FI117159B - Sterolijohdosten käyttö meioosin säätelyyn - Google Patents
Sterolijohdosten käyttö meioosin säätelyyn Download PDFInfo
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- FI117159B FI117159B FI965144A FI965144A FI117159B FI 117159 B FI117159 B FI 117159B FI 965144 A FI965144 A FI 965144A FI 965144 A FI965144 A FI 965144A FI 117159 B FI117159 B FI 117159B
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- 230000021121 meiosis Effects 0.000 title claims description 44
- 229930182558 Sterol Natural products 0.000 title abstract description 12
- 150000003432 sterols Chemical class 0.000 title abstract description 12
- 235000003702 sterols Nutrition 0.000 title abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 33
- 210000000287 oocyte Anatomy 0.000 claims description 28
- 125000004432 carbon atom Chemical group C* 0.000 claims description 27
- -1 sulpho group Chemical group 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 210000004602 germ cell Anatomy 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 241000282414 Homo sapiens Species 0.000 claims description 8
- 125000002252 acyl group Chemical group 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- CHGIKSSZNBCNDW-QGBOJXOESA-N 14-demethyllanosterol Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@@H](CCC=C(C)C)C)CC[C@H]21 CHGIKSSZNBCNDW-QGBOJXOESA-N 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 150000001721 carbon Chemical group 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical group 0.000 claims description 4
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 150000002431 hydrogen Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
- 125000004744 butyloxycarbonyl group Chemical group 0.000 claims description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 2
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 43
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- CGSJXLIKVBJVRY-XTGBIJOFSA-N zymosterol Chemical compound C([C@@]12C)C[C@H](O)C[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@@H](CCC=C(C)C)C)CC[C@H]21 CGSJXLIKVBJVRY-XTGBIJOFSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/001—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class spiro-linked
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK75394 | 1994-06-23 | ||
| DK75394 | 1994-06-23 | ||
| DK24195 | 1995-03-09 | ||
| DK24195 | 1995-03-09 | ||
| PCT/DK1995/000265 WO1996000235A1 (en) | 1994-06-23 | 1995-06-23 | Sterol derivatives used for regulation of meiosis |
| DK9500265 | 1995-06-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI965144A0 FI965144A0 (fi) | 1996-12-20 |
| FI965144L FI965144L (fi) | 1997-02-20 |
| FI117159B true FI117159B (fi) | 2006-07-14 |
Family
ID=26063596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI965144A FI117159B (fi) | 1994-06-23 | 1996-12-20 | Sterolijohdosten käyttö meioosin säätelyyn |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5716777A (cs) |
| EP (1) | EP0767798B1 (cs) |
| JP (1) | JP3987105B2 (cs) |
| KR (1) | KR100408369B1 (cs) |
| CN (1) | CN1068333C (cs) |
| AT (1) | ATE248852T1 (cs) |
| AU (1) | AU694240B2 (cs) |
| BG (1) | BG101067A (cs) |
| BR (1) | BR9508074A (cs) |
| CA (1) | CA2192941C (cs) |
| CZ (1) | CZ289407B6 (cs) |
| DE (1) | DE69531682T2 (cs) |
| DK (1) | DK0767798T3 (cs) |
| ES (1) | ES2204955T3 (cs) |
| FI (1) | FI117159B (cs) |
| HU (1) | HUT76343A (cs) |
| IL (1) | IL114294A (cs) |
| IS (1) | IS4404A (cs) |
| MX (1) | MX9700174A (cs) |
| NO (1) | NO314534B1 (cs) |
| PL (1) | PL186688B1 (cs) |
| RU (1) | RU2194510C2 (cs) |
| SI (1) | SI9520077A (cs) |
| SK (1) | SK165596A3 (cs) |
| UA (1) | UA51622C2 (cs) |
| WO (1) | WO1996000235A1 (cs) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ279797A3 (cs) * | 1995-03-06 | 1998-01-14 | Novo Nordisk A/S | Způsob stimulace miózy zárodečné buňky a použití sloučeniny, která způsobuje akumulaci látky aktivující endogenní miózu |
| US6645953B2 (en) * | 1995-06-23 | 2003-11-11 | Novo Nordisk A/S | Meiosis regulating compounds |
| WO1997000883A1 (en) * | 1995-06-23 | 1997-01-09 | Novo Nordisk A/S | Meiosis regulating compounds |
| ATE254628T1 (de) * | 1995-06-23 | 2003-12-15 | Novo Nordisk As | Meiose regulierende verbindungen. |
| ATE238339T1 (de) | 1996-12-20 | 2003-05-15 | Novo Nordisk As | Verbindungen zur regulierung der meiose |
| DE69809905T2 (de) * | 1997-05-16 | 2003-08-28 | Akzo Nobel N.V., Arnheim/Arnhem | 20-aralkyl-5,alpha,-pregnan derivate |
| CN1259138A (zh) * | 1997-06-04 | 2000-07-05 | 阿克佐诺贝尔公司 | 调节减数分裂的17β－烯丙氧基(硫代)烷基－雄甾烷衍生物 |
| ES2181321T3 (es) | 1997-12-18 | 2003-02-16 | Akzo Nobel Nv | Derivados 17beta-aril(arilmetil)oxi(tio)alquilandrostano. |
| ATE256144T1 (de) * | 1998-05-13 | 2003-12-15 | Novo Nordisk As | Verwendung von verbindungen mit der fähigkeit die meiose zu regulieren |
| IL139241A0 (en) * | 1998-05-13 | 2001-11-25 | Novo Nordisk As | Meiosis regulating compounds |
| AU5408999A (en) * | 1998-05-26 | 1999-12-13 | Schering Aktiengesellschaft | Treatment of infertility with camp-increasing compounds alone or in combination with at least one meiosis-stimulating compound |
| JP2003521444A (ja) * | 1998-06-19 | 2003-07-15 | ノボ ノルディスク アクティーゼルスカブ | 減数分裂調節化合物 |
| JP2002532511A (ja) * | 1998-12-11 | 2002-10-02 | アクゾ・ノベル・エヌ・ベー | 減数分裂調節活性を有する２２ｓ−ヒドロキシコレスタ−８，１４−ジエン誘導体 |
| AU3118200A (en) * | 1998-12-14 | 2000-07-03 | Merck & Co., Inc. | Hiv integrase inhibitors |
| KR20010101820A (ko) * | 1999-02-10 | 2001-11-14 | 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 | 불포화 콜레스탄 유도체 및 감수분열 조절 약제 제조에있어서 그의 용도 |
| DE60034662T2 (de) * | 1999-02-24 | 2008-01-03 | Novo Nordisk A/S | Behandlung von unfruchtbarkeit |
| EP1156822B1 (en) | 1999-02-24 | 2006-02-08 | Novo Nordisk A/S | Iin vitro method for synchronisation of oocyte maturation |
| MXPA01008657A (es) * | 1999-02-26 | 2003-06-24 | Novo Nordisk As | Aumento de la proporcion de implante por esterol que activa la meiosis. |
| JP2002539134A (ja) * | 1999-03-09 | 2002-11-19 | アクゾ・ノベル・エヌ・ベー | 減数分裂の阻害のための２２ｒ−ヒドロキシコレスタ−８，１４−ジエン誘導体 |
| CN1222319C (zh) * | 1999-09-16 | 2005-10-12 | 诺沃挪第克公司 | 用于体外受精的组合物 |
| EP1127890A1 (en) | 2000-02-22 | 2001-08-29 | Schering Aktiengesellschaft | Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments |
| AU3376501A (en) * | 2000-02-25 | 2001-09-03 | Novo Nordisk A/S | Improvement of implantation rate |
| EP1257279A2 (en) * | 2000-02-25 | 2002-11-20 | Schering Aktiengesellschaft | Improvement of implantation rate using ff-mas |
| MXPA02011271A (es) * | 2000-05-18 | 2003-04-25 | Schering Ag | Fertilizacion de oocitos envejecidos. |
| EP1245572A1 (en) | 2001-03-26 | 2002-10-02 | Schering Aktiengesellschaft | Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation |
| WO2003070766A2 (en) * | 2002-02-22 | 2003-08-28 | Novo Nordisk A/S | A transducer of mas signalling |
| US9376462B2 (en) | 2010-10-01 | 2016-06-28 | Indiana University Research And Technology Corporation | Process for preparing delta-7,9(11) steroids from Ganoderma lucidum and analogs thereof |
| US9165822B2 (en) | 2013-03-11 | 2015-10-20 | Taiwan Semiconductor Manufacturing Company, Ltd. | Semiconductor devices and methods of forming same |
| EA024619B1 (ru) * | 2014-11-21 | 2016-10-31 | Эльвин Гаджи оглы Керимли | ФРАКСИНОСТЕРИН - 24β-ЭТИЛХОЛЕСТА-20-КАРБОКСИ-6(7),8(9)-ДИЕН 3β-ОЛА И ЕГО ПРОИЗВОДНОЕ |
-
1995
- 1995-05-23 US US08/448,217 patent/US5716777A/en not_active Expired - Fee Related
- 1995-06-23 ES ES95922448T patent/ES2204955T3/es not_active Expired - Lifetime
- 1995-06-23 JP JP50272496A patent/JP3987105B2/ja not_active Expired - Lifetime
- 1995-06-23 DK DK95922448T patent/DK0767798T3/da active
- 1995-06-23 AU AU27343/95A patent/AU694240B2/en not_active Ceased
- 1995-06-23 PL PL95317830A patent/PL186688B1/pl not_active IP Right Cessation
- 1995-06-23 HU HU9603584A patent/HUT76343A/hu not_active Application Discontinuation
- 1995-06-23 AT AT95922448T patent/ATE248852T1/de not_active IP Right Cessation
- 1995-06-23 RU RU97101087/14A patent/RU2194510C2/ru not_active IP Right Cessation
- 1995-06-23 DE DE69531682T patent/DE69531682T2/de not_active Expired - Fee Related
- 1995-06-23 CA CA002192941A patent/CA2192941C/en not_active Expired - Fee Related
- 1995-06-23 WO PCT/DK1995/000265 patent/WO1996000235A1/en active IP Right Grant
- 1995-06-23 SI SI9520077A patent/SI9520077A/sl unknown
- 1995-06-23 MX MX9700174A patent/MX9700174A/es not_active IP Right Cessation
- 1995-06-23 CN CN95193731A patent/CN1068333C/zh not_active Expired - Fee Related
- 1995-06-23 BR BR9508074A patent/BR9508074A/pt not_active IP Right Cessation
- 1995-06-23 CZ CZ19963725A patent/CZ289407B6/cs not_active IP Right Cessation
- 1995-06-23 UA UA96124771A patent/UA51622C2/uk unknown
- 1995-06-23 IL IL11429495A patent/IL114294A/en not_active IP Right Cessation
- 1995-06-23 EP EP95922448A patent/EP0767798B1/en not_active Expired - Lifetime
- 1995-06-23 SK SK1655-96A patent/SK165596A3/sk unknown
- 1995-06-23 KR KR1019960707361A patent/KR100408369B1/ko not_active Expired - Fee Related
-
1996
- 1996-12-18 BG BG101067A patent/BG101067A/xx unknown
- 1996-12-20 NO NO19965516A patent/NO314534B1/no unknown
- 1996-12-20 FI FI965144A patent/FI117159B/fi active IP Right Grant
- 1996-12-23 IS IS4404A patent/IS4404A/is unknown
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