NO320231B1 - System, apparat og fremgangsmate for kontinuerlig magnetseparasjon av bestanddeler fra en blanding, og fremgangsmate for fremstilling av apparatet - Google Patents
System, apparat og fremgangsmate for kontinuerlig magnetseparasjon av bestanddeler fra en blanding, og fremgangsmate for fremstilling av apparatet Download PDFInfo
- Publication number
- NO320231B1 NO320231B1 NO20004163A NO20004163A NO320231B1 NO 320231 B1 NO320231 B1 NO 320231B1 NO 20004163 A NO20004163 A NO 20004163A NO 20004163 A NO20004163 A NO 20004163A NO 320231 B1 NO320231 B1 NO 320231B1
- Authority
- NO
- Norway
- Prior art keywords
- magnets
- magnetic
- stated
- separation chamber
- procedure
- Prior art date
Links
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- 239000000203 mixture Substances 0.000 title claims description 50
- 238000007885 magnetic separation Methods 0.000 title claims description 17
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Soft Magnetic Materials (AREA)
- Processing Of Solid Wastes (AREA)
- Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
- Paints Or Removers (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/027,084 US6036857A (en) | 1998-02-20 | 1998-02-20 | Apparatus for continuous magnetic separation of components from a mixture |
| PCT/US1999/003579 WO1999042219A1 (en) | 1998-02-20 | 1999-02-19 | Continuous magnetic separation of components from a mixture |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004163D0 NO20004163D0 (no) | 2000-08-18 |
| NO20004163L NO20004163L (no) | 2000-10-19 |
| NO320231B1 true NO320231B1 (no) | 2005-11-14 |
Family
ID=21835596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004163A NO320231B1 (no) | 1998-02-20 | 2000-08-18 | System, apparat og fremgangsmate for kontinuerlig magnetseparasjon av bestanddeler fra en blanding, og fremgangsmate for fremstilling av apparatet |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6036857A (cs) |
| EP (1) | EP1056544B1 (cs) |
| JP (2) | JP4642227B2 (cs) |
| CN (1) | CN1263548C (cs) |
| AT (1) | ATE304897T1 (cs) |
| AU (1) | AU3301999A (cs) |
| CA (1) | CA2320929C (cs) |
| CZ (1) | CZ302485B6 (cs) |
| DE (1) | DE69927359T2 (cs) |
| ES (1) | ES2249902T3 (cs) |
| HK (1) | HK1032554A1 (cs) |
| HU (1) | HU227544B1 (cs) |
| IL (3) | IL157807A (cs) |
| NO (1) | NO320231B1 (cs) |
| TR (3) | TR200002375T2 (cs) |
| WO (1) | WO1999042219A1 (cs) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6616623B1 (en) * | 1997-07-02 | 2003-09-09 | Idializa Ltd. | System for correction of a biological fluid |
| US6495366B1 (en) * | 1999-09-03 | 2002-12-17 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US8722422B2 (en) | 1999-09-03 | 2014-05-13 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US6692952B1 (en) * | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
| US20020001855A1 (en) * | 2000-03-22 | 2002-01-03 | Prentiss Mara G. | Methods and apparatus for parallel magnetic biological analysis and manipulation |
| US20040009614A1 (en) * | 2000-05-12 | 2004-01-15 | Ahn Chong H | Magnetic bead-based arrays |
| WO2002021130A2 (en) * | 2000-08-21 | 2002-03-14 | Darashkevitch Oleg N | Method and device for simultaneous detection of multiple components in a mixture |
| US6689615B1 (en) | 2000-10-04 | 2004-02-10 | James Murto | Methods and devices for processing blood samples |
| US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
| US20020166760A1 (en) * | 2001-05-11 | 2002-11-14 | Prentiss Mara G. | Micromagentic systems and methods for microfluidics |
| US7255793B2 (en) * | 2001-05-30 | 2007-08-14 | Cort Steven L | Methods for removing heavy metals from water using chemical precipitation and field separation methods |
| US7081489B2 (en) * | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
| US7329392B2 (en) * | 2001-10-19 | 2008-02-12 | Sri International | Device and method for handling reaction components |
| US20040234898A1 (en) * | 2002-02-06 | 2004-11-25 | Batishko Charles R. | Magnetic flowcell systems and methods |
| US7005408B2 (en) | 2002-05-01 | 2006-02-28 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
| JP2006501449A (ja) | 2002-09-27 | 2006-01-12 | ザ ジェネラル ホスピタル コーポレーション | 細胞分離のためのマイクロ流体デバイスおよびその使用 |
| US6989196B2 (en) * | 2002-10-02 | 2006-01-24 | Florida State University Research Foundation | Microencapsulation of magnetic material using heat stabilization |
| CN100538362C (zh) * | 2002-11-07 | 2009-09-09 | 株式会社三菱化学药得论 | 用于收集磁性颗粒的磁性材料及其应用 |
| US20040157219A1 (en) * | 2003-02-06 | 2004-08-12 | Jianrong Lou | Chemical treatment of biological samples for nucleic acid extraction and kits therefor |
| WO2004077021A2 (en) * | 2003-02-27 | 2004-09-10 | Lesko Stephen A | Standardized evaluation of therapeutic efficacy based on cellular biomarkers |
| AU2003209572A1 (en) * | 2003-03-08 | 2004-09-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | Magnetic bead manipulation and transport device |
| US20070160503A1 (en) * | 2003-06-13 | 2007-07-12 | Palaniappan Sethu | Microfluidic systems for size based removal of red blood cells and platelets from blood |
| RU2252037C1 (ru) * | 2003-10-14 | 2005-05-20 | Германов Евгений Павлович | Система коррекции биологической жидкости |
| FI20031635A0 (fi) * | 2003-11-11 | 2003-11-11 | Thermo Electron Oy | Partikkelien erotusväline |
| FR2863626B1 (fr) * | 2003-12-15 | 2006-08-04 | Commissariat Energie Atomique | Procede et dispositif de division d'un echantillon biologique par effet magnetique |
| WO2005065267A2 (en) * | 2003-12-24 | 2005-07-21 | Massachusetts Institute Of Technology | Magnetophoretic cell clarification |
| CN1311878C (zh) * | 2003-12-25 | 2007-04-25 | 东南大学 | 纳米磁性颗粒体内收集器及收集方法 |
| EP1776449A4 (en) * | 2004-03-03 | 2009-08-12 | Gen Hospital Corp | MAGNETIC DEVICE FOR ISOLATING CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT |
| US20050239091A1 (en) * | 2004-04-23 | 2005-10-27 | Collis Matthew P | Extraction of nucleic acids using small diameter magnetically-responsive particles |
| US7803262B2 (en) * | 2004-04-23 | 2010-09-28 | Florida State University Research Foundation | Alignment of carbon nanotubes using magnetic particles |
| US7842281B2 (en) * | 2004-05-10 | 2010-11-30 | The Florida State University Research Foundation | Magnetic particle composition for therapeutic hyperthermia |
| US7459121B2 (en) * | 2004-07-21 | 2008-12-02 | Florida State University Research Foundation | Method for continuous fabrication of carbon nanotube networks or membrane materials |
| US7641829B2 (en) * | 2004-07-21 | 2010-01-05 | Florida State University Research Foundation | Method for mechanically chopping carbon nanotube and nanoscale fibrous materials |
| WO2006017428A2 (en) * | 2004-08-03 | 2006-02-16 | Becton, Dickinson And Company | Use of magnetic material to direct isolation of compounds and fractionation of multipart samples |
| US7527980B2 (en) * | 2004-08-18 | 2009-05-05 | Florida State University Research Foundation | Indirect detection of cardiac markers for assessing acute myocardial infarction |
| US7527979B2 (en) * | 2004-08-18 | 2009-05-05 | Florida State University Research Foundation | Devices and methods for rapid detection of pathogens |
| US7147108B2 (en) * | 2004-10-29 | 2006-12-12 | Hewlett-Packard Development Company, Lp. | Method and apparatus for the separation and collection of particles |
| US20060171855A1 (en) * | 2005-02-03 | 2006-08-03 | Hongfeng Yin | Devices,systems and methods for multi-dimensional separation |
| JP4485380B2 (ja) * | 2005-02-21 | 2010-06-23 | 株式会社日立製作所 | 血液浄化装置 |
| US20070026415A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070026413A1 (en) * | 2005-07-29 | 2007-02-01 | Mehmet Toner | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| WO2006108087A2 (en) * | 2005-04-05 | 2006-10-12 | Cellpoint Diagnostics | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070026414A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070059680A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for cell enrichment |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070026416A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20090181421A1 (en) * | 2005-07-29 | 2009-07-16 | Ravi Kapur | Diagnosis of fetal abnormalities using nucleated red blood cells |
| US20070039894A1 (en) * | 2005-08-17 | 2007-02-22 | Cort Steven L | Water treatment using magnetic and other field separation technologies |
| US20070059774A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Kits for Prenatal Testing |
| US20070059716A1 (en) * | 2005-09-15 | 2007-03-15 | Ulysses Balis | Methods for detecting fetal abnormality |
| US20070059719A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Business methods for prenatal Diagnosis |
| US20070059781A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
| US20070059718A1 (en) * | 2005-09-15 | 2007-03-15 | Mehmet Toner | Systems and methods for enrichment of analytes |
| US20070059683A1 (en) * | 2005-09-15 | 2007-03-15 | Tom Barber | Veterinary diagnostic system |
| US7867765B2 (en) * | 2005-12-28 | 2011-01-11 | The General Hospital Corporation | Blood cell sorting methods and systems |
| US7955535B2 (en) * | 2006-02-02 | 2011-06-07 | Florida State University Research Foundation | Method for fabricating macroscale films comprising multiple-walled nanotubes |
| US8415012B2 (en) * | 2006-02-02 | 2013-04-09 | Florida State University Research Foundation, Inc. | Carbon nanotube and nanofiber film-based membrane electrode assemblies |
| US7862766B2 (en) * | 2006-05-16 | 2011-01-04 | Florida State University Research Foundation, Inc. | Method for functionalization of nanoscale fiber films |
| US20080057265A1 (en) * | 2006-05-22 | 2008-03-06 | Florida State University Research Foundation | Electromagnetic Interference Shielding Structure Including Carbon Nanotubes and Nanofibers |
| US20090280324A1 (en) * | 2006-05-22 | 2009-11-12 | Florida State University Research Foundation | Prepreg Nanoscale Fiber Films and Methods |
| US20080124721A1 (en) * | 2006-06-14 | 2008-05-29 | Martin Fuchs | Analysis of rare cell-enriched samples |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| US20070292889A1 (en) * | 2006-06-16 | 2007-12-20 | The Regents Of The University Of California | Immunoassay magnetic trapping device |
| TWI296713B (en) * | 2006-08-02 | 2008-05-11 | Ind Tech Res Inst | Magnetic beads-based sample separating device |
| CN101149376B (zh) * | 2006-09-19 | 2012-07-25 | 财团法人工业技术研究院 | 磁珠式检体分离装置 |
| EP2086688A2 (en) * | 2006-11-14 | 2009-08-12 | The Cleveland Clinic Foundation | Magnetic cell separation |
| JP5232858B2 (ja) * | 2007-06-29 | 2013-07-10 | ベクトン・ディキンソン・アンド・カンパニー | 生物学的試料の成分を抽出および精製するための方法 |
| WO2009022994A1 (en) | 2007-08-13 | 2009-02-19 | Agency For Science, Technology And Research | Microfluidic separation system |
| EP2030689B1 (de) * | 2007-08-31 | 2013-02-13 | Tecan Trading AG | Mikroplatten-Träger mit Magneten |
| AU2008294826B2 (en) * | 2007-09-03 | 2013-02-07 | Basf Se | Processing rich ores using magnetic particles |
| US20090148637A1 (en) * | 2007-10-26 | 2009-06-11 | Florida State University Research Foundation | Fabrication of fire retardant materials with nanoadditives |
| US8058364B2 (en) | 2008-04-15 | 2011-11-15 | Florida State University Research Foundation | Method for functionalization of nanoscale fibers and nanoscale fiber films |
| US8784603B2 (en) * | 2008-04-28 | 2014-07-22 | Florida State University Research Foundation, Inc. | Actuator device including nanoscale fiber films |
| US8020456B2 (en) * | 2008-05-30 | 2011-09-20 | Florida State University Research Foundation | Sensor and a method of making a sensor |
| JP2011526799A (ja) * | 2008-06-17 | 2011-10-20 | ジョージア テック リサーチ コーポレイション | 細胞、病原体又はウイルスを除去するための超常磁性ナノ粒子 |
| US20110177592A1 (en) * | 2008-07-11 | 2011-07-21 | Faustman Denise L | Magnetic apparatus for blood separation |
| US9254606B2 (en) | 2009-01-20 | 2016-02-09 | Florida State University Research Foundation | Nanoscale fiber films, composites, and methods for alignment of nanoscale fibers by mechanical stretching |
| DE102009005925B4 (de) | 2009-01-23 | 2013-04-04 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Vorrichtung und Verfahren zur Handhabung von Biomolekülen |
| US20110045274A1 (en) * | 2009-01-28 | 2011-02-24 | Florida State University Research Foundation | Functionalized nanoscale fiber films, composites, and methods for functionalization of nanoscale fiber films |
| CN101598738B (zh) * | 2009-04-13 | 2013-04-24 | 广州市怡文环境科技股份有限公司 | 一种应用于分析仪器的多通道桥式流路进样系统及其进样方法 |
| US8790916B2 (en) * | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
| ES2525537T3 (es) * | 2009-07-17 | 2014-12-26 | Florida State University Research Foundation, Inc. | Electrodo catalítico con porosidad gradiente y catalizador de densidad de pilas de combustible |
| US20130315796A1 (en) | 2010-02-17 | 2013-11-28 | The Ohio State University | Biological cell separator and disposable kit |
| US8585864B2 (en) | 2010-04-16 | 2013-11-19 | Florida State University Research Foundation, Inc. | Fire and smoke retardant composite materials |
| US8916651B2 (en) | 2010-04-20 | 2014-12-23 | Florida State University Research Foundation, Inc. | Composite materials and method for making high-performance carbon nanotube reinforced polymer composites |
| US20110262989A1 (en) * | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
| EP2537589A1 (de) * | 2011-06-21 | 2012-12-26 | Siemens Aktiengesellschaft | Verfahren zum Trennen eines ersten Stoffes aus einem fließfähigen Primärstoffstrom, Vorrichtung zum Trennen eines ersten Stoffes aus einem fließfähigen Primärstoffstrom und Steuer- und/oder Regeleinrichtung |
| WO2013126774A2 (en) * | 2012-02-24 | 2013-08-29 | President And Fellows Of Harvard College | Microfluidic devices for capture of target species |
| EP3043903B1 (en) * | 2013-09-09 | 2022-04-06 | Lab-on-a-Bead AB | Process and system for magnetic separation |
| EP3058316B1 (en) | 2013-10-18 | 2019-03-13 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| US10004841B2 (en) | 2013-12-09 | 2018-06-26 | Michael C. Larson | Blood purifier device and method |
| EP3061529A1 (en) | 2015-02-24 | 2016-08-31 | AdnaGen GmbH | Apparatus and method for the analysis, isolation and/or enrichment of target structures in a fluid sample |
| CN107438440A (zh) * | 2015-04-07 | 2017-12-05 | 泰尔茂比司特公司 | 去珠子 |
| CN107530486B (zh) | 2015-05-08 | 2020-12-11 | 生物磁溶液有限公司 | 免疫磁性细胞分离的装置和方法 |
| CN105413858A (zh) * | 2016-01-11 | 2016-03-23 | 潘静娴 | 一种利用微小磁极距形成高密度磁峰值的磁选装置 |
| US11112410B2 (en) | 2016-04-13 | 2021-09-07 | President And Fellows Of Harvard College | Methods for capturing, isolation, and targeting of circulating tumor cells and diagnostic and therapeutic applications thereof |
| CN109477100A (zh) * | 2016-05-06 | 2019-03-15 | 干细胞技术公司 | 平板磁体 |
| EP3454991A4 (en) * | 2016-05-12 | 2020-01-08 | University of Florida Research Foundation, Inc. | MAGNETIC SEPARATION SYSTEM AND DEVICES |
| JP6420433B1 (ja) * | 2017-09-12 | 2018-11-07 | 株式会社 マトリックス細胞研究所 | 反応促進装置及び反応促進方法 |
| CN108414305B (zh) * | 2018-01-24 | 2020-08-04 | 广州市丰华生物工程有限公司 | 一种用于结核感染t细胞测定的样本处理方法和处理剂 |
| JP6370018B1 (ja) * | 2018-03-15 | 2018-08-08 | 株式会社 マトリックス細胞研究所 | 反応促進装置及び反応促進方法 |
| JP6370017B1 (ja) * | 2018-03-15 | 2018-08-08 | 株式会社 マトリックス細胞研究所 | 反応促進装置及び反応促進方法 |
| US11413378B2 (en) | 2018-05-08 | 2022-08-16 | Biomagnetic Solutions Llc | Rigid chamber for cell separation from a flexible disposable bag |
| US11618963B2 (en) | 2018-10-01 | 2023-04-04 | Florida State University Research Foundation, Inc. | Method for making ultralow platinum loading and high durability membrane electrode assembly for polymer electrolyte membrane fuel cells |
| EP3922711A4 (en) * | 2019-02-05 | 2022-11-30 | Universal Bio Research Co., Ltd. | SAMPLE PROCESSING DEVICE |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2396592A1 (fr) * | 1977-07-08 | 1979-02-02 | Commissariat Energie Atomique | Filtre magnetique a aimants permanents |
| US4508625A (en) * | 1982-10-18 | 1985-04-02 | Graham Marshall D | Magnetic separation using chelated magnetic ions |
| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US4935147A (en) * | 1985-12-20 | 1990-06-19 | Syntex (U.S.A.) Inc. | Particle separation method |
| DE3764390D1 (de) * | 1986-04-21 | 1990-09-27 | Siemens Ag | Verfahren zur kontinuierlichen separation magnetisierbarer partikel und einrichtung zu seiner durchfuehrung. |
| NO162946C (no) * | 1987-08-21 | 1990-03-14 | Otto Soerensen | Anordning for magnetisk separasjon av celler. |
| US4988618A (en) * | 1987-11-16 | 1991-01-29 | Gene-Trak Systems | Magnetic separation device and methods for use in heterogeneous assays |
| JPH03501097A (ja) * | 1988-05-25 | 1991-03-14 | ウクラインスキ インスティテュト インジェネロフ ボドノゴ ホジアイストバ | 流体媒質から強磁性物質を分離する装置 |
| US5536475A (en) * | 1988-10-11 | 1996-07-16 | Baxter International Inc. | Apparatus for magnetic cell separation |
| US4946603A (en) * | 1988-11-17 | 1990-08-07 | Crystal Diagnostics, Inc. | Electronegatively charged blood filter and blood cell separation method |
| DD298055A5 (de) * | 1989-09-14 | 1992-02-06 | ����������@�����������@���Kk�� | Methode und nuetzlicher apparat zur darstellung pharmazeutischer zusammensetzungen |
| JP2953753B2 (ja) * | 1990-06-28 | 1999-09-27 | テルモ株式会社 | 血漿採取装置 |
| US5541072A (en) * | 1994-04-18 | 1996-07-30 | Immunivest Corporation | Method for magnetic separation featuring magnetic particles in a multi-phase system |
| US5622831A (en) * | 1990-09-26 | 1997-04-22 | Immunivest Corporation | Methods and devices for manipulation of magnetically collected material |
| FR2679660B1 (fr) * | 1991-07-22 | 1993-11-12 | Pasteur Diagnostics | Procede et dispositif magnetique d'analyse immunologique sur phase solide. |
| ATE195081T1 (de) * | 1992-09-24 | 2000-08-15 | Amersham Pharm Biotech Uk Ltd | Verfahren und vorrichtung zur magnetischen abscheidung |
| US5409813A (en) * | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
| EP0672458A3 (en) * | 1994-03-04 | 1996-02-28 | Cleveland Clinic Foundation | Magnetic cytometry method and apparatus. |
| US5567326A (en) * | 1994-09-19 | 1996-10-22 | Promega Corporation | Multisample magnetic separation device |
| GB2300258A (en) * | 1995-04-28 | 1996-10-30 | Philip John Jewess | A separation device for magnetisable particles |
| US5882514A (en) * | 1996-08-22 | 1999-03-16 | Fletcher; Charles J. | Apparatus for magnetically treating fluids |
-
1998
- 1998-02-20 US US09/027,084 patent/US6036857A/en not_active Expired - Lifetime
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