NO318759B1 - Forbindelse som spesifikt inhiberer faktor Xa-aktivitet, farmasoytisk preparat som inneholder forbindelsen, anvendelse av forbindelsen for fremstilling av et farmasoytisk preparat og anvendelse av forbindelsen som antikoagulant. - Google Patents
Forbindelse som spesifikt inhiberer faktor Xa-aktivitet, farmasoytisk preparat som inneholder forbindelsen, anvendelse av forbindelsen for fremstilling av et farmasoytisk preparat og anvendelse av forbindelsen som antikoagulant. Download PDFInfo
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- NO318759B1 NO318759B1 NO19964553A NO964553A NO318759B1 NO 318759 B1 NO318759 B1 NO 318759B1 NO 19964553 A NO19964553 A NO 19964553A NO 964553 A NO964553 A NO 964553A NO 318759 B1 NO318759 B1 NO 318759B1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0815—Tripeptides with the first amino acid being basic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23305494A | 1994-04-26 | 1994-04-26 | |
| PCT/US1995/005268 WO1995029189A1 (en) | 1994-04-26 | 1995-04-25 | FACTOR Xa INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964553D0 NO964553D0 (no) | 1996-10-25 |
| NO964553L NO964553L (no) | 1996-12-27 |
| NO318759B1 true NO318759B1 (no) | 2005-05-02 |
Family
ID=22875692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19964553A NO318759B1 (no) | 1994-04-26 | 1996-10-25 | Forbindelse som spesifikt inhiberer faktor Xa-aktivitet, farmasoytisk preparat som inneholder forbindelsen, anvendelse av forbindelsen for fremstilling av et farmasoytisk preparat og anvendelse av forbindelsen som antikoagulant. |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP0758341B1 (de) |
| JP (1) | JP3655632B2 (de) |
| KR (1) | KR100380124B1 (de) |
| CN (1) | CN1181091C (de) |
| AT (1) | ATE262536T1 (de) |
| AU (1) | AU707653B2 (de) |
| CA (1) | CA2186497C (de) |
| CZ (1) | CZ296439B6 (de) |
| DE (1) | DE69532754T2 (de) |
| DK (1) | DK0758341T3 (de) |
| EE (1) | EE03973B1 (de) |
| ES (1) | ES2214500T3 (de) |
| FI (1) | FI120494B (de) |
| HU (1) | HUT76346A (de) |
| IL (1) | IL113505A (de) |
| LT (1) | LT4218B (de) |
| LV (1) | LV11740B (de) |
| NO (1) | NO318759B1 (de) |
| NZ (1) | NZ284977A (de) |
| PL (1) | PL188132B1 (de) |
| PT (1) | PT758341E (de) |
| RU (1) | RU2152954C1 (de) |
| SI (1) | SI9520044B (de) |
| SK (1) | SK286094B6 (de) |
| TW (1) | TW409129B (de) |
| WO (1) | WO1995029189A1 (de) |
| ZA (1) | ZA953361B (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9607582A (pt) | 1995-02-17 | 1998-07-07 | Basf Ag | Composto e peptídeo ou substância peptidomimética |
| US5747458A (en) * | 1995-06-07 | 1998-05-05 | Chiron Corporation | Urokinase receptor ligands |
| US6069130A (en) * | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
| CN1087349C (zh) * | 1995-12-20 | 2002-07-10 | 阿温蒂斯药物公司 | N－乙酰基－(L)－4－氰基苯丙氨酸Ac-(L)-Phe(4－CN)－OH与N－乙酰基－(L)－对脒基苯丙氨酸－环己基甘氨酸－β－（3－N－甲基吡啶鎓）－丙氨酸AC－（L）－PAPh－chg－PaIMe(3)-NH2的新颖的制备方法 |
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| US4275153A (en) * | 1978-08-03 | 1981-06-23 | American Hospital Supply Corporation | Analytical fluorogenic substrates for proteolytic enzymes |
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| HU191961B (en) * | 1984-08-02 | 1987-04-28 | Richter Gedeon Vegyeszet | Process for producing 1,5 and 8 substituted peptides of angiotenzin-ii antagonistic activity |
| DE69321344D1 (de) * | 1992-02-14 | 1998-11-05 | Corvas Int Inc | Inhibitoren der thrombose |
-
1995
- 1995-04-25 AT AT95917736T patent/ATE262536T1/de not_active IP Right Cessation
- 1995-04-25 CN CNB951928112A patent/CN1181091C/zh not_active Expired - Fee Related
- 1995-04-25 EP EP95917736A patent/EP0758341B1/de not_active Expired - Lifetime
- 1995-04-25 KR KR1019960706004A patent/KR100380124B1/ko not_active IP Right Cessation
- 1995-04-25 DK DK95917736T patent/DK0758341T3/da active
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- 1995-04-25 CA CA002186497A patent/CA2186497C/en not_active Expired - Fee Related
- 1995-04-25 ZA ZA953361A patent/ZA953361B/xx unknown
- 1995-04-25 SK SK1366-96A patent/SK286094B6/sk not_active IP Right Cessation
- 1995-04-25 HU HU9602954A patent/HUT76346A/hu not_active Application Discontinuation
- 1995-04-25 WO PCT/US1995/005268 patent/WO1995029189A1/en active IP Right Grant
- 1995-04-25 RU RU96122647/04A patent/RU2152954C1/ru not_active IP Right Cessation
- 1995-04-25 ES ES95917736T patent/ES2214500T3/es not_active Expired - Lifetime
- 1995-04-25 SI SI9520044A patent/SI9520044B/sl not_active IP Right Cessation
- 1995-04-25 DE DE69532754T patent/DE69532754T2/de not_active Expired - Lifetime
- 1995-04-25 JP JP52785395A patent/JP3655632B2/ja not_active Expired - Fee Related
- 1995-04-25 EP EP03021617A patent/EP1384725A3/de not_active Withdrawn
- 1995-04-25 AU AU23683/95A patent/AU707653B2/en not_active Ceased
- 1995-04-25 EE EE9600146A patent/EE03973B1/xx not_active IP Right Cessation
- 1995-04-25 PT PT95917736T patent/PT758341E/pt unknown
- 1995-04-25 CZ CZ0314096A patent/CZ296439B6/cs not_active IP Right Cessation
- 1995-04-26 IL IL11350595A patent/IL113505A/xx not_active IP Right Cessation
- 1995-05-11 TW TW084104681A patent/TW409129B/zh active
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- 1996-10-25 FI FI964317A patent/FI120494B/fi not_active IP Right Cessation
- 1996-10-25 NO NO19964553A patent/NO318759B1/no not_active IP Right Cessation
- 1996-10-25 LT LT96-151A patent/LT4218B/lt not_active IP Right Cessation
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