NO325178B1 - Rekonstituert human anti-HM1.24 antistoff og H-kjede derav, DNA som koder for V-regionen til H-kjeden og L-kjeden av antistoffet, vektor som omfatter nevnte DNA, vertcelle som omfatter nevnte vektor, fremgangsmate for produksjon av antistoffet, samt farmasoytisk blanding og terapeutisk middel som inneholder antistoffet. - Google Patents
Rekonstituert human anti-HM1.24 antistoff og H-kjede derav, DNA som koder for V-regionen til H-kjeden og L-kjeden av antistoffet, vektor som omfatter nevnte DNA, vertcelle som omfatter nevnte vektor, fremgangsmate for produksjon av antistoffet, samt farmasoytisk blanding og terapeutisk middel som inneholder antistoffet. Download PDFInfo
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- NO325178B1 NO325178B1 NO19991591A NO991591A NO325178B1 NO 325178 B1 NO325178 B1 NO 325178B1 NO 19991591 A NO19991591 A NO 19991591A NO 991591 A NO991591 A NO 991591A NO 325178 B1 NO325178 B1 NO 325178B1
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26475696 | 1996-10-04 | ||
| PCT/JP1997/003553 WO1998014580A1 (fr) | 1996-10-04 | 1997-10-03 | Anticorps anti-hm1.24 humain reconstitue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991591D0 NO991591D0 (no) | 1999-03-31 |
| NO991591L NO991591L (no) | 1999-06-01 |
| NO325178B1 true NO325178B1 (no) | 2008-02-11 |
Family
ID=17407753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991591A NO325178B1 (no) | 1996-10-04 | 1999-03-31 | Rekonstituert human anti-HM1.24 antistoff og H-kjede derav, DNA som koder for V-regionen til H-kjeden og L-kjeden av antistoffet, vektor som omfatter nevnte DNA, vertcelle som omfatter nevnte vektor, fremgangsmate for produksjon av antistoffet, samt farmasoytisk blanding og terapeutisk middel som inneholder antistoffet. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6699974B2 (de) |
| EP (1) | EP0960936B1 (de) |
| KR (1) | KR100388256B1 (de) |
| CN (2) | CN1271205C (de) |
| AT (1) | ATE512224T1 (de) |
| AU (1) | AU715156B2 (de) |
| BR (1) | BR9712488A (de) |
| CA (1) | CA2267072C (de) |
| CZ (1) | CZ296790B6 (de) |
| HK (1) | HK1024261A1 (de) |
| IL (1) | IL129286A0 (de) |
| NO (1) | NO325178B1 (de) |
| PL (1) | PL187642B1 (de) |
| RU (1) | RU2184147C2 (de) |
| SK (1) | SK44399A3 (de) |
| TR (1) | TR199900722T2 (de) |
| TW (1) | TW530064B (de) |
| UA (1) | UA76934C2 (de) |
| WO (1) | WO1998014580A1 (de) |
| ZA (1) | ZA978865B (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69830492T2 (de) | 1997-02-12 | 2006-03-16 | Chugai Seiyaku K.K. | Antikörper als ARZNEIMITTEL GEGEN LYMPHOCYTISCHE TUMORE (AUSSCHLIESSLICH MYELOME) |
| WO1998037913A1 (fr) * | 1997-02-28 | 1998-09-03 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteurs d'activation de lymphocytes |
| AU732306B2 (en) | 1997-10-14 | 2001-04-12 | Chugai Seiyaku Kabushiki Kaisha | Potentiator for antibody against lymphoid tumor |
| EP1757941B1 (de) * | 1998-02-25 | 2010-03-31 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zum immunochemischen Testen des Anti-HM1.24-Antikörpers |
| WO2000017395A1 (en) | 1998-09-18 | 2000-03-30 | Chugai Seiyaku Kabushiki Kaisha | Method for detecting or measuring plasmocytomas |
| CA2372585A1 (en) * | 1999-05-10 | 2000-11-16 | Chugai Seiyaku Kabushiki Kaisha | Method of culturing cells |
| EP1213028B1 (de) | 1999-08-23 | 2008-08-13 | Chugai Seiyaku Kabushiki Kaisha | Verstärker der hm1.24 antigen-expression |
| WO2001077362A1 (fr) * | 2000-04-06 | 2001-10-18 | Chugai Seiyaku Kabushiki Kaisha | Dosage immunologique d'anticorps anti hm1 . 24 |
| EP1314437B1 (de) | 2000-08-11 | 2014-06-25 | Chugai Seiyaku Kabushiki Kaisha | Antikörper enthaltende stabilisierte präparate |
| DE60141297D1 (de) * | 2000-12-28 | 2010-03-25 | Kyowa Hakko Kirin Co Ltd | Gegen das menschliche bst2 antigen gerichteter monoklonaler antikörper |
| EP1364657B1 (de) | 2001-02-07 | 2016-12-28 | Chugai Seiyaku Kabushiki Kaisha | Mittel gegen myelozytenleukämie |
| EP3088412B1 (de) | 2001-03-09 | 2021-05-05 | Chugai Seiyaku Kabushiki Kaisha | Proteinaufreinigungsverfahren |
| CA2441228A1 (en) * | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
| WO2002084290A1 (fr) * | 2001-04-13 | 2002-10-24 | Chugai Seiyaku Kabushiki Kaisha | Procede permettant de quantifier l'expression d'antigenes |
| US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| PT1411118E (pt) * | 2001-06-22 | 2008-12-09 | Chugai Pharmaceutical Co Ltd | Inibidores da proliferação celular contendo um anticorpo anti-glipicano 3 |
| CA2450898A1 (en) * | 2001-07-09 | 2003-01-23 | Aphton Corporation | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
| SI1475101T1 (sl) * | 2002-02-14 | 2011-03-31 | Chugai Pharmaceutical Co Ltd | Farmacevtski proizvodi iz raztopine, ki vsebuje protitelo |
| US20080219974A1 (en) * | 2002-03-01 | 2008-09-11 | Bernett Matthew J | Optimized antibodies that target hm1.24 |
| EP1513879B1 (de) * | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Bibliotheken synthetischer antikörperphagen |
| EP1541165A4 (de) | 2002-08-27 | 2009-06-24 | Chugai Pharmaceutical Co Ltd | Verfahren zur stabilisierung einer proteinl sungszubereitung |
| CN100522989C (zh) | 2002-09-11 | 2009-08-05 | 中外制药株式会社 | 纯化蛋白质的方法 |
| JP4689597B2 (ja) * | 2003-03-28 | 2011-05-25 | レセプター バイオロジックス インク． | ガストリンホルモン免疫アッセイ |
| WO2005012531A2 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
| EP1666501A4 (de) * | 2003-08-11 | 2008-12-24 | Chugai Pharmaceutical Co Ltd | Zuckerkettenmodifizierter anti-hm1.24-antikörper |
| US8603481B2 (en) * | 2003-10-10 | 2013-12-10 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for solid tumors |
| LT2348051T (lt) * | 2003-11-05 | 2019-02-25 | Roche Glycart Ag | Cd20 antikūnai su padidintu fc receptoriaus prisijungimo giminingumu ir efektorine funkcija |
| ES2337473T3 (es) * | 2004-02-19 | 2010-04-26 | Genentech, Inc. | Anticuerpos reparadores con cdr. |
| WO2005095459A2 (en) * | 2004-03-29 | 2005-10-13 | Receptor Biologix, Inc. | Monoclonal antibodies to gastrin hormone |
| CA2580965C (en) | 2004-09-22 | 2014-04-08 | Receptor Biologix, Inc. | Monoclonal antibodies to progastrin |
| AU2012216702B2 (en) * | 2005-08-26 | 2014-12-04 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
| KR101379568B1 (ko) * | 2005-08-26 | 2014-04-08 | 로슈 글리카트 아게 | 변형된 세포 신호 활성을 가진 개질된 항원 결합 분자 |
| EP2465870A1 (de) | 2005-11-07 | 2012-06-20 | Genentech, Inc. | Bindepolypeptide mit verschiedenartigen und übereinstimmenden hypervariablen VH/VL-Sequenzen |
| US20070237764A1 (en) * | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| EP1977763A4 (de) | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | Antikörper-enthaltende stabilisierende zubereitung |
| CA2660795C (en) * | 2006-09-18 | 2014-11-18 | Xencor, Inc. | Optimized antibodies that target hm1.24 |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| SG178991A1 (en) * | 2009-09-03 | 2012-04-27 | Schering Corp | Anti-gitr antibodies |
| TWI609698B (zh) | 2010-01-20 | 2018-01-01 | Chugai Pharmaceutical Co Ltd | 穩定化的含抗體溶液製劑 |
| US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
| CN103889555B (zh) | 2011-09-01 | 2018-10-26 | 中外制药株式会社 | 通过超滤制备包含高度浓缩的抗体的组合物的方法 |
| CA3233584A1 (en) | 2013-12-27 | 2015-07-02 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying antibody having low isoelectric point |
| US20170362304A1 (en) | 2014-08-20 | 2017-12-21 | Chugai Seiyaku Kabushiki Kaisha | Method for measuring viscosity of protein solution |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| JP7469225B2 (ja) | 2017-06-15 | 2024-04-16 | キャンサー アドヴァンシーズ インク． | 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法 |
| CN109748964B (zh) * | 2017-11-01 | 2020-11-17 | 深圳宾德生物技术有限公司 | CD317单链抗体317scFv、其编码序列及制备方法和应用 |
| CA3096222A1 (en) | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| TWI840360B (zh) | 2018-05-21 | 2024-05-01 | 日商中外製藥股份有限公司 | 密封於玻璃容器之凍結乾燥的製劑、套組、製造凍結乾燥製劑的方法、防止或減低凍結乾燥製劑的玻璃容器成霧的方法、及容器內面經過硫酸銨處理或ｖｉｓｔ處理之玻璃容器 |
| CN115636141A (zh) | 2018-05-28 | 2023-01-24 | 中外制药株式会社 | 填充喷嘴 |
| EP4037711A4 (de) | 2019-10-03 | 2024-02-14 | Atyr Pharma, Inc. | Zusammensetzungen und verfahren mit anti-nrp2-antikörpern |
| JPWO2023058723A1 (de) | 2021-10-08 | 2023-04-13 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO873164L (no) * | 1986-07-30 | 1988-02-01 | Teijin Ltd | Muse-humane kimaere antistoffer. |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9014932D0 (en) * | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| DK0628639T3 (da) | 1991-04-25 | 2000-01-24 | Chugai Pharmaceutical Co Ltd | Rekonstitueret humant antistof mod human interleukin-6-receptor |
| WO1996004925A1 (en) * | 1994-08-12 | 1996-02-22 | Immunomedics, Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
| DE69830492T2 (de) * | 1997-02-12 | 2006-03-16 | Chugai Seiyaku K.K. | Antikörper als ARZNEIMITTEL GEGEN LYMPHOCYTISCHE TUMORE (AUSSCHLIESSLICH MYELOME) |
| US20020034507A1 (en) * | 1997-02-28 | 2002-03-21 | Yasuo Koishihara | Inhibitor of lymphocyte activation |
| ES2293691T3 (es) * | 1997-10-03 | 2008-03-16 | Chugai Seiyaku Kabushiki Kaisha | Anticuerpo humano natural. |
| AU732306B2 (en) * | 1997-10-14 | 2001-04-12 | Chugai Seiyaku Kabushiki Kaisha | Potentiator for antibody against lymphoid tumor |
| EP2135879A3 (de) * | 2002-06-28 | 2010-06-23 | Domantis Limited | Ligand |
-
1997
- 1997-03-10 UA UA99042469A patent/UA76934C2/uk unknown
- 1997-10-03 CA CA002267072A patent/CA2267072C/en not_active Expired - Fee Related
- 1997-10-03 SK SK443-99A patent/SK44399A3/sk unknown
- 1997-10-03 US US09/269,921 patent/US6699974B2/en not_active Expired - Lifetime
- 1997-10-03 WO PCT/JP1997/003553 patent/WO1998014580A1/ja active IP Right Grant
- 1997-10-03 ZA ZA9708865A patent/ZA978865B/xx unknown
- 1997-10-03 KR KR10-1999-7002902A patent/KR100388256B1/ko not_active IP Right Cessation
- 1997-10-03 CZ CZ0117399A patent/CZ296790B6/cs not_active IP Right Cessation
- 1997-10-03 TW TW086114474A patent/TW530064B/zh not_active IP Right Cessation
- 1997-10-03 IL IL12928697A patent/IL129286A0/xx not_active IP Right Cessation
- 1997-10-03 CN CNB971992150A patent/CN1271205C/zh not_active Expired - Fee Related
- 1997-10-03 RU RU99109034/13A patent/RU2184147C2/ru not_active IP Right Cessation
- 1997-10-03 TR TR1999/00722T patent/TR199900722T2/xx unknown
- 1997-10-03 AT AT97942246T patent/ATE512224T1/de not_active IP Right Cessation
- 1997-10-03 PL PL97332742A patent/PL187642B1/pl not_active IP Right Cessation
- 1997-10-03 BR BR9712488-5A patent/BR9712488A/pt not_active Application Discontinuation
- 1997-10-03 EP EP97942246A patent/EP0960936B1/de not_active Expired - Lifetime
- 1997-10-03 CN CNA2005100687876A patent/CN1765928A/zh active Pending
- 1997-10-03 AU AU43992/97A patent/AU715156B2/en not_active Ceased
-
1999
- 1999-03-31 NO NO19991591A patent/NO325178B1/no unknown
-
2000
- 2000-03-23 HK HK00101791A patent/HK1024261A1/xx not_active IP Right Cessation
-
2002
- 2002-08-13 US US10/218,253 patent/US7892543B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000048884A (ko) | 2000-07-25 |
| CN1271205C (zh) | 2006-08-23 |
| WO1998014580A1 (fr) | 1998-04-09 |
| CZ117399A3 (cs) | 1999-09-15 |
| ATE512224T1 (de) | 2011-06-15 |
| NO991591D0 (no) | 1999-03-31 |
| CN1235639A (zh) | 1999-11-17 |
| PL187642B1 (pl) | 2004-08-31 |
| CZ296790B6 (cs) | 2006-06-14 |
| IL129286A0 (en) | 2000-02-17 |
| US20030129185A1 (en) | 2003-07-10 |
| EP0960936B1 (de) | 2011-06-08 |
| UA76934C2 (en) | 2006-10-16 |
| SK44399A3 (en) | 2000-05-16 |
| CN1765928A (zh) | 2006-05-03 |
| TW530064B (en) | 2003-05-01 |
| BR9712488A (pt) | 1999-10-19 |
| US7892543B2 (en) | 2011-02-22 |
| RU2184147C2 (ru) | 2002-06-27 |
| KR100388256B1 (ko) | 2003-06-19 |
| CA2267072A1 (en) | 1998-04-09 |
| EP0960936A1 (de) | 1999-12-01 |
| HK1024261A1 (en) | 2000-10-05 |
| TR199900722T2 (xx) | 1999-12-21 |
| ZA978865B (en) | 1998-04-20 |
| AU4399297A (en) | 1998-04-24 |
| CA2267072C (en) | 2004-11-30 |
| AU715156B2 (en) | 2000-01-20 |
| US6699974B2 (en) | 2004-03-02 |
| PL332742A1 (en) | 1999-10-11 |
| US20030045691A1 (en) | 2003-03-06 |
| NO991591L (no) | 1999-06-01 |
| EP0960936A4 (de) | 2005-01-19 |
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