NO321576B1 - Nye morfolinderivater, fremgangsmater for fremstilling derav, anvendelser derav, og farmasoytiske preparater og medikamenter inneholdende de nevnte derivater. - Google Patents

Nye morfolinderivater, fremgangsmater for fremstilling derav, anvendelser derav, og farmasoytiske preparater og medikamenter inneholdende de nevnte derivater. Download PDF

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Publication number
NO321576B1
NO321576B1 NO20014632A NO20014632A NO321576B1 NO 321576 B1 NO321576 B1 NO 321576B1 NO 20014632 A NO20014632 A NO 20014632A NO 20014632 A NO20014632 A NO 20014632A NO 321576 B1 NO321576 B1 NO 321576B1
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NO
Norway
Prior art keywords
compound
formula
mixture
methyl
salts
Prior art date
Application number
NO20014632A
Other languages
English (en)
Norwegian (no)
Other versions
NO20014632L (no
NO20014632D0 (no
Inventor
Patrick Gueule
Vincenzo Proietto
Xavier Emonds-Alt
Jean Philippe Ducoux
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20014632D0 publication Critical patent/NO20014632D0/no
Publication of NO20014632L publication Critical patent/NO20014632L/no
Publication of NO321576B1 publication Critical patent/NO321576B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/10Antiepileptics; Anticonvulsants for petit-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20014632A 1999-03-25 2001-09-24 Nye morfolinderivater, fremgangsmater for fremstilling derav, anvendelser derav, og farmasoytiske preparater og medikamenter inneholdende de nevnte derivater. NO321576B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9903854A FR2791346B3 (fr) 1999-03-25 1999-03-25 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/000695 WO2000058292A1 (fr) 1999-03-25 2000-03-21 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (3)

Publication Number Publication Date
NO20014632D0 NO20014632D0 (no) 2001-09-24
NO20014632L NO20014632L (no) 2001-11-26
NO321576B1 true NO321576B1 (no) 2006-06-06

Family

ID=9543720

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014632A NO321576B1 (no) 1999-03-25 2001-09-24 Nye morfolinderivater, fremgangsmater for fremstilling derav, anvendelser derav, og farmasoytiske preparater og medikamenter inneholdende de nevnte derivater.

Country Status (41)

Country Link
US (1) US6506750B1 (xx)
EP (1) EP1165528B1 (xx)
JP (1) JP3853155B2 (xx)
KR (1) KR100696340B1 (xx)
CN (1) CN100422160C (xx)
AR (1) AR023139A1 (xx)
AT (1) ATE275136T1 (xx)
AU (1) AU756855B2 (xx)
BG (1) BG64623B1 (xx)
BR (1) BR0009281B1 (xx)
CA (1) CA2366829C (xx)
CO (1) CO5160340A1 (xx)
CZ (1) CZ300911B6 (xx)
DE (1) DE60013418T2 (xx)
DK (1) DK1165528T3 (xx)
EE (1) EE04525B1 (xx)
ES (1) ES2226794T3 (xx)
FR (1) FR2791346B3 (xx)
HK (1) HK1042092B (xx)
HR (1) HRP20010704B1 (xx)
HU (1) HUP0201863A3 (xx)
ID (1) ID29871A (xx)
IL (2) IL145041A0 (xx)
IS (1) IS2338B (xx)
ME (2) MEP12008A (xx)
MX (1) MXPA01009643A (xx)
NO (1) NO321576B1 (xx)
NZ (1) NZ513674A (xx)
PE (1) PE20001596A1 (xx)
PL (1) PL205318B1 (xx)
PT (1) PT1165528E (xx)
RS (1) RS50085B (xx)
RU (1) RU2222537C2 (xx)
SI (1) SI1165528T1 (xx)
SK (1) SK286977B6 (xx)
TR (1) TR200102639T2 (xx)
TW (1) TW534906B (xx)
UA (1) UA73931C2 (xx)
UY (1) UY26079A1 (xx)
WO (1) WO2000058292A1 (xx)
ZA (1) ZA200106981B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1353918B1 (en) * 2000-11-28 2005-01-12 Smithkline Beecham Plc Morpholine derivatives as antagonists of orexin receptors
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0228787D0 (en) * 2002-12-10 2003-01-15 Pfizer Ltd Morpholine dopamine agonists
ATE410426T1 (de) * 2002-12-13 2008-10-15 Smithkline Beecham Corp Heterocyclische verbindungen alsccr5-antagonisten
JO2485B1 (en) * 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
AR046769A1 (es) * 2003-12-22 2005-12-21 Schering Corp Composiciones farmaceuticas
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
CN103142569B (zh) * 2013-02-27 2016-01-20 南京医科大学 2,6-二异丙基苯甲酸及其衍生物作为神经保护剂的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ3134U1 (cs) * 1995-01-10 1995-03-17 Pavel Ing. Janda Rotor universálního radiálního ventilátoru
US5780466A (en) * 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
HU224225B1 (hu) * 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
JP3192631B2 (ja) * 1997-05-28 2001-07-30 三共株式会社 飽和複素環化合物からなる医薬
ATE297906T1 (de) * 1997-12-04 2005-07-15 Sankyo Co Alicyclische acylierte heterocyclenderivate

Also Published As

Publication number Publication date
BG64623B1 (bg) 2005-09-30
NO20014632L (no) 2001-11-26
RS50085B (sr) 2009-01-22
YU68201A (sh) 2004-03-12
HRP20010704B1 (en) 2005-04-30
AU3301600A (en) 2000-10-16
TW534906B (en) 2003-06-01
NO20014632D0 (no) 2001-09-24
HUP0201863A3 (en) 2003-03-28
HK1042092A1 (en) 2002-08-02
TR200102639T2 (tr) 2002-02-21
AU756855B2 (en) 2003-01-23
IL145041A (en) 2010-11-30
PL351317A1 (en) 2003-04-07
HK1042092B (zh) 2005-04-22
CA2366829A1 (fr) 2000-10-05
BR0009281B1 (pt) 2011-05-17
IL145041A0 (en) 2002-06-30
IS2338B (is) 2008-02-15
EE04525B1 (et) 2005-08-15
SK286977B6 (sk) 2009-08-06
US6506750B1 (en) 2003-01-14
JP3853155B2 (ja) 2006-12-06
ATE275136T1 (de) 2004-09-15
CZ20013365A3 (cs) 2002-01-16
EP1165528B1 (fr) 2004-09-01
CN1353698A (zh) 2002-06-12
ZA200106981B (en) 2002-10-24
ES2226794T3 (es) 2005-04-01
WO2000058292A1 (fr) 2000-10-05
CN100422160C (zh) 2008-10-01
EP1165528A1 (fr) 2002-01-02
SK13462001A3 (sk) 2002-05-09
MXPA01009643A (es) 2002-05-14
UY26079A1 (es) 2000-10-31
NZ513674A (en) 2003-05-30
FR2791346B3 (fr) 2001-04-27
EE200100499A (et) 2002-12-16
HUP0201863A2 (hu) 2002-12-28
ID29871A (id) 2001-10-18
PE20001596A1 (es) 2001-04-01
AR023139A1 (es) 2002-09-04
ME00057B (me) 2010-10-10
RU2222537C2 (ru) 2004-01-27
BR0009281A (pt) 2002-01-22
BG105923A (en) 2002-05-31
CZ300911B6 (cs) 2009-09-09
MEP12008A (en) 2010-06-10
DE60013418D1 (de) 2004-10-07
IS6063A (is) 2001-08-24
PL205318B1 (pl) 2010-04-30
SI1165528T1 (en) 2005-02-28
DK1165528T3 (da) 2005-01-10
JP2002540195A (ja) 2002-11-26
HRP20010704A2 (en) 2002-08-31
KR100696340B1 (ko) 2007-03-20
CO5160340A1 (es) 2002-05-30
PT1165528E (pt) 2005-01-31
DE60013418T2 (de) 2005-09-22
UA73931C2 (en) 2005-10-17
KR20010108381A (ko) 2001-12-07
FR2791346A1 (fr) 2000-09-29
CA2366829C (fr) 2007-05-15

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