NO322572B1 - Pseudopolymorf av (-)-cis-2-(2-klorfenyl)-5,7-dihydroksy-8[4R-(3S-hydroksy-1-metyl)piperidinyl]-4H-1-benzopyran-4-on hydroklorid, fremgangsmate til fremstilling derav, anvendelse derav ved kreftbehandling, samt farmasoytisk sammensetning som innbefatter pseudopolymorfen. - Google Patents
Pseudopolymorf av (-)-cis-2-(2-klorfenyl)-5,7-dihydroksy-8[4R-(3S-hydroksy-1-metyl)piperidinyl]-4H-1-benzopyran-4-on hydroklorid, fremgangsmate til fremstilling derav, anvendelse derav ved kreftbehandling, samt farmasoytisk sammensetning som innbefatter pseudopolymorfen. Download PDFInfo
- Publication number
- NO322572B1 NO322572B1 NO20023386A NO20023386A NO322572B1 NO 322572 B1 NO322572 B1 NO 322572B1 NO 20023386 A NO20023386 A NO 20023386A NO 20023386 A NO20023386 A NO 20023386A NO 322572 B1 NO322572 B1 NO 322572B1
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- pseudopolymorph
- cis
- hydrochloride
- flavopiridol
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims abstract description 9
- 206010028980 Neoplasm Diseases 0.000 title claims description 8
- 201000011510 cancer Diseases 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 4
- 125000003386 piperidinyl group Chemical group 0.000 title abstract description 7
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000002904 solvent Substances 0.000 claims description 22
- BIIVYFLTOXDAOV-YVEFUNNKSA-N alvocidib Chemical compound O[C@@H]1CN(C)CC[C@@H]1C1=C(O)C=C(O)C2=C1OC(C=1C(=CC=CC=1)Cl)=CC2=O BIIVYFLTOXDAOV-YVEFUNNKSA-N 0.000 claims description 19
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Stereophonic System (AREA)
- Inorganic Insulating Materials (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48471700A | 2000-01-18 | 2000-01-18 | |
| PCT/US2001/000519 WO2001053293A1 (en) | 2000-01-18 | 2001-01-08 | Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023386D0 NO20023386D0 (no) | 2002-07-12 |
| NO20023386L NO20023386L (no) | 2002-09-12 |
| NO322572B1 true NO322572B1 (no) | 2006-10-30 |
Family
ID=23925305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023386A NO322572B1 (no) | 2000-01-18 | 2002-07-12 | Pseudopolymorf av (-)-cis-2-(2-klorfenyl)-5,7-dihydroksy-8[4R-(3S-hydroksy-1-metyl)piperidinyl]-4H-1-benzopyran-4-on hydroklorid, fremgangsmate til fremstilling derav, anvendelse derav ved kreftbehandling, samt farmasoytisk sammensetning som innbefatter pseudopolymorfen. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1259507B1 (da) |
| JP (1) | JP2003520797A (da) |
| KR (1) | KR100806464B1 (da) |
| CN (1) | CN1174977C (da) |
| AT (1) | ATE273303T1 (da) |
| AU (1) | AU2001226346A1 (da) |
| BR (1) | BR0107726A (da) |
| CA (1) | CA2397593C (da) |
| CZ (1) | CZ301195B6 (da) |
| DE (1) | DE60104822T2 (da) |
| DK (1) | DK1259507T3 (da) |
| EA (1) | EA005247B1 (da) |
| ES (1) | ES2222332T3 (da) |
| HU (1) | HUP0204126A3 (da) |
| IL (2) | IL150638A0 (da) |
| MX (1) | MXPA02007005A (da) |
| NO (1) | NO322572B1 (da) |
| NZ (1) | NZ520280A (da) |
| PL (1) | PL200696B1 (da) |
| PT (1) | PT1259507E (da) |
| SI (1) | SI1259507T1 (da) |
| SK (1) | SK287404B6 (da) |
| TR (1) | TR200402036T4 (da) |
| TW (1) | TWI284129B (da) |
| WO (1) | WO2001053293A1 (da) |
| ZA (1) | ZA200205639B (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR102466192B1 (ko) | 2016-08-23 | 2022-11-14 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간세포성 암종의 치료를 위한 조합 요법 |
| CA3056701A1 (en) | 2017-03-16 | 2018-09-20 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of breast cancer |
| US20220040324A1 (en) | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN164232B (da) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| US5908934A (en) * | 1996-09-26 | 1999-06-01 | Bristol-Myers Squibb Company | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs |
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