NO327048B1 - Anvendelse av et aktivt kullfilter som en oksidasjonsinhibitor ved prosessering av prostanderivater, og fremgangsmate for fremstilling av medikamenter som inneholder prostanderivater. - Google Patents
Anvendelse av et aktivt kullfilter som en oksidasjonsinhibitor ved prosessering av prostanderivater, og fremgangsmate for fremstilling av medikamenter som inneholder prostanderivater. Download PDFInfo
- Publication number
- NO327048B1 NO327048B1 NO20006578A NO20006578A NO327048B1 NO 327048 B1 NO327048 B1 NO 327048B1 NO 20006578 A NO20006578 A NO 20006578A NO 20006578 A NO20006578 A NO 20006578A NO 327048 B1 NO327048 B1 NO 327048B1
- Authority
- NO
- Norway
- Prior art keywords
- prostane
- derivatives
- activated carbon
- hydroxy
- octen
- Prior art date
Links
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 230000003647 oxidation Effects 0.000 title claims abstract description 20
- 238000007254 oxidation reaction Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 19
- 239000003112 inhibitor Substances 0.000 title claims abstract description 11
- 239000003814 drug Substances 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title abstract description 9
- 210000002307 prostate Anatomy 0.000 title 2
- UKVVPDHLUHAJNZ-PMACEKPBSA-N prostane Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC UKVVPDHLUHAJNZ-PMACEKPBSA-N 0.000 claims abstract description 25
- 239000003570 air Substances 0.000 claims abstract description 20
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000012080 ambient air Substances 0.000 claims abstract description 6
- 229920000858 Cyclodextrin Polymers 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 5
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims description 4
- 229960002240 iloprost Drugs 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000009897 systematic effect Effects 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 abstract description 4
- 238000000354 decomposition reaction Methods 0.000 abstract description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 10
- -1 methanediol ketone Chemical class 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 125000002947 alkylene group Chemical group 0.000 description 5
- 239000007857 degradation product Substances 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 241000282485 Vulpes vulpes Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- CKFGINPQOCXMAZ-UHFFFAOYSA-N formaldehyde hydrate Natural products OCO CKFGINPQOCXMAZ-UHFFFAOYSA-N 0.000 description 1
- 125000006038 hexenyl group Chemical group 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19828881A DE19828881A1 (de) | 1998-06-22 | 1998-06-22 | Oxidationsinhibitor bei Prostan-Derivaten |
| PCT/EP1999/004278 WO1999067212A2 (de) | 1998-06-22 | 1999-06-22 | Aktivkohlefilter als oxidationsinhibitor bei protan-derivaten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20006578D0 NO20006578D0 (no) | 2000-12-21 |
| NO20006578L NO20006578L (no) | 2000-12-21 |
| NO327048B1 true NO327048B1 (no) | 2009-04-14 |
Family
ID=7872332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006578A NO327048B1 (no) | 1998-06-22 | 2000-12-21 | Anvendelse av et aktivt kullfilter som en oksidasjonsinhibitor ved prosessering av prostanderivater, og fremgangsmate for fremstilling av medikamenter som inneholder prostanderivater. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6512139B1 (cs) |
| EP (1) | EP1089970B1 (cs) |
| JP (1) | JP2002518475A (cs) |
| KR (1) | KR100689143B1 (cs) |
| AT (1) | ATE263757T1 (cs) |
| AU (1) | AU763442B2 (cs) |
| CA (1) | CA2335781A1 (cs) |
| CZ (1) | CZ301018B6 (cs) |
| DE (2) | DE19828881A1 (cs) |
| DK (1) | DK1089970T3 (cs) |
| ES (1) | ES2219043T3 (cs) |
| HU (1) | HUP0102870A3 (cs) |
| IL (1) | IL140334A (cs) |
| NO (1) | NO327048B1 (cs) |
| PL (1) | PL193957B1 (cs) |
| PT (1) | PT1089970E (cs) |
| RU (1) | RU2226525C2 (cs) |
| SK (1) | SK286011B6 (cs) |
| WO (1) | WO1999067212A2 (cs) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4054736A (en) * | 1970-06-10 | 1977-10-18 | Ono Pharmaceutical Co., Ltd. | Clathrate compounds of prostaglandins or their analogues with cyclodextrin |
| JPS503362B1 (cs) * | 1970-06-10 | 1975-02-04 | ||
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| JPS56150039A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Clathrate compound of prostacycline derivative |
| DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3608088C2 (de) * | 1986-03-07 | 1995-11-16 | Schering Ag | Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten |
| DE3708537A1 (de) * | 1987-03-13 | 1988-09-22 | Schering Ag | 6-oxoprostaglandin-e-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| DE3816801A1 (de) * | 1988-05-13 | 1989-11-23 | Schering Ag | Verfahren zur herstellung von carbacyclinen |
| JPH03220201A (ja) | 1988-11-18 | 1991-09-27 | Eisai Co Ltd | プロスタグランジン類と多糖類の結合体 |
| EP0686036B1 (de) * | 1992-08-07 | 1997-03-12 | Schering Aktiengesellschaft | Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis |
| AU5376994A (en) * | 1992-11-10 | 1994-06-08 | Nippon Shinyaku Co. Ltd. | Enclosure compound manufacturing method |
| JP2677779B2 (ja) * | 1996-06-28 | 1997-11-17 | 三共株式会社 | プロスタグランジン類 |
| DE19739693A1 (de) * | 1997-09-04 | 1999-03-11 | Schering Ag | Pharmazeutische Präparate zur Behandlung der Multiplen Sklerose |
| DE19808634A1 (de) | 1998-02-24 | 1999-08-26 | Schering Ag | Mantel für eine pharmazeutische Zusammensetzung |
| JPH11322612A (ja) * | 1998-03-13 | 1999-11-24 | Toray Ind Inc | 肝細胞増殖因子誘引剤 |
-
1998
- 1998-06-22 DE DE19828881A patent/DE19828881A1/de not_active Withdrawn
-
1999
- 1999-06-22 ES ES99938207T patent/ES2219043T3/es not_active Expired - Lifetime
- 1999-06-22 IL IL14033499A patent/IL140334A/xx not_active IP Right Cessation
- 1999-06-22 KR KR1020007014548A patent/KR100689143B1/ko not_active Expired - Fee Related
- 1999-06-22 JP JP2000555866A patent/JP2002518475A/ja active Pending
- 1999-06-22 WO PCT/EP1999/004278 patent/WO1999067212A2/de not_active Application Discontinuation
- 1999-06-22 AU AU52798/99A patent/AU763442B2/en not_active Ceased
- 1999-06-22 SK SK1936-2000A patent/SK286011B6/sk not_active IP Right Cessation
- 1999-06-22 DK DK99938207T patent/DK1089970T3/da active
- 1999-06-22 DE DE59909125T patent/DE59909125D1/de not_active Expired - Fee Related
- 1999-06-22 AT AT99938207T patent/ATE263757T1/de not_active IP Right Cessation
- 1999-06-22 RU RU2000132193/04A patent/RU2226525C2/ru not_active IP Right Cessation
- 1999-06-22 PT PT99938207T patent/PT1089970E/pt unknown
- 1999-06-22 EP EP99938207A patent/EP1089970B1/de not_active Expired - Lifetime
- 1999-06-22 PL PL99345288A patent/PL193957B1/pl not_active IP Right Cessation
- 1999-06-22 HU HU0102870A patent/HUP0102870A3/hu unknown
- 1999-06-22 CZ CZ20004791A patent/CZ301018B6/cs not_active IP Right Cessation
- 1999-06-22 CA CA002335781A patent/CA2335781A1/en not_active Abandoned
- 1999-06-22 US US09/720,134 patent/US6512139B1/en not_active Expired - Fee Related
-
2000
- 2000-12-21 NO NO20006578A patent/NO327048B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE59909125D1 (de) | 2004-05-13 |
| CA2335781A1 (en) | 1999-12-29 |
| US6512139B1 (en) | 2003-01-28 |
| DK1089970T3 (da) | 2004-08-02 |
| KR20010053075A (ko) | 2001-06-25 |
| DE19828881A1 (de) | 1999-12-23 |
| EP1089970A2 (de) | 2001-04-11 |
| NO20006578D0 (no) | 2000-12-21 |
| PT1089970E (pt) | 2004-08-31 |
| AU763442B2 (en) | 2003-07-24 |
| CZ301018B6 (cs) | 2009-10-14 |
| CZ20004791A3 (cs) | 2001-04-11 |
| KR100689143B1 (ko) | 2007-03-08 |
| WO1999067212A3 (de) | 2000-03-30 |
| IL140334A (en) | 2005-12-18 |
| RU2226525C2 (ru) | 2004-04-10 |
| JP2002518475A (ja) | 2002-06-25 |
| SK286011B6 (sk) | 2008-01-07 |
| HUP0102870A2 (hu) | 2001-12-28 |
| PL193957B1 (pl) | 2007-04-30 |
| AU5279899A (en) | 2000-01-10 |
| EP1089970B1 (de) | 2004-04-07 |
| NO20006578L (no) | 2000-12-21 |
| ES2219043T3 (es) | 2004-11-16 |
| HUP0102870A3 (en) | 2002-12-28 |
| ATE263757T1 (de) | 2004-04-15 |
| SK19362000A3 (sk) | 2001-05-10 |
| IL140334A0 (en) | 2002-02-10 |
| PL345288A1 (en) | 2001-12-03 |
| WO1999067212A2 (de) | 1999-12-29 |
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