NO321296B1 - Androgenglukosid forbindelser samt anvendelser derav - Google Patents
Androgenglukosid forbindelser samt anvendelser derav Download PDFInfo
- Publication number
- NO321296B1 NO321296B1 NO20015338A NO20015338A NO321296B1 NO 321296 B1 NO321296 B1 NO 321296B1 NO 20015338 A NO20015338 A NO 20015338A NO 20015338 A NO20015338 A NO 20015338A NO 321296 B1 NO321296 B1 NO 321296B1
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- compound according
- glucoside
- methyl
- compound
- Prior art date
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- 239000003098 androgen Substances 0.000 title claims abstract description 20
- -1 glucoside compounds Chemical class 0.000 title claims description 51
- 229930182478 glucoside Natural products 0.000 title claims description 40
- 229930182470 glycoside Natural products 0.000 claims abstract description 23
- 150000002338 glycosides Chemical class 0.000 claims abstract description 20
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testosterone Natural products O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 131
- 150000001875 compounds Chemical class 0.000 claims description 103
- 239000001257 hydrogen Substances 0.000 claims description 85
- 229910052739 hydrogen Inorganic materials 0.000 claims description 85
- 229960003604 testosterone Drugs 0.000 claims description 74
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 59
- 150000002431 hydrogen Chemical class 0.000 claims description 43
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 36
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 33
- 241001465754 Metazoa Species 0.000 claims description 27
- 238000002360 preparation method Methods 0.000 claims description 17
- 150000003431 steroids Chemical group 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 14
- 150000008131 glucosides Chemical class 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
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- 230000000699 topical effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229960000312 trenbolone Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0063—Nitrogen and oxygen at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13250099P | 1999-05-04 | 1999-05-04 | |
| US19529400P | 2000-04-07 | 2000-04-07 | |
| PCT/GB2000/001700 WO2000066612A1 (fr) | 1999-05-04 | 2000-05-04 | Glycosides d'androgenes et activite androgenique desdits glycosides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20015338D0 NO20015338D0 (no) | 2001-11-01 |
| NO20015338L NO20015338L (no) | 2001-11-19 |
| NO321296B1 true NO321296B1 (no) | 2006-04-18 |
Family
ID=26830416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20015338A NO321296B1 (no) | 1999-05-04 | 2001-11-01 | Androgenglukosid forbindelser samt anvendelser derav |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6630453B1 (fr) |
| EP (1) | EP1175433B1 (fr) |
| JP (1) | JP5005127B2 (fr) |
| KR (1) | KR20020013533A (fr) |
| CN (1) | CN1250563C (fr) |
| AT (1) | ATE301129T1 (fr) |
| AU (1) | AU777770C (fr) |
| BR (1) | BR0010708A (fr) |
| CA (1) | CA2372720C (fr) |
| CZ (1) | CZ20013912A3 (fr) |
| DE (1) | DE60021720T2 (fr) |
| DK (1) | DK1175433T3 (fr) |
| ES (1) | ES2246234T3 (fr) |
| HU (1) | HUP0200871A3 (fr) |
| IL (2) | IL146284A0 (fr) |
| MX (1) | MXPA01011227A (fr) |
| NO (1) | NO321296B1 (fr) |
| NZ (1) | NZ515134A (fr) |
| PT (1) | PT1175433E (fr) |
| WO (1) | WO2000066612A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026649A1 (fr) * | 2001-09-27 | 2003-04-03 | Applied Research Systems Ars Holding N.V. | Methodes pouvant augmenter des concentrations en testosterone endogene |
| WO2003073988A2 (fr) * | 2002-02-28 | 2003-09-12 | A & D Bioscience, Inc. | Glycuronamides, glycosides et glycosides d'orthoester de fluoxetine, analogues et utilisation de ceux-ci |
| WO2003079980A2 (fr) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Glucuronides, glucosamides et glucosides d'acide carboxylique, de quinolones, penicillines et analogues, et leurs utilisations |
| US20050255038A1 (en) * | 2002-04-12 | 2005-11-17 | A And D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof |
| US20050153928A1 (en) * | 2002-05-07 | 2005-07-14 | Holick Michael F. | Conjugates comprising a central nervous system-active drug linked to glucuronic acid or glucosamine through an amide bond and uses thereof |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
| CN107106429B (zh) | 2014-11-10 | 2021-06-29 | 宝洁公司 | 具有两种有益相的个人护理组合物 |
| EP3217949B1 (fr) | 2014-11-10 | 2020-06-17 | The Procter and Gamble Company | Compositions de soins personnels comportant deux phases à effet bénéfique |
| US10966916B2 (en) | 2014-11-10 | 2021-04-06 | The Procter And Gamble Company | Personal care compositions |
| CN105388245A (zh) * | 2015-12-25 | 2016-03-09 | 浙江省水产技术推广总站 | 适用于水产品中46种药物的筛查方法 |
| CN111225652A (zh) | 2017-10-20 | 2020-06-02 | 宝洁公司 | 气溶胶泡沫洁肤剂 |
| WO2019079409A1 (fr) | 2017-10-20 | 2019-04-25 | The Procter & Gamble Company | Nettoyant pour la peau en mousse aérosol |
| WO2020112486A1 (fr) | 2018-11-29 | 2020-06-04 | The Procter & Gamble Company | Méthodes de criblage de produits de soins personnels |
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-
2000
- 2000-05-04 AT AT00927493T patent/ATE301129T1/de active
- 2000-05-04 MX MXPA01011227A patent/MXPA01011227A/es active IP Right Grant
- 2000-05-04 HU HU0200871A patent/HUP0200871A3/hu unknown
- 2000-05-04 CA CA002372720A patent/CA2372720C/fr not_active Expired - Fee Related
- 2000-05-04 IL IL14628400A patent/IL146284A0/xx active IP Right Grant
- 2000-05-04 EP EP00927493A patent/EP1175433B1/fr not_active Expired - Lifetime
- 2000-05-04 JP JP2000615641A patent/JP5005127B2/ja not_active Expired - Fee Related
- 2000-05-04 CN CNB008096910A patent/CN1250563C/zh not_active Expired - Fee Related
- 2000-05-04 DK DK00927493T patent/DK1175433T3/da active
- 2000-05-04 CZ CZ20013912A patent/CZ20013912A3/cs unknown
- 2000-05-04 BR BR0010708-5A patent/BR0010708A/pt not_active IP Right Cessation
- 2000-05-04 AU AU45893/00A patent/AU777770C/en not_active Ceased
- 2000-05-04 ES ES00927493T patent/ES2246234T3/es not_active Expired - Lifetime
- 2000-05-04 NZ NZ515134A patent/NZ515134A/en unknown
- 2000-05-04 WO PCT/GB2000/001700 patent/WO2000066612A1/fr active IP Right Grant
- 2000-05-04 KR KR1020017014072A patent/KR20020013533A/ko not_active Application Discontinuation
- 2000-05-04 DE DE60021720T patent/DE60021720T2/de not_active Expired - Lifetime
- 2000-05-04 PT PT00927493T patent/PT1175433E/pt unknown
- 2000-05-04 US US09/565,122 patent/US6630453B1/en not_active Expired - Fee Related
-
2001
- 2001-11-01 NO NO20015338A patent/NO321296B1/no not_active IP Right Cessation
- 2001-11-01 IL IL146284A patent/IL146284A/en unknown
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2003
- 2003-05-30 US US10/452,004 patent/US6916791B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2372720C (fr) | 2007-09-11 |
| JP5005127B2 (ja) | 2012-08-22 |
| DE60021720T2 (de) | 2006-06-01 |
| MXPA01011227A (es) | 2002-07-02 |
| HUP0200871A3 (en) | 2004-04-28 |
| DK1175433T3 (da) | 2005-09-19 |
| AU777770B2 (en) | 2004-10-28 |
| CA2372720A1 (fr) | 2000-11-09 |
| DE60021720D1 (de) | 2005-09-08 |
| WO2000066612A1 (fr) | 2000-11-09 |
| US6916791B2 (en) | 2005-07-12 |
| CN1250563C (zh) | 2006-04-12 |
| NZ515134A (en) | 2004-01-30 |
| BR0010708A (pt) | 2002-02-19 |
| AU777770C (en) | 2005-11-10 |
| US6630453B1 (en) | 2003-10-07 |
| IL146284A0 (en) | 2002-07-25 |
| US20030216328A1 (en) | 2003-11-20 |
| NO20015338L (no) | 2001-11-19 |
| JP2002543217A (ja) | 2002-12-17 |
| AU4589300A (en) | 2000-11-17 |
| EP1175433A1 (fr) | 2002-01-30 |
| KR20020013533A (ko) | 2002-02-20 |
| NO20015338D0 (no) | 2001-11-01 |
| IL146284A (en) | 2006-07-05 |
| CZ20013912A3 (cs) | 2002-05-15 |
| CN1360590A (zh) | 2002-07-24 |
| EP1175433B1 (fr) | 2005-08-03 |
| ATE301129T1 (de) | 2005-08-15 |
| HUP0200871A2 (en) | 2002-08-28 |
| ES2246234T3 (es) | 2006-02-16 |
| PT1175433E (pt) | 2005-11-30 |
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