NO323128B1 - Innretning for avlevering av et middel gjennom en kroppsoverflate - Google Patents
Innretning for avlevering av et middel gjennom en kroppsoverflate Download PDFInfo
- Publication number
- NO323128B1 NO323128B1 NO20022721A NO20022721A NO323128B1 NO 323128 B1 NO323128 B1 NO 323128B1 NO 20022721 A NO20022721 A NO 20022721A NO 20022721 A NO20022721 A NO 20022721A NO 323128 B1 NO323128 B1 NO 323128B1
- Authority
- NO
- Norway
- Prior art keywords
- skin
- body surface
- stretching
- microprotrusions
- agent
- Prior art date
Links
- 210000003491 skin Anatomy 0.000 claims description 147
- 239000003795 chemical substances by application Substances 0.000 claims description 40
- 239000000853 adhesive Substances 0.000 claims description 16
- 230000001070 adhesive effect Effects 0.000 claims description 16
- 230000035515 penetration Effects 0.000 claims description 11
- 210000000434 stratum corneum Anatomy 0.000 claims description 7
- 230000007246 mechanism Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 25
- 229940079593 drug Drugs 0.000 abstract description 25
- 230000001934 delay Effects 0.000 abstract description 3
- 238000012377 drug delivery Methods 0.000 abstract description 3
- 230000004907 flux Effects 0.000 description 18
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 230000037361 pathway Effects 0.000 description 8
- 230000000149 penetrating effect Effects 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 230000037317 transdermal delivery Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000011253 protective coating Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 125000006850 spacer group Chemical group 0.000 description 5
- 241000700198 Cavia Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000013271 transdermal drug delivery Methods 0.000 description 4
- 238000003491 array Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 229910052722 tritium Inorganic materials 0.000 description 2
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000000438 stratum basale Anatomy 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000009864 tensile test Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17270499P | 1999-12-10 | 1999-12-10 | |
| PCT/US2000/033582 WO2001041864A1 (en) | 1999-12-10 | 2000-12-07 | Skin treatment apparatus for sustained transdermal drug delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20022721D0 NO20022721D0 (no) | 2002-06-07 |
| NO20022721L NO20022721L (no) | 2002-08-07 |
| NO323128B1 true NO323128B1 (no) | 2007-01-08 |
Family
ID=22628847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20022721A NO323128B1 (no) | 1999-12-10 | 2002-06-07 | Innretning for avlevering av et middel gjennom en kroppsoverflate |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20020111600A1 (es) |
| EP (1) | EP1239917B1 (es) |
| JP (1) | JP4312407B2 (es) |
| KR (1) | KR100832754B1 (es) |
| CN (1) | CN100402106C (es) |
| AT (1) | ATE295200T1 (es) |
| AU (1) | AU782610B2 (es) |
| CA (1) | CA2393537C (es) |
| DE (1) | DE60020159T2 (es) |
| DK (1) | DK1239917T3 (es) |
| ES (1) | ES2238333T3 (es) |
| HK (1) | HK1048773B (es) |
| HU (1) | HU225467B1 (es) |
| IL (1) | IL150091A0 (es) |
| MX (1) | MXPA02005765A (es) |
| NO (1) | NO323128B1 (es) |
| PT (1) | PT1239917E (es) |
| WO (1) | WO2001041864A1 (es) |
| ZA (1) | ZA200204597B (es) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
| US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| DE60129585T2 (de) * | 2000-09-08 | 2008-04-17 | Alza Corp., Mountain View | Transdermale vorrichtung |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| US20030093040A1 (en) * | 2001-10-29 | 2003-05-15 | Mikszta John A. | Method and device for the delivery of a substance |
| US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
| US20050072213A1 (en) * | 2001-11-26 | 2005-04-07 | Isabelle Besnard | Use of id semiconductor materials as chemical sensing materials, produced and operated close to room temperature |
| EP1675539A4 (en) * | 2003-10-24 | 2007-09-12 | Alza Corp | METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY |
| JP2007514489A (ja) * | 2003-12-18 | 2007-06-07 | ノボ・ノルデイスク・エー／エス | 皮膚引き伸ばし手段を有するノズルデバイス |
| AU2004311977A1 (en) * | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Medical devices and kits including same |
| EP1737357B1 (en) | 2004-03-24 | 2019-12-11 | Corium, Inc. | Transdermal delivery device |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US8267889B2 (en) | 2004-11-18 | 2012-09-18 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
| WO2006055802A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
| EP1871459B1 (en) | 2005-04-07 | 2019-06-19 | 3M Innovative Properties Company | System for tool feedback sensing |
| US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| EP1904158B1 (en) * | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
| EP1901799B1 (en) | 2005-06-27 | 2012-06-13 | 3M Innovative Properties Company | Microneedle array applicator device |
| US20070078414A1 (en) * | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
| EP1928537B1 (en) * | 2005-09-02 | 2015-01-21 | Intercell USA, Inc. | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs |
| WO2007064486A1 (en) | 2005-11-30 | 2007-06-07 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
| WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
| US8821446B2 (en) | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
| EP2146689B1 (en) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
| US8150505B2 (en) * | 2007-05-03 | 2012-04-03 | Path Scientific, Llc | Method and apparatus for the formation of multiple microconduits |
| WO2009021048A2 (en) | 2007-08-06 | 2009-02-12 | Transderm, Inc. | Microneedle arrays formed from polymer films |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| US8940013B2 (en) * | 2007-12-24 | 2015-01-27 | Peter Ar-Fu Lam | Human skin treatment arrangement |
| US8876856B2 (en) * | 2007-12-24 | 2014-11-04 | Peter Ar-Fu Lam | Human skin treatment arrangement |
| US20100010484A1 (en) * | 2008-07-14 | 2010-01-14 | Primaeva Medical, Inc. | Devices and methods for percutaneous energy delivery |
| CA2798145C (en) | 2010-05-04 | 2022-10-18 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| US20130012891A1 (en) * | 2011-07-05 | 2013-01-10 | Yossi Gross | Skin-treatment and drug-delivery devices |
| EP2779976A4 (en) * | 2011-11-16 | 2015-07-22 | Univ Mcgill | DEVICE, USE THEREOF AND METHOD OF REDUCING THE FORMATION OF A WOUND SCAR |
| KR102378235B1 (ko) | 2012-12-14 | 2022-03-25 | 민데라 코포레이션 | 바이오마커의 검출 및 취득을 위한 방법 및 디바이스 |
| AU2013364053B2 (en) | 2012-12-21 | 2018-08-30 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| CN105142711B (zh) | 2013-03-12 | 2019-01-22 | 考里安国际公司 | 微突起施加器 |
| JP6689187B2 (ja) | 2013-03-15 | 2020-04-28 | コリウム， インコーポレイテッド | 複数の衝突微小突起アプリケータおよび使用方法 |
| CA2906541C (en) | 2013-03-15 | 2022-06-21 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| JP2016512754A (ja) | 2013-03-15 | 2016-05-09 | コリウム インターナショナル， インコーポレイテッド | 治療剤の送達のためのマイクロアレイ、使用方法および製造方法 |
| US10194935B2 (en) * | 2013-12-31 | 2019-02-05 | L'oreal | Shear-induced dermal infusion |
| WO2015122838A1 (en) * | 2014-02-14 | 2015-08-20 | Chee Yen Lim | Rapidly dissolvable microneedles with drug-impregnated tips |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| KR102687585B1 (ko) * | 2016-02-05 | 2024-07-24 | 패스포트 테크놀로지스, 인크. | 경피 침투제 도포 장치 |
| CN106492341B (zh) * | 2016-11-11 | 2019-07-26 | 王春花 | 粉雾眉的纹绣控制方法及装置 |
| EP3582752A1 (en) | 2017-02-17 | 2019-12-25 | Allergan, Inc. | Microneedle array with active ingredient |
| EP3727141A4 (en) | 2017-12-21 | 2021-09-01 | Georgia Tech Research Corporation | IMPROVED INTERSTITIAL LIQUID COLLECTION METHODS AND SYSTEMS |
| CN108245742A (zh) * | 2018-01-19 | 2018-07-06 | 苏州英诺迈医学科技服务有限公司 | 一种胰岛素注射装置 |
| KR102568475B1 (ko) * | 2018-03-27 | 2023-08-18 | 카오카부시키가이샤 | 온열구 |
| JP6647607B1 (ja) * | 2019-04-25 | 2020-02-14 | 株式会社グリーンフィールド | 開口器具及び人工芝への固定具の打ち込み方法 |
| JP7267549B2 (ja) * | 2019-05-14 | 2023-05-02 | 学校法人 関西大学 | 穿刺補助具 |
| WO2023002848A1 (ja) * | 2021-07-21 | 2023-01-26 | テルモ株式会社 | 血管穿刺支援装置 |
| CN114632259B (zh) * | 2022-02-23 | 2024-09-03 | 黄雄仙 | 防漏上药的瘢痕上药设备 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| US4114619A (en) * | 1975-11-21 | 1978-09-19 | Wolfgang Wagner | Automatic injecting apparatus |
| US4787888A (en) * | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| JP2936678B2 (ja) * | 1990-09-05 | 1999-08-23 | アイシン精機株式会社 | クラツクセンサーを用いた暖房便座 |
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| SE9101022D0 (sv) * | 1991-01-09 | 1991-04-08 | Paal Svedman | Medicinsk suganordning |
| US5199952A (en) * | 1991-04-09 | 1993-04-06 | Morf, Inc. | Bird injection system |
| US5171215A (en) * | 1991-08-22 | 1992-12-15 | Flanagan Dennis F | Endermic method and apparatus |
| JPH05199952A (ja) * | 1992-01-30 | 1993-08-10 | Matsushita Electric Ind Co Ltd | 電動送風機 |
| US5486196A (en) * | 1992-02-13 | 1996-01-23 | Medchem Products, Inc. | Apparatus for the closure of wide skin defects by stretching of skin |
| DE59505328D1 (de) | 1994-12-09 | 1999-04-15 | Novartis Ag | Transdermales system |
| WO1996037256A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical patch for enhancing the delivery of compounds through the skin |
| AU5740496A (en) | 1995-05-22 | 1996-12-11 | General Hospital Corporation, The | Micromechanical device and method for enhancing delivery of compounds through the skin |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| US5857983A (en) * | 1996-05-17 | 1999-01-12 | Mercury Diagnostics, Inc. | Methods and apparatus for sampling body fluid |
| WO1998028037A1 (en) * | 1996-12-20 | 1998-07-02 | Alza Corporation | Device and method for enhancing transdermal agent flux |
| US5860957A (en) * | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
| AU739616B2 (en) * | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
| ES2244106T3 (es) * | 1997-12-11 | 2005-12-01 | Alza Corporation | Dispositivo para mejorar el flujo transdermico de agentes. |
| JP2000189453A (ja) * | 1998-12-28 | 2000-07-11 | Nichiban Co Ltd | 医療用粘着テ―プ |
| US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
| AU5461300A (en) * | 1999-06-04 | 2000-12-28 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
-
2000
- 2000-12-07 DE DE60020159T patent/DE60020159T2/de not_active Expired - Lifetime
- 2000-12-07 MX MXPA02005765A patent/MXPA02005765A/es active IP Right Grant
- 2000-12-07 ES ES00984209T patent/ES2238333T3/es not_active Expired - Lifetime
- 2000-12-07 PT PT00984209T patent/PT1239917E/pt unknown
- 2000-12-07 CA CA002393537A patent/CA2393537C/en not_active Expired - Fee Related
- 2000-12-07 CN CNB008183090A patent/CN100402106C/zh not_active Expired - Fee Related
- 2000-12-07 HU HU0204002A patent/HU225467B1/hu not_active IP Right Cessation
- 2000-12-07 AT AT00984209T patent/ATE295200T1/de not_active IP Right Cessation
- 2000-12-07 WO PCT/US2000/033582 patent/WO2001041864A1/en active IP Right Grant
- 2000-12-07 AU AU20870/01A patent/AU782610B2/en not_active Ceased
- 2000-12-07 EP EP00984209A patent/EP1239917B1/en not_active Expired - Lifetime
- 2000-12-07 IL IL15009100A patent/IL150091A0/xx unknown
- 2000-12-07 JP JP2001543208A patent/JP4312407B2/ja not_active Expired - Fee Related
- 2000-12-07 DK DK00984209T patent/DK1239917T3/da active
- 2000-12-07 KR KR1020027007426A patent/KR100832754B1/ko not_active IP Right Cessation
- 2000-12-08 US US09/733,305 patent/US20020111600A1/en not_active Abandoned
-
2002
- 2002-06-07 ZA ZA200204597A patent/ZA200204597B/xx unknown
- 2002-06-07 NO NO20022721A patent/NO323128B1/no unknown
-
2003
- 2003-02-10 HK HK03100953.2A patent/HK1048773B/zh not_active IP Right Cessation
-
2004
- 2004-03-05 US US10/794,637 patent/US20040181203A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2393537C (en) | 2009-02-03 |
| KR20020060996A (ko) | 2002-07-19 |
| ES2238333T3 (es) | 2005-09-01 |
| NO20022721D0 (no) | 2002-06-07 |
| MXPA02005765A (es) | 2003-01-28 |
| ZA200204597B (en) | 2004-09-29 |
| US20020111600A1 (en) | 2002-08-15 |
| CN1423571A (zh) | 2003-06-11 |
| JP2003516205A (ja) | 2003-05-13 |
| NO20022721L (no) | 2002-08-07 |
| AU2087001A (en) | 2001-06-18 |
| AU782610B2 (en) | 2005-08-11 |
| CN100402106C (zh) | 2008-07-16 |
| DK1239917T3 (da) | 2005-08-22 |
| EP1239917B1 (en) | 2005-05-11 |
| ATE295200T1 (de) | 2005-05-15 |
| WO2001041864A1 (en) | 2001-06-14 |
| HU225467B1 (en) | 2006-12-28 |
| JP4312407B2 (ja) | 2009-08-12 |
| HUP0204002A2 (en) | 2003-03-28 |
| IL150091A0 (en) | 2002-12-01 |
| HK1048773B (zh) | 2005-10-14 |
| EP1239917A1 (en) | 2002-09-18 |
| DE60020159D1 (de) | 2005-06-16 |
| US20040181203A1 (en) | 2004-09-16 |
| HK1048773A1 (en) | 2003-04-17 |
| KR100832754B1 (ko) | 2008-05-27 |
| DE60020159T2 (de) | 2005-10-06 |
| PT1239917E (pt) | 2005-08-31 |
| CA2393537A1 (en) | 2001-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO323128B1 (no) | Innretning for avlevering av et middel gjennom en kroppsoverflate | |
| EP1239916B1 (en) | Device and method for enhancing microprotrusion skin piercing | |
| CN100427159C (zh) | 将组合物输送给皮肤的微观结构 | |
| US7131960B2 (en) | Apparatus and method for piercing skin with microprotrusions | |
| DE69831268T2 (de) | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses | |
| KR100557261B1 (ko) | 경피성 작용제 유동률을 증진시키기 위한 장치 | |
| AU2003251831B2 (en) | Microneedle devices and microneedle delivery apparatus | |
| US7419481B2 (en) | Apparatus and method for piercing skin with microprotrusions | |
| AU2001296828A1 (en) | Apparatus and method for piercing skin with microprotrusions |