NO319160B1 - Anvendelse av forbindelser som kan antagonisere den oncogeniske aktivitet av proteinet mdm2, anvendelse av en nukleinsyre som koder for slike forbindelser, en viral vektor, et farmasoytisk preparat, samt anvendelse av en nukleinsyresekvens som koder for intracellulaere antistoffer. - Google Patents
Anvendelse av forbindelser som kan antagonisere den oncogeniske aktivitet av proteinet mdm2, anvendelse av en nukleinsyre som koder for slike forbindelser, en viral vektor, et farmasoytisk preparat, samt anvendelse av en nukleinsyresekvens som koder for intracellulaere antistoffer. Download PDFInfo
- Publication number
- NO319160B1 NO319160B1 NO19980905A NO980905A NO319160B1 NO 319160 B1 NO319160 B1 NO 319160B1 NO 19980905 A NO19980905 A NO 19980905A NO 980905 A NO980905 A NO 980905A NO 319160 B1 NO319160 B1 NO 319160B1
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- mdm2
- protein
- nucleic acid
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- protein mdm2
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- C07K14/4702—Regulators; Modulating activity
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- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N2799/00—Uses of viruses
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- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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- Plant Pathology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9510331A FR2738151B1 (fr) | 1995-09-04 | 1995-09-04 | Antagonistes de l'activite oncogenique de la proteine mdm2, et leur utilisation dans le traitement des cancers |
| PCT/FR1996/001340 WO1997009343A2 (fr) | 1995-09-04 | 1996-09-02 | Antagonistes de l'activite oncogenique de la proteine mdm2, et leur utilisation dans le traitement des cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO980905D0 NO980905D0 (no) | 1998-03-02 |
| NO980905L NO980905L (no) | 1998-03-02 |
| NO319160B1 true NO319160B1 (no) | 2005-06-27 |
Family
ID=9482234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19980905A NO319160B1 (no) | 1995-09-04 | 1998-03-02 | Anvendelse av forbindelser som kan antagonisere den oncogeniske aktivitet av proteinet mdm2, anvendelse av en nukleinsyre som koder for slike forbindelser, en viral vektor, et farmasoytisk preparat, samt anvendelse av en nukleinsyresekvens som koder for intracellulaere antistoffer. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20030060432A1 (ja) |
| EP (1) | EP0848720B1 (ja) |
| JP (2) | JPH11511980A (ja) |
| KR (1) | KR100592916B1 (ja) |
| AT (1) | ATE257711T1 (ja) |
| AU (1) | AU722782B2 (ja) |
| BR (1) | BR9610386A (ja) |
| CA (1) | CA2228667C (ja) |
| CZ (1) | CZ298806B6 (ja) |
| DE (1) | DE69631335T2 (ja) |
| DK (1) | DK0848720T3 (ja) |
| ES (1) | ES2210386T3 (ja) |
| FR (1) | FR2738151B1 (ja) |
| HU (1) | HU223597B1 (ja) |
| IL (1) | IL123514A (ja) |
| NO (1) | NO319160B1 (ja) |
| PT (1) | PT848720E (ja) |
| SK (1) | SK287127B6 (ja) |
| WO (1) | WO1997009343A2 (ja) |
| ZA (1) | ZA967451B (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9620028D0 (en) | 1996-09-26 | 1996-11-13 | Ludwig Inst Cancer Res | Factors which interact with oncoproteins |
| US6013786A (en) * | 1997-08-22 | 2000-01-11 | Hybridon, Inc. | MDM2-specific antisense oligonucleotides |
| US6238921B1 (en) | 1998-03-26 | 2001-05-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of human mdm2 expression |
| EP0947494A1 (en) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and phenoxymethyltetrazole having antitumor activity |
| GB9819860D0 (en) | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
| DE10109813A1 (de) * | 2001-03-01 | 2002-09-12 | Thomas Stanislawski | Tumor-Peptidantigen aus humanem mdm2 Proto-Onkogen |
| CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| WO2009009587A2 (en) * | 2007-07-09 | 2009-01-15 | Board Of Regents Of The University Of Nebraska | Apoptosis-modulating protein therapy for proliferative disorders and nanoparticles containing the same |
| WO2011098262A2 (en) | 2010-02-09 | 2011-08-18 | Universität Bremen | P19arf, hmga2 and mdm2 for use in the diagnosis and treatment of aberrant cell growth |
| RU2615143C2 (ru) | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
| WO2012021876A2 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| ES2817877T3 (es) | 2012-02-15 | 2021-04-08 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| JP6526563B2 (ja) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス，インコーポレイテッド | 二置換アミノ酸ならびにその調製および使用の方法 |
| EP3079707A4 (en) | 2013-12-02 | 2017-10-18 | RXi Pharmaceuticals Corporation | Immunotherapy of cancer |
| CA2947270A1 (en) * | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic acids targeting mdm2 or mycn |
| SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| BR112017005736A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e formulações dos mesmos |
| CA2979847A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108368161A (zh) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
| JP2019522633A (ja) | 2016-05-20 | 2019-08-15 | ジェネンテック， インコーポレイテッド | Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法 |
| US20210032364A1 (en) | 2017-07-27 | 2021-02-04 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| AU2019427766A1 (en) * | 2019-01-30 | 2021-09-16 | Nomocan Pharmaceuticals Llc | Antibodies to M(H)DM2/4 and their use in diagnosing and treating cancer |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411860A (en) * | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
| JP3399948B2 (ja) * | 1992-06-26 | 2003-04-28 | ザ トラスティーズ オブ プリンストン ユニバーシティ | Ｐ９０抗体またはプローブを用いた前癌細胞または癌細胞の検出方法 |
| FR2706486B1 (fr) * | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
| US5770377A (en) * | 1994-07-20 | 1998-06-23 | University Of Dundee | Interruption of binding of MDM2 and P53 protein and therapeutic application thereof |
-
1995
- 1995-09-04 FR FR9510331A patent/FR2738151B1/fr not_active Expired - Fee Related
-
1996
- 1996-09-02 ES ES96930195T patent/ES2210386T3/es not_active Expired - Lifetime
- 1996-09-02 AU AU69334/96A patent/AU722782B2/en not_active Ceased
- 1996-09-02 IL IL123514A patent/IL123514A/en not_active IP Right Cessation
- 1996-09-02 JP JP9510900A patent/JPH11511980A/ja not_active Withdrawn
- 1996-09-02 CZ CZ0063098A patent/CZ298806B6/cs not_active IP Right Cessation
- 1996-09-02 DE DE69631335T patent/DE69631335T2/de not_active Expired - Lifetime
- 1996-09-02 EP EP96930195A patent/EP0848720B1/fr not_active Expired - Lifetime
- 1996-09-02 BR BR9610386-8A patent/BR9610386A/pt active Search and Examination
- 1996-09-02 WO PCT/FR1996/001340 patent/WO1997009343A2/fr active IP Right Grant
- 1996-09-02 DK DK96930195T patent/DK0848720T3/da active
- 1996-09-02 AT AT96930195T patent/ATE257711T1/de active
- 1996-09-02 CA CA2228667A patent/CA2228667C/fr not_active Expired - Fee Related
- 1996-09-02 KR KR1019980701598A patent/KR100592916B1/ko not_active IP Right Cessation
- 1996-09-02 US US09/029,327 patent/US20030060432A1/en not_active Abandoned
- 1996-09-02 PT PT96930195T patent/PT848720E/pt unknown
- 1996-09-02 SK SK280-98A patent/SK287127B6/sk not_active IP Right Cessation
- 1996-09-02 HU HU9900406A patent/HU223597B1/hu not_active IP Right Cessation
- 1996-09-03 ZA ZA967451A patent/ZA967451B/xx unknown
-
1998
- 1998-03-02 NO NO19980905A patent/NO319160B1/no not_active IP Right Cessation
-
2003
- 2003-12-01 US US10/724,225 patent/US20040209834A1/en not_active Abandoned
-
2007
- 2007-01-10 US US11/651,486 patent/US20080311608A1/en not_active Abandoned
-
2011
- 2011-05-02 JP JP2011102826A patent/JP2011225571A/ja active Pending
-
2013
- 2013-03-15 US US13/835,524 patent/US20140030319A1/en not_active Abandoned
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