NO316311B1 - Liposomsuspensjoner som blod-poolbilde kontrastmidler og fremgangsmåte forfremstilling av samme - Google Patents
Liposomsuspensjoner som blod-poolbilde kontrastmidler og fremgangsmåte forfremstilling av samme Download PDFInfo
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- NO316311B1 NO316311B1 NO19964501A NO964501A NO316311B1 NO 316311 B1 NO316311 B1 NO 316311B1 NO 19964501 A NO19964501 A NO 19964501A NO 964501 A NO964501 A NO 964501A NO 316311 B1 NO316311 B1 NO 316311B1
- Authority
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- Norway
- Prior art keywords
- vesicles
- contrast agent
- blood pool
- blood
- liposomes
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- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229950002407 iodecimol Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229960004359 iodixanol Drugs 0.000 description 1
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 description 1
- 229960001025 iohexol Drugs 0.000 description 1
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 1
- 229960000824 iopentol Drugs 0.000 description 1
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 description 1
- 229960002603 iopromide Drugs 0.000 description 1
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 1
- 229950011065 iosimide Drugs 0.000 description 1
- 229950011097 iotasul Drugs 0.000 description 1
- 229960003182 iotrolan Drugs 0.000 description 1
- 229960004537 ioversol Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000001865 kupffer cell Anatomy 0.000 description 1
- 229910052747 lanthanoid Inorganic materials 0.000 description 1
- 150000002602 lanthanoids Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000002405 nuclear magnetic resonance imaging agent Substances 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000011146 organic particle Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 150000008103 phosphatidic acids Chemical class 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- VIFBVOSDYUIKIK-UHFFFAOYSA-J sodium;gadolinium(3+);2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate Chemical compound [Na+].[Gd+3].[O-]C(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 VIFBVOSDYUIKIK-UHFFFAOYSA-J 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003611 tocopherol derivatives Chemical class 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 230000007332 vesicle formation Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95810123 | 1995-02-24 | ||
| PCT/IB1996/000137 WO1996025955A1 (en) | 1995-02-24 | 1996-02-22 | Liposome suspensions as blood pool imaging contrast agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964501D0 NO964501D0 (no) | 1996-10-23 |
| NO964501L NO964501L (no) | 1996-12-10 |
| NO316311B1 true NO316311B1 (no) | 2004-01-12 |
Family
ID=8221706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19964501A NO316311B1 (no) | 1995-02-24 | 1996-10-23 | Liposomsuspensjoner som blod-poolbilde kontrastmidler og fremgangsmåte forfremstilling av samme |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0759785B1 (fi) |
| JP (1) | JPH10500999A (fi) |
| AT (1) | ATE207763T1 (fi) |
| AU (1) | AU4546996A (fi) |
| CA (1) | CA2187427A1 (fi) |
| DE (1) | DE69616453T2 (fi) |
| DK (1) | DK0759785T3 (fi) |
| ES (1) | ES2165971T3 (fi) |
| FI (1) | FI964250A0 (fi) |
| IL (1) | IL117248A (fi) |
| NO (1) | NO316311B1 (fi) |
| WO (1) | WO1996025955A1 (fi) |
| ZA (1) | ZA961485B (fi) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624918D0 (en) * | 1996-11-29 | 1997-01-15 | Nycomed Imaging As | Particulate components |
| KR100824068B1 (ko) * | 2000-04-28 | 2008-04-21 | 후지필름 홀딩스 가부시끼가이샤 | 소수성 요오드 화합물을 함유하는 리포솜 |
| EP2286843A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| ITMI20011706A1 (it) * | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic |
| US8518373B2 (en) | 2001-08-03 | 2013-08-27 | Bracco Imaging Spa | Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics |
| JP2008513533A (ja) * | 2004-09-23 | 2008-05-01 | ゲルベ | Ｃｅｓｔイメージング用の造影剤封入システム |
| WO2007129311A2 (en) * | 2006-05-04 | 2007-11-15 | Pan Sci Tech S.A. | Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct |
| FR2939318B1 (fr) * | 2008-12-10 | 2012-07-13 | Guerbet Sa | Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2 |
| WO2019010418A1 (en) | 2017-07-07 | 2019-01-10 | Drexel University | THERAPEUTIC, DIAGNOSTIC AND / OR THERANOSTIC CONSTRUCTS ACTIVATED BY VOLTAGE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| CH672733A5 (fi) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
| IS1685B (is) * | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
| DE69527194T2 (de) * | 1994-03-28 | 2003-02-06 | Daiichi Pharmaceutical Co., Ltd. | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
-
1996
- 1996-02-22 ES ES96901481T patent/ES2165971T3/es not_active Expired - Lifetime
- 1996-02-22 EP EP96901481A patent/EP0759785B1/en not_active Expired - Lifetime
- 1996-02-22 AU AU45469/96A patent/AU4546996A/en not_active Abandoned
- 1996-02-22 WO PCT/IB1996/000137 patent/WO1996025955A1/en active IP Right Grant
- 1996-02-22 AT AT96901481T patent/ATE207763T1/de not_active IP Right Cessation
- 1996-02-22 JP JP8525530A patent/JPH10500999A/ja not_active Ceased
- 1996-02-22 DK DK96901481T patent/DK0759785T3/da active
- 1996-02-22 CA CA002187427A patent/CA2187427A1/en not_active Abandoned
- 1996-02-22 DE DE69616453T patent/DE69616453T2/de not_active Expired - Lifetime
- 1996-02-23 IL IL11724896A patent/IL117248A/xx not_active IP Right Cessation
- 1996-02-23 ZA ZA961485A patent/ZA961485B/xx unknown
- 1996-10-22 FI FI964250A patent/FI964250A0/fi unknown
- 1996-10-23 NO NO19964501A patent/NO316311B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10500999A (ja) | 1998-01-27 |
| FI964250A (fi) | 1996-10-22 |
| EP0759785B1 (en) | 2001-10-31 |
| IL117248A (en) | 2000-06-29 |
| ES2165971T3 (es) | 2002-04-01 |
| EP0759785A1 (en) | 1997-03-05 |
| ZA961485B (en) | 1996-08-28 |
| NO964501L (no) | 1996-12-10 |
| IL117248A0 (en) | 1996-06-18 |
| AU4546996A (en) | 1996-09-11 |
| ATE207763T1 (de) | 2001-11-15 |
| DE69616453T2 (de) | 2002-07-11 |
| CA2187427A1 (en) | 1996-08-29 |
| DK0759785T3 (da) | 2002-02-18 |
| FI964250A0 (fi) | 1996-10-22 |
| DE69616453D1 (de) | 2001-12-06 |
| WO1996025955A1 (en) | 1996-08-29 |
| NO964501D0 (no) | 1996-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |