NO327732B1 - Antistoff med affinitet for en epitop fra fibronektins ED-B domene, konjugater og kit inneholdende slike antistoffer samt anvendelser derav. - Google Patents
Antistoff med affinitet for en epitop fra fibronektins ED-B domene, konjugater og kit inneholdende slike antistoffer samt anvendelser derav. Download PDFInfo
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- NO327732B1 NO327732B1 NO20005694A NO20005694A NO327732B1 NO 327732 B1 NO327732 B1 NO 327732B1 NO 20005694 A NO20005694 A NO 20005694A NO 20005694 A NO20005694 A NO 20005694A NO 327732 B1 NO327732 B1 NO 327732B1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Optics & Photonics (AREA)
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- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US7533898A | 1998-05-11 | 1998-05-11 | |
US09/300,425 US20030045681A1 (en) | 1998-05-11 | 1999-04-28 | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
PCT/EP1999/003210 WO1999058570A2 (en) | 1998-05-11 | 1999-05-11 | Antibodies to the ed-b domain of fibronectin, conjugates containing them and use therefor for diagnosis and therapy of tumors and diseases associated with angiogenesis |
Publications (3)
Publication Number | Publication Date |
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NO20005694D0 NO20005694D0 (no) | 2000-11-10 |
NO20005694L NO20005694L (no) | 2001-01-10 |
NO327732B1 true NO327732B1 (no) | 2009-09-14 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20005694A NO327732B1 (no) | 1998-05-11 | 2000-11-10 | Antistoff med affinitet for en epitop fra fibronektins ED-B domene, konjugater og kit inneholdende slike antistoffer samt anvendelser derav. |
Country Status (24)
Country | Link |
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US (1) | US20070189963A1 (de) |
EP (1) | EP1084145B1 (de) |
JP (1) | JP2002514405A (de) |
CN (1) | CN1250571C (de) |
AT (1) | ATE301676T1 (de) |
AU (1) | AU759207B2 (de) |
BR (1) | BRPI9910394B8 (de) |
CA (1) | CA2333833C (de) |
CZ (1) | CZ300495B6 (de) |
DE (1) | DE69926630T2 (de) |
DK (1) | DK1084145T3 (de) |
EA (1) | EA005685B1 (de) |
EE (1) | EE05435B1 (de) |
ES (1) | ES2247802T3 (de) |
HU (1) | HU225675B1 (de) |
IL (1) | IL139452A0 (de) |
IS (1) | IS2522B (de) |
NO (1) | NO327732B1 (de) |
NZ (1) | NZ508600A (de) |
PL (1) | PL199353B1 (de) |
SK (1) | SK286822B6 (de) |
TR (1) | TR200003317T2 (de) |
TW (1) | TWI259837B (de) |
WO (1) | WO1999058570A2 (de) |
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US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
DK1140170T3 (da) | 1999-01-05 | 2006-10-23 | Univ Southern Australia | Antistoffragmenter til topisk behandling af öjensygdomme |
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
DE19947559A1 (de) * | 1999-09-24 | 2001-04-19 | Schering Ag | Antikörper-Farbstoffkonjugate gegen Zielstrukturen der Angiogenese zur intraoperativen Tumorranddarstellung |
US6319273B1 (en) * | 1999-12-16 | 2001-11-20 | Light Sciences Corporation | Illuminating device for treating eye disease |
CA2400622A1 (en) | 2000-02-24 | 2001-08-30 | Eidgenossische Technische Hochschule Zurich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
PT1719528E (pt) * | 2000-02-24 | 2012-01-06 | Philogen Spa | Composições e métodos para tratamento de angiogénese em lesões patológicas |
DE10045803A1 (de) * | 2000-09-07 | 2002-04-11 | Schering Ag | Rezeptor der EDb Fibronektin-Domäne |
EP1381629B1 (de) * | 2000-09-07 | 2008-09-10 | Bayer Schering Pharma Aktiengesellschaft | REZEPTOR DER EDb-FIBRONEKTIN-DOMÄNE (II) |
US20030100010A1 (en) * | 2001-11-23 | 2003-05-29 | George Jackowski | Fibrinogen biopolymer Marker predictive of type II diabetes |
JP2005538033A (ja) * | 2001-12-04 | 2005-12-15 | ナノスペクトラ バイオサイエンセズ,インク. | 過剰なあるいは不適切な新脈管形成によって特徴付けられる病状の治療 |
ATE478095T1 (de) * | 2002-01-03 | 2010-09-15 | Bayer Schering Pharma Ag | Konjugate mit einem für die ed-b-domäne von fibronectin spezifischen antikörper, und deren verwendung zum nachweis und zur behandlung von tumoren |
EP2239274A1 (de) * | 2002-01-03 | 2010-10-13 | Bayer Schering Pharma AG | Neue Verfahren zur Diagnose und Behandlung von Tumoren |
US8491906B2 (en) | 2002-03-11 | 2013-07-23 | Philogen S.P.A. | Selective targeting of tumor vasculature using antibody molecules |
DK1537146T3 (da) | 2002-07-15 | 2011-04-04 | Univ Texas | Antistoffer, der binder til anioniske phospholipider og aminophospholipider, og deres anvendelse til behandling af virusinfektioner |
DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
DE10348319A1 (de) * | 2003-10-17 | 2005-05-19 | Schering Ag | Bindemoleküle für die Extra-Domäne B von Fibronectin zur Detektion von atherosklerotischen Plaques |
US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
EP1957531B1 (de) * | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Bindungspolypeptide mit diversifizierten und konsensus-vh/vl-hypervariablen sequenzen |
JP2009514540A (ja) * | 2005-11-09 | 2009-04-09 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 機能−阻止抗−ed−b−フィブロネクチン抗体(private)の同定及び特徴化 |
EP1842553A1 (de) * | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Kombination von einem Anti-EDb Fibronektin Domäne Antikörper/ IL2 Fusionsprotein und einem kleinen Molekül |
EP1925664A1 (de) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin |
ATE548052T1 (de) | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
EP2100621A1 (de) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether-Polyol-Dendron-Konjugate mit Effektormolekülen für biologisches Targeting |
JP2009244154A (ja) | 2008-03-31 | 2009-10-22 | Nationa Hospital Organization | 老化、および血管障害を伴う疾患の検定のための組成物、キットおよび方法 |
EP2116555A1 (de) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Verwendung eines spezifisch an ED-B Fibronectin bindenden radioaktiv markierten Moleküls bei einem Verfahren zur Behandlung von Hodgkin-Lymphom |
WO2010056889A2 (en) * | 2008-11-12 | 2010-05-20 | The Trustees Of The University Of Pennsylvania | Use of an antibody and a rare-earth based crystal |
JP5749733B2 (ja) | 2009-12-14 | 2015-07-15 | シル プロテインズ ゲーエムベーハーScil Proteins GmbH | フィブロネクチンのエキストラドメインbに対する特異的結合活性を有する修飾ユビキチンタンパク質 |
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AU2012268970B2 (en) | 2011-06-15 | 2016-01-28 | Navigo Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
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WO2024047237A1 (en) | 2022-09-01 | 2024-03-07 | Philogen S.P.A. | Tnf alpha and interleukin-2 combination therapy for non-melanoma skin cancer |
WO2024052333A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | Multivalent fibroblast activation protein ligands for targeted delivery applications |
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Publication number | Priority date | Publication date | Assignee | Title |
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GB9610967D0 (en) * | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
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1999
- 1999-05-10 TW TW088107648A patent/TWI259837B/zh active
- 1999-05-11 DK DK99923571T patent/DK1084145T3/da active
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- 1999-05-11 EP EP99923571A patent/EP1084145B1/de not_active Expired - Lifetime
- 1999-05-11 SK SK1679-2000A patent/SK286822B6/sk not_active IP Right Cessation
- 1999-05-11 DE DE69926630T patent/DE69926630T2/de not_active Expired - Lifetime
- 1999-05-11 WO PCT/EP1999/003210 patent/WO1999058570A2/en active IP Right Grant
- 1999-05-11 TR TR2000/03317T patent/TR200003317T2/xx unknown
- 1999-05-11 HU HU0102992A patent/HU225675B1/hu not_active IP Right Cessation
- 1999-05-11 PL PL345845A patent/PL199353B1/pl not_active IP Right Cessation
- 1999-05-11 CN CNB998060526A patent/CN1250571C/zh not_active Expired - Lifetime
- 1999-05-11 AU AU40398/99A patent/AU759207B2/en not_active Expired
- 1999-05-11 CA CA2333833A patent/CA2333833C/en not_active Expired - Lifetime
- 1999-05-11 IL IL13945299A patent/IL139452A0/xx unknown
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- 1999-05-11 AT AT99923571T patent/ATE301676T1/de active
- 1999-05-11 ES ES99923571T patent/ES2247802T3/es not_active Expired - Lifetime
- 1999-05-11 BR BRPI9910394 patent/BRPI9910394B8/pt not_active IP Right Cessation
- 1999-05-11 EE EEP200000802A patent/EE05435B1/xx not_active IP Right Cessation
- 1999-05-11 JP JP2000548372A patent/JP2002514405A/ja active Pending
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2000
- 2000-11-10 IS IS5708A patent/IS2522B/is unknown
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2006
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