NO323581B1 - Fremgangsmate for fremstilling av multivesikulaere liposomer for kontrollert frigiving av aktive midler - Google Patents

Fremgangsmate for fremstilling av multivesikulaere liposomer for kontrollert frigiving av aktive midler Download PDF

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Publication number
NO323581B1
NO323581B1 NO19971149A NO971149A NO323581B1 NO 323581 B1 NO323581 B1 NO 323581B1 NO 19971149 A NO19971149 A NO 19971149A NO 971149 A NO971149 A NO 971149A NO 323581 B1 NO323581 B1 NO 323581B1
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NO
Norway
Prior art keywords
lipid
biologically active
active compound
group
osmolarity
Prior art date
Application number
NO19971149A
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English (en)
Norwegian (no)
Other versions
NO971149L (no
NO971149D0 (no
Inventor
Sinil Kim
Mantripragada B Sankaram
Original Assignee
Skyepharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyepharma Inc filed Critical Skyepharma Inc
Publication of NO971149D0 publication Critical patent/NO971149D0/no
Publication of NO971149L publication Critical patent/NO971149L/no
Publication of NO323581B1 publication Critical patent/NO323581B1/no

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/829Liposomes, e.g. encapsulation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19971149A 1994-09-13 1997-03-12 Fremgangsmate for fremstilling av multivesikulaere liposomer for kontrollert frigiving av aktive midler NO323581B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/305,158 US5993850A (en) 1994-09-13 1994-09-13 Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
PCT/US1995/011609 WO1996008235A1 (en) 1994-09-13 1995-09-13 Preparation of multivesicular liposomes for controlled release of active agents

Publications (3)

Publication Number Publication Date
NO971149D0 NO971149D0 (no) 1997-03-12
NO971149L NO971149L (no) 1997-05-13
NO323581B1 true NO323581B1 (no) 2007-06-11

Family

ID=23179585

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19971149A NO323581B1 (no) 1994-09-13 1997-03-12 Fremgangsmate for fremstilling av multivesikulaere liposomer for kontrollert frigiving av aktive midler

Country Status (14)

Country Link
US (1) US5993850A (es)
EP (1) EP0781123B1 (es)
JP (1) JP3026271B2 (es)
KR (1) KR100387561B1 (es)
CN (1) CN1096850C (es)
AU (1) AU697484B2 (es)
BR (1) BR9508913A (es)
CA (1) CA2199004C (es)
DE (1) DE69535297T2 (es)
FI (1) FI119621B (es)
MX (1) MX9701856A (es)
NO (1) NO323581B1 (es)
NZ (2) NZ334561A (es)
WO (1) WO1996008235A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558952B1 (en) * 1992-12-14 2003-05-06 Waratah Pharmaceuticals, Inc. Treatment for diabetes
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
US5997899A (en) * 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
US5891467A (en) * 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
KR19980067138A (ko) * 1997-01-31 1998-10-15 박원훈 유전자 또는 생물학적 활성 약물을 세포내로 효과적으로 전달하는 지방 유제 및 그것의 제조방법
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
ES2343767T3 (es) 1997-09-18 2010-08-09 Pacira Pharmaceuticals, Inc. Composiciones anestesicas liposomicas de liberacion sostenida.
JP4575592B2 (ja) * 1997-11-14 2010-11-04 パシラ ファーマシューティカルズ インコーポレーテッド 多小胞リポソームの製造
JP2002520120A (ja) * 1998-07-17 2002-07-09 スカイファーマ インコーポレーテッド 封入物質の制御放出のための生分解性組成物
US20040037818A1 (en) * 1998-07-30 2004-02-26 Brand Stephen J. Treatment for diabetes
US20030059440A1 (en) * 1998-09-01 2003-03-27 Tim Clarot Composition and method for moisturizing nasal tissue
US6740643B2 (en) * 1999-01-21 2004-05-25 Mirus Corporation Compositions and methods for drug delivery using amphiphile binding molecules
WO2000059625A1 (en) * 1999-04-06 2000-10-12 E Ink Corporation Methods for producing droplets for use in capsule-based electrophoretic displays
AUPQ259399A0 (en) 1999-09-01 1999-09-23 Lustre Investments Pte Ltd Therapeutic agents
US6812217B2 (en) 2000-12-04 2004-11-02 Medtronic, Inc. Medical device and methods of use
US6897196B1 (en) * 2001-02-07 2005-05-24 The Regents Of The University Of California pH sensitive lipids based on ortho ester linkers, composition and method
DE10109897A1 (de) * 2001-02-21 2002-11-07 Novosom Ag Fakultativ kationische Liposomen und Verwendung dieser
US20050156340A1 (en) 2004-01-20 2005-07-21 E Ink Corporation Preparation of capsules
WO2003041682A2 (en) * 2001-11-13 2003-05-22 Celator Technologies, Inc. Lipid carrier compositions and methods for improved drug retention
US20040082521A1 (en) * 2002-03-29 2004-04-29 Azaya Therapeutics Inc. Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
WO2003100024A2 (en) * 2002-05-24 2003-12-04 Waratah Pharmaceuticals, Inc. Treatment for diabetes
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
JP2006506386A (ja) * 2002-10-22 2006-02-23 ワラタ ファーマシューティカルズ, インコーポレイテッド 糖尿病の処置
US20040229810A1 (en) * 2002-10-22 2004-11-18 Antonio Cruz Gastrin compositions and formulations, and methods of use and preparation
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
EP2363114B1 (en) * 2002-10-29 2015-05-20 Insmed Incorporated Sustained release of antiinfectives
JP2006508126A (ja) * 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
US7416756B2 (en) 2003-09-10 2008-08-26 Eastman Chemical Company Process for the recovery of a phytolipid composition
CN1315530C (zh) * 2005-07-04 2007-05-16 重庆大学 蛋白质类药物控制释放系统制备方法
US20070110674A1 (en) * 2005-07-29 2007-05-17 Yuhong Xu Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems
EP1962805B1 (en) 2005-12-08 2016-07-06 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
CN101190183B (zh) * 2006-11-29 2010-05-12 上海医药工业研究院 一种盐酸可乐定多泡脂质体及其制备方法
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US20100102142A1 (en) * 2008-10-28 2010-04-29 Daria Tagliareni Scent dispenser assembly
CN101756902B (zh) * 2008-12-23 2011-10-05 上海医药工业研究院 一种可乐定多囊脂质体及其制备方法
EP2555752B1 (en) 2010-04-09 2019-06-26 Pacira Pharmaceuticals, Inc. Method for formulating multivesicular liposomes
EP2394640A1 (en) * 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
HUE047796T2 (hu) 2010-07-06 2020-05-28 Glaxosmithkline Biologicals Sa RNS bevitele több immunútvonal bekapcsolására
WO2012006378A1 (en) 2010-07-06 2012-01-12 Novartis Ag Liposomes with lipids having an advantageous pka- value for rna delivery
PT2591114T (pt) 2010-07-06 2016-08-02 Glaxosmithkline Biologicals Sa Imunização de mamíferos de grande porte com doses baixas de arn
LT4066855T (lt) * 2010-08-31 2023-03-10 Glaxosmithkline Biologicals Sa Pegilintos liposomos, skirtos imunogeną koduojančios rnr tiekimui
ES2716243T3 (es) 2010-10-11 2019-06-11 Glaxosmithkline Biologicals Sa Plataformas de suministro de antígenos
CN103260702B (zh) * 2010-10-28 2018-07-27 帕西拉制药有限公司 非甾体类抗炎药的缓释制剂
EP2907504B1 (en) * 2011-02-08 2017-06-28 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
BR112013024655A2 (pt) * 2011-03-25 2016-12-20 Selecta Biosciences Inc nanotransportadores sintéticos para liberação mediada de modo osmótico
ES2656050T3 (es) 2011-07-06 2018-02-22 Glaxosmithkline Biologicals Sa Composiciones de combinación inmunogénica y usos de las mismas
CA2854054C (en) 2011-12-02 2020-05-12 Pegasus Laboratories, Inc. Amphipathic lipid-based sustained release compositions
US10722458B2 (en) 2011-12-02 2020-07-28 Pegasus Laboratories, Inc. Amphipathic lipid-based sustained release compositions
RU2664700C2 (ru) 2012-05-10 2018-08-21 Пейнреформ Лтд. Депо-составы местного анестетика и способы их получения
AU2013266400B2 (en) 2012-05-21 2017-06-22 Insmed Incorporated Systems for treating pulmonary infections
CN102764456B (zh) * 2012-07-24 2014-10-15 上海交通大学 血管栓塞剂及其用途、制备方法
EP3581186A1 (en) 2012-11-29 2019-12-18 Insmed Incorporated Stabilized vancomycin formulations
FR3008900B1 (fr) * 2013-07-25 2018-03-30 Centre Nat Rech Scient Nanoparticules lipidiques multicompartimentees
US9895385B2 (en) 2014-05-15 2018-02-20 Insmed Incorporated Methods for treating pulmonary non-tuberculous mycobacterial infections
JP6316182B2 (ja) 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
MA43184A (fr) * 2015-11-02 2021-04-14 Fujifilm Corp Composition liposomale et son procédé de production
WO2018094253A1 (en) * 2016-11-18 2018-05-24 Pacira Pharmaceuticals, Inc. Zinc meloxicam complex microparticle multivesicular liposome formulations and processes for making the same
KR102069670B1 (ko) * 2017-03-02 2020-01-23 단디바이오사이언스 주식회사 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물
CN106924185B (zh) * 2017-03-29 2019-11-26 烟台大学 一种载有囊泡的多囊脂质体的制备方法
US11571386B2 (en) 2018-03-30 2023-02-07 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
KR102186704B1 (ko) * 2019-02-18 2020-12-04 (주)아이엠디팜 서방성 지질 전구 제제 및 이를 포함하는 지질 용액 형태의 서방성 주사용 약학 조성물
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
CN113509440B (zh) * 2021-03-26 2022-08-30 中国药科大学 一种高包封率酮咯酸多囊脂质体制备及提高其稳定性方法
CN113171343A (zh) * 2021-05-14 2021-07-27 成都大学 一种局部注射用硫酸阿米卡星多囊脂质体及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH588887A5 (es) * 1974-07-19 1977-06-15 Battelle Memorial Institute
US4897308A (en) * 1975-06-30 1990-01-30 L'oreal Compositions comprising aqueous dispersions of lipid spheres
US4078052A (en) * 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (es) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
JPS55153713A (en) * 1979-05-02 1980-11-29 Kureha Chem Ind Co Ltd Pharmaceutical preparation of ribosome containing active substance
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
JPS60118666A (ja) * 1983-11-30 1985-06-26 太陽誘電株式会社 誘電体磁器組成物
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
JP2666345B2 (ja) * 1987-04-16 1997-10-22 武田薬品工業株式会社 リポソーム製剤およびその製造法
ATE77051T1 (de) * 1988-03-04 1992-06-15 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
US5576017A (en) * 1988-05-30 1996-11-19 Depotech Corporation Heterovesicular liposomes
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US5766627A (en) * 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
JP3002702B2 (ja) * 1993-11-16 2000-01-24 スカイファーム インコーポレーテッド 活性物質の制御放出を有する小胞

Also Published As

Publication number Publication date
MX9701856A (es) 1998-07-31
EP0781123A1 (en) 1997-07-02
NZ292830A (en) 1999-04-29
FI971037A (fi) 1997-05-12
CN1166136A (zh) 1997-11-26
KR100387561B1 (ko) 2003-10-08
NO971149L (no) 1997-05-13
US5993850A (en) 1999-11-30
AU697484B2 (en) 1998-10-08
CA2199004C (en) 2008-02-19
FI119621B (fi) 2009-01-30
NO971149D0 (no) 1997-03-12
JPH10502667A (ja) 1998-03-10
BR9508913A (pt) 1997-12-30
DE69535297T2 (de) 2007-05-16
EP0781123A4 (en) 2000-12-20
NZ334561A (en) 2000-01-28
AU3511595A (en) 1996-03-29
FI971037A0 (fi) 1997-03-12
DE69535297D1 (de) 2006-12-28
EP0781123B1 (en) 2006-11-15
CA2199004A1 (en) 1996-03-21
CN1096850C (zh) 2002-12-25
WO1996008235A1 (en) 1996-03-21
JP3026271B2 (ja) 2000-03-27

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