt)
WO (1) WO2004005233A1 (pt)
ZA (1) ZA200501082B (pt)

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EA011305B1 (ru) * 2004-01-08 2009-02-27 Жанфит Производные 1,3-дифенилпроп-2-ен-1-она, способ их получения и применение
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US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
TR201810393T4 (tr) * 2009-11-26 2018-08-27 Genfit Karaciğer rahatıszlıklarının tedavisi için 1,3-difenilprop-2-en-1-on türevlerinin kullanımı.
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
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US9115073B2 (en) 2011-12-28 2015-08-25 Genfit 1,3-diphenylpropane derivatives, preparations and uses thereof
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JP7259850B2 (ja) 2017-11-30 2023-04-18 シチュアン ケルン-バイオテック バイオファーマシューティカル カンパニー リミテッド 芳香族化合物、薬学的組成物及びその使用
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CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
WO2021083912A1 (en) 2019-10-28 2021-05-06 Genfit Combination therapy having antioxydant properties
WO2021098885A1 (zh) * 2019-11-21 2021-05-27 杭州百诚医药科技股份有限公司 α-氟代查耳酮类衍生物及其应用
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
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Also Published As

Publication number Publication date
PL372809A1 (en) 2005-08-08
JP2005532385A (ja) 2005-10-27
AU2003264698B2 (en) 2009-09-17
WO2004005233A1 (fr) 2004-01-15
US20110190515A1 (en) 2011-08-04
CA2490986A1 (fr) 2004-01-15
DE60314633D1 (de) 2007-08-09
MXPA05000427A (es) 2005-09-30
FR2841900A1 (fr) 2004-01-09
US20050176808A1 (en) 2005-08-11
SI1525177T1 (sl) 2007-10-31
CY1108085T1 (el) 2014-02-12
ATE365703T1 (de) 2007-07-15
NZ538051A (en) 2007-11-30
FR2841900B1 (fr) 2007-03-02
PL207362B1 (pl) 2010-12-31
IL165696A (en) 2012-09-24
US8058308B2 (en) 2011-11-15
BRPI0312398B8 (pt) 2021-05-25
ES2287528T3 (es) 2007-12-16
KR20050025327A (ko) 2005-03-14
EP1525177B1 (fr) 2007-06-27
EA200500169A1 (ru) 2005-06-30
KR100974577B1 (ko) 2010-08-06
DE60314633T2 (de) 2008-02-28
EP1525177A1 (fr) 2005-04-27
BRPI0312398B1 (pt) 2016-11-08
DK1525177T3 (da) 2007-10-22
US7566737B2 (en) 2009-07-28
ZA200501082B (en) 2007-01-31
CN1668565A (zh) 2005-09-14
US20070032543A1 (en) 2007-02-08
BR0312398A (pt) 2005-04-12
PT1525177E (pt) 2007-09-06
CA2490986C (fr) 2012-09-18
US7943661B2 (en) 2011-05-17
NO20045301L (no) 2005-02-04
CN100548960C (zh) 2009-10-14
EA011090B1 (ru) 2008-12-30
IL165696A0 (en) 2006-01-15
AU2003264698A1 (en) 2004-01-23
JP4575771B2 (ja) 2010-11-04

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