NO325687B1 - Antibakterielle, substituerte 7-acylamino-3-(metylhydrazono)metyl-cefalosporiner fremgangsmate for fremstilling derav og mellomprodukter, anvendelse av forbindelsene samt farmasoytiske preparater inneholdende disse - Google Patents
Antibakterielle, substituerte 7-acylamino-3-(metylhydrazono)metyl-cefalosporiner fremgangsmate for fremstilling derav og mellomprodukter, anvendelse av forbindelsene samt farmasoytiske preparater inneholdende disse Download PDFInfo
- Publication number
- NO325687B1 NO325687B1 NO19994719A NO994719A NO325687B1 NO 325687 B1 NO325687 B1 NO 325687B1 NO 19994719 A NO19994719 A NO 19994719A NO 994719 A NO994719 A NO 994719A NO 325687 B1 NO325687 B1 NO 325687B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- methyl
- formula
- alkyl
- piperazine
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 80
- -1 methylhydrazono Chemical group 0.000 title claims description 49
- 238000000034 method Methods 0.000 title claims description 13
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
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- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000004954 trialkylamino group Chemical group 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT54797A AT405180B (de) | 1997-04-01 | 1997-04-01 | Neue derivate von substituierten 3-cephem-4-carbonsäurederivaten und verfahren zu deren herstellung |
| AT54697 | 1997-04-01 | ||
| AT54897 | 1997-04-01 | ||
| PCT/EP1998/001890 WO1998043981A1 (en) | 1997-04-01 | 1998-04-01 | Antibacterial substituted 7-acylamino-3-(methylhydrazono)methyl -cephalosporins and intermediates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994719L NO994719L (no) | 1999-09-28 |
| NO994719D0 NO994719D0 (no) | 1999-09-28 |
| NO325687B1 true NO325687B1 (no) | 2008-07-07 |
Family
ID=27146440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994719A NO325687B1 (no) | 1997-04-01 | 1999-09-28 | Antibakterielle, substituerte 7-acylamino-3-(metylhydrazono)metyl-cefalosporiner fremgangsmate for fremstilling derav og mellomprodukter, anvendelse av forbindelsene samt farmasoytiske preparater inneholdende disse |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP0973780B1 (tr) |
| JP (2) | JP3363157B2 (tr) |
| KR (2) | KR100481143B1 (tr) |
| CN (1) | CN1117095C (tr) |
| AU (1) | AU734897B2 (tr) |
| BR (1) | BR9807913A (tr) |
| CA (1) | CA2284501C (tr) |
| DE (1) | DE69816057T2 (tr) |
| DK (1) | DK0973780T3 (tr) |
| ES (1) | ES2203955T3 (tr) |
| HK (1) | HK1026692A1 (tr) |
| ID (1) | ID22441A (tr) |
| IL (1) | IL131849A (tr) |
| NO (1) | NO325687B1 (tr) |
| NZ (1) | NZ337732A (tr) |
| PL (1) | PL200130B1 (tr) |
| PT (1) | PT973780E (tr) |
| RU (1) | RU2201933C2 (tr) |
| SK (1) | SK133099A3 (tr) |
| TR (1) | TR199902387T2 (tr) |
| WO (1) | WO1998043981A1 (tr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT406772B (de) * | 1998-03-23 | 2000-08-25 | Biochemie Gmbh | Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung |
| US6504025B2 (en) * | 2000-05-24 | 2003-01-07 | Basilea Pharmaceutica Ag | Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives |
| AT413282B (de) * | 2002-02-01 | 2006-01-15 | Sandoz Ag | Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl) |
| CN114401970A (zh) | 2019-09-06 | 2022-04-26 | 纳布里瓦治疗有限责任公司 | 铁载体头孢菌素缀合物及其用途 |
| CN111187281B (zh) * | 2020-02-11 | 2023-03-14 | 广西科技大学 | 含胍基的头孢菌素衍生物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190639B (en) * | 1983-12-12 | 1986-09-29 | Gyogyszerkutato Intezet Kv,Hu | Process for production of new aminoguanidin derivatives |
| FI851934L (fi) * | 1984-05-30 | 1985-12-01 | Ici Plc | Kefalosporinderivat. |
| RU2183212C2 (ru) * | 1995-05-11 | 2002-06-10 | Биохеми Гезельшафт Мбх | Антибактериальные цефалоспорины, фармацевтическая композиция на их основе и способ лечения |
-
1998
- 1998-04-01 TR TR1999/02387T patent/TR199902387T2/tr unknown
- 1998-04-01 NZ NZ337732A patent/NZ337732A/en unknown
- 1998-04-01 DE DE69816057T patent/DE69816057T2/de not_active Expired - Lifetime
- 1998-04-01 KR KR10-1999-7008385A patent/KR100481143B1/ko not_active IP Right Cessation
- 1998-04-01 WO PCT/EP1998/001890 patent/WO1998043981A1/en not_active Application Discontinuation
- 1998-04-01 DK DK98922631T patent/DK0973780T3/da active
- 1998-04-01 PT PT98922631T patent/PT973780E/pt unknown
- 1998-04-01 IL IL13184998A patent/IL131849A/en not_active IP Right Cessation
- 1998-04-01 KR KR10-2003-7001223A patent/KR20040000380A/ko not_active Application Discontinuation
- 1998-04-01 RU RU99122749/04A patent/RU2201933C2/ru not_active IP Right Cessation
- 1998-04-01 EP EP98922631A patent/EP0973780B1/en not_active Expired - Lifetime
- 1998-04-01 ES ES98922631T patent/ES2203955T3/es not_active Expired - Lifetime
- 1998-04-01 CA CA002284501A patent/CA2284501C/en not_active Expired - Fee Related
- 1998-04-01 JP JP54116298A patent/JP3363157B2/ja not_active Expired - Fee Related
- 1998-04-01 BR BR9807913-1A patent/BR9807913A/pt not_active Application Discontinuation
- 1998-04-01 ID IDW991129A patent/ID22441A/id unknown
- 1998-04-01 CN CN98803820A patent/CN1117095C/zh not_active Expired - Fee Related
- 1998-04-01 AU AU75213/98A patent/AU734897B2/en not_active Ceased
- 1998-04-01 EP EP03000220A patent/EP1300408A1/en not_active Ceased
- 1998-04-01 SK SK1330-99A patent/SK133099A3/sk unknown
- 1998-04-01 PL PL336004A patent/PL200130B1/pl unknown
-
1999
- 1999-09-28 NO NO19994719A patent/NO325687B1/no unknown
-
2000
- 2000-07-24 HK HK00104576A patent/HK1026692A1/xx unknown
-
2002
- 2002-03-08 JP JP2002064270A patent/JP2002316992A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2284501A1 (en) | 1998-10-08 |
| IL131849A (en) | 2004-05-12 |
| IL131849A0 (en) | 2001-03-19 |
| ID22441A (id) | 1999-10-14 |
| KR100481143B1 (ko) | 2005-04-08 |
| CN1251591A (zh) | 2000-04-26 |
| TR199902387T2 (tr) | 2000-01-21 |
| DE69816057D1 (de) | 2003-08-07 |
| RU2201933C2 (ru) | 2003-04-10 |
| NO994719L (no) | 1999-09-28 |
| CA2284501C (en) | 2007-07-17 |
| CN1117095C (zh) | 2003-08-06 |
| PL336004A1 (en) | 2000-06-05 |
| DK0973780T3 (da) | 2003-10-27 |
| NZ337732A (en) | 2001-09-28 |
| EP0973780A1 (en) | 2000-01-26 |
| BR9807913A (pt) | 2000-02-22 |
| KR20040000380A (ko) | 2004-01-03 |
| DE69816057T2 (de) | 2004-04-15 |
| WO1998043981A1 (en) | 1998-10-08 |
| HK1026692A1 (en) | 2000-12-22 |
| NO994719D0 (no) | 1999-09-28 |
| AU734897B2 (en) | 2001-06-28 |
| KR20000076288A (ko) | 2000-12-26 |
| AU7521398A (en) | 1998-10-22 |
| JP2002316992A (ja) | 2002-10-31 |
| EP0973780B1 (en) | 2003-07-02 |
| PL200130B1 (pl) | 2008-12-31 |
| JP2000514832A (ja) | 2000-11-07 |
| SK133099A3 (en) | 2001-03-12 |
| PT973780E (pt) | 2003-11-28 |
| ES2203955T3 (es) | 2004-04-16 |
| EP1300408A1 (en) | 2003-04-09 |
| JP3363157B2 (ja) | 2003-01-08 |
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