NO314082B1 - Trisykliske forbindelser som er anvendbare for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer - Google Patents
Trisykliske forbindelser som er anvendbare for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer Download PDFInfo
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- NO314082B1 NO314082B1 NO19974610A NO974610A NO314082B1 NO 314082 B1 NO314082 B1 NO 314082B1 NO 19974610 A NO19974610 A NO 19974610A NO 974610 A NO974610 A NO 974610A NO 314082 B1 NO314082 B1 NO 314082B1
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- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical class O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 1
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- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- GKJYPYQETZPQLS-ZDUSSCGKSA-N tert-butyl (2s)-2-(4-acetamidobutyl)piperazine-1-carboxylate Chemical compound CC(=O)NCCCC[C@H]1CNCCN1C(=O)OC(C)(C)C GKJYPYQETZPQLS-ZDUSSCGKSA-N 0.000 description 1
- QHOKENWFMZXSEU-UHFFFAOYSA-N tetrabutylazanium;nitrate Chemical compound [O-][N+]([O-])=O.CCCC[N+](CCCC)(CCCC)CCCC QHOKENWFMZXSEU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41832395A | 1995-04-07 | 1995-04-07 | |
| PCT/US1996/004172 WO1996031478A1 (en) | 1995-04-07 | 1996-04-03 | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO974610D0 NO974610D0 (no) | 1997-10-06 |
| NO974610L NO974610L (no) | 1997-12-08 |
| NO314082B1 true NO314082B1 (no) | 2003-01-27 |
Family
ID=23657636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19974610A NO314082B1 (no) | 1995-04-07 | 1997-10-06 | Trisykliske forbindelser som er anvendbare for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0819121B1 (cs) |
| JP (1) | JP3038017B2 (cs) |
| KR (1) | KR100329877B1 (cs) |
| AR (1) | AR003116A1 (cs) |
| AT (1) | ATE363472T1 (cs) |
| AU (1) | AU719990B2 (cs) |
| BR (1) | BR9604787A (cs) |
| CA (1) | CA2217499C (cs) |
| CZ (1) | CZ316597A3 (cs) |
| DE (1) | DE69637105T2 (cs) |
| ES (1) | ES2288302T3 (cs) |
| HU (1) | HUP9800456A3 (cs) |
| IL (1) | IL117798A (cs) |
| MX (1) | MX9707665A (cs) |
| NO (1) | NO314082B1 (cs) |
| NZ (1) | NZ306665A (cs) |
| PL (1) | PL322689A1 (cs) |
| SK (1) | SK135597A3 (cs) |
| TW (1) | TW462968B (cs) |
| WO (1) | WO1996031478A1 (cs) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| CN1326847C (zh) * | 1995-12-22 | 2007-07-18 | 先灵公司 | 三环酰胺类用于抑制g－蛋白功能及治疗增生疾病 |
| US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| US5767274A (en) * | 1996-06-28 | 1998-06-16 | Biomeasure, Incorporated | Prenyl transferase inhibitors |
| US5925757A (en) * | 1996-07-26 | 1999-07-20 | Schering Corporation | Method for preparing carboxamides |
| US6040305A (en) * | 1996-09-13 | 2000-03-21 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| BR9712035A (pt) * | 1996-09-13 | 1999-08-24 | Schering Corp | Compostos Úteis para inibi-Æo de transferase de prote¡na farnesila |
| US5945429A (en) * | 1996-09-13 | 1999-08-31 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| EP0927181A1 (en) * | 1996-09-13 | 1999-07-07 | Schering Corporation | Tricyclic compounds useful as fpt inhibitors |
| US5985879A (en) * | 1996-09-13 | 1999-11-16 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| KR20000036111A (ko) * | 1996-09-13 | 2000-06-26 | 둘락 노먼 씨. | 파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물 |
| US6030982A (en) * | 1996-09-13 | 2000-02-29 | Schering Corporationm | Compounds useful for inhibition of farnesyl protein transferase |
| US6071907A (en) * | 1996-09-13 | 2000-06-06 | Schering Corporation | Tricyclic compounds useful as FPT inhibitors |
| US5994364A (en) * | 1996-09-13 | 1999-11-30 | Schering Corporation | Tricyclic antitumor farnesyl protein transferase inhibitors |
| CA2266014A1 (en) * | 1996-09-13 | 1998-03-19 | Schering Corporation | Tricyclic compounds useful for inhibition of farnesyl protein transferase |
| CN1104427C (zh) * | 1996-09-13 | 2003-04-02 | 先灵公司 | 法呢基蛋白转移酶的三环抑制剂 |
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- 1996-04-03 EP EP96912469A patent/EP0819121B1/en not_active Expired - Lifetime
- 1996-04-03 SK SK1355-97A patent/SK135597A3/sk unknown
- 1996-04-03 DE DE69637105T patent/DE69637105T2/de not_active Expired - Lifetime
- 1996-04-03 PL PL96322689A patent/PL322689A1/xx unknown
- 1996-04-03 WO PCT/US1996/004172 patent/WO1996031478A1/en active IP Right Grant
- 1996-04-03 JP JP08530364A patent/JP3038017B2/ja not_active Expired - Fee Related
- 1996-04-03 AT AT96912469T patent/ATE363472T1/de not_active IP Right Cessation
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- 1996-04-03 KR KR1019970707063A patent/KR100329877B1/ko not_active IP Right Cessation
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| AR003116A1 (es) | 1998-07-08 |
| ATE363472T1 (de) | 2007-06-15 |
| DE69637105T2 (de) | 2008-04-24 |
| NO974610D0 (no) | 1997-10-06 |
| IL117798A0 (en) | 1996-08-04 |
| NO974610L (no) | 1997-12-08 |
| PL322689A1 (en) | 1998-02-16 |
| ES2288302T3 (es) | 2008-01-01 |
| AU719990B2 (en) | 2000-05-18 |
| HUP9800456A3 (en) | 2000-04-28 |
| BR9604787A (pt) | 1998-07-07 |
| NZ306665A (en) | 2000-01-28 |
| JPH10511981A (ja) | 1998-11-17 |
| AU5527996A (en) | 1996-10-23 |
| HUP9800456A2 (hu) | 1999-06-28 |
| SK135597A3 (en) | 1998-07-08 |
| TW462968B (en) | 2001-11-11 |
| EP0819121B1 (en) | 2007-05-30 |
| CZ316597A3 (cs) | 1998-03-18 |
| EP0819121A1 (en) | 1998-01-21 |
| CA2217499C (en) | 2004-03-30 |
| WO1996031478A1 (en) | 1996-10-10 |
| MX9707665A (es) | 1997-11-29 |
| JP3038017B2 (ja) | 2000-05-08 |
| CA2217499A1 (en) | 1996-10-10 |
| DE69637105D1 (de) | 2007-07-12 |
| KR100329877B1 (ko) | 2002-08-28 |
| IL117798A (en) | 2001-11-25 |
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