PT865609E - Processos para o diagnostico e terapia de carcinomas do epitelio escamoso - Google Patents

Processos para o diagnostico e terapia de carcinomas do epitelio escamoso

Info

Publication number
PT865609E
PT865609E PT96942362T PT96942362T PT865609E PT 865609 E PT865609 E PT 865609E PT 96942362 T PT96942362 T PT 96942362T PT 96942362 T PT96942362 T PT 96942362T PT 865609 E PT865609 E PT 865609E
Authority
PT
Portugal
Prior art keywords
scammable
carcinomas
epithelium
diagnosis
therapy
Prior art date
Application number
PT96942362T
Other languages
English (en)
Inventor
Erik Patzelt
Karl-Heinz Heider
Gunther Adolf
Elinborg Ostermann
Marlies Sproll
Original Assignee
Boehringer Ingelheim Int
Karlsruhe Forschzent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19545472A external-priority patent/DE19545472A1/de
Application filed by Boehringer Ingelheim Int, Karlsruhe Forschzent filed Critical Boehringer Ingelheim Int
Publication of PT865609E publication Critical patent/PT865609E/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT96942362T 1995-12-06 1996-12-05 Processos para o diagnostico e terapia de carcinomas do epitelio escamoso PT865609E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19545472A DE19545472A1 (de) 1995-12-06 1995-12-06 Verfahren zur Diagnose und Therapie von Plattenepithelkarzinomen
DE19615074 1996-04-17

Publications (1)

Publication Number Publication Date
PT865609E true PT865609E (pt) 2003-08-29

Family

ID=26020988

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96942362T PT865609E (pt) 1995-12-06 1996-12-05 Processos para o diagnostico e terapia de carcinomas do epitelio escamoso

Country Status (26)

Country Link
EP (1) EP0865609B1 (pt)
JP (1) JP2000502067A (pt)
KR (1) KR100473824B1 (pt)
CN (1) CN1151377C (pt)
AR (1) AR004360A1 (pt)
AT (1) ATE235056T1 (pt)
AU (1) AU726704B2 (pt)
BG (1) BG62985B1 (pt)
BR (1) BR9611901A (pt)
CA (1) CA2239709A1 (pt)
CO (1) CO4520233A1 (pt)
CZ (1) CZ174198A3 (pt)
DE (1) DE59610248D1 (pt)
DK (1) DK0865609T3 (pt)
EE (1) EE03783B1 (pt)
ES (1) ES2190484T3 (pt)
HK (1) HK1011560A1 (pt)
MX (1) MX9804459A (pt)
NO (1) NO319903B1 (pt)
NZ (1) NZ324314A (pt)
PL (1) PL184521B1 (pt)
PT (1) PT865609E (pt)
SK (1) SK284378B6 (pt)
TR (1) TR199801027T2 (pt)
UY (1) UY24389A1 (pt)
WO (1) WO1997021104A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
EP1258255A1 (en) * 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
US20030103985A1 (en) 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
CA2443437A1 (en) * 2001-05-18 2002-11-28 Boehringer Ingelheim International Gmbh Antibodies specific for cd44v6
EP1391213A1 (en) * 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
JP5763105B2 (ja) * 2010-02-04 2015-08-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 頭頸部扁平上皮癌の治療に使用されるｃｄ４４に対するモノクローナル抗体
US9218450B2 (en) 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
EP3755717A4 (en) * 2018-02-22 2022-01-26 Multitude Inc. THERAPEUTIC ANTIBODIES AND ASSOCIATED USES
WO2023227644A2 (en) 2022-05-25 2023-11-30 Akiram Therapeutics Ab Binding protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000658A1 (en) * 1993-06-18 1995-01-05 Sirpa Jalkanen COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6
EP0767380A1 (de) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Zervixkarzinomen
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
UA58482C2 (uk) * 1994-06-08 2003-08-15 Бьорінгер Інгельхайм Інтернаціональ Гмбх Моноклональне антитіло vff-18 проти сd44v6 і його фрагменти

Also Published As

Publication number Publication date
PL327066A1 (en) 1998-11-23
AU726704B2 (en) 2000-11-16
MX9804459A (es) 1998-09-30
TR199801027T2 (xx) 1998-10-21
SK73698A3 (en) 1999-01-11
BG102513A (en) 1999-02-26
CN1151377C (zh) 2004-05-26
AU1177397A (en) 1997-06-27
EP0865609B1 (de) 2003-03-19
KR19990071952A (ko) 1999-09-27
KR100473824B1 (ko) 2005-09-30
BG62985B1 (bg) 2000-12-29
UY24389A1 (es) 2001-10-25
EE03783B1 (et) 2002-06-17
JP2000502067A (ja) 2000-02-22
CZ174198A3 (cs) 1999-02-17
CA2239709A1 (en) 1997-06-12
EP0865609A1 (de) 1998-09-23
AR004360A1 (es) 1998-11-04
EE9800164A (et) 1998-12-15
WO1997021104A1 (de) 1997-06-12
DE59610248D1 (de) 2003-04-24
CO4520233A1 (es) 1997-10-15
SK284378B6 (sk) 2005-02-04
CN1207811A (zh) 1999-02-10
NO982588D0 (no) 1998-06-05
NO982588L (no) 1998-08-05
ES2190484T3 (es) 2003-08-01
BR9611901A (pt) 1999-03-02
DK0865609T3 (da) 2003-06-23
HK1011560A1 (en) 1999-07-16
NO319903B1 (no) 2005-09-26
ATE235056T1 (de) 2003-04-15
NZ324314A (en) 2000-02-28
PL184521B1 (pl) 2002-11-29

Similar Documents

Publication Publication Date Title
PT865609E (pt) Processos para o diagnostico e terapia de carcinomas do epitelio escamoso
AU7074698A (en) Detection and modulation of the iaps and naip for the diagnosis and treatment ofproliferative disease
ATE459715T1 (de) Regulierte gene und ihre verwendungen
CY1114164T1 (el) Μεθοδος ελεγχου της δραστικοτητας ανοσολογικα λειτουργικου μοριου
DE69942742D1 (de) Immuntherapeutische zusammensetzung und verfahren zur behandlung von prostatakrebs
DK0749325T3 (da) Bispecifikke molekyler med klinisk anvendelse
TR200103756T2 (tr) Hümanize anti-ErbB2 antikorları ve anti-ErbB2 antikorlarıyla tedavi.
ES2159318T3 (es) Inhibidores de la proteina quinasa c.
ATE424560T1 (de) Marker für neuromyelitis optica
BR9809778A (pt) Polinucleotìdeo isolado, vetor de expressão, peptìdeo ou polipetìdeo isolado, anticorpo, processo para produzir o mesmo, fragmentos de anticorpos, anticorpos de cadeia única ou anticorpos humanizados, e, anticorpo anti-idiotìpico.
DE69626683D1 (de) Verfahren zur feststellung von antipolymerantikörper und diagnosetestsatz zur feststellung von siliconabhängigen krankheiten
DE69934324D1 (de) Behandlung von entzündungskrankheiten
ATE226254T1 (de) Reagenz zur behandlung von arthritischen zustaenden
WO2000012703A3 (en) Protein transport-associated molecules
WO2000035950A3 (en) Reagents and methods useful for detecting diseases of the breast
WO2000020604A3 (en) Oxidoreductase molecules
ATE219515T1 (de) Methoden und reagenzien zur regulierung von apoptosis
DE69734890D1 (de) Rdgb-proteine
FR2720277B1 (fr) Méthode de traitement des cancers par régulation de la protéine P53.
FI970299A0 (fi) Oligomeeriset kantajamolekyylit, joissa on määritetysti sisällytettyjä merkitsinryhmiä ja hapteeneja
ATE406437T1 (de) Methode zur identifikation antifungischer moleküle, welche auf die glukanosyltransferaseaktivität wirken
HUP9904404A1 (hu) Eljárás laphám-karcinómák diagnosztizálására és kezelésére
ATE405646T1 (de) Ein verfahren zum auffinden vom prostatakrebs
CO4600645A1 (es) Agentes anticoagulantes utiles en el tratamiento de trombosis