NO319903B1 - Anvendelse av et antistoffmolekyl for fremstilling av et farmasoytisk preparat for behandling av plateepitelkarsinom. - Google Patents

Anvendelse av et antistoffmolekyl for fremstilling av et farmasoytisk preparat for behandling av plateepitelkarsinom. Download PDF

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Publication number
NO319903B1
NO319903B1 NO19982588A NO982588A NO319903B1 NO 319903 B1 NO319903 B1 NO 319903B1 NO 19982588 A NO19982588 A NO 19982588A NO 982588 A NO982588 A NO 982588A NO 319903 B1 NO319903 B1 NO 319903B1
Authority
NO
Norway
Prior art keywords
antibody
biwa
antibodies
tumor
expression
Prior art date
Application number
NO19982588A
Other languages
English (en)
Norwegian (no)
Other versions
NO982588L (no
NO982588D0 (no
Inventor
Elinborg Ostermann
Erik Patzelt
Karl-Heinz Heider
Guenter Adolf
Marlies Sproll
Original Assignee
Karlsruhe Forschzent
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19545472A external-priority patent/DE19545472A1/de
Application filed by Karlsruhe Forschzent, Boehringer Ingelheim Int filed Critical Karlsruhe Forschzent
Publication of NO982588D0 publication Critical patent/NO982588D0/no
Publication of NO982588L publication Critical patent/NO982588L/no
Publication of NO319903B1 publication Critical patent/NO319903B1/no

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585CD44
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO19982588A 1995-12-06 1998-06-05 Anvendelse av et antistoffmolekyl for fremstilling av et farmasoytisk preparat for behandling av plateepitelkarsinom. NO319903B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19545472A DE19545472A1 (de) 1995-12-06 1995-12-06 Verfahren zur Diagnose und Therapie von Plattenepithelkarzinomen
DE19615074 1996-04-17
PCT/EP1996/005448 WO1997021104A1 (de) 1995-12-06 1996-12-05 Verfahren zur diagnose und therapie von plattenepithelkarzinomen

Publications (3)

Publication Number Publication Date
NO982588D0 NO982588D0 (no) 1998-06-05
NO982588L NO982588L (no) 1998-08-05
NO319903B1 true NO319903B1 (no) 2005-09-26

Family

ID=26020988

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19982588A NO319903B1 (no) 1995-12-06 1998-06-05 Anvendelse av et antistoffmolekyl for fremstilling av et farmasoytisk preparat for behandling av plateepitelkarsinom.

Country Status (26)

Country Link
EP (1) EP0865609B1 (pt)
JP (1) JP2000502067A (pt)
KR (1) KR100473824B1 (pt)
CN (1) CN1151377C (pt)
AR (1) AR004360A1 (pt)
AT (1) ATE235056T1 (pt)
AU (1) AU726704B2 (pt)
BG (1) BG62985B1 (pt)
BR (1) BR9611901A (pt)
CA (1) CA2239709A1 (pt)
CO (1) CO4520233A1 (pt)
CZ (1) CZ174198A3 (pt)
DE (1) DE59610248D1 (pt)
DK (1) DK0865609T3 (pt)
EE (1) EE03783B1 (pt)
ES (1) ES2190484T3 (pt)
HK (1) HK1011560A1 (pt)
MX (1) MX9804459A (pt)
NO (1) NO319903B1 (pt)
NZ (1) NZ324314A (pt)
PL (1) PL184521B1 (pt)
PT (1) PT865609E (pt)
SK (1) SK284378B6 (pt)
TR (1) TR199801027T2 (pt)
UY (1) UY24389A1 (pt)
WO (1) WO1997021104A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
PE20021098A1 (es) * 2001-05-18 2003-02-11 Boehringer Ingelheim Int ANTICUERPOS ESPECIFICOS DE CD44v6
US20030103985A1 (en) 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
EP1258255A1 (en) * 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
EP1391213A1 (en) * 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
CN102741292B (zh) * 2010-02-04 2015-10-21 霍夫曼-拉罗奇有限公司 在治疗头和颈鳞状细胞癌中使用的cd44单克隆抗体
US9218450B2 (en) 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
WO2019161528A1 (en) * 2018-02-22 2019-08-29 Abmart Shanghai Co., Ltd. Therapeutic antibody and uses thereof
WO2023227644A2 (en) 2022-05-25 2023-11-30 Akiram Therapeutics Ab Binding protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08511419A (ja) * 1993-06-18 1996-12-03 ヤルカネン、シルパ 組成物およびCD44v6に対するモノクローナル抗体を用いる診断方法
EP0767378A1 (de) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Magenkarzinomen
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
UA58482C2 (uk) * 1994-06-08 2003-08-15 Бьорінгер Інгельхайм Інтернаціональ Гмбх Моноклональне антитіло vff-18 проти сd44v6 і його фрагменти

Also Published As

Publication number Publication date
ES2190484T3 (es) 2003-08-01
KR19990071952A (ko) 1999-09-27
KR100473824B1 (ko) 2005-09-30
WO1997021104A1 (de) 1997-06-12
JP2000502067A (ja) 2000-02-22
NO982588L (no) 1998-08-05
DE59610248D1 (de) 2003-04-24
EE9800164A (et) 1998-12-15
MX9804459A (es) 1998-09-30
EE03783B1 (et) 2002-06-17
CN1151377C (zh) 2004-05-26
PL184521B1 (pl) 2002-11-29
CZ174198A3 (cs) 1999-02-17
CN1207811A (zh) 1999-02-10
AR004360A1 (es) 1998-11-04
BG62985B1 (bg) 2000-12-29
PT865609E (pt) 2003-08-29
CO4520233A1 (es) 1997-10-15
NO982588D0 (no) 1998-06-05
ATE235056T1 (de) 2003-04-15
DK0865609T3 (da) 2003-06-23
UY24389A1 (es) 2001-10-25
AU726704B2 (en) 2000-11-16
BG102513A (en) 1999-02-26
PL327066A1 (en) 1998-11-23
SK284378B6 (sk) 2005-02-04
HK1011560A1 (en) 1999-07-16
SK73698A3 (en) 1999-01-11
NZ324314A (en) 2000-02-28
TR199801027T2 (xx) 1998-10-21
BR9611901A (pt) 1999-03-02
CA2239709A1 (en) 1997-06-12
EP0865609B1 (de) 2003-03-19
AU1177397A (en) 1997-06-27
EP0865609A1 (de) 1998-09-23

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