NO319209B1 - Aryl- og heteroarylsubstituerte ureaforbindelser og farmasoytiske preparater som omfatter disse - Google Patents
Aryl- og heteroarylsubstituerte ureaforbindelser og farmasoytiske preparater som omfatter disse Download PDFInfo
- Publication number
- NO319209B1 NO319209B1 NO20003231A NO20003231A NO319209B1 NO 319209 B1 NO319209 B1 NO 319209B1 NO 20003231 A NO20003231 A NO 20003231A NO 20003231 A NO20003231 A NO 20003231A NO 319209 B1 NO319209 B1 NO 319209B1
- Authority
- NO
- Norway
- Prior art keywords
- tert
- butyl
- urea
- pyrazolyl
- phenyl
- Prior art date
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- 125000001072 heteroaryl group Chemical group 0.000 title claims description 8
- 150000003672 ureas Chemical class 0.000 title abstract description 8
- 125000003118 aryl group Chemical group 0.000 title description 10
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 61
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 29
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
- 125000004076 pyridyl group Chemical group 0.000 claims description 20
- 239000004202 carbamide Substances 0.000 claims description 17
- 238000006467 substitution reaction Methods 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- CUYZHKUAFIPCSJ-UHFFFAOYSA-N 1-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-3-(4-phenoxyphenyl)urea Chemical compound C=1C=CC(N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CC=C1 CUYZHKUAFIPCSJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- ZFJZXGAFKPFNSG-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl ZFJZXGAFKPFNSG-UHFFFAOYSA-N 0.000 claims 1
- RCZQFYZVLCMFFN-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(2,4-difluorophenyl)urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=C(F)C=C1F RCZQFYZVLCMFFN-UHFFFAOYSA-N 0.000 claims 1
- UUUIRYMTQKTIML-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(3-cyanophenyl)urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(C#N)=C1 UUUIRYMTQKTIML-UHFFFAOYSA-N 0.000 claims 1
- TYQAQAZCZRPYRN-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(3-fluorophenyl)urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(F)=C1 TYQAQAZCZRPYRN-UHFFFAOYSA-N 0.000 claims 1
- IQRRXNHDVPPLBU-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(4-nitrophenyl)urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1 IQRRXNHDVPPLBU-UHFFFAOYSA-N 0.000 claims 1
- FFIUOTRLUBELIM-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1CC1=CC=NC=C1 FFIUOTRLUBELIM-UHFFFAOYSA-N 0.000 claims 1
- GDPHSKJEYFGMHV-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylthiophen-3-yl)-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=CC=CC=1C=1SC(C(C)(C)C)=CC=1NC(=O)NC1=CC=CC(Cl)=C1Cl GDPHSKJEYFGMHV-UHFFFAOYSA-N 0.000 claims 1
- HSQBWWZLDMOFSS-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-2-ylpyrazol-3-yl)-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=CC=NC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl HSQBWWZLDMOFSS-UHFFFAOYSA-N 0.000 claims 1
- JHVUVPPREJEJFT-UHFFFAOYSA-N 1-(5-tert-butyl-2-pyridin-4-ylpyrazol-3-yl)-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound C=1C=NC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1CC1=CC=NC=C1 JHVUVPPREJEJFT-UHFFFAOYSA-N 0.000 claims 1
- LDXAGTHPWDVZFU-UHFFFAOYSA-N 1-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=CC(N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl LDXAGTHPWDVZFU-UHFFFAOYSA-N 0.000 claims 1
- WJOFCYKMTBWGDE-UHFFFAOYSA-N 1-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-3-(4-pyridin-4-ylsulfanylphenyl)urea Chemical compound C=1C=CC(N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1SC1=CC=NC=C1 WJOFCYKMTBWGDE-UHFFFAOYSA-N 0.000 claims 1
- VQFFXUJUGHSTCN-UHFFFAOYSA-N 1-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound C=1C=CC(N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1CC1=CC=NC=C1 VQFFXUJUGHSTCN-UHFFFAOYSA-N 0.000 claims 1
- SMIBCPFPBUZPDB-UHFFFAOYSA-N 1-[2-(4-aminophenyl)-5-tert-butylpyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=C(N)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl SMIBCPFPBUZPDB-UHFFFAOYSA-N 0.000 claims 1
- NZXFWWIIOCLRBG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2,5-dichlorophenyl)pyrazol-3-yl]-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound C=1C(Cl)=CC=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1CC1=CC=NC=C1 NZXFWWIIOCLRBG-UHFFFAOYSA-N 0.000 claims 1
- HCXKSJKYSGOXPC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methylphenyl)pyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound CC1=CC=CC=C1N1C(NC(=O)NC=2C(=C(Cl)C=CC=2)Cl)=CC(C(C)(C)C)=N1 HCXKSJKYSGOXPC-UHFFFAOYSA-N 0.000 claims 1
- IIJPXSBAILRPBH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(2-methylphenyl)pyrazol-3-yl]-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound CC1=CC=CC=C1N1C(NC(=O)NC=2C=CC(CC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 IIJPXSBAILRPBH-UHFFFAOYSA-N 0.000 claims 1
- WUSBLDMZPYBKMT-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl WUSBLDMZPYBKMT-UHFFFAOYSA-N 0.000 claims 1
- ZUMZFZPWNCSPCR-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1CC1=CC=NC=C1 ZUMZFZPWNCSPCR-UHFFFAOYSA-N 0.000 claims 1
- PRKGLTOOEULMFS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C(=C(Cl)C=CC=2)Cl)=C1 PRKGLTOOEULMFS-UHFFFAOYSA-N 0.000 claims 1
- DHHUPNJXRLHQNZ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)NC=2C=CC(CC=3C=CN=CC=3)=CC=2)=C1 DHHUPNJXRLHQNZ-UHFFFAOYSA-N 0.000 claims 1
- KXQRNZIJVGMDMI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-nitrophenyl)pyrazol-3-yl]-3-(2,3-dichlorophenyl)urea Chemical compound C=1C=CC([N+]([O-])=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=CC(Cl)=C1Cl KXQRNZIJVGMDMI-UHFFFAOYSA-N 0.000 claims 1
- YQDHLCOTFVFZSP-UHFFFAOYSA-N 1-[5-tert-butyl-2-(3-nitrophenyl)pyrazol-3-yl]-3-(4-phenoxyphenyl)urea Chemical compound C=1C=CC([N+]([O-])=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1OC1=CC=CC=C1 YQDHLCOTFVFZSP-UHFFFAOYSA-N 0.000 claims 1
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- TUOYWZHLTSNOHS-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[4-(pyridin-4-ylmethyl)phenyl]urea Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC(C=C1)=CC=C1CC1=CC=NC=C1 TUOYWZHLTSNOHS-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US99618197A | 1997-12-22 | 1997-12-22 | |
PCT/US1998/026082 WO1999032455A1 (en) | 1997-12-22 | 1998-12-22 | Inhibition of raf kinase using aryl and heteroaryl substituted heterocyclic ureas |
Publications (3)
Publication Number | Publication Date |
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NO20003231D0 NO20003231D0 (no) | 2000-06-21 |
NO20003231L NO20003231L (no) | 2000-08-22 |
NO319209B1 true NO319209B1 (no) | 2005-06-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20003231A NO319209B1 (no) | 1997-12-22 | 2000-06-21 | Aryl- og heteroarylsubstituerte ureaforbindelser og farmasoytiske preparater som omfatter disse |
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EP (1) | EP1056725B1 (uk) |
JP (1) | JP4395823B2 (uk) |
KR (1) | KR100622138B1 (uk) |
CN (1) | CN1117081C (uk) |
AT (1) | ATE328873T1 (uk) |
AU (1) | AU765412B2 (uk) |
BG (1) | BG65207B1 (uk) |
BR (1) | BR9814361A (uk) |
CA (1) | CA2315713C (uk) |
CU (1) | CU23127A3 (uk) |
CY (1) | CY1105395T1 (uk) |
CZ (1) | CZ299836B6 (uk) |
DE (2) | DE69834842T2 (uk) |
DK (1) | DK1056725T3 (uk) |
ES (1) | ES2155045T3 (uk) |
GR (1) | GR20010300010T1 (uk) |
HK (1) | HK1029989A1 (uk) |
HU (1) | HUP0004426A3 (uk) |
ID (1) | ID26328A (uk) |
IL (2) | IL136773A0 (uk) |
NO (1) | NO319209B1 (uk) |
NZ (1) | NZ505845A (uk) |
PL (1) | PL341356A1 (uk) |
PT (1) | PT1056725E (uk) |
RU (1) | RU2265597C2 (uk) |
SK (1) | SK285371B6 (uk) |
TR (3) | TR200002617T2 (uk) |
UA (1) | UA67763C2 (uk) |
WO (1) | WO1999032455A1 (uk) |
Families Citing this family (90)
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EP1473292A1 (en) * | 1997-11-03 | 2004-11-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
AU2006201959B2 (en) * | 1997-12-22 | 2008-09-04 | Bayer Healthcare Llc | Inhibition of Raf Kinase using Substituted Heterocyclic Ureas |
MXPA00006233A (es) * | 1997-12-22 | 2002-09-18 | Bayer Ag | Inhibicion de la actividad de la cinasa p38 utilizando ureas heterociclicas sustituidas. |
CZ299156B6 (cs) * | 1997-12-22 | 2008-05-07 | Bayer Corporation | Substituované heterocyklické mocoviny, farmaceutické prípravky je obsahující a jejich použití |
ATE346600T1 (de) * | 1997-12-22 | 2006-12-15 | Bayer Pharmaceuticals Corp | Inhibierung der p38 kinase-aktivität durch die verwendung von aryl- und heteroarylsubstituierten harnstoffen |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
WO2000050425A1 (en) | 1999-02-22 | 2000-08-31 | Boehringer Ingelheim Pharmaceuticals, Inc. | Polycyclo heterocyclic derivatives as antiinflammatory agents |
CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
SK12832001A3 (sk) | 1999-03-12 | 2002-01-07 | Boehringer Ingelheim Pharmaceuticals, Inc. | Protizápalové látky, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
WO2000055152A1 (en) | 1999-03-12 | 2000-09-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
EP1200411B1 (en) | 1999-07-09 | 2005-12-14 | Boehringer Ingelheim Pharmaceuticals Inc. | Process for synthesis of heteroaryl-substituted urea compounds |
OA12046A (en) | 1999-08-12 | 2006-05-02 | Pharmacia Italia Spa | 3(5)-Amino-pyrazole derivatives, process for theirpreparation and their use as antitumor agents. |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US7026336B1 (en) * | 1999-11-22 | 2006-04-11 | Smithkline Beecham P.L.C. | Compounds |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
NZ524475A (en) | 2000-08-10 | 2004-11-26 | Pharmacia Italia S | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
AU2002232439A1 (en) | 2000-11-29 | 2002-06-11 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
EP1392661A1 (en) | 2001-05-16 | 2004-03-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
CA2448626A1 (en) | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Carbamate and oxamide compounds as inhibitors of cytokine production |
EP1709965A3 (en) * | 2001-07-11 | 2006-12-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediate diseases |
US7375105B2 (en) | 2001-09-05 | 2008-05-20 | Smithkline Beecham P.L.C. | Pyridine substituted furan derivatives as Raf kinase inhibitors |
ES2275931T5 (es) * | 2001-12-03 | 2018-10-23 | Bayer Healthcare Llc | Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos |
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US10653684B2 (en) | 2002-02-11 | 2020-05-19 | Bayer Healthcare Llc | Aryl ureas with angiogenisis inhibiting activity |
CA2475818C (en) | 2002-02-11 | 2011-07-19 | Bayer Pharmaceuticals Corporation | Aryl ureas as kinase inhibitors |
WO2003068223A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
AU2003213806A1 (en) | 2002-02-25 | 2003-09-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
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US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
JP5229853B2 (ja) | 2003-02-28 | 2013-07-03 | ニッポネックス インコーポレイテッド | 癌その他の疾患の治療に有用な新規な二環尿素誘導体 |
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