NO314932B1 - Nye metallkomplekser, deres anvendelse for fremstilling av midler for diagnostikk og fremgangsmåter for fremstilling av kompleksene - Google Patents
Nye metallkomplekser, deres anvendelse for fremstilling av midler for diagnostikk og fremgangsmåter for fremstilling av kompleksene Download PDFInfo
- Publication number
- NO314932B1 NO314932B1 NO19973846A NO973846A NO314932B1 NO 314932 B1 NO314932 B1 NO 314932B1 NO 19973846 A NO19973846 A NO 19973846A NO 973846 A NO973846 A NO 973846A NO 314932 B1 NO314932 B1 NO 314932B1
- Authority
- NO
- Norway
- Prior art keywords
- bis
- complex
- ethyl
- amino
- phenyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 14
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- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 16
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- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
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- 210000004185 liver Anatomy 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000006239 protecting group Chemical group 0.000 claims description 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
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- VBJZVLUMGGDVMO-UHFFFAOYSA-N hafnium atom Chemical compound [Hf] VBJZVLUMGGDVMO-UHFFFAOYSA-N 0.000 claims description 8
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- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 claims description 6
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N monoethanolamine hydrochloride Natural products NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 5
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052689 Holmium Inorganic materials 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
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- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 3
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- QUGJYNGNUBHTNS-UHFFFAOYSA-N ethyl 2-(benzhydrylideneamino)acetate Chemical compound C=1C=CC=CC=1C(=NCC(=O)OCC)C1=CC=CC=C1 QUGJYNGNUBHTNS-UHFFFAOYSA-N 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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- 229910003451 terbium oxide Inorganic materials 0.000 description 1
- SCRZPWWVSXWCMC-UHFFFAOYSA-N terbium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[Tb+3].[Tb+3] SCRZPWWVSXWCMC-UHFFFAOYSA-N 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19507820A DE19507820A1 (de) | 1995-02-21 | 1995-02-21 | Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
PCT/EP1996/000734 WO1996026180A1 (de) | 1995-02-21 | 1996-02-21 | Neuartig substituierte dtpa-derivate, deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie, sowie verfahren zur herstellung der komplexe und mittel |
Publications (3)
Publication Number | Publication Date |
---|---|
NO973846D0 NO973846D0 (no) | 1997-08-21 |
NO973846L NO973846L (no) | 1997-08-21 |
NO314932B1 true NO314932B1 (no) | 2003-06-16 |
Family
ID=7755787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19973846A NO314932B1 (no) | 1995-02-21 | 1997-08-21 | Nye metallkomplekser, deres anvendelse for fremstilling av midler for diagnostikk og fremgangsmåter for fremstilling av kompleksene |
Country Status (14)
Country | Link |
---|---|
US (2) | US6040432A (ja) |
EP (1) | EP0810989B1 (ja) |
JP (1) | JPH11501012A (ja) |
AT (1) | ATE182879T1 (ja) |
AU (1) | AU4718596A (ja) |
CA (1) | CA2213454A1 (ja) |
DE (2) | DE19507820A1 (ja) |
DK (1) | DK0810989T3 (ja) |
ES (1) | ES2136976T3 (ja) |
GR (1) | GR3031612T3 (ja) |
IL (1) | IL117199A0 (ja) |
NO (1) | NO314932B1 (ja) |
WO (1) | WO1996026180A1 (ja) |
ZA (1) | ZA961395B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19641197C2 (de) * | 1996-09-24 | 1999-02-18 | Schering Ag | Ionenpaare und ihre Verwendung als Kontrastmittel |
DE19646762B4 (de) * | 1996-11-04 | 2004-05-13 | Schering Ag | Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren |
US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
AU2005280455A1 (en) * | 2004-08-26 | 2006-03-09 | Mallinckrodt Inc. | Luminescent metal complexes for monitoring renal function |
US7431311B2 (en) * | 2005-01-27 | 2008-10-07 | Michael Hughesdon Turner | Combination scooter/backpack |
JP5064761B2 (ja) * | 2005-12-21 | 2012-10-31 | 富士フイルム株式会社 | ジエチレントリアミン型金属キレート構造を有する高級脂肪酸トリエステル及びアミド誘導体 |
WO2011046007A1 (ja) * | 2009-10-15 | 2011-04-21 | 国立大学法人徳島大学 | ジエチレントリアミン五酢酸誘導体の製造方法およびジエチレントリアミン五酢酸誘導体 |
EP2567702A1 (en) | 2011-09-12 | 2013-03-13 | Johannes-Gutenberg-Universität Mainz | A particulate system comprising lanthanides for use in diminishing cell growth/inducing cell killing |
US20130195756A1 (en) * | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
BR102013023479B1 (pt) * | 2013-09-12 | 2022-07-26 | Uniao Brasileira De Educação E Assistência | Processo de síntese de compostos de coordenação à base de lantanídeo |
GB201919073D0 (en) * | 2019-12-20 | 2020-02-05 | Ge Healthcare As | Novel manufacturing process |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
GB8413772D0 (en) * | 1984-05-30 | 1984-07-04 | Nyegaard & Co As | Chemical compounds |
US4687659A (en) * | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
US5250285A (en) * | 1985-05-08 | 1993-10-05 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
EP0529645B1 (en) * | 1986-09-05 | 1996-10-23 | GANSOW, Otto A. | Process for the preparation of backbone polysubstituted chelates |
IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
IT1224416B (it) * | 1987-12-24 | 1990-10-04 | Bracco Ind Chimica Spa | Chelanti macrociclici e loro chelati |
ATE137228T1 (de) * | 1987-07-16 | 1996-05-15 | Nycomed Imaging As | Aminocarbonsäure und derivate |
GB9007965D0 (en) * | 1990-04-09 | 1990-06-06 | Nycomed As | Compounds |
DE3927444A1 (de) * | 1989-08-16 | 1991-02-28 | Schering Ag | Verwendung von amid-komplexverbindungen |
WO1989006980A1 (en) * | 1988-01-29 | 1989-08-10 | University Of Queensland | Radiopharmaceuticals |
US4889931A (en) * | 1988-09-27 | 1989-12-26 | Salutar, Inc. | Manganese (II) chelate manufacture |
NZ231180A (en) * | 1988-10-31 | 1994-11-25 | Dow Chemical Co | Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof |
GB8900732D0 (en) * | 1989-01-13 | 1989-03-08 | Nycomed As | Agents |
US5395608A (en) * | 1989-04-26 | 1995-03-07 | The Curators Of The University Of Missouri | Triamine chelants, their derivatives, complexes and conjugates |
US5334729A (en) * | 1989-06-29 | 1994-08-02 | Associated Universities, Inc. | Stable radiometal antibody immunoconjugates |
DE3922005A1 (de) * | 1989-06-30 | 1991-01-10 | Schering Ag | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5124471A (en) * | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5274082A (en) * | 1990-04-10 | 1993-12-28 | Nihon Medi-Physics Co., Ltd. | Paramagnetic complexes of chelating compounds |
US5077037A (en) * | 1990-08-03 | 1991-12-31 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
US5162109A (en) * | 1990-09-13 | 1992-11-10 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
US5141740A (en) * | 1990-11-21 | 1992-08-25 | Mallinckrodt Medical, Inc. | Complexes and compositions for magnetic resonance imaging and usage methods |
GB9027922D0 (en) * | 1990-12-21 | 1991-02-13 | Nycomed As | Compounds |
DE4107570A1 (de) * | 1991-03-07 | 1992-11-19 | Diagnostikforschung Inst | Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie |
AU660013B2 (en) * | 1991-03-27 | 1995-06-08 | Nycomed Salutar, Inc. | Contrast media |
US5208375A (en) * | 1991-07-02 | 1993-05-04 | Mallinckrodt Medical, Inc. | Compositions for magnetic resonance imaging |
DE4136489A1 (de) * | 1991-11-06 | 1993-05-13 | Bayer Ag | Neue diethylentriamin-derivate und deren verwendung zu diagnostischen und therapeutischen zwecken |
ES2108269T5 (es) * | 1992-07-03 | 2001-09-01 | Welfide Corp | Nuevo agente quelante, compuesto complejo constituido por dicho agente y un atomo metalico, y agente de diagnostico que contiene dicho compuesto. |
DK6993D0 (da) * | 1993-01-20 | 1993-01-20 | Aminkemi Ab | Fremgangsmaade til fremstilling af jernholdige oploesninger |
DE4302287A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung |
DE19508058A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel |
-
1995
- 1995-02-21 DE DE19507820A patent/DE19507820A1/de not_active Withdrawn
- 1995-06-07 US US08/488,287 patent/US6040432A/en not_active Expired - Fee Related
-
1996
- 1996-02-20 IL IL11719996A patent/IL117199A0/xx unknown
- 1996-02-21 DE DE59602626T patent/DE59602626D1/de not_active Expired - Lifetime
- 1996-02-21 ZA ZA961395A patent/ZA961395B/xx unknown
- 1996-02-21 EP EP96902992A patent/EP0810989B1/de not_active Expired - Lifetime
- 1996-02-21 AT AT96902992T patent/ATE182879T1/de not_active IP Right Cessation
- 1996-02-21 AU AU47185/96A patent/AU4718596A/en not_active Abandoned
- 1996-02-21 DK DK96902992T patent/DK0810989T3/da active
- 1996-02-21 WO PCT/EP1996/000734 patent/WO1996026180A1/de active IP Right Grant
- 1996-02-21 JP JP8525403A patent/JPH11501012A/ja not_active Ceased
- 1996-02-21 ES ES96902992T patent/ES2136976T3/es not_active Expired - Lifetime
- 1996-02-21 CA CA002213454A patent/CA2213454A1/en not_active Abandoned
-
1997
- 1997-08-21 NO NO19973846A patent/NO314932B1/no unknown
-
1999
- 1999-10-25 GR GR990402710T patent/GR3031612T3/el unknown
-
2000
- 2000-01-10 US US09/480,153 patent/US6254850B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0810989T3 (da) | 2000-02-21 |
JPH11501012A (ja) | 1999-01-26 |
WO1996026180A1 (de) | 1996-08-29 |
DE19507820A1 (de) | 1996-08-22 |
CA2213454A1 (en) | 1996-08-29 |
DE59602626D1 (de) | 1999-09-09 |
GR3031612T3 (en) | 2000-01-31 |
NO973846D0 (no) | 1997-08-21 |
IL117199A0 (en) | 1996-06-18 |
US6254850B1 (en) | 2001-07-03 |
ATE182879T1 (de) | 1999-08-15 |
NO973846L (no) | 1997-08-21 |
AU4718596A (en) | 1996-09-11 |
ES2136976T3 (es) | 1999-12-01 |
ZA961395B (en) | 1996-08-26 |
EP0810989B1 (de) | 1999-08-04 |
US6040432A (en) | 2000-03-21 |
EP0810989A1 (de) | 1997-12-10 |
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