NO324554B1 - Anvendelse av et kjemisk modifisert polypeptid for fremstilling av et farmasoytisk preparat for a fremme blodplateproduksjon, samt kjemisk modifisert polypeptid. - Google Patents
Anvendelse av et kjemisk modifisert polypeptid for fremstilling av et farmasoytisk preparat for a fremme blodplateproduksjon, samt kjemisk modifisert polypeptid. Download PDFInfo
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- NO324554B1 NO324554B1 NO19963493A NO963493A NO324554B1 NO 324554 B1 NO324554 B1 NO 324554B1 NO 19963493 A NO19963493 A NO 19963493A NO 963493 A NO963493 A NO 963493A NO 324554 B1 NO324554 B1 NO 324554B1
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- chemically modified
- formula
- amino acid
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- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 238000001641 gel filtration chromatography Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940076264 interleukin-3 Drugs 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920005606 polypropylene copolymer Polymers 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2573594 | 1994-02-23 | ||
| PCT/JP1995/000266 WO1995023165A1 (fr) | 1994-02-23 | 1995-02-23 | Accelerateur de croissance des thrombocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO963493D0 NO963493D0 (no) | 1996-08-22 |
| NO963493L NO963493L (no) | 1996-10-23 |
| NO324554B1 true NO324554B1 (no) | 2007-11-19 |
Family
ID=12174082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19963493A NO324554B1 (no) | 1994-02-23 | 1996-08-22 | Anvendelse av et kjemisk modifisert polypeptid for fremstilling av et farmasoytisk preparat for a fremme blodplateproduksjon, samt kjemisk modifisert polypeptid. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6245900B1 (fr) |
| EP (1) | EP0744409B9 (fr) |
| JP (1) | JP4011106B2 (fr) |
| KR (1) | KR100403688B1 (fr) |
| CN (1) | CN1097058C (fr) |
| AT (1) | ATE403677T1 (fr) |
| AU (1) | AU711535B2 (fr) |
| CA (1) | CA2183871C (fr) |
| DE (1) | DE69535801D1 (fr) |
| DK (1) | DK0744409T3 (fr) |
| ES (1) | ES2312166T3 (fr) |
| FI (1) | FI120647B (fr) |
| HK (1) | HK1017818A1 (fr) |
| HU (1) | HU217872B (fr) |
| NO (1) | NO324554B1 (fr) |
| NZ (1) | NZ281329A (fr) |
| PT (1) | PT744409E (fr) |
| WO (1) | WO1995023165A1 (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2263795C (fr) * | 1997-06-06 | 2008-02-19 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptides chimiquement modifies |
| US6727259B2 (en) | 1997-09-05 | 2004-04-27 | Kyowa Hakko Kogyo Co., Ltd. | Remedial agent for neural degeneration |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| AU2002325819B2 (en) | 2001-07-11 | 2008-06-19 | Maxygen, Inc. | G-CSF Conjugates |
| EP1459759A4 (fr) * | 2001-11-19 | 2007-08-29 | Kyowa Hakko Kogyo Kk | Medicament mobilisant les cellules souches totipotentes d'un tissu dans le sang peripherique |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US6905612B2 (en) * | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
| US20040182795A1 (en) * | 2003-03-21 | 2004-09-23 | Randel Dorian | Apparatus and method for concentration of plasma from whole blood |
| US20030205538A1 (en) * | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) * | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| EP1539960B1 (fr) * | 2002-09-09 | 2010-04-28 | Hanall Pharmaceutical Co., Ltd. | Polypeptides modifiés d'interferon alpha résistant aux protéases |
| US7763625B2 (en) * | 2004-01-28 | 2010-07-27 | Kyowa Hakko Kirin Co., Ltd. | Agents for treating migraine |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| EP1848474B1 (fr) | 2005-02-07 | 2013-06-12 | Hanuman LLC | Appareil et procédé de concentration de plasma riche en plaquettes |
| JP4510898B2 (ja) * | 2005-02-07 | 2010-07-28 | ハヌマン リミテッド ライアビリティ カンパニー | 血漿濃縮装置 |
| JP4961354B2 (ja) | 2005-02-07 | 2012-06-27 | ハヌマン リミテッド ライアビリティ カンパニー | 多血小板血漿濃縮装置および方法 |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| CA2607844C (fr) | 2005-06-01 | 2012-07-10 | Maxygen Holdings Ltd. | Polypeptides g-csf pegyles et procedes de production correspondants |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| RS53404B (en) | 2007-08-27 | 2014-10-31 | Ratiopharm Gmbh | LIQUID FORMULATION OF G-CSF CONJUGATES |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| WO2009111338A1 (fr) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | Système et procédé pour la séparation d'une matière |
| US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US10485627B2 (en) * | 2016-04-07 | 2019-11-26 | Ethicon, Inc. | Containment sleeves for packages containing medical devices |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| JPS5959629A (ja) * | 1982-09-27 | 1984-04-05 | Nippon Chem Res Kk | 効力持続性組成物 |
| US4968616A (en) * | 1986-05-16 | 1990-11-06 | Masayasu Inoue | Superoxide dismutase derivatives, method of producing same and medicinal use of same |
| JPS6360938A (ja) * | 1986-09-02 | 1988-03-17 | Meiji Milk Prod Co Ltd | 修飾組織型プラスミノ−ゲン活性化因子およびその製造方法 |
| NO176799C (no) | 1986-12-23 | 1995-05-31 | Kyowa Hakko Kogyo Kk | DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid |
| US5681720A (en) | 1986-12-23 | 1997-10-28 | Kyowa Hakko Co., Ltd. | DNA encoding human granulocyte colony stimulating factor plasmids and host cells comprising same, and methods of expressing the encoded polypeptide |
| US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| JP2532515B2 (ja) | 1987-10-08 | 1996-09-11 | 水澤化学工業株式会社 | 血液凝集凝固剤 |
| CA1340810C (fr) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Derives de polypeptides actifs comme facteurs stimulant les colonies de granulocytes chez l'homme |
| JPH0796558B2 (ja) * | 1988-03-31 | 1995-10-18 | 協和醗酵工業株式会社 | 修飾ポリペプチド |
| CA2006596C (fr) * | 1988-12-22 | 2000-09-05 | Rika Ishikawa | G-csf modifie chimiquement |
| US5342940A (en) * | 1989-05-27 | 1994-08-30 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, process for preparing the same |
| IL96477A0 (en) * | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
| JPH03215499A (ja) * | 1990-01-19 | 1991-09-20 | Green Cross Corp:The | ヘモグロビン複合体 |
| JP2975632B2 (ja) * | 1990-03-30 | 1999-11-10 | 生化学工業株式会社 | グリコサミノグリカン修飾プロテイン |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| US6565841B1 (en) * | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
-
1995
- 1995-02-23 AU AU18237/95A patent/AU711535B2/en not_active Ceased
- 1995-02-23 AT AT95909967T patent/ATE403677T1/de active
- 1995-02-23 DK DK95909967T patent/DK0744409T3/da active
- 1995-02-23 KR KR1019960704628A patent/KR100403688B1/ko not_active IP Right Cessation
- 1995-02-23 WO PCT/JP1995/000266 patent/WO1995023165A1/fr active IP Right Grant
- 1995-02-23 DE DE69535801T patent/DE69535801D1/de not_active Expired - Lifetime
- 1995-02-23 CA CA002183871A patent/CA2183871C/fr not_active Expired - Lifetime
- 1995-02-23 CN CN95192717A patent/CN1097058C/zh not_active Expired - Fee Related
- 1995-02-23 EP EP95909967A patent/EP0744409B9/fr not_active Expired - Lifetime
- 1995-02-23 ES ES95909967T patent/ES2312166T3/es not_active Expired - Lifetime
- 1995-02-23 JP JP52225695A patent/JP4011106B2/ja not_active Expired - Fee Related
- 1995-02-23 HU HU9602312A patent/HU217872B/hu not_active IP Right Cessation
- 1995-02-23 NZ NZ281329A patent/NZ281329A/en not_active IP Right Cessation
- 1995-02-23 PT PT95909967T patent/PT744409E/pt unknown
- 1995-02-23 US US08/696,988 patent/US6245900B1/en not_active Expired - Lifetime
-
1996
- 1996-08-22 FI FI963278A patent/FI120647B/fi not_active IP Right Cessation
- 1996-08-22 NO NO19963493A patent/NO324554B1/no not_active IP Right Cessation
-
1998
- 1998-12-02 HK HK98112701.8A patent/HK1017818A1/xx not_active IP Right Cessation
-
2005
- 2005-10-20 US US11/253,617 patent/US7592311B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI120647B (fi) | 2010-01-15 |
| DK0744409T3 (da) | 2008-11-10 |
| CN1150434A (zh) | 1997-05-21 |
| AU1823795A (en) | 1995-09-11 |
| DE69535801D1 (de) | 2008-09-18 |
| NO963493D0 (no) | 1996-08-22 |
| ES2312166T3 (es) | 2009-02-16 |
| JP4011106B2 (ja) | 2007-11-21 |
| HU217872B (hu) | 2000-04-28 |
| EP0744409B9 (fr) | 2009-08-19 |
| FI963278A (fi) | 1996-08-22 |
| CN1097058C (zh) | 2002-12-25 |
| EP0744409B1 (fr) | 2008-08-06 |
| NO963493L (no) | 1996-10-23 |
| HUT74807A (en) | 1997-02-28 |
| HK1017818A1 (en) | 1999-11-26 |
| HU9602312D0 (en) | 1996-10-28 |
| CA2183871C (fr) | 2008-11-04 |
| CA2183871A1 (fr) | 1995-08-31 |
| NZ281329A (en) | 1997-07-27 |
| US7592311B2 (en) | 2009-09-22 |
| FI963278A0 (fi) | 1996-08-22 |
| US6245900B1 (en) | 2001-06-12 |
| US20060040865A1 (en) | 2006-02-23 |
| KR100403688B1 (ko) | 2004-02-05 |
| WO1995023165A1 (fr) | 1995-08-31 |
| EP0744409A1 (fr) | 1996-11-27 |
| ATE403677T1 (de) | 2008-08-15 |
| PT744409E (pt) | 2008-11-03 |
| AU711535B2 (en) | 1999-10-14 |
| EP0744409A4 (fr) | 1998-09-09 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |