NO324868B1 - Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat - Google Patents
Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat Download PDFInfo
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- NO324868B1 NO324868B1 NO20025035A NO20025035A NO324868B1 NO 324868 B1 NO324868 B1 NO 324868B1 NO 20025035 A NO20025035 A NO 20025035A NO 20025035 A NO20025035 A NO 20025035A NO 324868 B1 NO324868 B1 NO 324868B1
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- 239000011777 magnesium Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003797 solvolysis reaction Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000120234 | 2000-04-21 | ||
| PCT/JP2001/003214 WO2001083463A1 (fr) | 2000-04-21 | 2001-04-16 | Derives d'oxadiazole efficaces en matiere de traitement ou de prevention d'etats pathologiques glomerulaires |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20025035D0 NO20025035D0 (no) | 2002-10-18 |
| NO20025035L NO20025035L (no) | 2002-12-19 |
| NO324868B1 true NO324868B1 (no) | 2007-12-17 |
Family
ID=18631080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20025035A NO324868B1 (no) | 2000-04-21 | 2002-10-18 | Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6720343B2 (zh) |
| EP (1) | EP1277744A4 (zh) |
| JP (1) | JP3974781B2 (zh) |
| KR (1) | KR100542780B1 (zh) |
| CN (1) | CN1199956C (zh) |
| AU (2) | AU4691601A (zh) |
| BR (1) | BR0110211A (zh) |
| CA (1) | CA2406685C (zh) |
| HU (1) | HUP0300619A3 (zh) |
| MX (1) | MXPA02010325A (zh) |
| NO (1) | NO324868B1 (zh) |
| PL (1) | PL203161B1 (zh) |
| RU (1) | RU2275371C2 (zh) |
| TW (1) | TWI294877B (zh) |
| WO (1) | WO2001083463A1 (zh) |
| ZA (1) | ZA200208307B (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
| JPWO2005012268A1 (ja) | 2003-07-30 | 2006-09-14 | 塩野義製薬株式会社 | イソオキサゾール環を有するスルホンアミド誘導体 |
| AU2005299851B2 (en) * | 2004-10-22 | 2011-03-17 | Merck Sharp & Dohme Corp. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists |
| US7576222B2 (en) | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
| GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| RS20080525A (en) * | 2006-05-09 | 2009-09-08 | Pfizer Products Inc., | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
| KR100783585B1 (ko) | 2006-08-22 | 2007-12-07 | 한국생명공학연구원 | 스탯의 활성을 저해하는 옥사다이아졸 우레아 화합물을 유효성분으로 함유하는 암의 예방 또는 치료제 |
| US8222243B2 (en) | 2007-08-27 | 2012-07-17 | Dart Neuroscience (Cayman) Ltd | Therapeutic isoxazole compounds |
| CA2706834A1 (en) * | 2007-12-10 | 2009-06-18 | Actelion Pharmaceuticals Ltd | Thiophene derivatives as agonists of s1p1/edg1 |
| UY32858A (es) | 2009-08-31 | 2011-03-31 | Abbott Healthcare Products Bv | Derivados de (tio)morfolina como moduladores de sip |
| TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
| TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
| CN103450167A (zh) * | 2012-05-28 | 2013-12-18 | 南京大学 | 一类含1,3,4-噁二唑和吡嗪环的酰腙类衍生物及其制备方法与用途 |
| US10710994B2 (en) * | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
| AU2020373047A1 (en) | 2019-10-31 | 2022-05-19 | ESCAPE Bio, Inc. | Solid forms of an S1P-receptor modulator |
| CN113264899B (zh) * | 2021-04-09 | 2022-06-14 | 台州学院 | 一种1，3，5-噁二嗪类化合物及其制备和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2207849C2 (ru) | 1997-07-22 | 2003-07-10 | Шионоги & Ко., Лтд. | Композиция для лечения и профилактики гломерулопатии, новые соединения, в нее входящие, фармацевтическая композиция для ингибирования матриксных металлопротеиназ и композиция для ингибирования коллагеназ типа iv |
| AU5647099A (en) | 1998-09-11 | 2000-04-03 | Shionogi & Co., Ltd. | Remedal or preventive agent for congestive heart failure |
-
2001
- 2001-04-16 RU RU2002130247/04A patent/RU2275371C2/ru not_active IP Right Cessation
- 2001-04-16 BR BR0110211-7A patent/BR0110211A/pt not_active Withdrawn
- 2001-04-16 PL PL359415A patent/PL203161B1/pl not_active IP Right Cessation
- 2001-04-16 MX MXPA02010325A patent/MXPA02010325A/es active IP Right Grant
- 2001-04-16 US US10/257,917 patent/US6720343B2/en not_active Expired - Fee Related
- 2001-04-16 EP EP01919938A patent/EP1277744A4/en not_active Withdrawn
- 2001-04-16 HU HU0300619A patent/HUP0300619A3/hu unknown
- 2001-04-16 CA CA002406685A patent/CA2406685C/en not_active Expired - Fee Related
- 2001-04-16 CN CNB018112404A patent/CN1199956C/zh not_active Expired - Fee Related
- 2001-04-16 KR KR1020027013969A patent/KR100542780B1/ko not_active IP Right Cessation
- 2001-04-16 WO PCT/JP2001/003214 patent/WO2001083463A1/ja not_active Application Discontinuation
- 2001-04-16 AU AU4691601A patent/AU4691601A/xx active Pending
- 2001-04-16 AU AU2001246916A patent/AU2001246916B2/en not_active Ceased
- 2001-04-16 JP JP2001580892A patent/JP3974781B2/ja not_active Expired - Fee Related
- 2001-04-19 TW TW090109406A patent/TWI294877B/zh not_active IP Right Cessation
-
2002
- 2002-10-15 ZA ZA200208307A patent/ZA200208307B/xx unknown
- 2002-10-18 NO NO20025035A patent/NO324868B1/no not_active IP Right Cessation
-
2003
- 2003-12-10 US US10/730,946 patent/US20040122066A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0110211A (pt) | 2003-06-03 |
| KR100542780B1 (ko) | 2006-01-11 |
| ZA200208307B (en) | 2003-10-15 |
| WO2001083463A1 (fr) | 2001-11-08 |
| EP1277744A4 (en) | 2007-07-11 |
| PL203161B1 (pl) | 2009-08-31 |
| CA2406685C (en) | 2006-10-31 |
| TWI294877B (zh) | 2008-03-21 |
| US6720343B2 (en) | 2004-04-13 |
| RU2275371C2 (ru) | 2006-04-27 |
| JP3974781B2 (ja) | 2007-09-12 |
| EP1277744A1 (en) | 2003-01-22 |
| CN1436179A (zh) | 2003-08-13 |
| NO20025035D0 (no) | 2002-10-18 |
| PL359415A1 (en) | 2004-08-23 |
| US20040122066A1 (en) | 2004-06-24 |
| HUP0300619A3 (en) | 2006-02-28 |
| AU2001246916B2 (en) | 2004-10-07 |
| KR20030019357A (ko) | 2003-03-06 |
| CN1199956C (zh) | 2005-05-04 |
| HUP0300619A2 (hu) | 2003-07-28 |
| MXPA02010325A (es) | 2003-04-25 |
| NO20025035L (no) | 2002-12-19 |
| US20030203940A1 (en) | 2003-10-30 |
| CA2406685A1 (en) | 2002-10-17 |
| AU4691601A (en) | 2001-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |