HUP0101712A2 - Xa-Faktort gátló heterociklusos származékok és ezeket tartalmazó gyógyászati készítmények - Google Patents

Xa-Faktort gátló heterociklusos származékok és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0101712A2
HUP0101712A2 HU0101712A HUP0101712A HUP0101712A2 HU P0101712 A2 HUP0101712 A2 HU P0101712A2 HU 0101712 A HU0101712 A HU 0101712A HU P0101712 A HUP0101712 A HU P0101712A HU P0101712 A2 HUP0101712 A2 HU P0101712A2
Authority
HU
Hungary
Prior art keywords
substituents
attached
pharmaceutical compositions
compositions containing
heterocyclic derivatives
Prior art date
Application number
HU0101712A
Other languages
English (en)
Inventor
Peter William Rodney Caulkett
Roger James
Stuart Eric Pearson
Anthony Michael Slater
Rolf Peter Walker
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en
Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0101712A2 publication Critical patent/HUP0101712A2/hu
Publication of HUP0101712A3 publication Critical patent/HUP0101712A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány (I) általános képletű heterociklusos vegyületekre ésgyógyászatilag alkalmazható sóikra vonatkozik - a képletben A 1, 2vagy 3 gyűrűtag-heteroatomot tartalmazó, öt- vagy hattagú monociklusosaromás gyűrűt jelent, amihez adott esetben 1-3 szubsztituenskapcsolódhat, az 1,4-fenilén-gyűrűhöz adott esetben 1-2 szubsztituenskapcsolódhat, B =CH- vagy =N- csoportot jelent, és a B csoportottartalmazó heterociklusos gyűrűhöz adott esetben 1-2 szubsztituenskapcsolódhat, és D (a) , (b) , (c) , (d) , (e) vagy (f) képletűcsoportot jelent, amelyekhez adott esetben 1-3 szubsztituenskapcsolódhat. Ezek a vegyületek Xa-faktort gátló hatássalrendelkeznek, és gyógyszerekként hasznosíthatók. Ó
HU0101712A 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them HUP0101712A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9809351.1A GB9809351D0 (en) 1998-05-02 1998-05-02 Heterocyclic derivatives
GBGB9903337.5A GB9903337D0 (en) 1999-02-16 1999-02-16 Heterocyclic derivatives
PCT/GB1999/001308 WO1999057113A1 (en) 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa

Publications (2)

Publication Number Publication Date
HUP0101712A2 true HUP0101712A2 (hu) 2001-11-28
HUP0101712A3 HUP0101712A3 (en) 2003-01-28

Family

ID=26313572

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101712A HUP0101712A3 (en) 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (2) US6753331B1 (hu)
EP (2) EP1528061A1 (hu)
JP (1) JP2002513790A (hu)
KR (1) KR20010043246A (hu)
CN (1) CN1133634C (hu)
AT (1) ATE282610T1 (hu)
AU (1) AU754453B2 (hu)
BR (1) BR9910179A (hu)
CA (1) CA2331042A1 (hu)
DE (1) DE69921994T2 (hu)
EE (1) EE200000527A (hu)
ES (1) ES2232131T3 (hu)
HK (1) HK1034711A1 (hu)
HU (1) HUP0101712A3 (hu)
IL (1) IL139406A (hu)
NO (1) NO320893B1 (hu)
NZ (1) NZ507835A (hu)
PL (1) PL343706A1 (hu)
PT (1) PT1082321E (hu)
SI (1) SI1082321T1 (hu)
SK (1) SK16512000A3 (hu)
TR (1) TR200003200T2 (hu)
WO (1) WO1999057113A1 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
GB9902989D0 (en) * 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
GB9914342D0 (en) * 1999-06-19 1999-08-18 Zeneca Ltd Compound
GB9917344D0 (en) * 1999-07-24 1999-09-22 Zeneca Ltd Novel salt
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
GB0012448D0 (en) 2000-05-24 2000-07-12 Astrazeneca Ab New process
WO2002038184A1 (en) * 2000-11-09 2002-05-16 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
GB0104752D0 (en) * 2001-02-27 2001-04-18 Astrazeneca Ab Pharmaceutical compositions
WO2003000657A1 (fr) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
EP1650206A4 (en) * 2003-08-01 2006-12-20 Nippon Soda Co PHENYLAZOLE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND ANTIOXIDANTS
SE0400014D0 (sv) * 2004-01-08 2004-01-08 Astrazeneca Ab Heterocyclic derivatives
CN101218227A (zh) * 2005-07-08 2008-07-09 阿斯利康(瑞典)有限公司 作为因子Xa的抑制剂的杂环磺酰胺衍生物
WO2007008144A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008145A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008143A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
PL3762368T3 (pl) 2018-03-08 2022-06-06 Incyte Corporation ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
US20220380478A1 (en) 2019-07-01 2022-12-01 Tonix Pharma Holdings Limited Anti-cd154 antibodies and uses thereof
EP4274587A1 (en) 2021-01-06 2023-11-15 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
JP2001502655A (ja) * 1995-12-21 2001-02-27 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害薬であるイソオキサゾリン、イソチアゾリンおよびピラゾリン
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9602294D0 (en) * 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
EP0986551B1 (en) 1997-05-30 2006-08-02 Takeda Pharmaceutical Company Limited Sulfonamide derivatives, their production and use
GB9715894D0 (en) * 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
DE19743435A1 (de) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate

Also Published As

Publication number Publication date
HK1034711A1 (en) 2001-11-02
US6753331B1 (en) 2004-06-22
AU3620699A (en) 1999-11-23
HUP0101712A3 (en) 2003-01-28
EP1082321A1 (en) 2001-03-14
NZ507835A (en) 2003-01-31
IL139406A0 (en) 2001-11-25
NO20005497L (no) 2000-12-21
EP1082321B1 (en) 2004-11-17
IL139406A (en) 2004-07-25
ATE282610T1 (de) 2004-12-15
PT1082321E (pt) 2005-03-31
CN1133634C (zh) 2004-01-07
ES2232131T3 (es) 2005-05-16
EE200000527A (et) 2002-02-15
SK16512000A3 (sk) 2001-05-10
BR9910179A (pt) 2001-01-09
KR20010043246A (ko) 2001-05-25
CN1308631A (zh) 2001-08-15
AU754453B2 (en) 2002-11-14
PL343706A1 (en) 2001-08-27
DE69921994T2 (de) 2005-12-01
CA2331042A1 (en) 1999-11-11
NO20005497D0 (no) 2000-11-01
TR200003200T2 (tr) 2001-02-21
JP2002513790A (ja) 2002-05-14
SI1082321T1 (en) 2005-06-30
US20040266759A1 (en) 2004-12-30
DE69921994D1 (de) 2004-12-23
WO1999057113A1 (en) 1999-11-11
NO320893B1 (no) 2006-02-06
EP1528061A1 (en) 2005-05-04

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees