NO314534B1 - Anvendelse av sterolderivater til fremstilling av et preparat for regulering av meiose, forbindelser for anvendelse som terapeutika ogfremgangsmåte for regulering av meiose i en pattedyrkjönnscelle in vitro - Google Patents
Anvendelse av sterolderivater til fremstilling av et preparat for regulering av meiose, forbindelser for anvendelse som terapeutika ogfremgangsmåte for regulering av meiose i en pattedyrkjönnscelle in vitro Download PDFInfo
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- NO314534B1 NO314534B1 NO19965516A NO965516A NO314534B1 NO 314534 B1 NO314534 B1 NO 314534B1 NO 19965516 A NO19965516 A NO 19965516A NO 965516 A NO965516 A NO 965516A NO 314534 B1 NO314534 B1 NO 314534B1
- Authority
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- Norway
- Prior art keywords
- use according
- carbon atoms
- hydrogen
- meiosis
- attached
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- 229910010084 LiAlH4 Inorganic materials 0.000 description 1
- 208000007466 Male Infertility Diseases 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
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- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 229910020489 SiO3 Inorganic materials 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
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- DDIPOTFOPZLXDX-JKSOKBOYSA-N [(10s,13r,14r,17r)-15-hydroxy-4,4,10,13-tetramethyl-17-[(2r)-6-methylheptan-2-yl]-1,2,3,5,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-yl] benzoate Chemical compound C([C@]1(C)C2=C(CCC1C1(C)C)[C@@H]3C(O)C[C@@H]([C@]3(CC2)C)[C@H](C)CCCC(C)C)CC1OC(=O)C1=CC=CC=C1 DDIPOTFOPZLXDX-JKSOKBOYSA-N 0.000 description 1
- MAECKNFQQCZMJC-CCTRLIJASA-N [(10s,13r,14r,17r)-4,4,10,13-tetramethyl-17-[(2r)-6-methylheptan-2-yl]-1,2,3,5,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-yl] benzoate Chemical compound C([C@]1(C)C2=C(CCC1C1(C)C)[C@@H]3CC[C@@H]([C@]3(CC2)C)[C@H](C)CCCC(C)C)CC1OC(=O)C1=CC=CC=C1 MAECKNFQQCZMJC-CCTRLIJASA-N 0.000 description 1
- ZHGNFAXKDDMBSG-KHYKQYHXSA-N [(10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2r)-6-methylheptan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-yl] acetate Chemical compound C([C@@]12C)CC(OC(C)=O)C(C)(C)C1CCC1=C2CC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC=C21 ZHGNFAXKDDMBSG-KHYKQYHXSA-N 0.000 description 1
- NNIVXCLYMRREHT-PKGYEJRXSA-N [(10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2r)-6-methylheptan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate Chemical compound C([C@]1(C)C2=C(CCC1C1(C)C)C3=CC[C@@H]([C@]3(CC2)C)[C@H](C)CCCC(C)C)CC1OC(=O)C1=CC=CC=C1 NNIVXCLYMRREHT-PKGYEJRXSA-N 0.000 description 1
- PUIDLBOGPALAES-WZKVZTQXSA-N [(8r,9r,10s,13r,14r,17r)-8,10,13,14-tetramethyl-17-[(2r)-6-methylhepta-4,6-dien-2-yl]-2,3,4,5,6,7,9,11,12,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] acetate Chemical compound C1CC(OC(C)=O)CC2CC[C@@]3(C)[C@]4(C)CC[C@H]([C@@H](CC=CC(C)=C)C)[C@@]4(C)CC[C@@H]3[C@]21C PUIDLBOGPALAES-WZKVZTQXSA-N 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- 125000003277 amino group Chemical group 0.000 description 1
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- SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 description 1
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- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
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- 229910021641 deionized water Inorganic materials 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940124566 female contraceptive agent Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000002710 gonadal effect Effects 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- 210000002503 granulosa cell Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- BNTRVUUJBGBGLZ-UHFFFAOYSA-N hydron;pyridine-4-carbonyl chloride;chloride Chemical compound Cl.ClC(=O)C1=CC=NC=C1 BNTRVUUJBGBGLZ-UHFFFAOYSA-N 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000002394 ovarian follicle Anatomy 0.000 description 1
- 230000000624 ovulatory effect Effects 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
- 229940074439 potassium sodium tartrate Drugs 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000002191 proton-decoupled nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- HBEFYGYBMKPNSZ-UHFFFAOYSA-N s-phenyl chloromethanethioate Chemical compound ClC(=O)SC1=CC=CC=C1 HBEFYGYBMKPNSZ-UHFFFAOYSA-N 0.000 description 1
- 238000011894 semi-preparative HPLC Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000014639 sexual reproduction Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 125000002328 sterol group Chemical group 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000012485 toluene extract Substances 0.000 description 1
- 238000001551 total correlation spectroscopy Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000004104 two-dimensional total correlation spectroscopy Methods 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/001—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class spiro-linked
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK75394 | 1994-06-23 | ||
| DK24195 | 1995-03-09 | ||
| PCT/DK1995/000265 WO1996000235A1 (en) | 1994-06-23 | 1995-06-23 | Sterol derivatives used for regulation of meiosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO965516D0 NO965516D0 (no) | 1996-12-20 |
| NO965516L NO965516L (no) | 1997-02-21 |
| NO314534B1 true NO314534B1 (no) | 2003-04-07 |
Family
ID=26063596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19965516A NO314534B1 (no) | 1994-06-23 | 1996-12-20 | Anvendelse av sterolderivater til fremstilling av et preparat for regulering av meiose, forbindelser for anvendelse som terapeutika ogfremgangsmåte for regulering av meiose i en pattedyrkjönnscelle in vitro |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5716777A (cs) |
| EP (1) | EP0767798B1 (cs) |
| JP (1) | JP3987105B2 (cs) |
| KR (1) | KR100408369B1 (cs) |
| CN (1) | CN1068333C (cs) |
| AT (1) | ATE248852T1 (cs) |
| AU (1) | AU694240B2 (cs) |
| BG (1) | BG101067A (cs) |
| BR (1) | BR9508074A (cs) |
| CA (1) | CA2192941C (cs) |
| CZ (1) | CZ289407B6 (cs) |
| DE (1) | DE69531682T2 (cs) |
| DK (1) | DK0767798T3 (cs) |
| ES (1) | ES2204955T3 (cs) |
| FI (1) | FI117159B (cs) |
| HU (1) | HUT76343A (cs) |
| IL (1) | IL114294A (cs) |
| IS (1) | IS4404A (cs) |
| MX (1) | MX9700174A (cs) |
| NO (1) | NO314534B1 (cs) |
| PL (1) | PL186688B1 (cs) |
| RU (1) | RU2194510C2 (cs) |
| SI (1) | SI9520077A (cs) |
| SK (1) | SK165596A3 (cs) |
| UA (1) | UA51622C2 (cs) |
| WO (1) | WO1996000235A1 (cs) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2214126A1 (en) * | 1995-03-06 | 1996-09-12 | Novo Nordisk A/S | Stimulation of meiosis |
| US6645953B2 (en) * | 1995-06-23 | 2003-11-11 | Novo Nordisk A/S | Meiosis regulating compounds |
| AU6122696A (en) * | 1995-06-23 | 1997-01-22 | Novo Nordisk A/S | Meiosis regulating compounds |
| CN1191543A (zh) * | 1995-06-23 | 1998-08-26 | 诺沃挪第克公司 | 减数分裂调控化合物 |
| JP2001506656A (ja) * | 1996-12-20 | 2001-05-22 | ノボ ノルディスク アクティーゼルスカブ | 減数分裂調節化合物 |
| US6177420B1 (en) * | 1997-05-16 | 2001-01-23 | Akzo Nobel N.V. | 20-aralkyl-5α-pregnane derivatives |
| JP2002502404A (ja) * | 1997-06-04 | 2002-01-22 | アクゾ・ノベル・エヌ・ベー | 減数分裂の調節のための１７β−アリルオキシ（チオ）アルキル−アンドロスタン誘導体 |
| EP1042353B1 (en) * | 1997-12-18 | 2002-07-17 | Akzo Nobel N.V. | 17beta-aryl (arylmethyl) oxy(thio)alkyl -androstane derivatives |
| AU3701199A (en) * | 1998-05-13 | 1999-11-29 | Novo Nordisk A/S | Meiosis regulating compounds |
| IL139241A0 (en) | 1998-05-13 | 2001-11-25 | Novo Nordisk As | Meiosis regulating compounds |
| AU5408999A (en) * | 1998-05-26 | 1999-12-13 | Schering Aktiengesellschaft | Treatment of infertility with camp-increasing compounds alone or in combination with at least one meiosis-stimulating compound |
| EP1087988A1 (en) * | 1998-06-19 | 2001-04-04 | Novo Nordisk A/S | Meiosis regulating compounds |
| CA2352337A1 (en) * | 1998-12-11 | 2000-06-22 | Akzo Nobel Nv | 22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity |
| WO2000036132A1 (en) * | 1998-12-14 | 2000-06-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| HUP0200280A2 (hu) * | 1999-02-10 | 2002-07-29 | Schering Ag. | Telítetlen kolesztánszármazékok és ezeket tartalmazó gyógyászati készítmények |
| AU2794000A (en) * | 1999-02-24 | 2000-09-14 | Novo Nordisk A/S | Treatment of infertility |
| CZ20012967A3 (cs) * | 1999-02-24 | 2001-12-12 | Novo Nordisk A/S | Léčení neplodnosti |
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| DE60000978T2 (de) * | 1999-03-09 | 2003-07-17 | Akzo Nobel N.V., Arnheim/Arnhem | 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose |
| ES2252048T3 (es) * | 1999-09-16 | 2006-05-16 | Novo Nordisk A/S | Composicion para fiv. |
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| WO2001062260A2 (en) * | 2000-02-25 | 2001-08-30 | Schering Aktiengesellschaft | Improvement of implantation rate |
| WO2001062258A2 (en) * | 2000-02-25 | 2001-08-30 | Schering Aktiengesellschaft | Improvement of implantation rate using ff-mas |
| MXPA02011271A (es) * | 2000-05-18 | 2003-04-25 | Schering Ag | Fertilizacion de oocitos envejecidos. |
| EP1245572A1 (en) | 2001-03-26 | 2002-10-02 | Schering Aktiengesellschaft | Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation |
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| EA024619B1 (ru) * | 2014-11-21 | 2016-10-31 | Эльвин Гаджи оглы Керимли | ФРАКСИНОСТЕРИН - 24β-ЭТИЛХОЛЕСТА-20-КАРБОКСИ-6(7),8(9)-ДИЕН 3β-ОЛА И ЕГО ПРОИЗВОДНОЕ |
-
1995
- 1995-05-23 US US08/448,217 patent/US5716777A/en not_active Expired - Fee Related
- 1995-06-23 SK SK1655-96A patent/SK165596A3/sk unknown
- 1995-06-23 MX MX9700174A patent/MX9700174A/es not_active IP Right Cessation
- 1995-06-23 CA CA002192941A patent/CA2192941C/en not_active Expired - Fee Related
- 1995-06-23 RU RU97101087/14A patent/RU2194510C2/ru not_active IP Right Cessation
- 1995-06-23 KR KR1019960707361A patent/KR100408369B1/ko not_active Expired - Fee Related
- 1995-06-23 HU HU9603584A patent/HUT76343A/hu not_active Application Discontinuation
- 1995-06-23 SI SI9520077A patent/SI9520077A/sl unknown
- 1995-06-23 BR BR9508074A patent/BR9508074A/pt not_active IP Right Cessation
- 1995-06-23 JP JP50272496A patent/JP3987105B2/ja not_active Expired - Lifetime
- 1995-06-23 UA UA96124771A patent/UA51622C2/uk unknown
- 1995-06-23 EP EP95922448A patent/EP0767798B1/en not_active Expired - Lifetime
- 1995-06-23 AU AU27343/95A patent/AU694240B2/en not_active Ceased
- 1995-06-23 ES ES95922448T patent/ES2204955T3/es not_active Expired - Lifetime
- 1995-06-23 AT AT95922448T patent/ATE248852T1/de not_active IP Right Cessation
- 1995-06-23 WO PCT/DK1995/000265 patent/WO1996000235A1/en not_active Ceased
- 1995-06-23 DK DK95922448T patent/DK0767798T3/da active
- 1995-06-23 PL PL95317830A patent/PL186688B1/pl not_active IP Right Cessation
- 1995-06-23 CN CN95193731A patent/CN1068333C/zh not_active Expired - Fee Related
- 1995-06-23 CZ CZ19963725A patent/CZ289407B6/cs not_active IP Right Cessation
- 1995-06-23 IL IL11429495A patent/IL114294A/en not_active IP Right Cessation
- 1995-06-23 DE DE69531682T patent/DE69531682T2/de not_active Expired - Fee Related
-
1996
- 1996-12-18 BG BG101067A patent/BG101067A/xx unknown
- 1996-12-20 FI FI965144A patent/FI117159B/fi active IP Right Grant
- 1996-12-20 NO NO19965516A patent/NO314534B1/no unknown
- 1996-12-23 IS IS4404A patent/IS4404A/is unknown
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