NO324902B1 - Fremgangsmate ved utvinning av faktor VIII/vWF-kompleks ved hjelp av kationebytterkromatografi, faktor VIII/vWF-kompleks saledes fremstilt, samt preparat inneholdende samme og anvendelse derav - Google Patents
Fremgangsmate ved utvinning av faktor VIII/vWF-kompleks ved hjelp av kationebytterkromatografi, faktor VIII/vWF-kompleks saledes fremstilt, samt preparat inneholdende samme og anvendelse derav Download PDFInfo
- Publication number
- NO324902B1 NO324902B1 NO19994137A NO994137A NO324902B1 NO 324902 B1 NO324902 B1 NO 324902B1 NO 19994137 A NO19994137 A NO 19994137A NO 994137 A NO994137 A NO 994137A NO 324902 B1 NO324902 B1 NO 324902B1
- Authority
- NO
- Norway
- Prior art keywords
- vwf
- complex
- factor
- factor viii
- vwf complex
- Prior art date
Links
- 108010054218 Factor VIII Proteins 0.000 title claims description 84
- 102000001690 Factor VIII Human genes 0.000 title claims description 84
- 229960000301 factor viii Drugs 0.000 title claims description 84
- 238000000034 method Methods 0.000 title claims description 41
- 238000002360 preparation method Methods 0.000 title claims description 30
- 238000005277 cation exchange chromatography Methods 0.000 title claims description 24
- 238000011084 recovery Methods 0.000 title description 7
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 182
- 230000000694 effects Effects 0.000 claims description 49
- 150000001768 cations Chemical class 0.000 claims description 29
- 150000003839 salts Chemical class 0.000 claims description 24
- 102000004169 proteins and genes Human genes 0.000 claims description 23
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- 238000010828 elution Methods 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 8
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- 239000000047 product Substances 0.000 claims description 7
- 238000003776 cleavage reaction Methods 0.000 claims description 6
- 230000007017 scission Effects 0.000 claims description 6
- 208000031220 Hemophilia Diseases 0.000 claims description 5
- 201000003542 Factor VIII deficiency Diseases 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
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- 238000004458 analytical method Methods 0.000 description 4
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- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 3
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- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- 102000004411 Antithrombin III Human genes 0.000 description 1
- 108090000935 Antithrombin III Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
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- 150000007513 acids Chemical class 0.000 description 1
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- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0033897A AT406373B (de) | 1997-02-27 | 1997-02-27 | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
| PCT/AT1998/000043 WO1998038220A1 (de) | 1997-02-27 | 1998-02-27 | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994137D0 NO994137D0 (no) | 1999-08-26 |
| NO994137L NO994137L (no) | 1999-08-26 |
| NO324902B1 true NO324902B1 (no) | 2007-12-27 |
Family
ID=3487946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994137A NO324902B1 (no) | 1997-02-27 | 1999-08-26 | Fremgangsmate ved utvinning av faktor VIII/vWF-kompleks ved hjelp av kationebytterkromatografi, faktor VIII/vWF-kompleks saledes fremstilt, samt preparat inneholdende samme og anvendelse derav |
| NO20071357A NO326257B1 (no) | 1997-02-27 | 2007-03-13 | "Fremgangsmate ved utvinning av faktor VIII:C" |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071357A NO326257B1 (no) | 1997-02-27 | 2007-03-13 | "Fremgangsmate ved utvinning av faktor VIII:C" |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6831159B1 (instruction) |
| EP (1) | EP0971958B2 (instruction) |
| JP (1) | JP4250771B2 (instruction) |
| AR (2) | AR010121A1 (instruction) |
| AT (2) | AT406373B (instruction) |
| AU (1) | AU744919B2 (instruction) |
| CA (1) | CA2282841C (instruction) |
| DE (1) | DE59814211D1 (instruction) |
| ES (1) | ES2306471T5 (instruction) |
| NO (2) | NO324902B1 (instruction) |
| WO (1) | WO1998038220A1 (instruction) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
| EP1593388A1 (en) * | 2004-05-05 | 2005-11-09 | ZLB Behring GmbH | Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| ES2298096B1 (es) | 2008-01-08 | 2009-01-01 | Grifols, S.A. | Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos. |
| AR074054A1 (es) | 2008-10-21 | 2010-12-22 | Baxter Healthcare Sa | Formulaciones farmaceuticas de factor de von willebrand recombinante liofilizado |
| HUE026907T2 (en) * | 2009-08-20 | 2016-07-28 | Baxalta Inc | Clean VWF to enhance removal of non-lipid enveloped viruses |
| BR112012011740A2 (pt) | 2009-11-13 | 2018-03-27 | Grifols Therapeutics Inc | polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviii |
| CN108404453B (zh) * | 2010-07-30 | 2021-01-05 | Emd密理博公司 | 层析介质和方法 |
| EP2652491B1 (en) | 2010-12-15 | 2017-11-29 | Baxalta GmbH | Eluate collection using conductivity gradient |
| HUE039317T2 (hu) * | 2011-06-10 | 2018-12-28 | Baxalta GmbH | Koagulációs betegség kezelése rekombináns VWF adagolásával |
| WO2013019964A1 (en) | 2011-08-02 | 2013-02-07 | Baxter International, Inc. | Systems and methods to increase protein yield from recombinant manufacturing processes |
| SG11201408362SA (en) | 2012-06-15 | 2015-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| EP2925777B1 (en) * | 2012-11-30 | 2019-05-01 | Centre for Bioseparation Technology-VIT | Monolith-based pseudo-bioaffinity purification methods for factor viii and applications thereof |
| US10246485B2 (en) | 2013-11-08 | 2019-04-02 | Csl Limited | Method to concentrate von willebrand factor or complexes thereof |
| CN111154724B (zh) | 2013-12-18 | 2024-02-06 | 联邦科学技术研究组织 | 包含二十二碳六烯酸的提取的植物脂质 |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| KR102072529B1 (ko) | 2014-09-02 | 2020-02-25 | 이엠디 밀리포어 코포레이션 | 나노-피브릴화된 표면 특징을 갖는 고표면적 섬유 매질 |
| CN107001410A (zh) | 2014-12-08 | 2017-08-01 | Emd密理博公司 | 混合床离子交换吸附剂 |
| US10632176B2 (en) | 2017-07-07 | 2020-04-28 | Baxalta Incorporated | Treatment of gastrointestinal bleeding in patients with severe von Willebrand disease by administration of recombinant VWF |
| EP3917557A1 (en) | 2019-02-01 | 2021-12-08 | Takeda Pharmaceutical Company Limited | Methods of prophylactic treatment using recombinant vwf (rvwf) |
| CN114106145B (zh) * | 2021-10-22 | 2023-09-01 | 山东泰邦生物制品有限公司 | 一种血源人凝血因子ⅷ/血管性血友病因子复合物生产工艺 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540573A (en) | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| GB8403473D0 (en) * | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
| US5200510A (en) * | 1987-06-16 | 1993-04-06 | Zymogenetics, Inc. | Method for purifying factor viii:c, von willebrand factor and complexes thereof |
| FR2651437A1 (fr) | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
| NZ237244A (en) * | 1990-03-02 | 1992-10-28 | Bio Technology General Corp | Cloning and production of human von willebrand factor analogues and compositions thereof |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| IT1256622B (it) † | 1992-12-04 | 1995-12-12 | Sclavo Spa | Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale. |
| CA2159044A1 (en) | 1994-09-26 | 1996-03-27 | Falko-Guenter Falkner | Method of quantitating nucleic acids |
| AT401270B (de) * | 1994-09-26 | 1996-07-25 | Immuno Ag | Verfahren zur quantifizierung von genomischer dna |
| DE4435392B4 (de) | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| AT403764B (de) † | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| AT403765B (de) * | 1996-04-12 | 1998-05-25 | Immuno Ag | Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex |
| CA2251558C (en) | 1996-04-12 | 2005-11-22 | Immuno Aktiengesellschaft | Highly purified factor viii complex |
| AT405403B (de) | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
| AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
-
1997
- 1997-02-27 AT AT0033897A patent/AT406373B/de not_active IP Right Cessation
-
1998
- 1998-02-25 AR ARP980100835A patent/AR010121A1/es active IP Right Grant
- 1998-02-27 US US09/367,459 patent/US6831159B1/en not_active Expired - Lifetime
- 1998-02-27 CA CA002282841A patent/CA2282841C/en not_active Expired - Lifetime
- 1998-02-27 AT AT98905132T patent/ATE391728T1/de active
- 1998-02-27 AU AU60806/98A patent/AU744919B2/en not_active Expired
- 1998-02-27 ES ES98905132T patent/ES2306471T5/es not_active Expired - Lifetime
- 1998-02-27 JP JP53706098A patent/JP4250771B2/ja not_active Expired - Lifetime
- 1998-02-27 WO PCT/AT1998/000043 patent/WO1998038220A1/de active IP Right Grant
- 1998-02-27 EP EP98905132A patent/EP0971958B2/de not_active Expired - Lifetime
- 1998-02-27 DE DE59814211T patent/DE59814211D1/de not_active Expired - Lifetime
-
1999
- 1999-08-26 NO NO19994137A patent/NO324902B1/no not_active IP Right Cessation
-
2001
- 2001-11-02 US US10/003,621 patent/US6953837B2/en not_active Expired - Lifetime
-
2004
- 2004-02-27 US US10/789,562 patent/US7648958B2/en not_active Expired - Fee Related
-
2007
- 2007-03-13 NO NO20071357A patent/NO326257B1/no not_active IP Right Cessation
- 2007-03-15 AR ARP070101059A patent/AR059902A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU744919B2 (en) | 2002-03-07 |
| WO1998038220A1 (de) | 1998-09-03 |
| AT406373B (de) | 2000-04-25 |
| NO994137D0 (no) | 1999-08-26 |
| US20020058625A1 (en) | 2002-05-16 |
| NO20071357L (no) | 1999-08-26 |
| ATA33897A (de) | 1999-09-15 |
| NO994137L (no) | 1999-08-26 |
| JP4250771B2 (ja) | 2009-04-08 |
| DE59814211D1 (de) | 2008-05-21 |
| AR010121A1 (es) | 2000-05-17 |
| CA2282841A1 (en) | 1998-09-03 |
| US6831159B1 (en) | 2004-12-14 |
| NO326257B1 (no) | 2008-10-27 |
| US20050239171A1 (en) | 2005-10-27 |
| ES2306471T5 (es) | 2012-06-07 |
| ATE391728T1 (de) | 2008-04-15 |
| EP0971958A1 (de) | 2000-01-19 |
| ES2306471T3 (es) | 2008-11-01 |
| AR059902A2 (es) | 2008-05-07 |
| CA2282841C (en) | 2008-12-02 |
| AU6080698A (en) | 1998-09-18 |
| US7648958B2 (en) | 2010-01-19 |
| US6953837B2 (en) | 2005-10-11 |
| EP0971958B1 (de) | 2008-04-09 |
| EP0971958B2 (de) | 2012-02-08 |
| JP2001517212A (ja) | 2001-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BAXALTA INCORPORATED, CH |
|
| MK1K | Patent expired |