NO324689B1 - Nye forbindelser med hypolidemisk og hypokolesteremisk virkning, deres fremstilling samt preparater inneholdende forbindelsene - Google Patents
Nye forbindelser med hypolidemisk og hypokolesteremisk virkning, deres fremstilling samt preparater inneholdende forbindelsene Download PDFInfo
- Publication number
- NO324689B1 NO324689B1 NO20023400A NO20023400A NO324689B1 NO 324689 B1 NO324689 B1 NO 324689B1 NO 20023400 A NO20023400 A NO 20023400A NO 20023400 A NO20023400 A NO 20023400A NO 324689 B1 NO324689 B1 NO 324689B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- ethoxy
- pharmaceutically acceptable
- fluorophenyl
- acceptable salts
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 130
- 238000002360 preparation method Methods 0.000 title claims description 34
- 230000000871 hypocholesterolemic effect Effects 0.000 title description 3
- 150000003839 salts Chemical class 0.000 claims description 92
- 238000006243 chemical reaction Methods 0.000 claims description 43
- -1 phenylaminocarbonyl Chemical group 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 25
- 238000002560 therapeutic procedure Methods 0.000 claims description 25
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
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- 239000001257 hydrogen Substances 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
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- PYDPHQUQJDNYRJ-UHFFFAOYSA-N ethyl 2-ethoxy-3-[4-[3-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]propoxy]phenyl]propanoate Chemical compound C1=CC(CC(OCC)C(=O)OCC)=CC=C1OCCCN1C(C=2C=CC(F)=CC=2)=C(C=2C=CC=CC=2)C(C(=O)NC=2C=CC=CC=2)=C1C(C)C PYDPHQUQJDNYRJ-UHFFFAOYSA-N 0.000 claims description 7
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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IN57MU2000 | 2000-01-19 | ||
PCT/IN2001/000005 WO2001053257A2 (en) | 2000-01-19 | 2001-01-17 | Compounds having hypolipedemic and hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them |
Publications (3)
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BR9812770A (pt) | 1997-10-27 | 2000-12-12 | Reddy Research Foundation | Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos |
US6369067B1 (en) | 1997-10-27 | 2002-04-09 | Dr. Reddy's Research Foundation | Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
PL193086B1 (pl) | 1997-10-27 | 2007-01-31 | Reddys Lab Ltd Dr | Nowe związki tricykliczne i związki pośrednie, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie |
US6531596B1 (en) | 1998-10-29 | 2003-03-11 | Dr. Reddy's Laboratories Ltd. | Process for the preparation of new antidiabetic agents |
CZ2001826A3 (cs) | 1998-10-29 | 2001-08-15 | Dr. Reddy's Research Foundation | Zlepšený způsob přípravy nových antidiabetických prostředků |
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AU2003268184A1 (en) * | 2002-08-23 | 2004-03-11 | Chiron Corporation | Pyrrole based inhibitors of glycogen synthase kinase 3 |
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EA201592020A1 (ru) | 2013-04-22 | 2016-05-31 | Кадила Хелзкэр Лимитед | Новая композиция для неалкогольной жировой болезни печени (нажбп) |
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CN1280574A (zh) * | 1997-10-27 | 2001-01-17 | 雷迪研究基金会 | 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物 |
PL193086B1 (pl) * | 1997-10-27 | 2007-01-31 | Reddys Lab Ltd Dr | Nowe związki tricykliczne i związki pośrednie, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie |
EP1073643B1 (en) * | 1998-04-23 | 2004-12-29 | Dr. Reddy's Laboratories Ltd. | New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
PL341795A1 (en) * | 1998-05-27 | 2001-05-07 | Reddy Research Foundation | Bicycle compounds, process for obtaining them and pharmacological compositions containing such compounds |
US6747188B2 (en) * | 1998-10-01 | 2004-06-08 | North Carolina State University | Transgenic plants expressing a mutant geminivirus AL3/C3 coding sequence |
JP2002527520A (ja) * | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、その製造及び使用 |
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