SI1082321T1 - Heterocyclic derivatives which inhibit factor xa - Google Patents

Heterocyclic derivatives which inhibit factor xa

Info

Publication number
SI1082321T1
SI1082321T1 SI9930725T SI9930725T SI1082321T1 SI 1082321 T1 SI1082321 T1 SI 1082321T1 SI 9930725 T SI9930725 T SI 9930725T SI 9930725 T SI9930725 T SI 9930725T SI 1082321 T1 SI1082321 T1 SI 1082321T1
Authority
SI
Slovenia
Prior art keywords
heterocyclic derivatives
inhibit factor
relates
antithrombotic
anticoagulant
Prior art date
Application number
SI9930725T
Other languages
English (en)
Slovenian (sl)
Inventor
Peter William Rodney Caulkett
Roger James
Stuart Eric Pearson
Anthony Michael Slater
Rolf Peter Walker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en
Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SI1082321T1 publication Critical patent/SI1082321T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI9930725T 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa SI1082321T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9809351.1A GB9809351D0 (en) 1998-05-02 1998-05-02 Heterocyclic derivatives
GBGB9903337.5A GB9903337D0 (en) 1999-02-16 1999-02-16 Heterocyclic derivatives
EP99918178A EP1082321B1 (en) 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa
PCT/GB1999/001308 WO1999057113A1 (en) 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa

Publications (1)

Publication Number Publication Date
SI1082321T1 true SI1082321T1 (en) 2005-06-30

Family

ID=26313572

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930725T SI1082321T1 (en) 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa

Country Status (23)

Country Link
US (2) US6753331B1 (xx)
EP (2) EP1528061A1 (xx)
JP (1) JP2002513790A (xx)
KR (1) KR20010043246A (xx)
CN (1) CN1133634C (xx)
AT (1) ATE282610T1 (xx)
AU (1) AU754453B2 (xx)
BR (1) BR9910179A (xx)
CA (1) CA2331042A1 (xx)
DE (1) DE69921994T2 (xx)
EE (1) EE200000527A (xx)
ES (1) ES2232131T3 (xx)
HK (1) HK1034711A1 (xx)
HU (1) HUP0101712A3 (xx)
IL (1) IL139406A (xx)
NO (1) NO320893B1 (xx)
NZ (1) NZ507835A (xx)
PL (1) PL343706A1 (xx)
PT (1) PT1082321E (xx)
SI (1) SI1082321T1 (xx)
SK (1) SK16512000A3 (xx)
TR (1) TR200003200T2 (xx)
WO (1) WO1999057113A1 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
GB9914342D0 (en) * 1999-06-19 1999-08-18 Zeneca Ltd Compound
GB9917344D0 (en) * 1999-07-24 1999-09-22 Zeneca Ltd Novel salt
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
GB0012448D0 (en) 2000-05-24 2000-07-12 Astrazeneca Ab New process
NZ525726A (en) * 2000-11-09 2004-10-29 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
GB0104752D0 (en) * 2001-02-27 2001-04-18 Astrazeneca Ab Pharmaceutical compositions
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
CA2534263A1 (en) * 2003-08-01 2005-02-10 Nippon Soda Co., Ltd. Phenylazole compounds, production process and antioxidants
SE0400014D0 (sv) * 2004-01-08 2004-01-08 Astrazeneca Ab Heterocyclic derivatives
WO2007008143A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008142A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008145A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008144A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
HUE057970T2 (hu) 2018-03-08 2022-06-28 Incyte Corp Aminopirazindiol-vegyületek mint PI3K-Y inhibitorok
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
JP2022538674A (ja) 2019-07-01 2022-09-05 トニックス ファーマ リミテッド 抗ｃｄ１５４抗体およびその使用
AU2022205313A1 (en) 2021-01-06 2023-07-20 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
EP0874629B1 (en) * 1995-12-21 2004-05-19 Bristol-Myers Squibb Pharma Company ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9602294D0 (en) 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
WO1998054164A1 (en) * 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
GB9715894D0 (en) * 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate

Also Published As

Publication number Publication date
EP1528061A1 (en) 2005-05-04
IL139406A0 (en) 2001-11-25
NO320893B1 (no) 2006-02-06
CN1133634C (zh) 2004-01-07
ATE282610T1 (de) 2004-12-15
JP2002513790A (ja) 2002-05-14
EP1082321A1 (en) 2001-03-14
ES2232131T3 (es) 2005-05-16
HK1034711A1 (en) 2001-11-02
IL139406A (en) 2004-07-25
US6753331B1 (en) 2004-06-22
TR200003200T2 (tr) 2001-02-21
WO1999057113A1 (en) 1999-11-11
DE69921994T2 (de) 2005-12-01
CN1308631A (zh) 2001-08-15
EE200000527A (et) 2002-02-15
US20040266759A1 (en) 2004-12-30
NO20005497L (no) 2000-12-21
SK16512000A3 (sk) 2001-05-10
AU754453B2 (en) 2002-11-14
PT1082321E (pt) 2005-03-31
AU3620699A (en) 1999-11-23
NO20005497D0 (no) 2000-11-01
BR9910179A (pt) 2001-01-09
PL343706A1 (en) 2001-08-27
HUP0101712A3 (en) 2003-01-28
NZ507835A (en) 2003-01-31
KR20010043246A (ko) 2001-05-25
CA2331042A1 (en) 1999-11-11
HUP0101712A2 (hu) 2001-11-28
EP1082321B1 (en) 2004-11-17
DE69921994D1 (de) 2004-12-23

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