NO320893B1 - Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning. - Google Patents
Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning. Download PDFInfo
- Publication number
- NO320893B1 NO320893B1 NO20005497A NO20005497A NO320893B1 NO 320893 B1 NO320893 B1 NO 320893B1 NO 20005497 A NO20005497 A NO 20005497A NO 20005497 A NO20005497 A NO 20005497A NO 320893 B1 NO320893 B1 NO 320893B1
- Authority
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- Norway
- Prior art keywords
- ppm
- pyridyl
- ylsulfonyl
- formula
- piperazine
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 5
- 108010074860 Factor Xa Proteins 0.000 title claims description 18
- 125000000623 heterocyclic group Chemical group 0.000 title abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 37
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 230000002429 anti-coagulating effect Effects 0.000 claims abstract description 8
- 230000002785 anti-thrombosis Effects 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 7
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 57
- -1 cyano, amino, hydroxy Chemical group 0.000 claims description 29
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- 239000000460 chlorine Chemical group 0.000 claims description 6
- 125000002883 imidazolyl group Chemical group 0.000 claims description 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
- FFELGYNQPHSTQI-UHFFFAOYSA-N [4-[(5-chloro-1-benzofuran-2-yl)sulfonyl]piperazin-1-yl]-(4-pyridin-4-ylphenyl)methanone Chemical compound C=1C2=CC(Cl)=CC=C2OC=1S(=O)(=O)N(CC1)CCN1C(=O)C(C=C1)=CC=C1C1=CC=NC=C1 FFELGYNQPHSTQI-UHFFFAOYSA-N 0.000 claims description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052794 bromium Chemical group 0.000 claims description 4
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
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- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- DJBPJIZCEJIUJR-UHFFFAOYSA-N [4-[(5-chloro-1h-indol-2-yl)sulfonyl]piperazin-1-yl]-(4-imidazol-1-ylphenyl)methanone Chemical group C=1C2=CC(Cl)=CC=C2NC=1S(=O)(=O)N(CC1)CCN1C(=O)C(C=C1)=CC=C1N1C=CN=C1 DJBPJIZCEJIUJR-UHFFFAOYSA-N 0.000 claims description 3
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- 239000002585 base Substances 0.000 description 6
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- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 6
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- 238000001228 spectrum Methods 0.000 description 6
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9809351.1A GB9809351D0 (en) | 1998-05-02 | 1998-05-02 | Heterocyclic derivatives |
| GBGB9903337.5A GB9903337D0 (en) | 1999-02-16 | 1999-02-16 | Heterocyclic derivatives |
| PCT/GB1999/001308 WO1999057113A1 (en) | 1998-05-02 | 1999-04-27 | Heterocyclic derivatives which inhibit factor xa |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20005497D0 NO20005497D0 (no) | 2000-11-01 |
| NO20005497L NO20005497L (no) | 2000-12-21 |
| NO320893B1 true NO320893B1 (no) | 2006-02-06 |
Family
ID=26313572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005497A NO320893B1 (no) | 1998-05-02 | 2000-11-01 | Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6753331B1 (pt) |
| EP (2) | EP1528061A1 (pt) |
| JP (1) | JP2002513790A (pt) |
| KR (1) | KR20010043246A (pt) |
| CN (1) | CN1133634C (pt) |
| AT (1) | ATE282610T1 (pt) |
| AU (1) | AU754453B2 (pt) |
| BR (1) | BR9910179A (pt) |
| CA (1) | CA2331042A1 (pt) |
| DE (1) | DE69921994T2 (pt) |
| EE (1) | EE200000527A (pt) |
| ES (1) | ES2232131T3 (pt) |
| HK (1) | HK1034711A1 (pt) |
| HU (1) | HUP0101712A3 (pt) |
| IL (1) | IL139406A (pt) |
| NO (1) | NO320893B1 (pt) |
| NZ (1) | NZ507835A (pt) |
| PL (1) | PL343706A1 (pt) |
| PT (1) | PT1082321E (pt) |
| SI (1) | SI1082321T1 (pt) |
| SK (1) | SK16512000A3 (pt) |
| TR (1) | TR200003200T2 (pt) |
| WO (1) | WO1999057113A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9902989D0 (en) * | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| GB9914342D0 (en) * | 1999-06-19 | 1999-08-18 | Zeneca Ltd | Compound |
| GB9917344D0 (en) * | 1999-07-24 | 1999-09-22 | Zeneca Ltd | Novel salt |
| TWI288745B (en) | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| GB0012448D0 (en) | 2000-05-24 | 2000-07-12 | Astrazeneca Ab | New process |
| WO2002038184A1 (en) * | 2000-11-09 | 2002-05-16 | Astrazeneca Ab | Oral pharmaceutical composition containing a block copolymer |
| GB0104752D0 (en) * | 2001-02-27 | 2001-04-18 | Astrazeneca Ab | Pharmaceutical compositions |
| WO2003000657A1 (fr) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
| US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| EP1650206A4 (en) * | 2003-08-01 | 2006-12-20 | Nippon Soda Co | PHENYLAZOLE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND ANTIOXIDANTS |
| SE0400014D0 (sv) * | 2004-01-08 | 2004-01-08 | Astrazeneca Ab | Heterocyclic derivatives |
| CN101218227A (zh) * | 2005-07-08 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为因子Xa的抑制剂的杂环磺酰胺衍生物 |
| WO2007008144A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| WO2007008145A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| WO2007008143A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| PL3762368T3 (pl) | 2018-03-08 | 2022-06-06 | Incyte Corporation | ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| US20220380478A1 (en) | 2019-07-01 | 2022-12-01 | Tonix Pharma Holdings Limited | Anti-cd154 antibodies and uses thereof |
| EP4274587A1 (en) | 2021-01-06 | 2023-11-15 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| JP2001502655A (ja) * | 1995-12-21 | 2001-02-27 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害薬であるイソオキサゾリン、イソチアゾリンおよびピラゾリン |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602294D0 (en) * | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
| UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| EP0986551B1 (en) | 1997-05-30 | 2006-08-02 | Takeda Pharmaceutical Company Limited | Sulfonamide derivatives, their production and use |
| GB9715894D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
-
1999
- 1999-04-27 JP JP2000547083A patent/JP2002513790A/ja active Pending
- 1999-04-27 EP EP04022155A patent/EP1528061A1/en not_active Withdrawn
- 1999-04-27 DE DE69921994T patent/DE69921994T2/de not_active Expired - Lifetime
- 1999-04-27 EP EP99918178A patent/EP1082321B1/en not_active Expired - Lifetime
- 1999-04-27 WO PCT/GB1999/001308 patent/WO1999057113A1/en not_active Application Discontinuation
- 1999-04-27 CN CNB99808218XA patent/CN1133634C/zh not_active Expired - Fee Related
- 1999-04-27 TR TR2000/03200T patent/TR200003200T2/xx unknown
- 1999-04-27 SK SK1651-2000A patent/SK16512000A3/sk unknown
- 1999-04-27 US US09/674,559 patent/US6753331B1/en not_active Expired - Fee Related
- 1999-04-27 PL PL99343706A patent/PL343706A1/xx not_active Application Discontinuation
- 1999-04-27 EE EEP200000527A patent/EE200000527A/xx unknown
- 1999-04-27 IL IL13940699A patent/IL139406A/en not_active IP Right Cessation
- 1999-04-27 BR BR9910179-3A patent/BR9910179A/pt not_active Application Discontinuation
- 1999-04-27 KR KR1020007012193A patent/KR20010043246A/ko not_active Application Discontinuation
- 1999-04-27 ES ES99918178T patent/ES2232131T3/es not_active Expired - Lifetime
- 1999-04-27 HU HU0101712A patent/HUP0101712A3/hu unknown
- 1999-04-27 NZ NZ507835A patent/NZ507835A/xx unknown
- 1999-04-27 SI SI9930725T patent/SI1082321T1/xx unknown
- 1999-04-27 AU AU36206/99A patent/AU754453B2/en not_active Ceased
- 1999-04-27 AT AT99918178T patent/ATE282610T1/de not_active IP Right Cessation
- 1999-04-27 PT PT99918178T patent/PT1082321E/pt unknown
- 1999-04-27 CA CA002331042A patent/CA2331042A1/en not_active Abandoned
-
2000
- 2000-11-01 NO NO20005497A patent/NO320893B1/no unknown
-
2001
- 2001-07-26 HK HK01105226A patent/HK1034711A1/xx not_active IP Right Cessation
-
2004
- 2004-04-06 US US10/817,960 patent/US20040266759A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1034711A1 (en) | 2001-11-02 |
| US6753331B1 (en) | 2004-06-22 |
| AU3620699A (en) | 1999-11-23 |
| HUP0101712A3 (en) | 2003-01-28 |
| EP1082321A1 (en) | 2001-03-14 |
| NZ507835A (en) | 2003-01-31 |
| IL139406A0 (en) | 2001-11-25 |
| NO20005497L (no) | 2000-12-21 |
| EP1082321B1 (en) | 2004-11-17 |
| IL139406A (en) | 2004-07-25 |
| ATE282610T1 (de) | 2004-12-15 |
| PT1082321E (pt) | 2005-03-31 |
| CN1133634C (zh) | 2004-01-07 |
| HUP0101712A2 (hu) | 2001-11-28 |
| ES2232131T3 (es) | 2005-05-16 |
| EE200000527A (et) | 2002-02-15 |
| SK16512000A3 (sk) | 2001-05-10 |
| BR9910179A (pt) | 2001-01-09 |
| KR20010043246A (ko) | 2001-05-25 |
| CN1308631A (zh) | 2001-08-15 |
| AU754453B2 (en) | 2002-11-14 |
| PL343706A1 (en) | 2001-08-27 |
| DE69921994T2 (de) | 2005-12-01 |
| CA2331042A1 (en) | 1999-11-11 |
| NO20005497D0 (no) | 2000-11-01 |
| TR200003200T2 (tr) | 2001-02-21 |
| JP2002513790A (ja) | 2002-05-14 |
| SI1082321T1 (en) | 2005-06-30 |
| US20040266759A1 (en) | 2004-12-30 |
| DE69921994D1 (de) | 2004-12-23 |
| WO1999057113A1 (en) | 1999-11-11 |
| EP1528061A1 (en) | 2005-05-04 |
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