NO326409B1 - 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse - Google Patents
1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse Download PDFInfo
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- NO326409B1 NO326409B1 NO20024134A NO20024134A NO326409B1 NO 326409 B1 NO326409 B1 NO 326409B1 NO 20024134 A NO20024134 A NO 20024134A NO 20024134 A NO20024134 A NO 20024134A NO 326409 B1 NO326409 B1 NO 326409B1
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- Norway
- Prior art keywords
- pyrimidin
- pyrimido
- difluorophenyl
- dihydro
- fluoro
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- XIIOFHFUYBLOLW-UHFFFAOYSA-N selpercatinib Chemical compound OC(COC=1C=C(C=2N(C=1)N=CC=2C#N)C=1C=NC(=CC=1)N1CC2N(C(C1)C2)CC=1C=NC(=CC=1)OC)(C)C XIIOFHFUYBLOLW-UHFFFAOYSA-N 0.000 description 1
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- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US18641900P | 2000-03-02 | 2000-03-02 | |
PCT/US2001/006688 WO2001064679A1 (en) | 2000-03-02 | 2001-03-02 | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
Publications (3)
Publication Number | Publication Date |
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NO20024134D0 NO20024134D0 (no) | 2002-08-30 |
NO20024134L NO20024134L (no) | 2002-10-24 |
NO326409B1 true NO326409B1 (no) | 2008-12-01 |
Family
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Application Number | Title | Priority Date | Filing Date |
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NO20024134A NO326409B1 (no) | 2000-03-02 | 2002-08-30 | 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse |
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EP (1) | EP1265900B1 (zh) |
JP (1) | JP2003525295A (zh) |
KR (1) | KR100806978B1 (zh) |
CN (1) | CN100482664C (zh) |
AR (2) | AR030053A1 (zh) |
AT (1) | ATE362473T1 (zh) |
AU (2) | AU3999201A (zh) |
BR (1) | BR0108715A (zh) |
CA (1) | CA2402092C (zh) |
CY (1) | CY1106816T1 (zh) |
CZ (1) | CZ20022933A3 (zh) |
DE (1) | DE60128457T2 (zh) |
DK (1) | DK1265900T3 (zh) |
ES (1) | ES2287107T3 (zh) |
HK (1) | HK1052932A1 (zh) |
HU (1) | HUP0204431A3 (zh) |
IL (3) | IL151426A0 (zh) |
MX (1) | MXPA02008588A (zh) |
MY (1) | MY141144A (zh) |
NO (1) | NO326409B1 (zh) |
NZ (1) | NZ520914A (zh) |
PL (1) | PL358280A1 (zh) |
PT (1) | PT1265900E (zh) |
TW (1) | TWI290926B (zh) |
WO (1) | WO2001064679A1 (zh) |
ZA (1) | ZA200207017B (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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DE69939168D1 (de) | 1998-05-26 | 2008-09-04 | Warner Lambert Co | Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung |
DK1333833T3 (da) * | 2000-10-23 | 2011-12-12 | Glaxosmithkline Llc | Ny trisubstitueret 8H-pyridol[2,3-d]pyrimidin-7-on-forbindelse til behandling af CSBP/RK/p38-kinnasemedierede sygdomme |
EP1345603A4 (en) | 2000-12-20 | 2004-09-08 | Merck & Co Inc | P38 KINASE INHIBITORS (HALO-BENZO CARBONYL) HETEROCYCLO- FUSIONNES PHENYL |
GB0124848D0 (en) | 2001-10-16 | 2001-12-05 | Celltech R&D Ltd | Chemical compounds |
DK1474395T3 (da) | 2002-02-12 | 2008-02-11 | Smithkline Beecham Corp | Nicotinamidderivater, der er nyttige som p38-inhibitorer |
JP4359146B2 (ja) * | 2002-02-13 | 2009-11-04 | エフ.ホフマン−ラ ロシュ アーゲー | 新規なピリジン−およびピリミジン−誘導体 |
CA2482022A1 (en) * | 2002-04-19 | 2003-10-30 | Smithkline Beecham Corporation | Novel compounds |
GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
PA8577501A1 (es) | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
GB0218800D0 (en) * | 2002-08-13 | 2002-09-18 | Celltech R&D Ltd | Chemical compounds |
US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
AU2003262911A1 (en) | 2002-08-29 | 2004-03-19 | Scios Inc. | Methods of promoting osteogenesis |
US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
US7384937B2 (en) | 2002-11-06 | 2008-06-10 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
CA2521124A1 (en) | 2003-04-10 | 2004-10-21 | F. Hoffmann-La Roche Ag | Pyrimido compounds |
WO2005030091A2 (en) | 2003-09-25 | 2005-04-07 | Scios Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
PT1699800E (pt) * | 2003-12-23 | 2010-04-12 | Novartis Ag | Inibidores de quinase p-38 heterocíclicos bicíclicos |
AU2005316668B2 (en) * | 2004-12-13 | 2012-09-06 | Millennium Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
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