BR9712488A - Anticorpo anti-hm 1.24 humano remodelado - Google Patents

Anticorpo anti-hm 1.24 humano remodelado

Info

Publication number
BR9712488A
BR9712488A BR9712488-5A BR9712488A BR9712488A BR 9712488 A BR9712488 A BR 9712488A BR 9712488 A BR9712488 A BR 9712488A BR 9712488 A BR9712488 A BR 9712488A
Authority
BR
Brazil
Prior art keywords
chain
antibody
human
region
human anti
Prior art date
Application number
BR9712488-5A
Other languages
English (en)
Inventor
Koichiro Ono
Toshihiko Ohtomo
Masayuki Tsuchiya
Yasushi Yoshimura
Yasuo Koishihara
Masaaki Kosaka
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR9712488A publication Critical patent/BR9712488A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>''ANTICORPO ANTI-HM 1.24 HUMANO REMODELADO''<D>. Um anticorpo anti-HM 1.24 humano remodelado compreendendo: (A) uma cadeia L compreendendo (1) a região C de uma cadeia L humana, e (2) a região V de uma cadeia L compreendendo a FR de uma cadeia L humana e a CDR da cadeia L de um anticorpo monoclonal anti-HM 1.24 de camundongo; e (B) uma cadeia H compreendendo (1) a região C de uma cadeia H humana, e (2) a região V de uma cadeia H compreendendo a FR de uma cadeia H humana e a CDR da cadeia H de um anticorpo monoclonal anti-HM 1.24 de camundongo. Como a maior parte desse anticorpo humano remodelado é derivada de anticorpo humano e a CDR tem baixa antigenicidade, o anticorpo humano remodelado da presente invenção tem uma antigenicidade baixa e, portanto, será usado para tratamento médico.
BR9712488-5A 1996-10-04 1997-10-03 Anticorpo anti-hm 1.24 humano remodelado BR9712488A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26475696 1996-10-04
PCT/JP1997/003553 WO1998014580A1 (fr) 1996-10-04 1997-10-03 Anticorps anti-hm1.24 humain reconstitue

Publications (1)

Publication Number Publication Date
BR9712488A true BR9712488A (pt) 1999-10-19

Family

ID=17407753

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712488-5A BR9712488A (pt) 1996-10-04 1997-10-03 Anticorpo anti-hm 1.24 humano remodelado

Country Status (20)

Country Link
US (2) US6699974B2 (pt)
EP (1) EP0960936B1 (pt)
KR (1) KR100388256B1 (pt)
CN (2) CN1271205C (pt)
AT (1) ATE512224T1 (pt)
AU (1) AU715156B2 (pt)
BR (1) BR9712488A (pt)
CA (1) CA2267072C (pt)
CZ (1) CZ296790B6 (pt)
HK (1) HK1024261A1 (pt)
IL (1) IL129286A0 (pt)
NO (1) NO325178B1 (pt)
PL (1) PL187642B1 (pt)
RU (1) RU2184147C2 (pt)
SK (1) SK44399A3 (pt)
TR (1) TR199900722T2 (pt)
TW (1) TW530064B (pt)
UA (1) UA76934C2 (pt)
WO (1) WO1998014580A1 (pt)
ZA (1) ZA978865B (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69830492T2 (de) 1997-02-12 2006-03-16 Chugai Seiyaku K.K. Antikörper als ARZNEIMITTEL GEGEN LYMPHOCYTISCHE TUMORE (AUSSCHLIESSLICH MYELOME)
WO1998037913A1 (fr) * 1997-02-28 1998-09-03 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs d'activation de lymphocytes
AU732306B2 (en) 1997-10-14 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Potentiator for antibody against lymphoid tumor
EP1757941B1 (en) * 1998-02-25 2010-03-31 Chugai Seiyaku Kabushiki Kaisha Method for immunochemically assaying anti-hm1.24 antibody
WO2000017395A1 (en) 1998-09-18 2000-03-30 Chugai Seiyaku Kabushiki Kaisha Method for detecting or measuring plasmocytomas
CA2372585A1 (en) * 1999-05-10 2000-11-16 Chugai Seiyaku Kabushiki Kaisha Method of culturing cells
EP1213028B1 (en) 1999-08-23 2008-08-13 Chugai Seiyaku Kabushiki Kaisha Hm1.24 antigen expression potentiators
WO2001077362A1 (fr) * 2000-04-06 2001-10-18 Chugai Seiyaku Kabushiki Kaisha Dosage immunologique d'anticorps anti hm1 . 24
EP1314437B1 (en) 2000-08-11 2014-06-25 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
DE60141297D1 (de) * 2000-12-28 2010-03-25 Kyowa Hakko Kirin Co Ltd Gegen das menschliche bst2 antigen gerichteter monoklonaler antikörper
EP1364657B1 (en) 2001-02-07 2016-12-28 Chugai Seiyaku Kabushiki Kaisha Remedies for myelocytic leukemia
EP3088412B1 (en) 2001-03-09 2021-05-05 Chugai Seiyaku Kabushiki Kaisha Protein purification method
CA2441228A1 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
WO2002084290A1 (fr) * 2001-04-13 2002-10-24 Chugai Seiyaku Kabushiki Kaisha Procede permettant de quantifier l'expression d'antigenes
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
PT1411118E (pt) * 2001-06-22 2008-12-09 Chugai Pharmaceutical Co Ltd Inibidores da proliferação celular contendo um anticorpo anti-glipicano 3
CA2450898A1 (en) * 2001-07-09 2003-01-23 Aphton Corporation Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
SI1475101T1 (sl) * 2002-02-14 2011-03-31 Chugai Pharmaceutical Co Ltd Farmacevtski proizvodi iz raztopine, ki vsebuje protitelo
US20080219974A1 (en) * 2002-03-01 2008-09-11 Bernett Matthew J Optimized antibodies that target hm1.24
EP1513879B1 (en) * 2002-06-03 2018-08-22 Genentech, Inc. Synthetic antibody phage libraries
EP1541165A4 (en) 2002-08-27 2009-06-24 Chugai Pharmaceutical Co Ltd METHOD FOR STABILIZING PROTEIN PREPARATION
CN100522989C (zh) 2002-09-11 2009-08-05 中外制药株式会社 纯化蛋白质的方法
JP4689597B2 (ja) * 2003-03-28 2011-05-25 レセプター バイオロジックス インク． ガストリンホルモン免疫アッセイ
WO2005012531A2 (en) * 2003-08-01 2005-02-10 Genentech, Inc. Antibody cdr polypeptide sequences with restricted diversity
EP1666501A4 (en) * 2003-08-11 2008-12-24 Chugai Pharmaceutical Co Ltd ANTI-HM1.24 ANTIBODIES WITH MODIFIED SUGAR CHAIN
US8603481B2 (en) * 2003-10-10 2013-12-10 Chugai Seiyaku Kabushiki Kaisha Therapeutic agents for solid tumors
LT2348051T (lt) * 2003-11-05 2019-02-25 Roche Glycart Ag Cd20 antikūnai su padidintu fc receptoriaus prisijungimo giminingumu ir efektorine funkcija
ES2337473T3 (es) * 2004-02-19 2010-04-26 Genentech, Inc. Anticuerpos reparadores con cdr.
WO2005095459A2 (en) * 2004-03-29 2005-10-13 Receptor Biologix, Inc. Monoclonal antibodies to gastrin hormone
CA2580965C (en) 2004-09-22 2014-04-08 Receptor Biologix, Inc. Monoclonal antibodies to progastrin
AU2012216702B2 (en) * 2005-08-26 2014-12-04 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
KR101379568B1 (ko) * 2005-08-26 2014-04-08 로슈 글리카트 아게 변형된 세포 신호 활성을 가진 개질된 항원 결합 분자
EP2465870A1 (en) 2005-11-07 2012-06-20 Genentech, Inc. Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
US20070237764A1 (en) * 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
EP1977763A4 (en) 2005-12-28 2010-06-02 Chugai Pharmaceutical Co Ltd STABILIZER PREPARATION CONTAINING ANTIBODIES
CA2660795C (en) * 2006-09-18 2014-11-18 Xencor, Inc. Optimized antibodies that target hm1.24
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
SG178991A1 (en) * 2009-09-03 2012-04-27 Schering Corp Anti-gitr antibodies
TWI609698B (zh) 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd 穩定化的含抗體溶液製劑
US9574005B2 (en) 2011-07-19 2017-02-21 Chugai Seiyaku Kabushiki Kaisha Stable Protein-containing preparation containing argininamide or analogous compound thereof
CN103889555B (zh) 2011-09-01 2018-10-26 中外制药株式会社 通过超滤制备包含高度浓缩的抗体的组合物的方法
CA3233584A1 (en) 2013-12-27 2015-07-02 Chugai Seiyaku Kabushiki Kaisha Method for purifying antibody having low isoelectric point
US20170362304A1 (en) 2014-08-20 2017-12-21 Chugai Seiyaku Kabushiki Kaisha Method for measuring viscosity of protein solution
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
JP7469225B2 (ja) 2017-06-15 2024-04-16 キャンサー アドヴァンシーズ インク． 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法
CN109748964B (zh) * 2017-11-01 2020-11-17 深圳宾德生物技术有限公司 CD317单链抗体317scFv、其编码序列及制备方法和应用
CA3096222A1 (en) 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
TWI840360B (zh) 2018-05-21 2024-05-01 日商中外製藥股份有限公司 密封於玻璃容器之凍結乾燥的製劑、套組、製造凍結乾燥製劑的方法、防止或減低凍結乾燥製劑的玻璃容器成霧的方法、及容器內面經過硫酸銨處理或ｖｉｓｔ處理之玻璃容器
CN115636141A (zh) 2018-05-28 2023-01-24 中外制药株式会社 填充喷嘴
EP4037711A4 (en) 2019-10-03 2024-02-14 Atyr Pharma, Inc. COMPOSITIONS AND METHODS USING ANTI-NRP2 ANTIBODIES
JPWO2023058723A1 (pt) 2021-10-08 2023-04-13

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO873164L (no) * 1986-07-30 1988-02-01 Teijin Ltd Muse-humane kimaere antistoffer.
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
DK0628639T3 (da) 1991-04-25 2000-01-24 Chugai Pharmaceutical Co Ltd Rekonstitueret humant antistof mod human interleukin-6-receptor
WO1996004925A1 (en) * 1994-08-12 1996-02-22 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
DE69830492T2 (de) * 1997-02-12 2006-03-16 Chugai Seiyaku K.K. Antikörper als ARZNEIMITTEL GEGEN LYMPHOCYTISCHE TUMORE (AUSSCHLIESSLICH MYELOME)
US20020034507A1 (en) * 1997-02-28 2002-03-21 Yasuo Koishihara Inhibitor of lymphocyte activation
ES2293691T3 (es) * 1997-10-03 2008-03-16 Chugai Seiyaku Kabushiki Kaisha Anticuerpo humano natural.
AU732306B2 (en) * 1997-10-14 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Potentiator for antibody against lymphoid tumor
EP2135879A3 (en) * 2002-06-28 2010-06-23 Domantis Limited Ligand

Also Published As

Publication number Publication date
KR20000048884A (ko) 2000-07-25
CN1271205C (zh) 2006-08-23
WO1998014580A1 (fr) 1998-04-09
CZ117399A3 (cs) 1999-09-15
ATE512224T1 (de) 2011-06-15
NO991591D0 (no) 1999-03-31
CN1235639A (zh) 1999-11-17
PL187642B1 (pl) 2004-08-31
CZ296790B6 (cs) 2006-06-14
IL129286A0 (en) 2000-02-17
US20030129185A1 (en) 2003-07-10
EP0960936B1 (en) 2011-06-08
UA76934C2 (en) 2006-10-16
SK44399A3 (en) 2000-05-16
CN1765928A (zh) 2006-05-03
TW530064B (en) 2003-05-01
NO325178B1 (no) 2008-02-11
US7892543B2 (en) 2011-02-22
RU2184147C2 (ru) 2002-06-27
KR100388256B1 (ko) 2003-06-19
CA2267072A1 (en) 1998-04-09
EP0960936A1 (en) 1999-12-01
HK1024261A1 (en) 2000-10-05
TR199900722T2 (xx) 1999-12-21
ZA978865B (en) 1998-04-20
AU4399297A (en) 1998-04-24
CA2267072C (en) 2004-11-30
AU715156B2 (en) 2000-01-20
US6699974B2 (en) 2004-03-02
PL332742A1 (en) 1999-10-11
US20030045691A1 (en) 2003-03-06
NO991591L (no) 1999-06-01
EP0960936A4 (en) 2005-01-19

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Legal Events

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FA10 Dismissal: dismissal - article 33 of industrial property law
HKFN Application deemed withdrawn (deleted)
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements