NO315705B1 - Baktericid/permeabilitetsökende protein eller et fragment derav, DNA som koder for dette, autonomt replikerende DNA-vektor, vertscelle,fremgangsmåte for fremstilling av dette, hybrid fusjonsprotein, farmasöytiskpreparat, polypeptid for medisin - Google Patents
Baktericid/permeabilitetsökende protein eller et fragment derav, DNA som koder for dette, autonomt replikerende DNA-vektor, vertscelle,fremgangsmåte for fremstilling av dette, hybrid fusjonsprotein, farmasöytiskpreparat, polypeptid for medisin Download PDFInfo
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- NO315705B1 NO315705B1 NO19953033A NO953033A NO315705B1 NO 315705 B1 NO315705 B1 NO 315705B1 NO 19953033 A NO19953033 A NO 19953033A NO 953033 A NO953033 A NO 953033A NO 315705 B1 NO315705 B1 NO 315705B1
- Authority
- NO
- Norway
- Prior art keywords
- rbpi
- bactericidal
- dna
- fragment
- permeability
- Prior art date
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- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/013,801 US5420019A (en) | 1993-02-02 | 1993-02-02 | Stable bactericidal/permeability-increasing protein muteins |
| PCT/US1994/001235 WO1994018323A1 (en) | 1993-02-02 | 1994-02-02 | Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO953033D0 NO953033D0 (no) | 1995-08-01 |
| NO953033L NO953033L (no) | 1995-10-02 |
| NO315705B1 true NO315705B1 (no) | 2003-10-13 |
Family
ID=21761817
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19953033A NO315705B1 (no) | 1993-02-02 | 1995-08-01 | Baktericid/permeabilitetsökende protein eller et fragment derav, DNA som koder for dette, autonomt replikerende DNA-vektor, vertscelle,fremgangsmåte for fremstilling av dette, hybrid fusjonsprotein, farmasöytiskpreparat, polypeptid for medisin |
| NO20023224A NO319156B1 (no) | 1993-02-02 | 2002-07-03 | DNA som koder for et biologisk aktivt fragment av baktericid/permeabilitetsokende protein, fremgangsmate for fremstilling av dette, samt farmasoytisk preparat inneholdende dette og isolert, biologisk aktivt fragment av baktericid/permeabilitetsokende protein. |
| NO20050998A NO20050998D0 (no) | 1993-02-02 | 2005-02-24 | DNA som koder for et biologisk aktivt fragment av baktericid/premeabilitetsokende protein fremgangsmate for fremstilling av dette, samt farmasoytisk preparat inneholdende dette |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023224A NO319156B1 (no) | 1993-02-02 | 2002-07-03 | DNA som koder for et biologisk aktivt fragment av baktericid/permeabilitetsokende protein, fremgangsmate for fremstilling av dette, samt farmasoytisk preparat inneholdende dette og isolert, biologisk aktivt fragment av baktericid/permeabilitetsokende protein. |
| NO20050998A NO20050998D0 (no) | 1993-02-02 | 2005-02-24 | DNA som koder for et biologisk aktivt fragment av baktericid/premeabilitetsokende protein fremgangsmate for fremstilling av dette, samt farmasoytisk preparat inneholdende dette |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US5420019A (de) |
| EP (3) | EP0689592B1 (de) |
| JP (4) | JP4139867B2 (de) |
| KR (1) | KR100361997B1 (de) |
| CN (1) | CN1142996C (de) |
| AT (3) | ATE230797T1 (de) |
| AU (1) | AU693089B2 (de) |
| CA (1) | CA2155004C (de) |
| DE (3) | DE69431995T2 (de) |
| DK (2) | DK1310558T3 (de) |
| ES (2) | ES2288199T3 (de) |
| FI (2) | FI112367B (de) |
| GR (1) | GR3034492T3 (de) |
| HK (1) | HK1014548A1 (de) |
| NO (3) | NO315705B1 (de) |
| NZ (1) | NZ262284A (de) |
| PT (2) | PT689592E (de) |
| WO (1) | WO1994018323A1 (de) |
| ZA (1) | ZA94703B (de) |
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| US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
| US6265187B1 (en) * | 1989-02-14 | 2001-07-24 | Incyte Pharmaceuticals, Inc. | Recombinant endotoxin-neutralizing proteins |
| US5840836A (en) * | 1989-02-17 | 1998-11-24 | Bayer Corporation | Pancreatic islet cell antigens obtained by molecular cloning |
| US6811989B1 (en) * | 1989-02-17 | 2004-11-02 | Bayer Corporation | Pancreatic islet cell antigens obtained by molecular cloning |
| US5643570A (en) * | 1992-05-19 | 1997-07-01 | Xoma Corporation | BPI-immunoglobulin fusion proteins |
| US6274348B1 (en) | 1992-05-19 | 2001-08-14 | Xoma Corporation | Methods for the preparation of positively charged proteins |
| US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| US6214789B1 (en) | 1993-03-12 | 2001-04-10 | Xoma Corporation | Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products |
| NZ263057A (en) * | 1993-03-12 | 2000-12-22 | Xoma Corp | Use of bactericidal permeability increasing proteins or derivative for treating chronic inflammatory diseases, neutralising heparin, inhibiting angiogenesis, tumour and epithelial cell proliferation |
| US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
| AU7175694A (en) * | 1993-06-17 | 1995-01-17 | Xoma Corporation | Lipopolysaccharide binding protein derivatives |
| US5770561A (en) * | 1993-07-14 | 1998-06-23 | Xoma Corporation | Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products |
| WO1995002414A1 (en) * | 1993-07-14 | 1995-01-26 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
| CN1133634A (zh) * | 1993-09-22 | 1996-10-16 | 爱克斯欧玛公司 | 定量体液中的bpi的方法 |
| ES2178656T3 (es) * | 1993-09-22 | 2003-01-01 | Xoma Technology Ltd | Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos. |
| US6759203B1 (en) | 1993-09-22 | 2004-07-06 | Xoma Corporation | Method for quantifying BPI in body fluids |
| JPH09508359A (ja) * | 1994-01-14 | 1997-08-26 | ゾーマ コーポレイション | 抗グラム陽性細菌学的方法および物質 |
| WO1995019179A1 (en) * | 1994-01-14 | 1995-07-20 | Xoma Corporation | Anti-fungal methods and materials |
| US5447913A (en) * | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
| US5786324A (en) * | 1994-03-24 | 1998-07-28 | Regents Of The University Of Minnesota | Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5830860A (en) * | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5578568A (en) * | 1994-04-22 | 1996-11-26 | Xoma Corporation | Method of treating conditions associated with intestinal ischemia/reperfusion |
| US5646114A (en) * | 1994-07-11 | 1997-07-08 | Xoma Corporation | Anti-protozoan methods |
| US6271203B1 (en) | 1994-07-07 | 2001-08-07 | Xoma Corporation | Anti-protozoan methods and materials |
| AU4230396A (en) * | 1994-11-08 | 1996-05-31 | Novagen, Inc. | Method for in vitro protein synthesis |
| US5494896A (en) * | 1995-03-31 | 1996-02-27 | Xoma Corporation | Method of treating conditions associated with burn injuries |
| WO1997004008A1 (en) * | 1995-07-20 | 1997-02-06 | Xoma Corporation | Anti-fungal peptides |
| JP2000501386A (ja) * | 1995-11-14 | 2000-02-08 | ゾーマ コーポレイション | 角膜損傷に関連する病態を処置するための、殺菌性／透過性増強（ｂｐｉ）タンパク質 |
| US5686414A (en) * | 1995-11-14 | 1997-11-11 | Xoma Corporation | Methods of treating conditions associated with corneal transplantation |
| US5856159A (en) * | 1996-03-27 | 1999-01-05 | Cytel Corporation | Production of galactosyltransferase |
| DK0914144T3 (da) | 1996-05-10 | 2001-04-09 | Univ Texas | Terapeutiske anvendelser af BPI-protein-produkter til human meningokokæmi |
| US5741779A (en) | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
| US5945399A (en) * | 1996-05-23 | 1999-08-31 | Xoma Corporation | Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma |
| WO1997044354A2 (en) | 1996-05-24 | 1997-11-27 | Regents Of The University Of Minnesota | Synthesis of soluble beta-sheet forming peptides |
| US5888973A (en) | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
| US6482796B2 (en) | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
| CN1062564C (zh) * | 1996-12-20 | 2001-02-28 | 周红 | 猪血中提纯杀菌性/通透性增加蛋白的方法 |
| CA2278924A1 (en) * | 1997-01-24 | 1998-07-30 | Avi Biopharma, Inc. | Method and conjugate for treating h. pylori infection |
| US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
| FR2767323B1 (fr) * | 1997-08-12 | 2001-01-05 | Synt Em | Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives |
| US6013631A (en) * | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
| US6156514A (en) | 1998-12-03 | 2000-12-05 | Sunol Molecular Corporation | Methods for making recombinant cells |
| US6242219B1 (en) | 1999-03-18 | 2001-06-05 | Xoma (Us) Llc | Methods for recombinant peptide production |
| US6153584A (en) * | 1999-04-01 | 2000-11-28 | Levy; Ofer | Therapeutic uses of BPI protein products in BPI-deficient humans |
| US7041644B2 (en) * | 1999-04-01 | 2006-05-09 | Xoma Technology | Therapeutic uses of BPI protein products in BPI-deficient humans |
| WO2001025254A2 (en) | 1999-10-04 | 2001-04-12 | University Of Maryland Biotechnology Institute | Novel adjuvant comprising a lipopolysaccharide antagonist |
| WO2002055099A2 (en) * | 2000-12-01 | 2002-07-18 | Xoma Technology Ltd | Modulation of pericyte proliferation using bpi protein products or bpi inhibitors |
| US20030049616A1 (en) * | 2001-01-08 | 2003-03-13 | Sydney Brenner | Enzymatic synthesis of oligonucleotide tags |
| AU2002248557A1 (en) * | 2001-03-05 | 2002-09-19 | Transtech Pharma, Inc. | High level insect expression of rage proteins |
| WO2003070751A2 (en) | 2002-02-20 | 2003-08-28 | Regents Of The University Of Minnesota | Partial peptide mimetics and methods |
| PL376821A1 (pl) * | 2002-03-27 | 2006-01-09 | Immunex Corporation | Sposoby zwiększania produkcji polipeptydów |
| JP4554370B2 (ja) | 2002-03-29 | 2010-09-29 | ゾーマ テクノロジー リミテッド | 多重遺伝子プラスミドおよび組み換えポリペプチドの発現増加法 |
| US7906722B2 (en) * | 2005-04-19 | 2011-03-15 | Palo Alto Research Center Incorporated | Concentrating solar collector with solid optical element |
| EP1741440A1 (de) | 2005-07-08 | 2007-01-10 | Mellitus S.L. | Verwendung von BPI-proteine zur Behandlung von stoffwechselbedingten Erkrankungen und Herzkreislaufstörungen |
| PT2592148T (pt) | 2007-10-12 | 2018-11-12 | Hoffmann La Roche | Expressão proteica de múltiplos ácidos nucleicos |
| CN108042807B (zh) | 2011-04-05 | 2020-10-16 | 达纳-法伯癌症研究所有限公司 | 作为辐射缓和剂和辐射防护剂的bpi和其同源物的用途 |
| GB201319621D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Antimicrobial agents and their use in therapy |
| GB201319620D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Immunosuppressive agents and their use in therapy |
| CN110402253B (zh) | 2017-03-10 | 2024-01-05 | 豪夫迈·罗氏有限公司 | 用于生产多特异性抗体的方法 |
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| US4853332A (en) * | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
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| AU9127591A (en) * | 1990-12-03 | 1992-06-25 | New York University | Biologically active bactericidal/permeability-increasing protein fragments |
| JPH07502642A (ja) * | 1991-09-26 | 1995-03-23 | インサイト ファーマシューティカルズ，インコーポレイテッド | 新規な形態のリポ糖結合性タンパク質（ｌｂｐ） |
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| PT682524E (pt) * | 1993-02-02 | 2002-03-28 | Xoma Technology Ltd | Composicoes farmaceuticas que contem a proteina bactericida indutora da permeabilidade e um agente tensioactivo |
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| NZ263057A (en) * | 1993-03-12 | 2000-12-22 | Xoma Corp | Use of bactericidal permeability increasing proteins or derivative for treating chronic inflammatory diseases, neutralising heparin, inhibiting angiogenesis, tumour and epithelial cell proliferation |
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-
1993
- 1993-02-02 US US08/013,801 patent/US5420019A/en not_active Expired - Lifetime
-
1994
- 1994-02-02 DE DE69431995T patent/DE69431995T2/de not_active Expired - Fee Related
- 1994-02-02 DE DE69434980T patent/DE69434980T2/de not_active Expired - Fee Related
- 1994-02-02 EP EP94908704A patent/EP0689592B1/de not_active Expired - Lifetime
- 1994-02-02 DE DE69426019T patent/DE69426019T2/de not_active Expired - Lifetime
- 1994-02-02 AT AT00103901T patent/ATE230797T1/de not_active IP Right Cessation
- 1994-02-02 AT AT03000252T patent/ATE363535T1/de not_active IP Right Cessation
- 1994-02-02 PT PT94908704T patent/PT689592E/pt unknown
- 1994-02-02 ES ES03000252T patent/ES2288199T3/es not_active Expired - Lifetime
- 1994-02-02 CN CNB941916723A patent/CN1142996C/zh not_active Expired - Fee Related
- 1994-02-02 CA CA2155004A patent/CA2155004C/en not_active Expired - Fee Related
- 1994-02-02 DK DK03000252T patent/DK1310558T3/da active
- 1994-02-02 JP JP51821094A patent/JP4139867B2/ja not_active Expired - Fee Related
- 1994-02-02 KR KR1019950703197A patent/KR100361997B1/ko not_active IP Right Cessation
- 1994-02-02 AT AT94908704T patent/ATE196650T1/de not_active IP Right Cessation
- 1994-02-02 EP EP03000252A patent/EP1310558B1/de not_active Expired - Lifetime
- 1994-02-02 DK DK94908704T patent/DK0689592T3/da active
- 1994-02-02 WO PCT/US1994/001235 patent/WO1994018323A1/en active IP Right Grant
- 1994-02-02 ZA ZA94703A patent/ZA94703B/xx unknown
- 1994-02-02 AU AU61702/94A patent/AU693089B2/en not_active Ceased
- 1994-02-02 PT PT03000252T patent/PT1310558E/pt unknown
- 1994-02-02 NZ NZ262284A patent/NZ262284A/en not_active IP Right Cessation
- 1994-02-02 ES ES94908704T patent/ES2150983T3/es not_active Expired - Lifetime
- 1994-02-02 EP EP00103901A patent/EP1013760B1/de not_active Expired - Lifetime
-
1995
- 1995-04-28 US US08/430,417 patent/US5674834A/en not_active Expired - Lifetime
- 1995-06-06 US US08/466,822 patent/US5827816A/en not_active Expired - Lifetime
- 1995-08-01 FI FI953658A patent/FI112367B/fi active
- 1995-08-01 NO NO19953033A patent/NO315705B1/no not_active IP Right Cessation
-
1998
- 1998-12-28 HK HK98115811A patent/HK1014548A1/xx not_active IP Right Cessation
-
1999
- 1999-10-19 US US09/425,034 patent/US6433140B1/en not_active Expired - Fee Related
-
2000
- 2000-09-28 GR GR20000402074T patent/GR3034492T3/el not_active IP Right Cessation
-
2002
- 2002-07-03 NO NO20023224A patent/NO319156B1/no unknown
- 2002-07-16 US US10/196,460 patent/US6828418B2/en not_active Expired - Fee Related
-
2003
- 2003-08-26 FI FI20031199A patent/FI115633B/fi active IP Right Grant
- 2003-10-15 JP JP2003355706A patent/JP2004024276A/ja not_active Withdrawn
-
2004
- 2004-03-31 JP JP2004108131A patent/JP2004254697A/ja not_active Withdrawn
- 2004-11-03 US US10/980,722 patent/US20060009383A1/en not_active Abandoned
-
2005
- 2005-02-24 NO NO20050998A patent/NO20050998D0/no not_active Application Discontinuation
-
2006
- 2006-07-26 JP JP2006204005A patent/JP2006321813A/ja not_active Withdrawn
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