NO317888B1 - Arylalkanoylpyridaziner, fremgangsmate for fremstilling av forbindelsene, forbindelsene foranvendelse som legemidler, farmasoytiske preparater som inneholder dem, fremgangsmatefor fremstilling av preparatene, samt anvendelse av forbindelsene til fremstilling av legemidler - Google Patents
Arylalkanoylpyridaziner, fremgangsmate for fremstilling av forbindelsene, forbindelsene foranvendelse som legemidler, farmasoytiske preparater som inneholder dem, fremgangsmatefor fremstilling av preparatene, samt anvendelse av forbindelsene til fremstilling av legemidler Download PDFInfo
- Publication number
- NO317888B1 NO317888B1 NO20006412A NO20006412A NO317888B1 NO 317888 B1 NO317888 B1 NO 317888B1 NO 20006412 A NO20006412 A NO 20006412A NO 20006412 A NO20006412 A NO 20006412A NO 317888 B1 NO317888 B1 NO 317888B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- formula
- carboxamide
- ylcarbonyl
- methoxyphenyl
- Prior art date
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- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
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- 239000007921 spray Substances 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
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- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19826841A DE19826841A1 (de) | 1998-06-16 | 1998-06-16 | Arylalkanoylpyridazine |
| PCT/EP1999/003151 WO1999065880A1 (de) | 1998-06-16 | 1999-05-07 | Arylalkanoylpyridazine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20006412L NO20006412L (no) | 2000-12-15 |
| NO20006412D0 NO20006412D0 (no) | 2000-12-15 |
| NO317888B1 true NO317888B1 (no) | 2004-12-27 |
Family
ID=7871071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006412A NO317888B1 (no) | 1998-06-16 | 2000-12-15 | Arylalkanoylpyridaziner, fremgangsmate for fremstilling av forbindelsene, forbindelsene foranvendelse som legemidler, farmasoytiske preparater som inneholder dem, fremgangsmatefor fremstilling av preparatene, samt anvendelse av forbindelsene til fremstilling av legemidler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6417188B1 (id) |
| EP (1) | EP1087946B1 (id) |
| JP (1) | JP4137378B2 (id) |
| KR (1) | KR100673638B1 (id) |
| CN (1) | CN1168720C (id) |
| AR (1) | AR019676A1 (id) |
| AU (1) | AU750019B2 (id) |
| BR (1) | BR9911177A (id) |
| CA (1) | CA2335104C (id) |
| CZ (1) | CZ298805B6 (id) |
| DE (2) | DE19826841A1 (id) |
| ES (1) | ES2277444T3 (id) |
| HU (1) | HUP0102215A3 (id) |
| ID (1) | ID27735A (id) |
| NO (1) | NO317888B1 (id) |
| PL (1) | PL344796A1 (id) |
| SK (1) | SK287362B6 (id) |
| TW (1) | TW515795B (id) |
| WO (1) | WO1999065880A1 (id) |
| ZA (1) | ZA200100418B (id) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19915364A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Verwendung von Arylalkanoylpyridazinen |
| DE19932315A1 (de) * | 1999-07-10 | 2001-01-11 | Merck Patent Gmbh | Benzoylpyridazine |
| FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| DE10064997A1 (de) * | 2000-12-23 | 2002-06-27 | Merck Patent Gmbh | Benzoylpyridazine |
| KR20040012720A (ko) * | 2001-02-12 | 2004-02-11 | 메르크 파텐트 게엠베하 | 심근 질환에서 제 4형 포스포디에스테라제 저해제의 용도 |
| HUP0401984A3 (en) * | 2001-10-31 | 2005-06-28 | Merck Patent Gmbh | Use of type 4 phosphodiesterase inhibitors for preparation of pharmaceutical compositions and combination with other active ingredients |
| ATE335486T1 (de) | 2001-11-05 | 2006-09-15 | Merck Patent Gmbh | Hydrazono-malonitrile |
| DE10224888A1 (de) * | 2002-06-05 | 2003-12-24 | Merck Patent Gmbh | Pyridazinderivate |
| DE10225574A1 (de) * | 2002-06-10 | 2003-12-18 | Merck Patent Gmbh | Aryloxime |
| KR100878737B1 (ko) | 2003-08-29 | 2009-01-14 | 미쓰이 가가쿠 가부시키가이샤 | 농업용 또는 원예용 살충제 및 그의 이용 방법 |
| NZ548793A (en) * | 2004-01-28 | 2009-12-24 | Mitsui Chemicals Inc | Amide derivatives, process for preparation thereof and use thereof as insecticide |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| FR2953836B1 (fr) | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
-
1998
- 1998-06-16 DE DE19826841A patent/DE19826841A1/de not_active Withdrawn
-
1999
- 1999-05-07 SK SK1893-2000A patent/SK287362B6/sk not_active IP Right Cessation
- 1999-05-07 CN CNB998074187A patent/CN1168720C/zh not_active Expired - Fee Related
- 1999-05-07 KR KR1020007013328A patent/KR100673638B1/ko not_active IP Right Cessation
- 1999-05-07 CZ CZ20004632A patent/CZ298805B6/cs not_active IP Right Cessation
- 1999-05-07 ID IDW20010080A patent/ID27735A/id unknown
- 1999-05-07 AU AU42590/99A patent/AU750019B2/en not_active Ceased
- 1999-05-07 DE DE59914151T patent/DE59914151D1/de not_active Expired - Lifetime
- 1999-05-07 WO PCT/EP1999/003151 patent/WO1999065880A1/de active IP Right Grant
- 1999-05-07 HU HU0102215A patent/HUP0102215A3/hu unknown
- 1999-05-07 BR BR9911177-2A patent/BR9911177A/pt not_active IP Right Cessation
- 1999-05-07 PL PL99344796A patent/PL344796A1/xx unknown
- 1999-05-07 EP EP99939760A patent/EP1087946B1/de not_active Expired - Lifetime
- 1999-05-07 US US09/719,467 patent/US6417188B1/en not_active Expired - Fee Related
- 1999-05-07 ES ES99939760T patent/ES2277444T3/es not_active Expired - Lifetime
- 1999-05-07 JP JP2000554707A patent/JP4137378B2/ja not_active Expired - Fee Related
- 1999-05-07 CA CA002335104A patent/CA2335104C/en not_active Expired - Fee Related
- 1999-06-14 TW TW088109913A patent/TW515795B/zh not_active IP Right Cessation
- 1999-06-16 AR ARP990102875A patent/AR019676A1/es not_active Application Discontinuation
-
2000
- 2000-12-15 NO NO20006412A patent/NO317888B1/no not_active IP Right Cessation
-
2001
- 2001-01-15 ZA ZA200100418A patent/ZA200100418B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20006412L (no) | 2000-12-15 |
| DE59914151D1 (en) | 2007-02-22 |
| SK18932000A3 (sk) | 2001-06-11 |
| CA2335104A1 (en) | 1999-12-23 |
| BR9911177A (pt) | 2001-03-13 |
| ES2277444T3 (es) | 2007-07-01 |
| AU750019B2 (en) | 2002-07-11 |
| NO20006412D0 (no) | 2000-12-15 |
| KR100673638B1 (ko) | 2007-01-23 |
| HUP0102215A3 (en) | 2002-05-28 |
| US6417188B1 (en) | 2002-07-09 |
| JP4137378B2 (ja) | 2008-08-20 |
| DE19826841A1 (de) | 1999-12-23 |
| WO1999065880A1 (de) | 1999-12-23 |
| AR019676A1 (es) | 2002-03-13 |
| ID27735A (id) | 2001-04-26 |
| TW515795B (en) | 2003-01-01 |
| HUP0102215A2 (hu) | 2002-03-28 |
| CN1168720C (zh) | 2004-09-29 |
| KR20010043858A (ko) | 2001-05-25 |
| EP1087946B1 (de) | 2007-01-10 |
| PL344796A1 (en) | 2001-11-19 |
| CZ298805B6 (cs) | 2008-02-06 |
| CN1305465A (zh) | 2001-07-25 |
| AU4259099A (en) | 2000-01-05 |
| CA2335104C (en) | 2008-03-11 |
| EP1087946A1 (de) | 2001-04-04 |
| CZ20004632A3 (cs) | 2001-04-11 |
| SK287362B6 (sk) | 2010-08-09 |
| ZA200100418B (en) | 2002-05-07 |
| JP2002518377A (ja) | 2002-06-25 |
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